326 results match your criteria low-dose lithium

Rationale and Design of Assessing the Effectiveness of Short-Term Low-Dose Lithium Therapy in Averting Cardiac Surgery-Associated Acute Kidney Injury: A Randomized, Double Blinded, Placebo Controlled Pilot Trial.

Front Med (Lausanne) 2021 14;8:639402. Epub 2021 Jun 14.

Division of Kidney Disease and Hypertension, Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence, RI, United States.

Burgeoning pre-clinical evidence suggests that therapeutic targeting of glycogen synthase kinase 3β (GSK3β), a convergence point of multiple cellular protective signaling pathways, confers a beneficial effect on acute kidney injury (AKI) in experimental models. However, it remains unknown if GSK3β inhibition likewise mitigates AKI in humans. Cardiac surgery associated acute kidney injury (CSA-AKI) poses a significant challenge for clinicians and currently the only treatment available is general supportive measures. Read More

View Article and Full-Text PDF

Low-Dose Lithium for Management of Neuropsychiatric Symptoms in Alzheimer Disease.

Am J Geriatr Psychiatry 2021 May 21. Epub 2021 May 21.

Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, MD.

View Article and Full-Text PDF

Glucosamine promotes seizure activity via activation of the PI3K/Akt pathway in epileptic rats.

Epilepsy Res 2021 Sep 3;175:106679. Epub 2021 Jun 3.

Department of Neurology, Affiliated Hospital of North Sichuan Medical College, 63 Wenhua Road, Nanchong, 637000, China; Institute of Neurological Diseases, North Sichuan Medical College, 234 Fujiang Road, Nanchong, Sichuan, China. Electronic address:

Context: Glucosamine is an amino monosaccharide with a small molecular weight and has a protective effect against various neurological diseases including multiple sclerosis and encephalomyelitis. Interestingly, low-dose glucosamine has exhibited anti-epilepsy activity. Recent studies have shown that the activation of the protein kinase B (Akt) signaling pathway may promote epilepsy. Read More

View Article and Full-Text PDF
September 2021

Lithium: A therapeutic option in Alzheimer's disease and its prodromal stages?

Neurosci Lett 2021 08 10;760:136044. Epub 2021 Jun 10.

Department of Psychiatry, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany.

Experimental data reveal that lithium is capable of attenuating Alzheimer's disease pathology and stimulating adult hippocampal neurogenesis. Clinical studies show procognitive effects in lithium-treated patients with amnestic MCI and Alzheimer's disease. These procognitive effects are associated with changes of CSF biomarkers of Alzheimer's disease. Read More

View Article and Full-Text PDF

Low Dose Lithium Treatment of Behavioral Complications in Alzheimer's Disease: Lit-AD Randomized Clinical Trial.

Am J Geriatr Psychiatry 2021 May 12. Epub 2021 May 12.

Division of Geriatric Psychiatry (DPD, LSP, EDH, DAD, GHP), New York State Psychiatric Institute, NY; Department of Psychiatry (DPD, SL, HA, EDH, BAD, GHP), Columbia University Medical Center, NY; Department of Neurology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, (DPD, EDH), Columbia University Medical Center, NY; Center for Cognitive Neuroscience and Aging, Department of Psychiatry and Behavioral Sciences (EC, LL), University of Miami Miller School of Medicine Miami, FL; Division of Geriatric Psychiatry (BPF, IVV), McLean Hospital, Harvard Medical School, MA; Departments of Psychiatry and Neurology (MMH, NI), University of Texas Southwestern Medical Center, TX; Mental Health Data Science, Department of Psychiatry (SL, HA), Columbia University Medical Center and New York State Psychiatric Institute, NY.

Background: A case series suggested efficacy for lithium to treat agitation in dementia, but no placebo-controlled trials have been conducted.

Objectives: To evaluate low-dose lithium treatment of agitation in Alzheimer's disease (AD).

Method: In a four-site trial, patients with AD and agitation/aggression score ≥4 on the Neuropsychiatric Inventory (NPI) were randomized, double-blind, to lithium carbonate 150-600 mg daily or placebo for 12 weeks. Read More

View Article and Full-Text PDF

Population Pharmacokinetics of Lithium in Young Pediatric Patients With Intellectual Disability.

Front Pharmacol 2021 15;12:650298. Epub 2021 Apr 15.

Henan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center, Institute of Neuroscience and Third Affiliated Hospital and of Zhengzhou University, Zhengzhou, China.

Lithium is a well-established treatment for bipolar disorders and has been shown to be neuroprotective, and thus low doses might be useful for the treatment of childhood brain injury and neurological sequelae. However, pharmacokinetic (PK) data in children are limited. This study was to investigate the PKs after oral administration of low-dose lithium carbonate in young children with intellectual disability. Read More

View Article and Full-Text PDF

Poor Stability of Li CO in the Solid Electrolyte Interphase of a Lithium-Metal Anode Revealed by Cryo-Electron Microscopy.

Adv Mater 2021 Jun 25;33(22):e2100404. Epub 2021 Apr 25.

Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen, 518055, China.

The solid electrolyte interphase (SEI) dictates the cycling stability of lithium-metal batteries. Here, direct atomic imaging of the SEI's phase components and their spatial arrangement is achieved, using ultralow-dosage cryogenic transmission electron microscopy. The results show that, surprisingly, a lot of the deposited Li metal has amorphous atomic structure, likely due to carbon and oxygen impurities, and that crystalline lithium carbonate is not stable and readily decomposes when contacting the lithium metal. Read More

View Article and Full-Text PDF

Less Can Be More: The Hormesis Theory of Stress Adaptation in the Global Biosphere and Its Implications.

Biomedicines 2021 Mar 13;9(3). Epub 2021 Mar 13.

Immune-Oncological Center Cologne (IOZK), D-50674 Cologne, Germany.

A dose-response relationship to stressors, according to the hormesis theory, is characterized by low-dose stimulation and high-dose inhibition. It is non-linear with a low-dose optimum. Stress responses by cells lead to adapted vitality and fitness. Read More

View Article and Full-Text PDF

Statistical limitations in ion imaging.

Phys Med Biol 2021 May 10;66(10). Epub 2021 May 10.

Chemical, Medical and Environmental Science, National Physical Laboratory, Hampton Road, Teddington, United Kingdom.

In this study, we investigated the capacity of various ion beams available for radiotherapy to produce high quality relative stopping power map acquired from energy-loss measurements. The image quality metrics chosen to compare the different ions were signal-to-noise ratio (SNR) as a function of dose and spatial resolution. Geant4 Monte Carlo simulations were performed for: hydrogen, helium, lithium, boron and carbon ion beams crossing a 20 cm diameter water phantom to determine SNR and spatial resolution. Read More

View Article and Full-Text PDF

Lithium enhances exercise-induced glycogen breakdown and insulin-induced AKT activation to facilitate glucose uptake in rodent skeletal muscle.

Pflugers Arch 2021 04 3;473(4):673-682. Epub 2021 Mar 3.

Department of Physiology, College of Medicine, Yeungnam University, Gyeongsan, Republic of Korea.

The purpose of this study was to investigate the effect of lithium on glucose disposal in a high-fat diet-induced type 2 diabetes mellitus (T2DM) and streptozotocin-induced type 1 diabetes mellitus (T1DM) animal model along with low-volume exercise and low-dose insulin. Lithium decreased body weight, fasting plasma glucose, and insulin levels when to treat with low-volume exercise training; however, there were no adaptive responses like an increase in GLUT4 content and translocation factor levels. We discovered that lithium enhanced glucose uptake by acute low-volume exercise-induced glycogen breakdown, which was facilitated by the dephosphorylation of serine 473-AKT (Ser473-AKT) and serine 9-GSK3β. Read More

View Article and Full-Text PDF

Using mitochondrial respiration inhibitors to design a novel model of bipolar disorder-like phenotype with construct, face and predictive validity.

Transl Psychiatry 2021 02 12;11(1):123. Epub 2021 Feb 12.

Department of Clinical Biochemistry and Pharmacology and Psychiatry Research Unit, Faculty of Health Sciences, Ben-Gurion University of the Negev and Mental Health Center, Beer-Sheva, Israel.

We mimicked mild mitochondrial-distress robustly reported in bipolar-disorder (BD) by chronic exposure to uniquely low doses of inhibitors of mitochondrial-respiration complexes in vitro and in vivo. Exposure of the neuronal-originating SH-SY5Y cells to very low dose (10 pM) rotenone, a mitochondrial-respiration complex (Co)I inhibitor, for 72 or 96 h did not affect cell viability and reactive oxygen species (ROS) levels. Yet, it induced a dual effect on mitochondrial-respiration: overshooting statistically significant several-fold increase of most oxygen-consumption-rate (OCR) parameters vs. Read More

View Article and Full-Text PDF
February 2021

Cognitive effects of the GSK-3 inhibitor "lithium" in LPS/chronic mild stress rat model of depression: Hippocampal and cortical neuroinflammation and tauopathy.

Neurotoxicology 2021 03 6;83:77-88. Epub 2021 Jan 6.

Department of Pharmacology, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Clinical Pharmacology Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Low-dose repeated lipopolysaccharide pre-challenge followed by chronic mild stress (LPS/CMS) protocol has been introduced as a rodent model of depression combining the roles of immune activation and chronic psychological stress. However, the impact of this paradigm on cognitive functioning has not been investigated hitherto.

Methods: This study evaluated LPS/CMS-induced cognitive effects and the role of glycogen synthase kinase-3β (GSK-3β) activation with subsequent neuroinflammation and pathological tau deposition in the pathogenesis of these effects using lithium (Li) as a tool for GSK-3 inhibition. Read More

View Article and Full-Text PDF

Monitoring of Thermally Induced Effects in Nickel-Rich Layered Oxide Cathode Materials at the Atomic Level.

ACS Appl Mater Interfaces 2020 Dec 9;12(51):57047-57054. Epub 2020 Dec 9.

Materials Science Center (WZMW) and Department of Physics, Philipps-University Marburg, Hans-Meerwein -Str.6, 35032, Marburg, Germany.

The thermal stability of cathode active materials (CAMs) is of major importance for the safety of lithium-ion batteries (LIBs). A thorough understanding of how commercially viable layered oxide CAMs behave at the atomic length scale upon heating is indispensable for the further development of LIBs. Here, structural changes of Li(NiCoMn)O (NCM851005) at elevated temperatures are studied by aberration-corrected scanning transmission electron microscopy (AC-STEM). Read More

View Article and Full-Text PDF
December 2020

Lithium for Carbamazepine-Induced Syndrome of Inappropriate Antidiuretic Hormone.

Clin Neuropharmacol 2021 Jan-Feb 01;44(1):33-34

James A Haley VA Hospital, Mental Health and Behavioral Sciences Service, Tampa, FL.

Objectives: To examine the effectiveness of low-dose lithium carbonate for managing carbamazepine-induced hyponatremia.

Methods: Single case study in an 88 year old man with bipolar illness and vascular dementia who had failed to respond to other mood stabilizers.

Results: The patient had developed hyponatremia on two separate occasions when treated with carbamazepine. Read More

View Article and Full-Text PDF
November 2020

Ultra-high contrast STEM imaging for segmented/pixelated detectors by maximizing the signal-to-noise ratio.

Ultramicroscopy 2021 Jan 16;220:113133. Epub 2020 Oct 16.

Institute of Engineering Innovation, School of Engineering, the University of Tokyo, Yayoi 2-11-16, Bunkyo, Tokyo, 113-0032, Japan; Nanostructures Research Laboratory, Japan Fine Ceramics Center, Mutsuno 2-4-1, Atsuta, Nagoya, 456-8587, Japan. Electronic address:

Atomic-resolution low-dose imaging for beam-sensitive materials is one of the most challenging topics in electron microscopy research. In this study, we theoretically developed a new scanning transmission electron microscopy (STEM) imaging technique by maximizing the signal-to-noise ratio of an obtainable image under the weak phase object approximation (WPOA), which we will call optimum bright-field (OBF) imaging. OBF images are obtained by processing multiple images acquired by segmented/pixelated detectors through complex frequency filtering. Read More

View Article and Full-Text PDF
January 2021

A DNA Repair-Based Model of Cell Survival with Important Clinical Consequences.

Anders Brahme

Radiat Res 2020 09;194(3):202-235

Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.

This work provides a description of a new interaction, cross-section-based model for radiation-induced cellular inactivation, sublethal damage, DNA repair and cell survival, with the ability to more accurately elucidate different radiation-response phenomena. The principal goal of this work is to describe the damage-induction cross sections, as well as repair and survival, as Poisson processes with two main types of damage: mild damage that can be rapidly handled by the most basic repair processes; and more complex damage requiring longer repair times and the high-fidelity homologous recombination (HR) repair process to ensure accuracy and safety in the survival. This work is unique in its use of Poisson statistics to quantify the main repairable cell compartments that are exposed to simple and more complex sublethal hits, the cross section of which determines what is homologically and non-homologically repairable. Read More

View Article and Full-Text PDF
September 2020

Randomized feasibility trial to assess tolerance and clinical effects of lithium in progressive multiple sclerosis.

Heliyon 2020 Jul 28;6(7):e04528. Epub 2020 Jul 28.

Birmingham VA Medical Center, 700 19 Street South, Birmingham, AL, 35233, USA.

Background: Disability accumulation in progressive multiple sclerosis (MS) results from inflammatory and neurodegenerative mechanisms. In animal models of MS, lithium acts to reduce inflammatory demyelination, and in models of neurodegenerative diseases, lithium also slows neuronal death. Prospective studies of lithium in MS patients have not been previously undertaken. Read More

View Article and Full-Text PDF

Low-dose lithium against dementia.

Int J Bipolar Disord 2020 Aug 3;8(1):25. Epub 2020 Aug 3.

Department of Psychiatry and Psychotherapy, Faculty of Medicine, University of Cologne Medical School, Kerpener Str. 62, 50931, Cologne, Germany.

View Article and Full-Text PDF

GSK3 inhibition with low dose lithium supplementation augments murine muscle fatigue resistance and specific force production.

Physiol Rep 2020 07;8(14):e14517

Department of Kinesiology, Brock University, St. Catharines, ON, Canada.

Calcineurin is a Ca -dependent serine/threonine phosphatase that dephosphorylates nuclear factor of activated T cells (NFAT), allowing for NFAT entry into the nucleus. In skeletal muscle, calcineurin signaling and NFAT activation increases the expression of proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1α) and slow myosin heavy chain (MHC) I ultimately promoting fatigue resistance. Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that antagonizes calcineurin by re-phosphorylating NFAT preventing its entry into the nucleus. Read More

View Article and Full-Text PDF

Beneficial effects of low-dose lithium on cognitive ability and pathological alteration of Alzheimer's disease transgenic mice model.

Neuroreport 2020 09;31(13):943-951

Department of Neurology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Lithium has been shown to delay the progression of Alzheimer's disease to reduce the prevalence of dementia. However, its narrow therapeutic index and numerous toxic effects at conventional dosage limited its long-term use to older subjects. Here, we tested the effect of low-dose lithium on cognitive impairment and pathology alterations in a mouse model of Alzheimer's disease, the amyloid precursor protein/presenilin-1 (APP/PS1) transgenic mouse. Read More

View Article and Full-Text PDF
September 2020

Microdose lithium reduces cellular senescence in human astrocytes - a potential pharmacotherapy for COVID-19?

Aging (Albany NY) 2020 06 13;12(11):10035-10040. Epub 2020 Jun 13.

Buck Institute for Research on Aging, Novato, CA 94945, USA.

Cell senescence is a process that causes growth arrest and the release of a senescence associated secretory phenotype (SASP), characterized by secretion of chemokines, cytokines, cell growth factors and metalloproteases, leading to a tissue condition that may precipitate cancers and neurodegenerative processes. With the recent pandemic of coronavirus, senolytic drugs are being considered as possible therapeutic tools to reduce the virulence of SARS-CoV-2. In the last few years, our research group showed that lithium carbonate at microdose levels was able to stabilize memory and change neuropathological characteristics of Alzheimer's disease (AD). Read More

View Article and Full-Text PDF


Prostaglandins Leukot Essent Fatty Acids 2020 08 21;159:102118. Epub 2020 May 21.

Section on Nutritional Neurosciences, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892.

Background: Studies in unanesthetized rats suggest that mood stabilizers approved for treating bipolar disorder downregulate brain arachidonic acid (AA) metabolism. AA plays a role in neurotransmission and neuroinflammation, among other processes. Other drugs that reduce brain AA metabolism may add to mood stabilizer action. Read More

View Article and Full-Text PDF

Neuroprotective effect of lithium in cold- induced traumatic brain injury in mice.

Behav Brain Res 2020 08 30;392:112719. Epub 2020 May 30.

Istanbul Medipol University, Regenerative and Restorative Medical Research Center, Istanbul, Turkey; Istanbul Medipol University, Faculty of Medicine, Dept. of Physiology, Istanbul, Turkey. Electronic address:

Apart from its well-established therapeutic activity on bipolar disorder and depression, lithium exerts neuroprotective activity upon neurodegenerative disorders, such as traumatic brain injury (TBI). However, the cellular signaling mechanisms mediating lithium's neuroprotective activity and long-term dose- and time-dependent effects on close and remote proximity are largely unknown. Herein, we tested prophylactic and acute effects of lithium (2 mmol/kg) after cold- induced TBI. Read More

View Article and Full-Text PDF

Low-dose lithium feeding increases the SERCA2a-to-phospholamban ratio, improving SERCA function in murine left ventricles.

Exp Physiol 2020 04 18;105(4):666-675. Epub 2020 Mar 18.

Department of Kinesiology, Brock University, St. Catharines, ON, L2S 3A1, Canada.

New Findings: What is the central question of this study? Inhibition of glycogen synthase kinase-3 (GSK3) has been shown to improve cardiac SERCA2a function. Lithium can inhibit GSK3, but therapeutic doses used in treating bipolar disorder can have toxic effects. It has not been determined whether subtherapeutic doses of lithium can improve cardiac SERCA function. Read More

View Article and Full-Text PDF

Perceptions of using lithium in fracture management: a survey of orthopaedic surgeons, fracture patients and the general public.

BMC Musculoskelet Disord 2019 Aug 31;20(1):389. Epub 2019 Aug 31.

Sunnybrook Research Institute, 2075 Bayview Avenue, MG301, Toronto, ON, M4N 3M5, Canada.

Background: Lithium, an established psychiatric medication, has recently been shown to enhance new bone formation in preclinical fracture models. Current research is focused on evaluating the efficacy of low-dose, short-term lithium treatment to improve long bone fracture healing through a Phase II randomized clinical trial (LiFT NCT02999022). In working towards future applications of lithium for fracture management, this study aimed to understand the current perceptions of lithium as a psychiatric drug and the potential barriers to its orthopaedic adoption. Read More

View Article and Full-Text PDF

Recruitment, Retainment, and Biomarkers of Response; A Pilot Trial of Lithium in Humans With Mild Cognitive Impairment.

Front Mol Neurosci 2019 28;12:163. Epub 2019 Jun 28.

Division of Cellular Medicine, University of Dundee, Dundee, United Kingdom.

Lithium has been used for decades to treat Bipolar Disorder. Some of its therapeutic benefits may be through inhibition of Glycogen Synthase Kinase (GSK)-3. Enhanced GSK3 activity associates with development of Alzheimer's disease (AD), therefore lithium is a currently used therapeutic with potential to be repurposed for prevention of Dementia. Read More

View Article and Full-Text PDF

Combined low-dose LiCl and LY294002 for the treatment of osteoporosis in ovariectomized rats.

J Orthop Surg Res 2019 Jun 13;14(1):177. Epub 2019 Jun 13.

The Fourth Affiliated Hospital of Nanchang University, 133 Guangchangnan St., Xihu District, Nanchang, China.

Background: To provide a low-toxicity and high-efficacy clinical treatment for osteoporosis via a novel combination of LiCl and LY294002.

Methods: The protein levels of p-AKT, AKT, p-GSK3β, GSK3β, β-catenin, p-β-catenin, and NFATC1 were measured in osteoblasts and osteoclasts by Western blot. ALP activity and TRACP activity were measured using the corresponding kit. Read More

View Article and Full-Text PDF