100,811 results match your criteria low toxicity


An integrated approach for chemical water quality assessment of an urban river stretch through Effect-Based Methods and emerging pollutants analysis with a focus on genotoxicity.

J Environ Manage 2021 Sep 17;300:113549. Epub 2021 Sep 17.

Italian Institute of Health, Department: Environment and Health, Viale Regina Elena 299, Rome, Italy.

The impact of emerging chemical pollutants, on both status and functionality of aquatic ecosystems is worldwide recognized as a relevant issue of concern that should be assessed and managed by researchers, policymakers, and all relevant stakeholders. In Europe, the Reach Regulation has registered more than 100.000 chemical substances daily released in the environment. Read More

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September 2021

Multigeneration toxicity of Geunsami® (a glyphosate-based herbicide) to Allonychiurus kimi (Lee) (Collembola) from sub-individual to population levels.

Environ Pollut 2021 Sep 13;291:118172. Epub 2021 Sep 13.

Department of Environmental Science and Ecological Engineering, Korea University, Seoul, 02841, Republic of Korea. Electronic address:

Glyphosate-based herbicide (GBH) is the most widely used herbicide worldwide and has long been considered to have significantly low toxicity to non-target soil invertebrates based on short-term toxicity tests (<56 d). However, long-term GBH toxicity assessment is necessary as GBH is repeatedly applied in the same field annually because of the advent of glyphosate-resistant crops. In this study, a multigeneration test was conducted where Allonychiurus kimi (Collembola) was exposed to GBH for three generations (referred to as F, F, and F) to evaluate the long-term toxic effect. Read More

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September 2021

Vincristine-doxorubicin co-loaded artificial low-density lipoproteins towards solid tumours.

Eur J Med Chem 2021 Sep 4;226:113802. Epub 2021 Sep 4.

Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing, 100850, China. Electronic address:

To construct an artificial low-density lipoprotein (aLDL) that highly mimics low-density lipoprotein (LDL) in vivo, and deliver vincristine (VCR) - doxorubicin (DOX) simultaneously, the 100 nm and 35 nm DOX-VCR-aLDLs (DV-aLDLs) were constructed, then the physicochemical characteristics were evaluated. Through in vitro inverse gravity diffusion experiment, the tumour cake and sphere model experiment, draw a conclusion that the diffusion of 35 nm DV-aLDLs was stronger than 100 nm DV-aLDLs, and the tumour retention of 35 nm DV-aLDLs was better than the DV-solution. In addition, the three-dimension (3D) in vivo distribution imaging of aLDLs was performed on HepG-2 tumour-bearing nude mice, followed by the biodistribution and therapeutic efficacy on these xenograft models. Read More

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September 2021

YAC128 mouse model of Huntington disease is protected against subtle chronic manganese (Mn)-induced behavioral and neuropathological changes.

Neurotoxicology 2021 Sep 17. Epub 2021 Sep 17.

School of Health Sciences, Purdue University, West Lafayette, IN, United States. Electronic address:

Manganese (Mn) is an essential micronutrient but excessive levels induce neurotoxic effects. Increasing evidence suggests a deficit of bioavailable Mn in Huntington disease (HD), an inherited neurodegenerative disease characterized by motor and cognitive disturbances. Previous studies have shown rescue of some molecular HD phenotypes by acute Mn exposure. Read More

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September 2021

Low molecular weight chondroitin sulfate ameliorates pathological changes in 5XFAD mice by improving various functions in the brain.

Neuropharmacology 2021 Sep 17:108796. Epub 2021 Sep 17.

Key Laboratory of Chemical Biology (Ministry of Education), Institute of Biochemical and Biotechnological Drug, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China; Laboratory of Carbohydrate Chemistry and Glycobiology, National Glycoengineering Research Center, Shandong University, Jinan, 250012, China; NMPA Key Laboratory for Quality Research and Evaluation of Carbohydrate-based Medicine, Shandong University, Jinan, 250012, China. Electronic address:

Our previous study found that low molecular weight chondroitin sulfate (LMWCS) had neuroprotective effects against the toxicity of amyloid-β (Aβ) peptides both in vitro and in vivo, and we speculated that the effects might be related with its anti-oxidative activities. In this study, the anti-Alzheimer's disease (AD) activity of LMWCS was further studied in 5XFAD transgenic mice. After 4-month gavage, the levels of Aβ level, amyloid precursor protein (APP) and presenilin 1 (PS1) were significantly decreased in the brains of 5XFAD mice, indicating the alteration of APP metabolism by LMWCS. Read More

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September 2021

Phase 1/2 study of uproleselan added to chemotherapy in patients with relapsed or refractory acute myeloid leukemia.

Blood 2021 Sep 20. Epub 2021 Sep 20.

Fred Hutchinson, United States.

Uproleselan (GMI-1271) is a novel E-selectin antagonist that disrupts cell survival pathways, enhances chemotherapy response, improves survival in mouse xenograft and syngeneic models, and decreases chemotherapy toxicity in vivo. A phase 1/2 study (NCT02306291) evaluated the safety, tolerability, and anti-leukemic activity of uproleselan (5-20 mg/kg) with MEC (mitoxantrone, etoposide, cytarabine) among patients with relapsed/refractory (R/R) acute myeloid leukemia (AML). Among the first 19 patients, no dose-limiting toxicities were observed. Read More

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September 2021

Aidi injection as adjunctive treatment to gemcitabine-based chemotherapy for advanced non-small cell lung cancer: a systematic review and meta-analysis.

Pharm Biol 2021 Dec;59(1):1260-1275

Department of Pharmacy, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China.

Context: Aidi injection is one of the most commonly use antitumor Chinese medicine injections for advanced non-small cell lung cancer (NSCLC). It is made from the extraction of , and

Objective: To evaluate the efficacy and safety of Aidi injection in combination with gemcitabine-based chemotherapy (GBC) for advanced NSCLC.

Materials And Methods: PubMed, Embase, Cochrane Library, Chinese Biological Medicine, China National Knowledge Infrastructure, Wanfang, and VIP were searched for relevant randomised controlled trials (RCTs) comparing Aidi injection plus GBC treatment with GBC alone in NSCLC, from inception up to October 2020. Read More

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December 2021

The role of immunotherapy for management of advanced thymic epithelial tumors: a narrative review.

Mediastinum 2021 Sep 25;5. Epub 2021 Sep 25.

Thoracic and Gastrointestinal Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

The emergence of immunotherapy as a modern pillar of cancer treatment has changed the treatment landscape for various cancers. Immune checkpoint inhibitors directed at programed death-1 (PD-1) or its ligand (PD-L1), in particular, have found widespread clinical applications and have resulted in durable responses and an improvement in survival of patients with advanced or metastatic disease. Tumor cell PD-L1 expression and tumor mutation burden (TMB) are biomarkers of response and efforts are underway to identify other biomarkers that might predict benefit with these drugs. Read More

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September 2021

Low-Dose Apatinib Combined With S-1 in Refractory Metastatic Colorectal Cancer: A Phase 2, Multicenter, Single-Arm, Prospective Study.

Front Oncol 2021 2;11:728854. Epub 2021 Sep 2.

Department of Hematology, Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China.

Purpose: Apatinib is an approved third-line treatment for metastatic gastric cancer in China and demonstrates good safety, tolerability, and efficacy in other advanced solid tumors. The aim of this prospective, single-arm, multicenter, phase 2 study was to assess the efficacy and safety of low-dose apatinib combined with S-1 in the treatment of refractory mCRC.

Patients And Methods: Patients with refractory mCRC were enrolled and administered apatinib combined with S-1 until disease progression, patient decision to withdraw, or unacceptable toxic effects. Read More

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September 2021

The development and improvement of ribonucleic acid therapy strategies.

Mol Ther Nucleic Acids 2021 Sep 14. Epub 2021 Sep 14.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China.

The biological understanding of RNA has evolved since the discovery of catalytic RNAs in the early 1980s and the establishment of RNA interference (RNAi) in the 1990s. RNA is no longer seen as the simple mid-product between transcription and translation, but potential molecules to be developed as RNA therapeutic drugs. RNA-based therapeutic drugs have gained recognition due to their ability to regulate gene expression and perform cellular functions. Read More

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September 2021

Identification and Simultaneous Determination of the Main Toxical Pyrrolizidine Alkaloids in a Compound Prescription of Traditional Chinese Medicine: Qianbai Biyan Tablet.

Int J Anal Chem 2021 9;2021:5209618. Epub 2021 Sep 9.

Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, School of Pharmacy, Zunyi Medical University, Zunyi, Guizhou 563000, China.

Qianbai biyan tablet (QT) is a compound prescription of traditional Chinese medicine which is used to treat nasal congestion, rhinitis, and nasosinusitis, with as its main plant material. Several pyrrolizidine alkaloids (PAs) were reported in and others of species. Although is assigned as the legal plant material of QT, whether replaced use of it by other plants can bring toxicity is unknown because of the lack of quantitative data about toxic PAs between different species. Read More

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September 2021

Advances in Chemical Constituents, Clinical Applications, Pharmacology, Pharmacokinetics and Toxicology of .

Front Pharmacol 2021 2;12:656335. Epub 2021 Sep 2.

College of Ethnomedicine, Chengdu University of Traditional Chinese Medicine, Sichuan, China.

Dengzhanxixin (DZXX), the dried whole plant of (Vaniot) Hand.-Mazz., belonging to and first published in by Lan Mao in the Ming Dynasty (1368 AD-1644 AD), is included in Medicinal Materials and Decoction Pieces of the 2020 edition of the Pharmacopeia of the . Read More

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September 2021

Biological Investigations of Ru(II) Complexes With Diverse β-diketone Ligands.

Eur J Inorg Chem 2021 Sep 21;2021(35):3611-3621. Epub 2021 Jul 21.

Department of Chemistry, University of Kentucky, 505 Rose Street, Lexington, Kentucky 40506, USA.

The β-diketone scaffold is a commonly used synthetic intermediate, and is a functional group found in natural products such as curcuminoids. This core structure can also act as a chelating ligand for a variety of metals. In order to assess the potential of this scaffold for medicinal inorganic chemistry, seven different κ-O,O'-chelating ligands were used to construct Ru(II) complexes with polypyridyl co-ligands, and their biological activity was evaluated. Read More

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September 2021

Formulating RALA/Au nanocomplexes to enhance nanoparticle internalisation efficiency, sensitising prostate tumour models to radiation treatment.

J Nanobiotechnology 2021 Sep 19;19(1):279. Epub 2021 Sep 19.

School of Pharmacy, Queen's University Belfast, Belfast, BT9 7BL, Northern Ireland, UK.

Background: Gold nanoparticles (AuNP) are effective radiosensitisers, however, successful clinical translation has been impeded by short systemic circulation times and poor internalisation efficiency. This work examines the potential of RALA, a short amphipathic peptide, to enhance the uptake efficiency of negatively charged AuNPs in tumour cells, detailing the subsequent impact of AuNP internalisation on tumour cell radiation sensitivity.

Results: RALA/Au nanoparticles were formed by optimising the ratio of RALA to citrate capped AuNPs, with assembly occurring through electrostatic interactions. Read More

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September 2021

The combined toxicity of binary mixtures of antibiotics against the cyanobacterium Microcystis is dose-dependent: insight from a theoretical nonlinear combined toxicity assessment method.

Environ Sci Pollut Res Int 2021 Sep 18. Epub 2021 Sep 18.

College of Natural Resources and Environment, Northwest A&F University, Yangling, 712100, China.

The entry of antibiotics into aquatic ecosystems has a serious impact. Antibiotics usually exist as mixtures in natural water bodies. Therefore, it is particularly important to evaluate the mixed toxicity of antibiotic mixtures. Read More

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September 2021

Comparison of limestone calcined clay cement and ordinary Portland cement for stabilization/solidification of Pb-Zn smelter residue.

Environ Sci Pollut Res Int 2021 Sep 18. Epub 2021 Sep 18.

Jiangsu Key Laboratory of Urban Underground Engineering & Environmental Safety, Institute of Geotechnical Engineering, Southeast University, Nanjing, 210096, China.

Decreasing carbon emissions by replacing Portland cement (PC) with supplementary cementitious materials (SCMs), such as low-grade limestone (LS) and calcined clays (CC), has tremendous potential for stabilization/solidification (S/S) of industrial hazardous waste primarily with heavy metals. Recently, a low-carbon-based cementitious binder, namely, limestone calcined clay cement (LC), has emerged as an alternative for S/S treatment of wastes. However, comprehensive comparison between LC and PC application in solidifying/stabilizing wastes has not been conducted. Read More

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September 2021

Interactive effects of gibberellic acid and NPK on morpho-physio-biochemical traits and organic acid exudation pattern in coriander (Coriandrum sativum L.) grown in soil artificially spiked with boron.

Plant Physiol Biochem 2021 Sep 14;167:884-900. Epub 2021 Sep 14.

Department of Environmental Sciences and Engineering, Government College University, Allama Iqbal Road, 38000, Faisalabad, Pakistan; Department of Biological Sciences and Technology, China Medical University, Taichung, 40402, Taiwan. Electronic address:

It was aimed to examine the role of gibberellic acid (GA) and NPK fertilizer in alleviating boron (B) toxicity in coriander (Coriandrum sativum L.) plants. Two weeks old C. Read More

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September 2021

Assessment of oil refinery wastewater and effluent integrating bioassays, mechanistic modelling and bioavailability evaluation.

Chemosphere 2021 Sep 4;287(Pt 3):132146. Epub 2021 Sep 4.

Department of Environment & Health, Vrije Universiteit Amsterdam, 1081 HV, Amsterdam, the Netherlands.

Water is used in petroleum oil refineries in significant volumes for cooling, steam generation and processing of raw materials. Effective water management is required at refineries to ensure their efficient and responsible operation with respect to the water environment. However, ascertaining the potential environmental risks associated with discharge of refinery effluents to receiving waters is challenging because of their compositional complexity. Read More

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September 2021

Residual chlorine disrupts the microbial communities and spreads antibiotic resistance in freshwater.

J Hazard Mater 2021 Sep 9;423(Pt B):127152. Epub 2021 Sep 9.

College of Environment, Zhejiang University of Technology, Hangzhou, Zhejiang 310032, PR China. Electronic address:

Chlorine disinfection is a key global public health strategy for the prevention and control of diseases, such as COVID-19. However, little is known about effects of low levels of residual chlorine on freshwater microbial communities and antibiotic resistomes. Here, we treated freshwater microcosms with continuous low concentrations of chlorine and quantified the effects on aquatic and zebrafish intestinal microbial communities and antibiotic resistomes, using shotgun metagenome and 16S rRNA gene sequencing. Read More

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September 2021

A review on environmental occurrence, toxicity and microbial degradation of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs).

J Environ Manage 2021 Sep 16;300:113694. Epub 2021 Sep 16.

Department of Civil Engineering, Indian Institute of Technology, Kharagpur, 721302, India.

In recent years, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) have surfaced as a novel class of pollutants due to their incomplete degradation in wastewater treatment plants and their inherent ability to promote physiological predicaments in humans even at low doses. The occurrence of the most common NSAIDs (diclofenac, ibuprofen, naproxen, and ketoprofen) in river water, groundwater, finished water samples, WWTPs, and hospital wastewater effluents along with their toxicity effects were reviewed. The typical concentrations of NSAIDs in natural waters were mostly below 1 μg/L, the rivers receiving untreated wastewater discharge have often showed higher concentrations, highlighting the importance of effective wastewater treatment. Read More

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September 2021

Supramolecular host-guest hyaluronic acid hydrogels enhance corneal wound healing through dynamic spatiotemporal effects.

Ocul Surf 2021 Sep 16. Epub 2021 Sep 16.

Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA, United States; Chemical Engineering, Stanford University, Palo Alto, CA, United States; VA Palo Alto HealthCare System, Palo Alto, CA, United States. Electronic address:

Large abrasions and deeper ulcers of the cornea can lead to corneal scarring, ulceration and thinning if not promptly and adequately treated. Hyaluronic acid (HA) has been investigated for the treatment of corneal wounds due to its remarkable biocompatibility, transparency and mucoadhesive properties. However, intact linear HA has low retention time on the cornea and chemical crosslinkers to synthesize HA hydrogels can cause toxicity limiting their clinical ocular applications. Read More

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September 2021

Identification and validation of reference genes for RT-qPCR analysis in fetal rat pancreas.

Reprod Toxicol 2021 Sep 16. Epub 2021 Sep 16.

Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan, 430071, Hubei Province, People's Republic of China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, 430071, Hubei Province, People's Republic of China. Electronic address:

The choice of reference gene is crucial for quantitative reverse transcriptase-polymerase chain reaction (RT-qPCR) assay. To screen and determine the suitable reference genes in fetal rat pancreas, we selected eight candidate reference genes (Gapdh, Actb, Rn18 s, B2m, Rpl13a, Tbp, Ywhaz and Ubc), and evaluated the constancy of gene expression from fetal rat pancreases in non-pathological situation and prenatal dexamethasone exposure (PDE) model, using four algorithms: GeNorm, NormFinder, Bestkeeper and Comparative ΔCt method. In addition, the alteration of mRNA levels of pancreatic insulin was compared between control and PDE groups to validate the reliability of selected reference genes for data normalization of RT-qPCR. Read More

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September 2021

Anti-damage effect of theaflavin-3'-gallate from black tea on UVB-irradiated HaCaT cells by photoprotection and maintaining cell homeostasis.

J Photochem Photobiol B 2021 Sep 11;224:112304. Epub 2021 Sep 11.

National Research Center of Engineering Technology for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128, China; Key Laboratory of Ministry of Education for Tea Science, Hunan Agricultural University, Changsha 410128, China; Co-Innovation Center of Education Ministry for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128, China. Electronic address:

Keratinocytes are rich in lipids and are the main sensitive cells to ultraviolet (UV) rays. Theaflavins are the core functional components of black tea and are known as the "soft gold" in tea. In this study, ultraviolet-B (UVB) irradiation caused apoptosis and necrosis of human epidermal keratinocytes (HaCaT). Read More

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September 2021

Graphene oxide toxicity in W flies.

Sci Total Environ 2021 Sep 11;805:150302. Epub 2021 Sep 11.

State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China; Institute of Quantitative Biology and College of Life Sciences, Zhejiang University, 310058 Hangzhou, China.

The risk of graphene oxide (GO) exposure to various species has been greatly amplified in recent years due to its booming production and applications in various fields. However, a deep understanding of the GO biosafety lags its wide applications. Herein, we used W flies as a model organism to study GO toxicity at relatively low concentrations. Read More

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September 2021

Microplastics from miscellaneous plastic wastes: Physico-chemical characterization and impact on fish and amphibian development.

Ecotoxicol Environ Saf 2021 Sep 15;225:112775. Epub 2021 Sep 15.

Department of Earth and Environmental Sciences, Research Centre POLARIS, University of Milano - Bicocca, Milano, Italy. Electronic address:

Microplastic pollution represents a global problem with negative impacts on aquatic environment and organisms' health. To date, most of the laboratory toxicological studies on microplastics (MPs) have made use of single commercial micro and nano-polymers, which do not reflect the heterogeneity of environmental MPs. To improve the relevance of the hazard assessment, micrometer-sized plastic particles of miscellaneous non-reusable waste plastics, with size <100 µm and <50 µm (waste microplastics, wMPs), were characterized by microscopic and spectroscopic techniques and tested on developing zebrafish and Xenopus laevis by FET and FETAX assays respectively. Read More

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September 2021

A prospective, phase II trial of monotherapy with low-dose afatinib for patients with EGFR, mutation-positive, non-small cell lung cancer: Thoracic oncology research group 1632.

Lung Cancer 2021 Aug 31;161:49-54. Epub 2021 Aug 31.

Department of Pulmonary Medicine and Oncology, Nippon Medical School Hospital, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, Japan. Electronic address:

Objectives: Afatinib is an effective treatment for patients with epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer (NSCLC). However, the toxicity associated with this agent often leads to dose modifications. The aim of this study was to assess the efficacy, safety and plasma concentrations of low dose afatinib monotherapy in patients with EGFR mutation-positive NSCLC. Read More

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The barnacle Chthamalus bisinuatus is the only sessile invertebrate colonizing oil patches on beachrocks one year after a massive oil spill on the Northeastern Brazilian coast.

Mar Pollut Bull 2021 Sep 15;173(Pt A):112952. Epub 2021 Sep 15.

Programa de Pós-Graduação em Geoquímica: Petróleo e Meio Ambiente (POSPETRO), Instituto de Geociências, Universidade Federal da Bahia (IGEO/UFBA), Bahia 40170-020, Brazil; Departamento de Oceanografia, Instituto de Geociências, Universidade Federal da Bahia (IGEO/UFBA), Bahia 40170-020, Brazil. Electronic address:

A large-scale oil spill has reached over 3000 km of the NE Brazilian coast since August 2019. The cause and origin of this spill remain mysterious, and the impacts on coastal ecosystems have not been clearly understood so far. Despite the efforts to remove the oil (mainly from local communities), oil stains are still present in beaches, mangroves, and beachrocks. Read More

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September 2021

Size-dependent impact of polystyrene microplastics on the toxicity of cadmium through altering neutrophil expression and metabolic regulation in zebrafish larvae.

Environ Pollut 2021 Sep 13;291:118169. Epub 2021 Sep 13.

Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria / Tianjin Key Laboratory of Environmental Remediation and Pollution Control, Nankai University, Tianjin, 300071, China.

Insufficient evidence exists regarding the visible physiological toxic endpoints of MPs exposures on zebrafish larvae due to their small sizes. Herein, the impacts of micro-polystyrene particles (μ-PS) and 100 nm polystyrene particles (n-PS) on the toxicity of cadmium (Cd) through altering neutrophil expressions were identified and quantified in the transgenic zebrafish (Danio rerio) larvae Tg(lyz:DsRed2), and the effects were size-dependent. When exposed together with μ-PS, the amount of neutrophils in Cd treated zebrafish larvae decreased by 25. Read More

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September 2021

Low skeletal muscle mass is a predictor of treatment related toxicity in oncologic patients. A meta-analysis.

Clin Nutr 2021 Sep 3;40(10):5298-5310. Epub 2021 Sep 3.

Institute of Medical Epidemiology, Biostatistics, and Informatics, Martin-Luther-University Halle-Wittenberg, Halle, Germany.

Background & Aims: The purpose of this meta-analysis was to summarize the published data regarding associations between occurrence of severe treatment related toxicity and low skeletal muscle mass (LSMM) in oncologic patients and to perform a meta-analysis based on a large sample.

Methods: MEDLINE, Cochrane, and SCOPUS databases were screened for associations between LSMM and treatment related toxicity in oncologic patients up to June 2021. Overall, 48 studies met the inclusion criteria. Read More

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September 2021

Endoscopic Management of Low-Grade Upper Tract Urothelial Carcinoma: Characterizing the Long-term Burden of Care in Comparison to Radical Nephroureterectomy.

Urology 2021 Sep 15. Epub 2021 Sep 15.

Department of Urology, Rabin Medical Center, Petah Tikva, Israel, affiliated with the Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel. Electronic address:

Objectives: To compare procedure burden, oncologic, surgical and renal-function outcomes between patients with low-grade upper urothelial cancer (UTUC) who were referred for either radical management (RM) or kidney-sparing endoscopic management (EM).

Patients And Methods: We retrospectively reviewed data of all patients treated for UTUC at our tertiary medical center between 2000 and 2018 and selected patients diagnosed with unilateral low-grade UTUC.

Results: 24 patients were treated with EM and 37 with RM. Read More

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September 2021