179,360 results match your criteria low quality


Sorption of sulfadiazine and flow modeling in an alluvial deposit of a dry riverbed in the Brazilian semiarid.

J Contam Hydrol 2021 May 4;241:103818. Epub 2021 May 4.

Department of Nuclear Energy, Federal University of Pernambuco, Recife, Brazil.

The Brazilian semiarid region is subjected to irregular rainfall, prolonged droughts, and high temperatures, hampering the surface water accumulation. The water access is restricted to the alluvium in the valleys, which are used for cattle and poultry livestock development. These activities trigger the excessive use of veterinary antibiotics. Read More

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Applying enzymatic biomarkers of the in situ microbial community to assess the sediment risk from Sepetiba Bay (Brazil).

Mar Pollut Bull 2021 Jun 9;169:112547. Epub 2021 Jun 9.

Programa de Pós-Graduação em Geociências (Geoquímica), Instituto de Química, Universidade Federal Fluminense, Niterói, RJ 24020-150, Brazil.

The Quality Ratio (QR) index was applied in Sepetiba Bay to integrate geochemical and microbiological parameters of the in situ microbial community in order to classify the ecological risk of sediments. Total concentrations (C) of Hg, Cd, As, Pb, Cr, Cu and Zn (indicators of the mixture of contaminants) were determined at 26 stations and at a background area (C) to calculate the contamination factor (CF = C/C) and the degree of contamination (ΣCF). Enzymatic biomarkers of energy production into cell (dehydrogenase - DHA) and hydrolase of organic matter outside the cell (esterases - EST) were determined. Read More

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Automated detection of artefacts in neonatal EEG with residual neural networks.

Comput Methods Programs Biomed 2021 May 24;208:106194. Epub 2021 May 24.

Brain Modelling Group, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia; BaBA center, Department of Children's Clinical Neurophysiology, Children's hospital, HUS Medical Imaging center, Helsinki University Central Hospital and University of Helsinki, Finland. Electronic address:

Background And Objective: To develop a computational algorithm that detects and identifies different artefact types in neonatal electroencephalography (EEG) signals.

Methods: As part of a larger algorithm, we trained a Residual Deep Neural Network on expert human annotations of EEG recordings from 79 term infants recorded in a neonatal intensive care unit (112 h of 18-channel recording). The network was trained using 10 fold cross validation in Matlab. Read More

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Point-of-care testing for sexually transmitted infections in low-resource settings.

Clin Microbiol Infect 2021 Jun 9. Epub 2021 Jun 9.

UNDP-UNFPA-UNICEF-WHO-World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), Department of Sexual and Reproductive Health and Research, World Health Organization, 20 Avenue Appia, 1211 Geneva, Switzerland.

Background: Both the global incidence and prevalence of sexually transmitted infections continue to increase, affecting hundreds of millions of individuals, particularly in low-to middle-income countries. While a definitive diagnosis is desirable to inform STI treatment, syndromic management is the most widely used strategy in resource-limited settings. With the development of point-of-care (POC) tests, it is important to discuss how laboratories will need to adapt to new training and supervisory roles in support of testing which will largely be performed by peripheral clinical staff. Read More

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HAART exacerbates testicular damage and impaired spermatogenesis in anti-Koch-treated rats via dysregulation of lactate transport and glutathione content.

Reprod Toxicol 2021 Jun 9;103:96-107. Epub 2021 Jun 9.

Reproductive Biology and Toxicology Research Laboratories, Oasis of Grace Hospital, Osogbo, Osun State, Nigeria; Department of Morbid Anatomy, Obafemi Awolowo University Teaching Hospital Complex (OAUTHC), Ile-Ife, Osun State, Nigeria.

Highly active anti-retroviral therapy (HAART) is an effective anti-retroviral cocktail. Similarly, anti-Koch is highly potent against Mycobacterium tuberculosis. However, these drugs have been shown to impair male fertility. Read More

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Recommendations for planning and delivery of radical radiotherapy for localized urothelial carcinoma of the bladder.

Radiother Oncol 2021 Jun 9. Epub 2021 Jun 9.

Department of Radiotherapy, Institut Bergonié, Bordeaux, France. Electronic address:

Purpose: Curative radio-chemotherapy is recognized as a standard treatment option for muscle-invasive bladder cancer (MIBC). Nevertheless, the technical aspects for MIBC radiotherapy are heterogeneous with a lack of practical recommendations.

Methods And Materials: In 2018, a workshop identified the need for two cooperative groups to develop consistent, evidence-based guidelines for irradiation technique in the delivery of curative radiotherapy. Read More

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Prognostic performance of seven biomarkers compared to liver biopsy in early alcohol-related liver disease.

J Hepatol 2021 Jun 9. Epub 2021 Jun 9.

Department of Gastroenterology and Hepatology, Odense University Hospital, Denmark; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.

Background & Aims: Alcohol is the most common cause of liver-related mortality and morbidity. We therefore aimed to assess and compare the prognostic performance of elastography and blood-based markers to predict time to the first liver-related event, severe infection, and all-cause mortality in patients with a history of excess drinking.

Methods: Prospective cohort study of patients with early, compensated alcohol-related liver disease. Read More

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The effectiveness of preoperative stoma site marking on patient outcomes: A systematic review and meta-analysis.

J Adv Nurs 2021 Jun 12. Epub 2021 Jun 12.

Department of Nursing, Yonsei Cancer Center, Yonsei University Health System, Seoul, Republic of Korea.

Aims: This study systematically reviews the literature regarding preoperative stoma site marking and discusses the effectiveness of the procedure on complication rates, self-care deficits and health-related quality of life (HRQOL).

Design: Systematic review and meta-analysis.

Data Source: Our review was conducted following the PRISMA guidelines. Read More

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Using Item Response Theory to Identify Responders to Treatment: Examples with the Patient-Reported Outcomes Measurement Information System (PROMIS®) Physical Function Scale and Emotional Distress Composite.

Psychometrika 2021 Jun 12. Epub 2021 Jun 12.

Department of psychology, UCLA, Los Angeles, CA, 90095-1563, USA.

The reliable change index has been used to evaluate the significance of individual change in health-related quality of life. We estimate reliable change for two measures (physical function and emotional distress) in the Patient-Reported Outcomes Measurement Information System (PROMIS®) 29-item health-related quality of life measure (PROMIS-29 v2.1). Read More

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Ecological factors and post-transplant outcomes: Causation or correlation?

Am J Transplant 2021 Jun 12. Epub 2021 Jun 12.

Division of Surgery, University of Iowa, Iowa City, IA, USA.

Social determinants of health (SDOH), defined by the World Health Organization as "the conditions in which people are born, work, live, and age, and the wider set of forces and systems shaping the conditions of daily life", are widely acknowledged to contribute to variation in health outcomes. The Healthy People 2030 framework identifies an individual's neighborhood as one of the five key areas of SDOH. The neighborhoods where people live can influence health outcomes through a variety of pathways, including access to transportation, availability of healthy foods and physical activity spaces, rates of crime and violence, and prevalence of poor air and water quality. Read More

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Bioethics in Africa: A contextually enlightened analysis of three cases.

Dev World Bioeth 2021 Jun 11. Epub 2021 Jun 11.

Across sub-Saharan Africa, bioethics is an emerging field of scholarly inquiry, informed by contextual features distinct to the region. A cultural mix comprised of Euro-American influences, indigenous traditions, Christian faiths and Muslim communities, a bioethics for the sub-Saharan region must be responsive to this milieu. This paper asks, what values and methods can best promote the practice of bioethics in Africa? We set forth a strategy that leans one way or another in response to contextual features of a particular setting. Read More

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Households' willingness to pay and preferences for improved cook stoves in Ethiopia.

Environ Sci Pollut Res Int 2021 Jun 12. Epub 2021 Jun 12.

Department of Economics, Addis Ababa University, Addis Ababa, Ethiopia.

This paper examines households' preferences, willingness to pay, and determinants of adopting improved cook stoves in rural Ethiopia. The study uses primary household data selected randomly from three districts in Ethiopia's Oromia region. The data was collected using a mix of contingent and choice experiment methods of valuation. Read More

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Clinical outcomes with a low add multifocal and an extended depth of focus intraocular lenses both implanted with mini-monovision.

Eye (Lond) 2021 Jun 11. Epub 2021 Jun 11.

Department of Ophthalmology, Marmara University School of Medicine, Istanbul, Turkey.

Objectives: To compare the visual acuity, contrast sensitivity (CS), spectacle needs, photic phenomena, and quality of life parameters of patients bilaterally implanted with a low add multifocal (MIOL) or an extended depth of focus (EDOF) intraocular lens (IOL), both with intended mini-monovision.

Methods: In this prospective, randomized, comparative study, patients were randomized to receive either Tecnis +2.75 D (ZKB00) (MIOL Group, n = 15) or Tecnis Symfony (ZXR00) (EDOF Group, n = 14) for bilateral implantation with mini-monovision (-0. Read More

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State and Trait Fatigue and Energy Predictors of Postural Control and Gait.

Motor Control 2021 Jun 10:1-18. Epub 2021 Jun 10.

University of Western Ontario.

Compromised attentional resources during perceived fatigue has been suggested to alter motor control. The authors determined if measures of postural control and gait are predicted by state and trait physical and mental fatigue and energy, and how these relationships are modified by sex, sleep quality, and physical activity. Young adults (n = 119) completed the Modified Clinical Test of Sensory Integration, overground walking, and questionnaires to quantify fatigue and energy, sleep quality, and physical activity. Read More

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Interventions to improve district-level routine health data in low-income and middle-income countries: a systematic review.

BMJ Glob Health 2021 Jun;6(6)

Department of Disease Control, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK

Background: Routine health information system(s) (RHIS) facilitate the collection of health data at all levels of the health system allowing estimates of disease prevalence, treatment and preventive intervention coverage, and risk factors to guide disease control strategies. This core health system pillar remains underdeveloped in many low-income and middle-income countries. Efforts to improve RHIS data coverage, quality and timeliness were launched over 10 years ago. Read More

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Nutrition status of adults with phenylketonuria treated with pegvaliase.

Mol Genet Metab 2021 Jun 7. Epub 2021 Jun 7.

Met Ed, Boulder, CO 80302, United States.

Background: Pegvaliase is an enzyme substitution therapy that reduces blood phenylalanine (Phe) in adults with phenylketonuria (PKU), and often allows normalization of protein intake (≥0.8 g protein/kg). Here we examine the nutrition status of adults with PKU consuming a normal protein intake without medical food after being treated with pegvaliase for ≥1 year. Read More

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Don't forget about the future: The impact of including future costs on the cost-effectiveness of adult pneumococcal conjugate vaccination with PCV13 in the Netherlands.

Vaccine 2021 Jun 8. Epub 2021 Jun 8.

Erasmus School of Health Policy and Management, Erasmus University Rotterdam, the Netherlands.

Background: When vaccines increase longevity, vaccinated people may experience costs and benefits during added life-years. These future benefits and costs may include increased productivity as well as medical and non-medical costs. Such impacts should be considered in cost-effectiveness analyses (CEA) of vaccines but are often omitted. Read More

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The systematic development of a mobile phone-delivered brief intervention for hazardous drinking in India.

J Subst Abuse Treat 2021 Jul 15;126:108331. Epub 2021 Feb 15.

Addictions Research Group, Sangath, H No 451 (168), Bhatkar Waddo, Socorro, Bardez, Porvorim, Goa 403501, India; Tees, Esk and Wear NHS Foundation Trust, UK.

Background: The treatment gap for alcohol use disorders (AUD) in India is the highest among all mental health and substance use disorders. Despite evidence of the cost effectiveness of brief interventions (BIs) for hazardous drinking, implementation in low- and middle-income countries (LMICs) is rare due to several human resource-related barriers. This paper describes the processes and outputs of a study aimed at systematically developing a mobile phone-delivered BI to overcome such barriers. Read More

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American Association of Clinical Endocrinology Clinical Practice Guideline: The Use of Advanced Technology in the Management of Persons With Diabetes Mellitus.

Endocr Pract 2021 Jun;27(6):505-537

Unger Primary Care Concierge Medical Group, Rancho Cucamonga, California.

Objective: To provide evidence-based recommendations regarding the use of advanced technology in the management of persons with diabetes mellitus to clinicians, diabetes-care teams, health care professionals, and other stakeholders.

Methods: The American Association of Clinical Endocrinology (AACE) conducted literature searches for relevant articles published from 2012 to 2021. A task force of medical experts developed evidence-based guideline recommendations based on a review of clinical evidence, expertise, and informal consensus, according to established AACE protocol for guideline development. Read More

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Glucose oxidase-mediated sodium alginate gelation: Equipment-Free detection of glucose in fruit samples.

Enzyme Microb Technol 2021 Aug 22;148:109805. Epub 2021 Apr 22.

School of Chemistry and Chemical Engineering, Chongqing University, Chongqing, 401331, China. Electronic address:

In this study, a paper-based sensor, combined with a visual distance-readout method, was developed to determine glucose in fruit samples based on the glucose oxidase-mediated sodium alginate gelation. The type of filter paper, the concentration of sodium alginate and the enzymatic reaction conditions were systematically investigated. Under optimal conditions, the increase in diffusion diameter showed a good linear relationship with glucose concentration between 1. Read More

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Selenogenome and AMPK signal insight into the protective effect of dietary selenium on chronic heat stress-induced hepatic metabolic disorder in growing pigs.

J Anim Sci Biotechnol 2021 Jun 12;12(1):68. Epub 2021 Jun 12.

Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.

Background: Chronic heat stress (CHS) disrupts hepatic metabolic homeostasis and jeopardizes product quality of pigs. Selenium (Se) may regulate the metabolic state through affect selenoprotein. Thus, we investigate the protective effect of dietary hydroxy-4-methylselenobutanoic acid (HMSeBA) on CHS induced hepatic metabolic disorder in growing pigs, and the corresponding response of selenoprotein. Read More

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Low intensity pulsed ultrasound (LIPUS) use for the management of instrumented, infected, and fragility non-unions: a systematic review and meta-analysis of healing proportions.

BMC Musculoskelet Disord 2021 Jun 11;22(1):532. Epub 2021 Jun 11.

Department of Orthopaedic Surgery, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.

Background: Non-union occurs in approximately 5 to 10% of fracture patients, with certain bones at greater risk of failing to heal. Non-unions have a significant impact on socioeconomic costs and the patients short and long-term quality of life. Low intensity pulsed ultrasound (LIPUS) is a non-invasive therapy for non-union treatment that can improve the long-term outcome. Read More

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2D-quantitative structure-activity relationships model using PLS method for anti-malarial activities of anti-haemozoin compounds.

Malar J 2021 Jun 11;20(1):264. Epub 2021 Jun 11.

Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan.

Background: Emergence of cross-resistance to current anti-malarial drugs has led to an urgent need for identification of potential compounds with novel modes of action and anti-malarial activity against the resistant strains. One of the most promising therapeutic targets of anti-malarial agents related to food vacuole of malaria parasite is haemozoin, a product formed by the parasite through haemoglobin degradation.

Methods: With this in mind, this study developed two-dimensional-quantitative structure-activity relationships (QSAR) models of a series of 21 haemozoin inhibitors to explore the useful physicochemical parameters of the active compounds for estimation of anti-malarial activities. Read More

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Pre-sleep cognitive arousal exacerbates sleep disturbance in chronic pain: an exploratory daily diary and actigraphy study.

Scand J Pain 2021 Jun 14. Epub 2021 Jun 14.

Department of Psychological Medicine, The University of Auckland, Auckland, New Zealand.

Objectives: Insomnia is commonly comorbid with chronic pain, and typically leads to worse outcomes. Two factors that could contribute to a cycle of pain and sleeplessness are pre-sleep cognitive arousal (repetitive thought processes) and low mood. This study aimed to examine how pain, sleep disturbance, mood, and pre-sleep cognitive arousal inter-relate, to determine whether low mood or pre-sleep cognitive arousal contribute to a vicious cycle of pain and insomnia. Read More

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[Pulmonary Rehabilitation in Patients with Chronic Obstructive Airway Diseases].

Pneumologie 2021 Jun 11;75(6):457-473. Epub 2021 Jun 11.

Pulmonary rehabilitation of asthma and COPD patients can improve their physical performance and quality of life, maintain participation in social and professional life and actively promote self-help. In addition, the resources for acute medical treatment can be spared. In case of COPD, rehabilitation directly after exacerbation can also improve the poor survival prognosis and reduce the risk of emergency hospital readmission. Read More

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Providing universal access to modern contraceptive methods: An extended cost-effectiveness analysis of meeting the demand for modern contraception in Ethiopia.

Soc Sci Med 2021 May 25;281:114076. Epub 2021 May 25.

Bergen Centre for Ethics and Priority Setting, Institute of Global Public Health and Primary Care, University of Bergen, Årstadveien 21, 5009, Bergen, Norway; Harvard T.H. Chan School of Public Health, Harvard University, 677 Huntington Ave, Boston, MA, 02115, United States. Electronic address:

Despite recent advances in access to and use of modern contraception in Ethiopia, further improvement is needed, particularly among poorer women. This extended cost-effectiveness analysis investigated the health outcomes, their distribution, and financial risk protection associated with meeting the demand for modern contraception for all Ethiopian women. We developed five Markov models with wealth quintile-specific input data to investigate the effects of meeting this demand and followed a hypothetical cohort of 1,252,000 women through their reproductive lives from ages 15-49 years. Read More

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Does the evidence support brief (≤30-mins), moderate (31-60-mins), or long duration naps (61+ mins) on the night shift? A systematic review.

Sleep Med Rev 2021 May 19;59:101509. Epub 2021 May 19.

University of Pittsburgh, School of Medicine, Department of Emergency Medicine, Pittsburgh, PA, 15261, USA.

We performed a systematic review of four databases to determine if the evidence supports a short or long duration nap during night shifts to mitigate fatigue, and/or improve health, safety, or performance for emergency services and public safety personnel (PROSPERO CRD42020156780). We focused on experimental research and evaluated the quality of evidence with the grading of recommendations, assessment, development, and evaluation (GRADE) framework. We used the Cochrane Collaboration's risk of bias tool to assess bias and reported findings using the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement. Read More

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Posttraumatic stress disorder symptoms and neurocognitive functioning in fire fighters: The mediating role of sleep problems and resilience.

Compr Psychiatry 2021 May 19;109:152250. Epub 2021 May 19.

Department of Neuropsychiatry, Eulji University School of Medicine, Eulji University Hospital, Daejeon, Republic of Korea. Electronic address:

Background: Firefighters are often exposed to terrible and dangerous scenes due to their duties, and thus have a high risk of developing posttraumatic stress disorder(PTSD). The purpose of the study is to examine the relationship between PTSD symptoms, sleep problems, resilience and neurocognitive functioning of firefighters, and to identify the sequential mediating effects of sleep problems and resilience on the relationship between PTSD symptoms and neurocognitive functioning (especially psychomotor speed and processing speed).

Methods: Data were collected from 325 firefighters in eight fire departments in four regions of Korea. Read More

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