1,345 results match your criteria low-grade endometrial

Seborrheic Keratosis-Like Lesion of the Cervix: First Report of the Cytological Features of a Low-Risk HPV 42-Associated Lesion.

Acta Cytol 2021 Jul 22:1-5. Epub 2021 Jul 22.

Department of Pathology, Belfast Health and Social Care Trust, Belfast, United Kingdom.

Introduction: Seborrheic keratosis-like lesion of the cervix and vagina is a rare lesion and shows similar morphology to vulvar seborrheic keratosis; 3 of the 7 previously reported cases were associated with low-risk human papillomavirus (HPV) type 42. We report a case of seborrheic keratosis-like lesion of the cervix and provide the first description of the cytological features of this lesion.

Case Presentation: A woman in her late forties presented with postcoital bleeding. Read More

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Severe Abdominal Recurrence of Low-grade Endometrial Stromal Sarcoma After Hysteroscopic Surgery.

Anticancer Res 2021 Aug;41(8):4013-4016

Department of Gynecology, Akita Red Cross Hospital, Akita, Japan.

Background: Low-grade endometrial stromal sarcoma (LG-ESS) is an indolent tumor harboring gene fusion involving polycomb family genes. While early LG-ESS has a good clinical course, some tumors have pelvic recurrence. The etiology and genetic alterations involved in the process remain unknown. Read More

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PD-L1 expression in tumor cells is associated with a favorable prognosis in patients with high-risk endometrial cancer.

Gynecol Oncol 2021 Jul 13. Epub 2021 Jul 13.

Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, China. Electronic address:

Objective: To investigate programmed cell death ligand 1 (PD-L1) expression patterns and define the associations among PD-L1, molecular subtypes, pathological features, and survival in a cohort of 833 patients with endometrial cancer, of whom approximately half had high-risk disease.

Methods: Using direct sequencing of the polymerase epsilon (POLE) exonuclease domain as well as immunohistochemistry for mismatch repair (MMR) proteins (MLH1, PMS2, MSH2, and MSH6) and p53, we stratified endometrial cancers into four molecular subtypes: POLE ultramutated, MMR-deficient, p53-mutant, and non-specific molecular profile (NSMP). PD-L1 was detected via immunohistochemistry and evaluated in tumor cells (TCs) and immune cells (ICs) individually and using the combined positive score (CPS). Read More

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Phase I evaluation of lenvatinib and weekly paclitaxel in patients with recurrent endometrial, ovarian, fallopian tube, or primary peritoneal Cancer.

Gynecol Oncol 2021 Jul 13. Epub 2021 Jul 13.

Division of Gynecologic Oncology, The Ohio State University Wexner Medical Center and James Cancer Hospital, Columbus, OH, United States.

Objectives: To estimate the maximally tolerated dose (MTD) and describe toxicities associated with lenvatinib and weekly paclitaxel in patients with recurrent endometrial and platinum resistant epithelial ovarian cancer.

Methods: Using a 3 + 3 design patients were given weekly paclitaxel 80 mg/m2 IV day 1, 8, 15 and oral levantinib daily on a 28-day cycle. Lenvatinib dose levels were 8 mg, 12 mg, 16 mg, 20 mg. Read More

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Infrequent loss of SMARCA4, SMARCA2, and SMARCB1 expression in uterine mesenchymal tumors.

Hum Pathol 2021 Jul 13. Epub 2021 Jul 13.

Department of Pathology, Jichi Medical University, Tochigi, Japan.

SMARCA4-deficient uterine sarcoma (SMARCA4-DUS) was recently proposed as a new entity of uterine sarcoma. Reported cases of SMARCA4-DUS showed the loss of SMARCA4 and SMARCA2 expression. However, the prevalence of their deficiency in uterine mesenchymal tumors remains unclear. Read More

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Advances in management of nonendometrioid endometrial carcinoma, with an emphasis on the sentinel lymph node technique.

Curr Opin Oncol 2021 Jul 8. Epub 2021 Jul 8.

Department of Gynecologic Oncology, Oslo University Hospital, Norwegian Radium Hospital Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway Department of Surgery, Gynecology Service, Memorial Sloan Kettering Cancer Center Joan & Sanford I. Weill Medical College of Cornell University, New York, New York, USA.

Purpose Of Review: During the last few years there have been important advances in our understanding of endometrial cancer biology, staging, and therapy. In this article, we discuss updates and controversies in the treatment of nonendometrioid endometrial carcinoma (non-EEC), with an emphasis on the role of sentinel lymph node (SLN) biopsy.

Recent Findings: Lymph node involvement is an important factor in determining prognosis and guiding adjuvant therapy in endometrial cancer. Read More

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Intravascular Papillary Endothelial Hyperplasia Mimicking Vaginal Malignant Tumor in a Post-Radiotherapy Patient: A Case Report and Literature Review.

Onco Targets Ther 2021 29;14:3945-3948. Epub 2021 Jun 29.

Obstetrics and Gynecology Hospital of Fudan University, Shanghai, 200011, People's Republic of China.

Intravascular papillary endothelial hyperplasia (IPEH) is a rare benign lesion that occurs in the soft tissue of any site, including the central nervous system, extremities, head, and female reproductive system. But no case occurred in vagina was reported previously. Here, we report a case of vaginal IPEH in a 54-year-old woman who has a history of radical hysterectomy for endometrial cancer with postoperative radiotherapy. Read More

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Correlation between pre-operative diagnosis and final pathological diagnosis of endometrial malignancies; impact on primary surgical treatment.

Eur J Obstet Gynecol Reprod Biol 2021 Jun 15;263:100-105. Epub 2021 Jun 15.

Department of Obstetrics and Gynecology, Ain Shams Maternity Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Electronic address:

Objectives: to compare the accuracy of preoperative and postoperative endometrial sampling obtained by dilatation and curettage (D&C), Pipelle and hysteroscopy to diagnose endometrial malignancies and to evaluate the adequacy of surgical treatment for these patients.

Study Design: This retrospective record-based study was conducted at Gynecology Oncology Unit, Ain Shams University Maternity Hospital, Cairo, Egypt. Records of patients with an initial preoperative or a final postoperative pathological diagnosis of endometrial hyperplasia or endometrial malignancies were retrieved over a six year period from January 2013 until March 2019. Read More

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Low-grade extrauterine endometrial stromal sarcoma of the peritoneum: A case report and literature review.

Rev Esp Patol 2021 Jul-Sep;54(3):201-205. Epub 2020 Sep 3.

Bioaraba Research Health Institute, Vitoria-Gasteiz, Spain; Osakidetza Basque Health Service, Araba University Hospital, Pathology Department, Alava, Vitoria-Gasteiz, Spain.

Endometrial stromal sarcoma (ESS) is an uncommon mesenchymal tumor that accounts for less than 1% of all primary uterine malignancies and extrauterine endometrial stromal sarcoma (EESS) is even rarer. We report the case of a 75-year-old woman with an abdominal tumor and multiple peritoneal implants. Histological analysis of the surgical specimens showed bland cellularity resembling normal endometrial stroma. Read More

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September 2020

First case of intracaval recurrence of high-grade endometrial stromal sarcoma: A case report.

Int J Gynaecol Obstet 2021 Jun 26. Epub 2021 Jun 26.

Unit of Surgical Gynecologic Oncology, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.

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New imaging modalities to distinguish rare uterine mesenchymal cancers from benign uterine lesions.

Curr Opin Oncol 2021 Jun 23. Epub 2021 Jun 23.

Department of Radiology. Memorial Sloan Kettering Cancer Center, New York, USA Department of Radiology, Seoul National University College of Medicine, Seoul, Korea Department of Radiology, Naval Pohang Hospital, Pohang, Korea Department of Pathology. Memorial Sloan Kettering Cancer Center Department of Radiology. Hospital for Special Surgery, New York, USA.

Purpose Of Review: Uterine sarcomas are rare and are often challenging to differentiate on imaging from benign mimics, such as leiomyoma. As functional MRI techniques have improved and new adjuncts, such as machine learning and texture analysis, are now being investigated, it is helpful to be aware of the current literature on imaging features that may sometimes allow for preoperative distinction.

Recent Findings: MRI, with both conventional and functional imaging, is the modality of choice for evaluating uterine mesenchymal tumors, especially in differentiating uterine leiomyosarcoma from leiomyoma through validated diagnostic algorithms. Read More

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The struggle against endometrial cancer: ten years of experience of a tertiary center.

Ginekol Pol 2021 Jun 22. Epub 2021 Jun 22.

Department of Obstetrics and Gynecology, Selcuk University Medicine Faculty, Selçuklu, Konya, Turkey.

Objectives: We aimed to investigate the clinical and pathological factors of our patients who were diagnosed with endometrial cancer in terms of prognosis. With this study, we present our 10 years of surgical experience in endometrial carcinoma cases.

Material And Methods: Four hundred twelve patients with endometrial carcinoma who applied to our center between 2010-2019 and that we followed up were evaluated retrospectively. Read More

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Cervical stromal involvement by endometrial 'hyperplasia': a previously unreported phenomenon with recommendations to report as stage II endometrial carcinoma.

Pathology 2021 Aug 18;53(5):568-573. Epub 2021 Jun 18.

Department of Pathology, Belfast Health and Social Care Trust, Belfast, United Kingdom. Electronic address:

A subtle 'burrowing' pattern of cervical stromal involvement by low-grade endometrioid adenocarcinoma of the uterine corpus is described in the literature. We report a small case series in which this pattern of cervical stromal involvement, warranting a diagnosis of endometrioid adenocarcinoma in the cervix, occurred in association with sometimes subtle endometrioid proliferations within the endometrium which fall short of the criteria for endometrioid adenocarcinoma and are in keeping with atypical hyperplasia or hyperplasia without atypia. In reporting this phenomenon, which has not been described previously, we highlight the importance of immunohistochemistry in the differential diagnosis, particularly in the exclusion of primary cervical glandular lesions, including those of mesonephric type. Read More

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Colposcopic outcomes for symptomatic patients with a negative oncogenic human papillomavirus test.

Aust N Z J Obstet Gynaecol 2021 Jun 20. Epub 2021 Jun 20.

Maternity and Gynaecology, John Hunter Hospital, New Lambton Heights, New South Wales, Australia.

This study assesses outcomes of colposcopy referrals for post-coital, intermenstrual, or other abnormal bleeding with negative oncogenic human papillomavirus and negative to low-grade cytology. Of 112 cases with median age of 34.5 years, cervical biopsy occurred in 19%, treatment of ectropion in 19%, endometrial sampling in 8%, polypectomy in 4%, and contraceptive change in 2%. Read More

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Uterine Inflammatory Myofibroblastic Neoplasms With Aggressive Behavior, Including an Epithelioid Inflammatory Myofibroblastic Sarcoma: A Clinicopathologic Study of 9 Cases.

Am J Surg Pathol 2021 Jun 17. Epub 2021 Jun 17.

Department of Pathology, The University of Texas MD Anderson Cancer, Houston, TX Vall d'Hebron University Hospital, Barcelona, Spain.

The experience with uterine inflammatory myofibroblastic neoplasms with an unfavorable outcome is limited. We present the clinicopathologic features of 9 such cases, including 8 inflammatory myofibroblastic tumors (IMTs) and 1 epithelioid inflammatory myofibroblastic sarcoma (EIMS). Median patient age for the IMT group was 50. Read More

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A Rare Case of Intestinal Low-Grade Endometrial Stromal Sarcoma With Glandular Differentiation and Associated Endometriosis.

Cureus 2021 May 2;13(5):e14801. Epub 2021 May 2.

Histopathology, Northern Care Alliance National Health Service (NHS) Trust, Oldham, GBR.

Endometrial stromal sarcoma is a rare tumour. It is even rarer to find it arising in the background of endometriosis in an extrauterine location. This case report describes a case of missed diagnosis of intestinal extra-uterine endometrial stromal sarcoma associated with endometriosis, and the subsequent presentation with distant metastases. Read More

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Prognostic impact of histological review of high-grade endometrial carcinomas in a large Danish cohort.

Virchows Arch 2021 Jun 11. Epub 2021 Jun 11.

Department of Pathology, Copenhagen University Hospital, Herlev and Gentofte Hospital, Copenhagen University, Borgmester Ib Juuls Vej 73, 2730, Herlev, Denmark.

The aim of this study was to investigate the outcome of histological subtype review of high-grade endometrial carcinoma (EC) and its prognostic impact in a large well-documented Danish nationwide cohort. From the Danish Gynecological Cancer Database (DGCD) 2005-2012 cohort, we included 425 patients with an original diagnosis of high-grade EC, independent of histologic subtype. Of these, at least one hematoxylin and eosin (H&E)-stained slide from 396 cases (93. Read More

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Corded and Hyalinized and Spindled Endometrioid Endometrial Carcinoma: A Clinicopathologic and Molecular Analysis of 9 Tumors Based on the TCGA Classifier.

Am J Surg Pathol 2021 Aug;45(8):1038-1046

James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Corded and hyalinized and spindled carcinomas are rare variants of endometrioid carcinoma (EC) characterized by cords of low-grade epithelial cells (±spindle cells) within a hyalinized stroma or spindled epithelial cells, respectively, that merge with conventional low-grade EC. Due to their "biphasic" morphology, these tumors are often misdiagnosed as carcinosarcoma. The clinicopathologic features including mismatch repair protein (PMS2 and MSH6) and p53 immunohistochemical expression and POLE mutational status of 9 corded and hyalinized and spindled endometrial ECs were evaluated and classified into The Cancer Genome Atlas (TCGA) based molecular subgroups. Read More

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Quantitative diffusion and perfusion MRI in the evaluation of endometrial cancer: validation with histopathological parameters.

Br J Radiol 2021 Jun 16:20210054. Epub 2021 Jun 16.

Department of Radiological, Oncological and Pathological Sciences, Umberto I Hospital,"Sapienza" University of Rome, Rome, Italy.

Objectives: To investigate the role of quantitative Magnetic Resonance Imaging (MRI) in preoperative assessment of tumour aggressiveness in patients with endometrial cancer, correlating multiple parameters obtained from diffusion and dynamic contrast-enhanced (DCE) MR sequences with conventional histopathological prognostic factors and inflammatory tumour infiltrate.

Methods: Forty-four patients with biopsy-proven endometrial cancer underwent preoperative MR imaging at 3T scanner, including DCE imaging, diffusion-weighted imaging (DWI) and intravoxel incoherent motion imaging (IVIM). Images were analysed on dedicated post-processing workstations and quantitative parameters were extracted: , , and from the DCE; from DWI; diffusion , pseudo diffusion , perfusion fraction from IVIM and tumour from DWI. Read More

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Atypical Endometrial Hyperplasia, Low-grade: "Much ADO About Nothing".

Am J Surg Pathol 2021 Jul;45(7):988-996

Department of Pathology, Hospital de la Santa Creu i Sant Pau, Institute of Biomedical Research (IIB Sant Pau), Autonomous University of Barcelona, Barcelona, Spain.

Atypical endometrial hyperplasia (AEH) is considered a precursor of endometrioid carcinoma. The 2020 World Health Organization (WHO) classification divides endometrial hyperplasia into 2 categories: hyperplasia without atypia and atypical hyperplasia/endometrioid intraepithelial neoplasia (EIN); however, this classification does not consider the degree of nuclear atypia. We graded nuclear atypia for estimating the risk of finding carcinoma at hysterectomy. Read More

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Major clinical research advances in gynecologic cancer in 2020.

J Gynecol Oncol 2021 Jul;32(4):e53

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.

In 2020 series, we summarized the major clinical research advances in gynecologic oncology with providing representative figures of the most influential study for 1 of each 3 gynecologic cancers: cervix, ovary, and uterine corpus. Review for cervical cancer covered targeted agents and immune checkpoint inhibitors, adjuvant radiation therapy or concurrent/sequential chemoradiation therapy after radical hysterectomy in early cervical cancer, radical surgery in early cervical cancer; and prevention and screening. Ovarian cancer research included studies of various combinations of poly (ADP-ribose) polymerase inhibitors with chemotherapy, immune checkpoint inhibitors, and/or vascular endothelial growth factor inhibitors according to the clinical setting. Read More

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Low-grade Endometrial Stromal Sarcoma With Sex Cord-like Differentiation and PHF1-JAZF1 Fusion With Deletions: A Diagnostic Pitfall of JAZF1 FISH.

Int J Gynecol Pathol 2021 Jun 2. Epub 2021 Jun 2.

Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts (Z.O., V.N. D.D.-S., E.O.) Department of Pathology, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, Ohio (S.A.).

The molecular knowledge on endometrial stromal neoplasms has been rapidly increasing and is considered complementary to morphologic and immunohistochemical findings for better categorization of these tumors. The most common molecular alteration observed in low-grade endometrial stromal sarcomas is the JAZF1-SUZ12 fusion, whereas, low-grade endometrial stromal sarcoma with sex cord-like differentiation have been shown more commonly to have fusions involving PHF1. Herein, we present a low-grade endometrial stromal sarcoma with sex cord-like differentiation with a fluorescence in situ hybridization showing the apparent loss of one copy of JAZF1 5' and 3' signals, rather than the expected "break-apart" pattern seen in the setting of a JAZF1 fusion. Read More

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Mesonephric-Like Carcinosarcoma of the Ovary Associated with Low-Grade Serous Carcinoma: A Case Report.

Diagnostics (Basel) 2021 May 3;11(5). Epub 2021 May 3.

Department of Emergency and Organ Transplantation, Section of Pathology, University of Bari "Aldo Moro", 70124 Bari, Italy.

Mesonephric adenocarcinomas are rare tumors of the female genital tract, thought to arise from embryonic mesonephric remnants, primarily in the cervix and vagina. Conversely, endometrial and ovarian mesonephric adenocarcinomas may have a different pathogenesis, probably originating from transdifferentiated Müllerian carcinomas, as demonstrated by the association of these neoplasms with endometriosis and ovarian serous tumors. For this reason, in the endometrium and in the ovary, they are defined as "mesonephric-like adenocarcinomas". Read More

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Sentinel lymph node biopsy in high-grade endometrial cancer: a systematic review and meta-analysis of performance characteristics.

Am J Obstet Gynecol 2021 May 29. Epub 2021 May 29.

Division of Gynaecologic Oncology, Department of Obstetrics and Gynecology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Objective: A sentinel lymph node biopsy is widely accepted as the standard of care for surgical staging in low-grade endometrial cancer, but its value in high-grade endometrial cancer remains controversial. The aim of this systematic review and meta-analysis was to evaluate the performance characteristics of sentinel lymph node biopsy in patients with endometrial cancer with high-grade histology (registered in the International Prospective Register of Systematic Reviews with identifying number CRD42020160280).

Data Sources: We systematically searched the MEDLINE, Epub Ahead of Print, MEDLINE In-Process & Other Non-Indexed Citations, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Embase databases all through the OvidSP platform. Read More

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Epidemiological link between obesity, type 2 diabetes mellitus and cancer.

World J Methodol 2021 May 20;11(3):23-45. Epub 2021 May 20.

Department of Endocrinology and Metabolism, Lancashire Teaching Hospitals NHS Trust, Preston PR2 9HT, United Kingdom.

There exists a complex interaction between obesity, type 2 diabetes mellitus (T2DM) and cancer, and an increase in the incidence of cancer is expected with the growing obesity-diabetes pandemic. The association of cancer with diabetes mellitus and obesity appears to be site-specific, the highest risk being for post-menopausal breast cancer, endometrial cancer, and colorectal cancer. Moreover, there is worsening of hyperglycaemia with the onset of cancer, evidencing a bi-directional link between cancer and diabetes mellitus and the need for monitoring for diabetes in cancer survivors. Read More

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Ossifying low grade endometrial stromal sarcoma with PHF1-BRD8 fusion.

Cancer Genet 2021 Aug 22;256-257:81-85. Epub 2021 Apr 22.

Department of Pathology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 11217, Taiwan; Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.

Low-grade endometrial stromal sarcoma and ossifying fibromyxoid tumors are two types of mesenchymal tumors that share no similarities in terms of site, sex, and morphological characteristics. They are rare, low grade tumors of uncertain lineage, with no definite immunological markers. Interestingly, a common PHF1 gene- related rearrangement was observed in these two tumors. Read More

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Role of lymphadenectomy for apparent early stage uterine sarcoma; a comprehensive analysis of the National Cancer Database.

Surg Oncol 2021 Apr 24;38:101589. Epub 2021 Apr 24.

Division of Gynecologic Oncology, University of Pennsylvania Health System, Philadelphia, PA, USA.

Objective: Investigate the role of lymphadenectomy for patients with apparent stage I uterine sarcoma.

Methods: The National Cancer Database was accessed and patients without a history of another tumor diagnosed between 2004 and 2015 with an apparent early stage leiomyosarcoma, adenosarcoma, low-grade endometrial stromal and high-grade endometrial stromal/undifferentiated sarcoma who underwent hysterectomy with or without lymphadenectomy were identified. Overall survival was assessed after stratification by histology with the log-rank test while Cox models were constructed to control for confounders. Read More

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Complete remission of advanced low-grade endometrial stromal sarcoma after aromatase inhibitor therapy: a case report.

J Med Case Rep 2021 May 5;15(1):262. Epub 2021 May 5.

Intern, King Abdullah University Hospital, Jordan University of Science & Technology, Irbid, 22110, Jordan.

Background: Low-grade endometrial stromal sarcoma is a rare neoplastic growth in the uterine cavity, representing less than 1% of uterine tumors. Such tumors usually affect premenopausal and perimenopausal women, with a mean age of 46 years. Treatment generally starts with surgical resection of the tumor, followed by chemotherapy, radiotherapy, or hormonal therapy. Read More

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Survey on Reporting of Endometrial Biopsies From Women on Progestogen Therapy for Endometrial Atypical Hyperplasia/Endometrioid Carcinoma.

Int J Gynecol Pathol 2021 May 3. Epub 2021 May 3.

Department of Cellular Pathology, Birmingham Women's Hospital, Birmingham (R.G.) Department of Pathology, Belfast Health and Social Care Trust, Belfast (W.G.M.), UK Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada (C.B.G.) Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY (R.A.S.).

Histologic assessment of response to progestogen therapy is a cornerstone of nonsurgical management of atypical hyperplasia/low-grade endometrioid carcinoma. Pathologists are required to assess whether there is ongoing preneoplastic or neoplastic change in the biopsies (often multiple) taken during therapy. There have been few studies documenting the specific histologic changes induced by therapeutic progestogens and currently there are no guidelines on terminology used in this scenario. Read More

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Fibroblast Growth Factor Receptor 2 Isoforms Detected via Novel RNA ISH as Predictive Biomarkers for Progestin Therapy in Atypical Hyperplasia and Low-Grade Endometrial Cancer.

Cancers (Basel) 2021 Apr 3;13(7). Epub 2021 Apr 3.

School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Translational Research Institute, Princess Alexandra (PA) Hospital Campus, 37 Kent St., Woolloongabba, Brisbane, Queensland 4102, Australia.

Women with atypical hyperplasia (AH) or well-differentiated early-stage endometrioid endometrial carcinoma (EEC) who wish to retain fertility and/or with comorbidities precluding surgery, are treated with progestin. Clinically approved predictive biomarkers for progestin therapy remain an unmet need. The objectives of this study were to document the overall response rate (ORR) of levonorgestrel intrauterine device (LNG-IUD) treatment, and determine the association of FGFR2b and FGFR2c expression with treatment outcome. Read More

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