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Eur J Nucl Med Mol Imaging 2021 Apr 3;48(4):1081-1092. Epub 2020 Oct 3.

Department of Respiratory Medicine, University Hospital Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany.

Purpose: Pulmonary hypertension (PH) is characterized by a progressive remodelling of the pulmonary vasculature resulting in right heart failure and eventually death. The serotonin transporter (SERT) may be involved in the pathogenesis of PH in patients with chronic-obstructive pulmonary disease (COPD). This study investigated for the first time the SERT in vivo availability in the lungs of patients with COPD and PH (COPD+PH). Read More

Eurasian J Med 2020 Jun 2;52(2):166-170. Epub 2020 Jun 2.

Department of Pulmonary Diseases, Ataturk University School of Medicine, Erzurum, Turkey.

Objective: Pulmonary hypertension (PH) is a common complication of chronic obstructive pulmonary disease (COPD) associated with a decrease in the survival rate of patients with COPD. Our aim was to investigate whether PH impairs the functional capacity and symptoms in patients with COPD. In addition, we aimed to evaluate the correlation between the functional capacity and symptoms score in patients with COPD. Read More

Indian J Crit Care Med 2020 Jan;24(Suppl 1):S61-S81

Department of Division of Critical Care Medicine, Department of Anaesthesia, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India, , e-mail:

A. ACUTE HYPERCAPNIC RESPIRATORY FAILURE A1. Acute Exacerbation of COPD: Recommendations: NIV should be used in management of acute exacerbation of COPD in patients with acute or acute-on-chronic respiratory acidosis (pH = 7. Read More

Arch Bronconeumol 2020 08 23;56(8):499-505. Epub 2019 Nov 23.

Department of Pulmonary Medicine, Hospital Clínic-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Spain.

Introduction: The impact of pulmonary hypertension (PH) on exercise tolerance in chronic obstructive pulmonary disease (COPD) has not been fully elucidated. It is necessary to characterize pulmonary hemodynamics in patients with moderate to severe COPD in order to improve their management. The aim of the study was to determine whether in COPD the presence of PH is associated with reduced exercise tolerance in a cohort of stable COPD patients. Read More

Genet Test Mol Biomarkers 2019 Sep 6;23(9):634-643. Epub 2019 Aug 6.

Department of Pneumology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.

Caveolin-1, which is encoded by the caveolin-1 () gene, plays an important role in the development of pulmonary hypertension (PH). The purpose of this study was to determine the relationship between 3' untranslated region (UTR) single nucleotide polymorphisms (SNPs) of the gene and the risk of PH in Chinese Han patients with chronic obstructive pulmonary disease (COPD). From March 2016 to October 2018, 235 patients with COPD combined with PH (COPD/PH) and 240 patients with COPD and without PH (COPD/PH) were recruited to the study. Read More

Immunology 2019 08 24;157(4):304-311. Epub 2019 Jun 24.

Department of Respiratory and Critical Medicine, The Affiliated Huaian No.1, People's Hospital of Nanjing Medical University, Huaian, Jiangsu, China.

Pulmonary hypertension (PH) is a common but dangerous complication in chronic obstructive pulmonary disease (COPD). We hypothesized that dysregulation in the T helper type 17 (Th17) compartment could contribute to the development of COPD-associated PH (COPD-PH). To investigate this hypothesis, patients with COPD-PH and age- and sex-matched healthy controls were recruited, and their circulating CD4 T cells were activated using anti-CD3/CD28 antibodies. Read More

Biomed Res Int 2015 11;2015:173970. Epub 2015 Oct 11.

Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan ; School of Medicine, China Medical University, Taichung, Taiwan ; Department of Life Science, Tunghai University, Taichung, Taiwan.

Pulmonary arterial hypertension (PAH) is a rare disease but with significant morbidity and high mortality. There is no specific way to diagnose PAH. Thus, an easy used with good sensitivity and specificity biomarker of PAH is highly desirable to aid in the screening, diagnosis, and follow-up. Read More

Respirology 2010 Jan 23;15(1):155-9. Epub 2009 Nov 23.

Department of Internal Medicine, Pulmonology, Philipps-University Marburg, Germany.

Background And Objective: Analysis of exhaled breath condensate (EBC) pH is a non-invasive method to study airway inflammation. Low pH is correlated with inflammatory diseases like asthma and COPD. The aim of this study was to assess the influence of measurement temperature on pH values of EBC. Read More

Respir Res 2009 Aug 24;10:78. Epub 2009 Aug 24.

Department of Pulmonology, Leiden University Medical Center, the Netherlands.

Background: Analysis of exhaled breath condensate (EBC) is a non-invasive method for studying the acidity (pH) of airway secretions in patients with inflammatory lung diseases.

Aim: To assess the reproducibility of EBC pH for two commercially available devices (portable RTube and non-portable ECoScreen) in healthy controls, patients with asthma or COPD, and subjects suffering from an acute cold with lower-airway symptoms. In addition, we assessed the repeatability in healthy controls. Read More

Respiration 2008 25;76(2):160-7. Epub 2007 Oct 25.

Department of Pulmonary Diseases, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands.

Background: Pulmonary hypertension (PH) is a well-known complication of chronic obstructive pulmonary disease (COPD). It remains unclear whether exercise parameters can be used to discriminate between COPD patients with associated PH (COPD-PH) and COPD patients without associated PH (COPD-nonPH).

Objective: To study whether the existence of pulmonary hypertension in COPD is related to characteristic findings in gas exchange and circulatory parameters during cardiopulmonary exercise testing (CPET). Read More