17,761 results match your criteria lower finland


Polygenic Score for Physical Activity Is Associated with Multiple Common Diseases.

Med Sci Sports Exerc 2021 Sep 20. Epub 2021 Sep 20.

Gerontology Research Center, Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, FINLAND Institute for Molecular Medicine Finland, HiLIFE, Helsinki, FINLAND Department of Public Health, University of Helsinki, Helsinki, FINLAND, University of Helsinki Broad Institute of MIT & Harvard, Cambridge, MA Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, FINLAND.

Introduction: Genetic pleiotropy, in which the same genes affect two or more traits, may partially explain the frequently observed associations between high physical activity (PA) and later reduced morbidity or mortality. This study investigated associations between PA polygenic risk scores (PRSs) and cardiometabolic diseases among the Finnish population.

Methods: PRSs for device-measured overall PA were adapted to a FinnGen study cohort of 218,792 individuals with genome-wide genotyping and extensive digital longitudinal health register data. Read More

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September 2021

Cost-Effectiveness Analysis of Seven Measures to Reduce Tail Biting Lesions in Fattening Pigs.

Front Vet Sci 2021 7;8:682330. Epub 2021 Sep 7.

Research Centre for Animal Welfare, University of Helsinki, Helsinki, Finland.

Tail biting is an important animal welfare issue in the pig sector. Studies have identified various risk factors which can lead to biting incidents and proposed mitigation measures. This study focused on the following seven key measures which have been identified to affect the risk of tail biting lesions: improvements in straw provision, housing ventilation, genetics, stocking density, herd health, provision of point-source enrichment objects, and adoption of early warning systems. Read More

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September 2021

Severe Asthma in a General Population Study: Prevalence and Clinical Characteristics.

J Asthma Allergy 2021 16;14:1105-1115. Epub 2021 Sep 16.

Krefting Research Centre, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.

Purpose: Current guidelines primarily use medication levels to distinguish severe asthma from other types of asthma. In addition, severe asthma must also be uncontrolled at high-intensity treatment or become uncontrolled if treatment level is decreased. To date, only a few studies have used this definition to investigate the prevalence and clinical characteristics of severe asthma in population-based samples. Read More

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September 2021

Analyses of child cardiometabolic phenotype following assisted reproductive technologies using a pragmatic trial emulation approach.

Nat Commun 2021 Sep 23;12(1):5613. Epub 2021 Sep 23.

Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology, and Research (A*STAR), Singapore, Singapore.

Assisted reproductive technologies (ART) are increasingly used, however little is known about the long-term health of ART-conceived offspring. Weak selection of comparison groups and poorly characterized mechanisms impede current understanding. In a prospective cohort (Growing Up in Singapore Towards healthy Outcomes; GUSTO; Clinical Trials ID: NCT01174875) including 83 ART-conceived and 1095 spontaneously-conceived singletons, we estimate effects of ART on anthropometry, blood pressure, serum metabolic biomarkers, and cord tissue DNA methylation by emulating a pragmatic trial supported by machine learning-based estimators. Read More

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September 2021

CMC is more than a measure of corticospinal tract integrity in acute stroke patients.

Neuroimage Clin 2021 Sep 2;32:102818. Epub 2021 Sep 2.

Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, P.O. Box 12200, 00760 AALTO, Espoo, Finland; Aalto NeuroImaging, Aalto University School of Science, P.O. Box 12200, 00760 AALTO, Espoo, Finland; Department of Neurology, Helsinki University Hospital and Clinical Neurosciences, Neurology, University of Helsinki, P.O. Box 340, 00029 HUS, Helsinki, Finland.

In healthy subjects, motor cortex activity and electromyographic (EMG) signals from contracting contralateral muscle show coherence in the beta (15-30 Hz) range. Corticomuscular coherence (CMC) is considered a sign of functional coupling between muscle and brain. Based on prior studies, CMC is altered in stroke, but functional significance of this finding has remained unclear. Read More

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September 2021

"The New State That We Are Building": Authoritarianism and System-Justification in an Illiberal Democracy.

Front Psychol 2021 6;12:703280. Epub 2021 Sep 6.

Department of Social and Organizational Psychology, University of Pécs, Pécs, Hungary.

The authoritarian personality is characterized by unquestionining obedience and respect to authority. System justification theory (SJT) argues that people are motivated to defend, bolster, and justify aspects of existing social, economic, and political systems. Commitment to the is also a key characteristic of the authoritarian personality. Read More

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September 2021

Diversity and transmission of Aleutian mink disease virus in feral and farmed American mink and native mustelids.

Virus Evol 2021 28;7(2):veab075. Epub 2021 Aug 28.

Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, Helsinki 00790, Finland.

Aleutian mink disease virus (AMDV), which causes Aleutian disease, is widely spread both in farmed mink and wild mustelids. However, only limited data are available on the role of wild animals in AMDV transmission and spread. Our aim was to shed light on AMDV transmission among wild mustelids and estimate the effect of intense farming practices on the virus circulation by studying AMDV prevalence and genetic diversity among wild mustelids in Poland. Read More

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Outcomes of surgery for extensive infective endocarditis.

J Card Surg 2021 Sep 21. Epub 2021 Sep 21.

Department of Cardiac Surgery, Heart and Lung Center, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.

Objective: Extensive infective endocarditis (EIE) involving the valve annulus or the intervalvular fibrous body (IFB) is a treatment challenge. We sought to clarify the outcomes of patients undergoing surgery for EIE.

Methods: We retrospectively reviewed all 197 consecutive patients who underwent an operation for infective endocarditis (IE) between 2005 and 2016 in the Helsinki University Hospital. Read More

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September 2021

Therapy outcome related to adalimumab trough levels in pediatric patients with inflammatory bowel disease.

Scand J Gastroenterol 2021 Sep 21:1-6. Epub 2021 Sep 21.

University of Helsinki, Children's Hospital, Helsinki, Finland.

Objectives: We evaluated the relationship between serum concentration and efficacy of adalimumab (ADA), an anti-tumor necrosis factor-alpha agent, in pediatric patients with inflammatory bowel disease (PIBD).

Materials And Methods: This retrospective cross-sectional study traced 75 patients with PIBD (Crohn's disease,  = 57) treated with ADA at two tertiary centers in Finland in 2012-2018. Drug levels and drug antibody titers were chart-reviewed, and the treatment continuation rate of ADA therapy was evaluated. Read More

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September 2021

The elephant in the family: Costs and benefits of elder siblings on younger offspring life-history trajectory in a matrilineal mammal.

J Anim Ecol 2021 Sep 20. Epub 2021 Sep 20.

Department of Biology, University of Turku, Turku, Finland.

Many mammals grow up with siblings, and interactions between them can influence offspring phenotype and fitness. Among these interactions, sibling competition between different-age offspring should lead to reproductive and survival costs on the younger sibling, while sibling cooperation should improve younger sibling's reproductive potential and survival. However, little is known about the consequences of sibling effects on younger offspring life-history trajectory, especially in long-lived mammals. Read More

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September 2021

Small-Quantity Lipid-Based Nutrient Supplements Increase Infants' Plasma Essential Fatty Acid Levels in Ghana and Malawi: A Secondary Outcome Analysis of the iLiNS-DYAD Randomized Trials.

J Nutr 2021 Sep 20. Epub 2021 Sep 20.

Institute for Global Nutrition, Department of Nutrition, University of California, Davis, CA, USA.

Introduction: Small-quantity lipid-based nutrient supplements (SQ-LNSs) may influence infants' plasma fatty acid (FA) profiles, which could be associated with short- and long-term outcomes.

Objectives: We aimed to determine the impact of SQ-LNS consumption on infants' plasma FA profiles in Ghana and Malawi.

Methods: Ghanaian (n = 1320) and Malawian (n = 1391) women ≤ 20 wk pregnant were assigned to consume daily: 60 mg iron and 400 µg folic acid until delivery (IFA group); or multiple micronutrients until 6 mo postpartum (MMN); or SQ-LNSs (∼7. Read More

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September 2021

The association between epigenetic clocks and physical functioning in older women: a three-year follow-up.

J Gerontol A Biol Sci Med Sci 2021 Sep 20. Epub 2021 Sep 20.

Faculty of Sport and Health Sciences, Gerontology Research Center (GEREC), University of Jyväskylä, Jyväskylä, Finland.

Background: Epigenetic clocks are composite markers developed to predict chronological age or mortality risk from DNA methylation (DNAm) data. The present study investigated the associations between four epigenetic clocks (Horvath's and Hannum's DNAmAge and DNAm GrimAge and PhenoAge) and physical functioning during a three-year follow-up.

Methods: We studied 63-76-year-old women (n = 413) from the Finnish Twin Study on Aging. Read More

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September 2021

Feasibility of T2 relaxation time in predicting the technical outcome of MR-guided high-intensity focused ultrasound treatment of uterine fibroids.

Int J Hyperthermia 2021 ;38(1):1384-1393

Department of Radiology, Turku University Hospital, Turku, Finland.

Purpose: The aim of this study was to assess the feasibility of T2 relaxation time in predicting the immediate technical outcome i.e., nonperfused volume ratio (NPVr) of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU) treatment of symptomatic uterine fibroids and to compare it with existing T2-weighted imaging methods (Funaki classification and scaled signal intensity, SSI). Read More

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January 2021

Purpuric Herpes Zoster of the Lower Limb Mistaken for Cutaneous Vasculitis: Four Cases.

Authors:
Nicolas Kluger

Int J Low Extrem Wounds 2021 Sep 20:15347346211044605. Epub 2021 Sep 20.

Helsinki University Hospital, Helsinki, Finland.

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September 2021

Sleepy drivers on a slippery road: A pilot study using a driving simulator.

J Sleep Res 2021 Sep 19:e13488. Epub 2021 Sep 19.

Department of Psychology, Stress Research Institute, Stockholm University, Stockholm, Sweden.

Sleepy drivers have problems with keeping the vehicle within the lines, and might often need to apply a sudden or hard corrective steering wheel movement. Such movements, if they occur while driving on a slippery road, might increase the risk of ending off road due to the unforgiving nature of slippery roads. We tested this hypothesis. Read More

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September 2021

Chlorhexidine and other alternatives for povidone-iodine in ophthalmic surgery: review of comparative studies.

J Cataract Refract Surg 2021 Jul 20. Epub 2021 Jul 20.

Hygeia Clinic, Gdańsk, Poland Helsinki Retina Research Group, University of Helsinki, Finland Northwestern University, Chicago, IL, USA.

Abstract: Povidone-iodine (PVI) is a universally accepted antiseptic agent used in ophthalmic surgery. Insufficient antisepsis in patients with self-reported allergies to iodine has led to devastating complications. The aim of this study was to review the current evidence for alternatives to PVI in ocular surgery. Read More

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Inflammatory biomarkers in very preterm infants during early intravenous paracetamol administration.

Early Hum Dev 2021 Sep 7;161:105464. Epub 2021 Sep 7.

PEDEGO Research Unit and MRC Oulu, University of Oulu, Oulu, Finland; Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland.

Background: Paracetamol promotes early closure of patent ductus arteriosus (PDA), and it may affect inflammation after preterm birth.

Objective: The aim of this study was to evaluate the association between paracetamol treatment and serum inflammatory biomarkers in very preterm infants with respiratory distress.

Study Design: The infants were randomly assigned to intravenous paracetamol or placebo during the first 4 days of life, and others received a lower dose of paracetamol unblinded. Read More

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September 2021

The clinical relevance of formal thought disorder in the early stages of psychosis: results from the PRONIA study.

Eur Arch Psychiatry Clin Neurosci 2021 Sep 17. Epub 2021 Sep 17.

Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University Munich, Nussbaumstr. 7, 80336, Munich, Germany.

Background: Formal thought disorder (FTD) has been associated with more severe illness courses and functional deficits in patients with psychotic disorders. However, it remains unclear whether the presence of FTD characterises a specific subgroup of patients showing more prominent illness severity, neurocognitive and functional impairments. This study aimed to identify stable and generalizable FTD-subgroups of patients with recent-onset psychosis (ROP) by applying a comprehensive data-driven clustering approach and to test the validity of these subgroups by assessing associations between this FTD-related stratification, social and occupational functioning, and neurocognition. Read More

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September 2021

Nursing students' competence profiles in gerontological nursing-A cross-sectional study.

Nurs Open 2021 Sep 17. Epub 2021 Sep 17.

Oulu UAS, Oulu, Finland.

Aim: The study aimed to describe and explain the self-assessed gerontological nursing competence levels of Finnish nursing students and factors relating to it.

Design: A cross-sectional study design, reported by The Strengthening the Reporting of Observational studies in Epidemiology guidelines.

Methods: Data were collected with the GeroNursingCom instrument, which features 53 items relating to 11 competence factors. Read More

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September 2021

The association of body mass index with quality of life and working ability: a Finnish population-based study.

Qual Life Res 2021 Sep 17. Epub 2021 Sep 17.

Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Purpose: The impact of obesity on quality of life (QoL) and working ability vary in different dimensions. This study investigated the association of obesity with QoL and working ability in Finnish adults. Comorbidities as associative factors were also characterised. Read More

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September 2021

Oestrogen therapy for postpartum depression: efficacy and adverse effects. A double-blind, randomized, placebo-controlled pilot study.

Nord J Psychiatry 2021 Sep 17:1-10. Epub 2021 Sep 17.

Department of Obstetrics and Gynaecology, Turku University Hospital, Turku, Finland.

Background: Postpartum depression (PPD) is detrimental to the mother and the family as a whole. Early initiation of appropriate treatment is important. The aim of this pilot study was to evaluate the efficacy and adverse effects of oestradiol treatment. Read More

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September 2021

Coffee, Atrial Fibrillation, and Circulating Ceramides in Patients with Chronic Heart Failure.

J Agric Food Chem 2021 Sep 17. Epub 2021 Sep 17.

Department of Cardiovascular Medicine, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan 20157, Italy.

Ceramides are sphingolipids that play roles as structural lipids and as second messengers in biological processes. Circulating ceramides are influenced by diet/food and predict major cardiovascular (CV) events, such as atrial fibrillation (AF). In 1227 patients with symptomatic chronic heart failure (HF), an association between diet and ceramides was found for coffee consumption of ≥3 cups and Cer(d18:1/24:0). Read More

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September 2021

Effectiveness of a Gamification Strategy to Prevent Childhood Obesity in Schools: A Cluster Controlled Trial.

Obesity (Silver Spring) 2021 Sep 17. Epub 2021 Sep 17.

Health Service & Population Research Department, Institute of Psychiatry, Psychology Neuroscience, King's College, London, UK.

Objective: The aim of this study was to examine the effectiveness of a school-based gamification strategy to prevent childhood obesity.

Methods: Schools were randomized in Santiago, Chile, between March and May 2018 to control or to receive a nutrition and physical activity intervention using a gamification strategy (i.e. Read More

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September 2021

Replacement of barley with oats and dehulled oats: Effects on milk production, enteric methane emissions, and energy utilization in dairy cows fed a grass silage-based diet.

J Dairy Sci 2021 Sep 13. Epub 2021 Sep 13.

Department of Agricultural Research for Northern Sweden, Swedish University of Agricultural Sciences, SE-901 83 Umeå, Sweden; Milk Production, Production Systems, Natural Resources Institute Finland (Luke), FI-31600 Jokioinen, Finland. Electronic address:

Sixteen Nordic Red dairy cows, at 80 ± 4.6 d in milk and with an average body weight of 624 ± 91.8 kg, were used in a replicated 4 × 4 Latin square design to investigate the effects of different concentrate supplements on milk production, enteric CH emissions, ruminal fermentation, digestibility, and energy utilization. Read More

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September 2021

Characterization of occlusal splint materials: CAD-CAM versus conventional resins.

J Mech Behav Biomed Mater 2021 Sep 7;124:104813. Epub 2021 Sep 7.

Turku Clinical Biomaterials Centre-TCBC, Institute of Dentistry, University of Turku, Turku, Finland.

Aim: The aim of this in vitro study was to assess the mechanical properties of five commercially available subtractive computer-aided design and computer-aided manufacturing (CAD-CAM) milled splint materials, as well as to compare them with conventional heat-polymerized and autopolymerizing resins used in the construction of conventional splints.

Material And Methods: Five CAD-CAM milled (ProArt CAD Splint, Therapon Transpa, Temp Premium Flexible Transpa, Cast, and Aqua), one autopolymerizing (Palapress), and one heat-polymerized (Paladon 65) resin materials were evaluated. Flexural strength, E-modulus, Vickers hardness, fracture toughness, fracture work, water sorption, and water solubility were measured. Read More

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September 2021

Immune cell profiles in the tumor microenvironment of early-onset, intermediate-onset, and later-onset colorectal cancer.

Cancer Immunol Immunother 2021 Sep 16. Epub 2021 Sep 16.

Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Ave., EBRC Room 404A, Boston, MA, 02115, USA.

Background: Despite heightened interest in early-onset colorectal cancer (CRC) diagnosed before age 50, little is known on immune cell profiles of early-onset CRC. It also remains to be studied whether CRCs diagnosed at or shortly after age 50 are similar to early-onset CRC. We therefore hypothesized that immune cell infiltrates in CRC tissue might show differential heterogeneity patterns between three age groups (< 50 "early onset," 50-54 "intermediate onset,"  ≥ 55 "later onset"). Read More

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September 2021

Alternative femoral endarterectomies: technical aspects and short-term results.

Angiol Sosud Khir 2021 ;27(3):104-113

Centre for Vascular Surgery and Interventional Radiology, Tampere University Hospital, Tampere, Finland; Department of Surgery, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Finnish Cardiovascular Research Center, Tampere, Finland.

Background: Femoral endarterectomies are often performed by means of longitudinal arteriotomies with patching. Autologous and synthetic patches can be used. Synthetic patches in the groin may expose patients to infection. Read More

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September 2021

A randomized trial comparing inspiratory training and positive pressure training in immediate lung recovery after minor pleuro-pulmonary surgery.

J Thorac Dis 2021 Aug;13(8):4690-4702

Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Background: Two respiratory physiotherapy modalities were compared in a randomized controlled trial on patients undergoing minor pleuro-pulmonary surgery.

Methods: Forty-five patients were randomly allocated into positive expiratory pressure (PEP) therapy (n=23) and inspiratory muscle training (IMT) groups (n=22). Individualized group specific physiotherapeutic guidance was administered preoperatively, and once a day postoperatively. Read More

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Functional independence in the Finnish spinal cord injury population.

Spinal Cord 2021 Sep 15. Epub 2021 Sep 15.

The Finnish Association of People with Physical Disabilities, Helsinki, Finland.

Study Design: A cross-sectional survey of the Finnish population with spinal cord injury (FinSCI database).

Objectives: To describe the functional independence of the population with spinal cord injury (SCI) in Finland and to identify how generic and lesion characteristics affect their functional independence.

Setting: The participants were recruited from the registers of three SCI outpatient clinics responsible for lifelong follow-up and care for people with SCI in Finland. Read More

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September 2021

Sustainability analysis of Finnish pre-schoolers' diet based on targets of the EAT-Lancet reference diet.

Eur J Nutr 2021 Sep 15. Epub 2021 Sep 15.

Department of Food and Nutrition, University of Helsinki, P.O. Box 66, 00014, Helsinki, Finland.

Purpose: The EAT-Lancet reference diet is a healthy plant-based diet produced within planetary boundaries. To inform the food system transformation, we compared Finnish pre-schoolers' food consumption with the reference diet's food group targets.

Methods: Food record data for 3- to 6-year-old pre-schoolers were collected in the cross-sectional DAGIS survey. Read More

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September 2021