181,639 results match your criteria lower concentrations

Effect of Nosodes on Lettuce, Parasitized or Not by Meloidogyne enterolobii.

Homeopathy 2021 May 4. Epub 2021 May 4.

Department of Entomology and Plant Pathology, Universidade Estadual do Norte Fluminense Darcy Ribeiro (UENF), Campos dos Goytacazes, Brazil.

Background:  Nosodes are homeopathic preparations (HPs) obtained from tissues or substances associated with the targeted disease or from culture of the pathogenic agent. Nosodes are thought to modulate host resistance, easing symptoms or promoting cure. A few studies have been published about control of plant-parasitic nematodes with HPs, but none with nosodes. Read More

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Comprehensive metabolic amino acid flux analysis in critically ill patients.

Clin Nutr 2021 Mar 18;40(5):2876-2897. Epub 2021 Mar 18.

Dept of Adult Intensive Care, Lausanne University Hospital (CHUV), Lausanne, Switzerland.

Amino acid (AA) metabolism is severely disturbed in critically ill ICU patients. To be able to make a more scientifically based decision on the type of protein or AA nutrition to deliver in ICU patients, comprehensive AA phenotyping with measurements of plasma concentrations and whole body production (WBP) is needed. Therefore, we studied ICU patients and matched control subjects using a novel pulse isotope method to obtain in-depth metabolic analysis. Read More

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Persistent organic pollutants and the size of ovarian reserve in reproductive-aged women.

Environ Int 2021 May 1;155:106589. Epub 2021 May 1.

Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet and Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden. Electronic address:

Industrial chemicals such as persistent organic pollutants (POPs) have been associated with reduced fertility in women, including longer time-to-pregnancy (TTP), higher odds for infertility, and earlier reproductive senescence. Fertility is highly dependent on the ovarian reserve, which is composed of a prenatally determined stock of non-growing follicles. The quantity and quality of the follicles decline with age, thereby eventually leading to menopause. Read More

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Uptake and translocation of polybrominated diphenyl ethers in the rhizosphere soil-crop-atmosphere system in e-waste dismantling areas in Taizhou, China.

Chemosphere 2021 Apr 28;280:130586. Epub 2021 Apr 28.

School of Environment and Natural Resources, Renmin University of China, Beijing, 100872, PR China. Electronic address:

Air, crop, and rhizosphere soil samples were collected from e-waste dismantling areas in Taizhou City (Zhejiang Province, China). The mean PBDEs (Polybrominated diphenyl ethers) concentrations in air in the Fengjiang and Binhai areas were 27.8 and 25. Read More

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Impact of Ambient Air Quality Standards revision on the exposure-response of air pollution in Tianjin, China.

Environ Res 2021 May 1:111269. Epub 2021 May 1.

School of Public Health, Tianjin Medical University, Tianjin 300070, China; Tianjin Center for Disease Control and Prevention, Tianjin 300011, China. Electronic address:

To improve air quality, China issued a new version of Ambient Air Quality Standards in 2012, and Tianjin officially implemented these new standards in 2013. In order to observe whether the atmospheric quality and health had been improved after the release of the new standards, this study compared the exposure-response relationships between pollutant concentrations and daily deaths (and years of life lost, YLL) in the six central districts of Tianjin in 2007-2010 and 2014-2017, which were the two periods around the release of the new standards. The exposure-response coefficients were calculated by using the generalized additive model with the time series data. Read More

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Heavy Metals in Indoor Dust Across China: Occurrence, Sources and Health Risk Assessment.

Arch Environ Contam Toxicol 2021 May 4. Epub 2021 May 4.

College of Chemistry, Changchun Normal University, Changchun, 130032, China.

In this study, the occurrence of heavy metals including cadmium (Cd), chromium (Cr), copper (Cu), lead (Pb), and zinc (Zn) was investigated in indoor dust samples collected from 33 urban and rural areas in 11 provinces, China. The concentrations of the selected heavy metals were determined by an inductively coupled plasma mass spectrometry. The mean concentrations of Zn (166 mg kg), Pb (40. Read More

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The Effects of Ditch Management in Agroecosystems on Embryonic and Tadpole Survival, Growth, and Development of Northern Leopard Frogs (Lithobates pipiens).

Arch Environ Contam Toxicol 2021 May 4. Epub 2021 May 4.

Department of Biology, University of Ottawa, Ottawa, ON, Canada.

Agricultural drainage ditches help remove excess water from fields and provide habitat for wildlife. Drainage ditch management, which includes various forms of vegetation clearing and sediment dredging, can variably affect the ecological function of these systems. To determine whether ditch conditions following dredging/vegetation clearing management affected the survival, growth, and development of embryos and tadpoles of northern leopard frogs (Lithobates pipiens), we conducted three field studies using in situ cages over 2 years. Read More

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Inhibitory effect of HTLV-1 infection on the production of B-cell activating factors in established follicular dendritic cell-like cells.

Immun Inflamm Dis 2021 May 4. Epub 2021 May 4.

Division of Advanced Preventive Medical Sciences, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Introduction: The low frequency of ectopic germinal center in labial salivary glands of patients with human T-cell leukemia virus type 1 (HTLV-1) antibody-positive Sjögren's syndrome (SS) suggests that HTLV-1 has some effects on follicular dendritic cells (FDCs).

Methods: We used flow cytometry, immunofluorescence, and enzyme-linked immunosorbent assays (ELISAs) to investigate the direct effect of HTLV-1 on B-cell activating factors produced by established FDC like cells obtained from excised human tonsils. We then measured the serum B-cell activating factor (BAFF) and C-X-C motif ligand (CXCL) 13 concentrations of the HTLV-1-seropositive SS patients and the HTLV-1-seronegative SS patients by ELISA. Read More

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Food cravings and loss-of-control eating in youth: Associations with gonadal hormone concentrations.

Int J Eat Disord 2021 May 4. Epub 2021 May 4.

Section on Growth and Obesity, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA.

Objective: Among youth with overweight, food cravings (FC) are associated with loss-of-control (LOC)-eating, but the impact of sex-associated biological characteristics on this relationship is unknown. We examined whether sex and gonadal hormone concentrations moderated the relationships between FC and LOC-eating severity among healthy boys and girls across the weight strata in natural and laboratory environments.

Method: Using ecological momentary assessment (EMA), FC, and LOC-eating severity were reported 3-5 times a day for 2 weeks. Read More

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Reduced purine biosynthesis in humans after their divergence from Neandertals.

Elife 2021 May 4;10. Epub 2021 May 4.

Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.

We analyze the metabolomes of humans, chimpanzees and macaques in muscle, kidney and three different regions of the brain. Whereas several compounds in amino acid metabolism occur at either higher or lower concentrations in humans than in the other primates, metabolites downstream of adenylosuccinate lyase, which catalyzes two reactions in purine synthesis, occur at lower concentrations in humans. This enzyme carries an amino acid substitution that is present in all humans today but absent in Neandertals. Read More

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Evaluation of the Roche MagNA Pure 96 nucleic acid extraction platform for the Seegene Anyplex II HPV28 detection assay.

J Appl Microbiol 2021 May 3. Epub 2021 May 3.

Centre for Women's Infectious Diseases, The Royal Women's Hospital, Melbourne, Victoria, Australia.

Aim: Validate the Roche, MagNAPure96 (MP96) nucleic acid extraction platform for Seegene Anyplex II HPV28 (Anyplex28) detection of Human Papillomavirus.

Methods And Results: Comparisons were made for Anyplex28 genotyping from 115 cervical samples extracted on the Hamilton, STARlet and the MP96. Two DNA concentrations were used for the MP96, one matched for sample input to the STARlet, and another 5x concentration (laboratory standard). Read More

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Genome-wide association mapping of sodium and potassium concentration in rice grains and shoots under alternate wetting and drying and continuously flooded irrigation.

Theor Appl Genet 2021 May 4. Epub 2021 May 4.

School of Biological Sciences, University of Aberdeen, Aberdeen, AB24 3UU, UK.

Key Message: Identification of a large number of QTL and candidate genes for sodium accumulation in a field grown population of rice derived from the aus subpopulation. Rice (Oryza sativa L.) is a globally important cereal crop. Read More

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Subjective symptoms and serum methadone concentrations: what should guide dose adjustments in methadone maintenance treatment? A naturalistic cohort study from Norway.

Subst Abuse Treat Prev Policy 2021 May 3;16(1):39. Epub 2021 May 3.

Institute of Clinical Medicine, UiT - Norway's Arctic University, Tromsø, Norway.

Background: There is little evidence-based guidance on how to optimize methadone dosages among patients with opioid addiction undergoing methadone maintenance treatment (MMT). This study aims to investigate whether self-perceived opioid withdrawal symptoms, adverse effects, and self-reported substance use in patients on MMT are related to serum methadone concentrations and the role that these variables could play in clinical decisions on dose adjustments.

Methods: This naturalistic prospective cohort study included clinical and laboratory measurements from 83 patients undergoing MMT in outpatient clinics in Bergen, Norway, from May 2017 to January 2020. Read More

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Biomarkers of lipid metabolism in patients with juvenile idiopathic arthritis: relationship with disease subtype and inflammatory activity.

Pediatr Rheumatol Online J 2021 May 3;19(1):66. Epub 2021 May 3.

Department of Pediatrics, Universidade Federal de São Paulo, Rua Borges Lagoa, 802 - Vila Clementino, São Paulo, SP, CEP: 04038-001, Brazil.

Background: To describe the biomarkers of lipid metabolism in children and adolescents with polyarticular and systemic JIA and to relate them to diseases subtypes, diseases activity markers, and nutritional status.

Methods: A cross-sectional study including 62 JIA patients was performed. The following variables were evaluated: disease activity and medications used, body mass index, height for age (z-score), skin folds (bicipital, tricipital, subscapular and suprailiac), food intake based on three 24-h food recalls, lipid profile (total cholesterol (CT), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG) and non-HDL (N-HDLc), glycemia and insulin, erythrocyte sedimentation rate (ESR), ultrasensitive C-reactive protein (us-CRP) and apolipoproteins A-I and B (Apo A-I and Apo B). Read More

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Comparison of remifentanil concentrations with and without dexmedetomidine for the prevention of emergence cough after nasal surgery: a randomized double-blinded trial.

BMC Anesthesiol 2021 May 4;21(1):136. Epub 2021 May 4.

Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine, 164, World cup-ro, Yeongtong-gu, Suwon, 16499, South Korea.

Background: Preventing emergence cough after nasal surgery is critical. Emergence cough can provoke immediate postoperative bleeding, which leads to upper airway obstruction. In the present study, we compared the effect-site concentration (Ce) of remifentanil to prevent emergence cough after propofol anesthesia for nasal surgery when remifentanil was or was not combined with dexmedetomidine. Read More

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Effect of increasing doses of neem () seed oil on feed intake, nutrients digestibility, ruminal fermentation and nitrogen utilization of Omani sheep.

Anim Biotechnol 2021 May 3:1-9. Epub 2021 May 3.

Department of Animal and Veterinary Sciences, College of Agricultural and Marine Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman.

This study was conducted to examine the effects of neem () seed oil (NSO) on feed intake, ruminal fermentability, feed digestibility, nitrogen balance, and blood parameters in Omani sheep. Nine Omani male sheep (BW; 54.44 ± 8 kg/sheep) were used in a replicated 3 × 3 Latin Square design with three dietary treatments and three periods, with each period lasting 21 days. Read More

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Wild boar in the city: Phenotypic responses to urbanisation.

Sci Total Environ 2021 Jun 4;773:145593. Epub 2021 Feb 4.

Wildlife Ecology & Health group and Servei d'Ecopatologia de Fauna Salvatge, Departament de Medicina i Cirurgia Animals, Universitat Autònoma de Barcelona, Travessera dels Turons s/n, 08193, Bellaterra, Barcelona, Spain. Electronic address:

Urbanisation is a global human-induced environmental change and one of the most important threats to biodiversity. To survive in human-modified environments, wildlife must adjust to the challenging selection pressures of urban areas through behaviour, morphology, physiology and/or genetic changes. Here we explore the effect of urbanisation in a large, highly adaptable and generalist urban adapter species, the wild boar (Sus scrofa, Linnaeus 1758). Read More

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Health risks from groundwater arsenic on residents in northern China coal-rich region.

Sci Total Environ 2021 Jun 2;773:145003. Epub 2021 Feb 2.

State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China. Electronic address:

Shanxi Province of northern China is a typical mining concentration and arsenism area. Years of mining activities have resulted in serious regional groundwater problems in Shanxi. Therefore, it is of great significance to know the health risk of groundwater arsenic on residents under the background of mining activities. Read More

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Activity concentrations of U, Th, Ra Cs and K radionuclides in honey samples from Romania. Lifetime cancer risk estimated.

J Environ Radioact 2021 Apr 30;234:106626. Epub 2021 Apr 30.

National Research and Development Institute for Cryogenics and Isotopic Technologies, 4 Uzinei Street, PO Râureni Box 7, 240050, Rm. Vâlcea, Romania.

Romania is on the first place in Europe with an annual production of honey of 30.9 thousand tons in 2018, while the European Union is on the second place in the world with a total of 283 thousand tons. The most part of the honey production from Romania is exported. Read More

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Polyethylene glycol-20k reduces post-resuscitation cerebral dysfunction in a rat model of cardiac arrest and resuscitation: A potential mechanism.

Biomed Pharmacother 2021 May 1;139:111646. Epub 2021 May 1.

Department of Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Street, Xi'an, Shaanxi 710061, China; Weil Institute of Emergency and Critical Care Research, Virginia Commonwealth University, Richmond, VA, USA; Department of Emergency Medicine, Virginia Commonwealth University Health System, Richmond, VA, USA. Electronic address:

Out-of-hospital cardiac arrest (CA) is a leading cause of death in the United States. Severe post-resuscitation cerebral dysfunction is a primary cause of poor outcome. Therefore, we investigate the effects of polyethylene glycol-20k (PEG-20k), a cell impermeant, on post-resuscitation cerebral function. Read More

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Rapid monitoring of heavy metal pollution in lake water using nitrogen and phosphorus nutrients and physicochemical indicators by support vector machine.

Chemosphere 2021 Apr 27;280:130599. Epub 2021 Apr 27.

School of Environment, Nanjing Normal University, Nanjing, 210023, PR China. Electronic address:

A novel method of predicting heavy metal concentration in lake water by support vector machine (SVM) model was developed, combined with low-cost, easy to obtain nutrients and physicochemical indicators as input variables. 115 surface water samples were collected from 23 sites in Chaohu Lake, China, during different hydrological periods. The particulate concentrations of heavy metals in water were much higher than the dissolved concentrations. Read More

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Effects of mechanical ventilation on indoor air quality and occupant health status in energy-efficient homes: A longitudinal field study.

Sci Total Environ 2021 Apr 26;785:147324. Epub 2021 Apr 26.

Department of Social and Preventive Medicine, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea. Electronic address:

Despite the growing interest in energy-efficient homes (EEHs), there is still a lack of evidence regarding whether the mechanical ventilation system of an EEH positively or negatively impacts indoor air quality (IAQ) and the health and wellbeing of occupants. This study aimed to evaluate the IAQ level and daily health symptoms of adults and children living in EEHs compared to conventional buildings over the course of one year. A two-way mixed analysis of variance was conducted to compare the level of IAQ between the two housing types. Read More

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Increased ozone pollution alongside reduced nitrogen dioxide concentrations during Vienna's first COVID-19 lockdown: Significance for air quality management.

Marlon Brancher

Environ Pollut 2021 Apr 15;284:117153. Epub 2021 Apr 15.

WG Environmental Health, Department of Biomedical Sciences, University of Veterinary Medicine Vienna, Veterinärplatz 1, A-1210, Vienna, Austria. Electronic address:

Background: Lockdowns amid the COVID-19 pandemic have offered a real-world opportunity to better understand air quality responses to previously unseen anthropogenic emission reductions.

Methods And Main Objective: This work examines the impact of Vienna's first lockdown on ground-level concentrations of nitrogen dioxide (NO), ozone (O) and total oxidant (O). The analysis runs over January to September 2020 and considers business as usual scenarios created with machine learning models to provide a baseline for robustly diagnosing lockdown-related air quality changes. Read More

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Mineralocorticoid receptor modulation by dietary sodium influences NAFLD development in mice.

Ann Hepatol 2021 Apr 30:100357. Epub 2021 Apr 30.

Departamento de Gastroenterologia, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile; Centro de Envejecimiento y Regeneracion (CARE), Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas Pontificia Universidad Catolica de Chile, Santiago, Chile. Electronic address:

Introduction And Objectives: Nonalcoholic-fatty-liver disease (NAFLD) is considered the hepatic manifestation of metabolic syndrome (MetS). Mineralocorticoid receptor (MR) activation is associated with increased risk of MetS but few studies have assessed the role of liver MR on NAFLD. We aimed to evaluate the effect of MR modulation by sodium intake in liver injury in experimental models of NAFLD. Read More

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Protoporphyrin IX (PpIX) loaded PLGA nanoparticles for topical Photodynamic Therapy on melanoma cells.

Photodiagnosis Photodyn Ther 2021 Apr 30:102317. Epub 2021 Apr 30.

School of Pharmacy, Federal University of Rio de Janeiro, Av. Carlos Chagas Filho 373, 21.941.902, Rio de Janeiro, RJ, Brazil. Electronic address:

Introduction: Nanoparticles (Np) can increase drug efficacy well as overcome problems associated with solubility and aggregation in a solution of PpIX.

Purpose: Evaluate if Np interferes in the photophysical and photobiological capacity of the PpIX comparing with free PpIX intended for topical PDT of melanoma.

Methods: In vitro photophysical evaluation of Np-PpIX was carried out through singlet oxygen (O) quantum yield. Read More

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Nitric-oxide releasing chitosan nanoparticles towards effective treatment of cutaneous leishmaniasis.

Nitric Oxide 2021 Apr 30. Epub 2021 Apr 30.

Center for Lasers and Applications, Energy and Nuclear Research Institute (IPEN-CNEN/SP), Av. Prof. Lineu Prestes, 2242, CEP 05508-000, São Paulo, SP, Brazil. Electronic address:

Cutaneous leishmaniasis (CL) is a major public health problem caused by Leishmania parasites that produce destructive and disfiguring skin conditions. There is an urgent need for alternative topical therapies due to the limitations of current systemic treatments. Recently, we have synthesized nitric oxide-releasing chitosan nanoparticles (NONPs) and shown their potential in vitro against Leishmania amazonensis. Read More

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Severe Sleep Restriction Suppresses Appetite Independent of Effects on Appetite Regulating Hormones in Healthy Young Men Without Obesity.

Physiol Behav 2021 Apr 30:113438. Epub 2021 Apr 30.

U.S. Army Research Institute of Environmental Medicine, Natick, MA, USA. Electronic address:

Objective: Several nights of moderate (4-5 hr/night) sleep restriction increases appetite and energy intake, and may alter circulating concentrations of appetite regulating hormones. Whether more severe sleep restriction has similar effects is unclear. This study aimed to determine the effects of severe, short-term sleep restriction on appetite, ad libitum energy intake during a single meal, appetite regulating hormones, and food preferences. Read More

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Association between serum selenium concentrations and learning disability in a nationally representative sample of U.S. children.

Nutr Neurosci 2021 May 3:1-7. Epub 2021 May 3.

Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA.

Background: Oxidative stress has been implicated in the pathogenesis of neurodevelopmental disorders. As an anti-oxidative agent, selenium plays an important role in human health. However, the relationship between selenium status and learning disability (LD), a common neurodevelopmental disorder, is unknown. Read More

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Association between ABCB1 Polymorphisms and Artesunate-Mefloquine Treatment Responses of Patients with Falciparum Malaria on the Thailand-Myanmar Border.

Am J Trop Med Hyg 2021 May 3. Epub 2021 May 3.

1Chulabhorn International College of Medicine, Thammasat University (Rangsit Campus), Pathum Thani, Thailand.

A decrease in the clinical efficacy of a 3-day artesunate-mefloquine combination treatment was reported in the areas of multidrug-resistant Plasmodium falciparum along the Thailand-Myanmar border. The current study investigated the possible contribution of genetic polymorphisms of the three major genes encoding drug efflux transporters, ABCB1, ABCG2, and ABCC1, to responses to the aforementioned treatment in 91 patients with acute uncomplicated falciparum malaria residing along the Thailand-Myanmar border. Patients carrying homozygous mutant genotype ABCB1 c. Read More

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Oseltamivir treatment of influenza A and B infections in infants.

Influenza Other Respir Viruses 2021 May 3. Epub 2021 May 3.

Department of Pediatrics, University of Turku, Turku University Hospital, Turku, Finland.

Background: Oseltamivir treatment is currently the only way of managing influenza in young infants for whom influenza vaccines are not licensed, but little data exist on the effectiveness of the treatment in this age group.

Methods: In a prospective study, we enrolled 431 newborn infants and followed them up for 10 months during their first respiratory season (September 2017-June 2018). During each respiratory illness, we examined the infants and obtained nasopharyngeal specimens for determination of the viral etiology. Read More

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