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Type 2A and 2M von Willebrand Disease: Differences in Phenotypic Parameters According to the Affected Domain by Disease-Causing Variants and Assessment of Pathophysiological Mechanisms.

Semin Thromb Hemost 2021 Jun 15. Epub 2021 Jun 15.

Laboratorio de Hemostasia y Trombosis, IMEX-CONICET-Academia Nacional de Medicina de Buenos Aires. CABA, Argentina.

Type 2A and 2M von Willebrand disease (VWD) broadly show similar phenotypic parameters, but involve different pathophysiological mechanisms. This report presents the clinical and laboratory profiles of type 2A and type 2M patients genotypically diagnosed at one large center. Higher bleeding score values and a higher incidence of major bleeding episodes were observed in type 2A compared with type 2M, potentially reflective of the absence of large and intermediate von Willebrand factor (VWF) multimers in 2A. Read More

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Fullerenol as a water-soluble MALDI-MS matrix for rapid analysis of small molecules and efficient quantification of saccharin sodium in foods.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Jun 4;1178:122819. Epub 2021 Jun 4.

Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, China. Electronic address:

Due to the strong background interferences in the low-mass region and poor reproducibility of conventional organic matrices, it is of great importance to develop a novel matrix for matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) to qualitatively and quantitatively analyze small molecules. In this work, water-soluble fullerenol C(OH) was selected as a MALDI matrix for the analysis of low-molecular-weight compounds in consideration of optical absorption property, water solubility and stability. Compared with the traditional matrices, fullerenol demonstrated lower background interference and stronger peak intensity. Read More

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Effects of nerol on paracetamol-induced liver damage in Wistar albino rats.

Biomed Pharmacother 2021 Jun 12;140:111732. Epub 2021 Jun 12.

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Nerol, a monoterpene is evident to possess diverse biological activities, including antioxidant, anti-microbial, anti-spasmodic, anthelmintic, and anti-arrhythmias. This study aims to evaluate its hepatoprotective effect against paracetamol-induced liver toxicity in a rat model. Five groups of rats (n = 7) were orally treated (once daily) with 0. Read More

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USP22 regulates the formation and function of placental vasculature during the development of fetal growth restriction.

Placenta 2021 Jun 9;111:19-25. Epub 2021 Jun 9.

Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China. Electronic address:

Introduction: Fetal growth restriction (FGR) is a common obstetric complication that can lead to a variety of adverse perinatal outcomes and is associated with chronic diseases in adulthood. Since ubiquitin-specific protease 22 (USP22) is closely related to cell growth, differentiation and proliferation, we aimed to investigate the role of USP22 in FGR development.

Methods: USP22 expression was detected in the placentas of eight normal and eight pregnant women with FGR. Read More

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The advice given by physiotherapists to people with back pain in primary care.

Musculoskelet Sci Pract 2021 May 29;55:102403. Epub 2021 May 29.

University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton, UK; School of Health Sciences, University of Southampton, Highfield, Southampton, UK. Electronic address:

Background: Back pain guidelines endorse giving advice to enable people to self-manage and continue normal activities. Little is known however, about the content of advice that clinicians give and this project aimed to identify the advice given by clinicians to patients with back pain at their initial consultation.

Methods: A secondary analysis was conducted with 25 audio-recordings and transcriptions of consultations between patients with back pain and physiotherapists in a primary care outpatients department. Read More

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Different nutritional screening tools and recommended screening algorithm for pediatric oncology patients.

Clin Nutr 2021 May 24;40(6):3836-3841. Epub 2021 May 24.

2nd Department of Pediatrics, Semmelweis University, Budapest, 1094, 7-9 Tuzolto Street, Hungary.

Background & Aims: Cancer is one of the leading causes of death for children; however, appropriate nutritional status can positively affect disease progression and outcome. The aim of this study was to present our self-developed nutritional risk screening method, relate it to another validated tool and to objective bio-impedance measures. We intended to recommend a screening algorithm which can be used in our pediatric oncology facilities. Read More

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Saponins from Panax japonicus alleviate HFD-induced impaired behaviors through inhibiting NLRP3 inflammasome to upregulate AMPA receptors.

Neurochem Int 2021 Jun 12:105098. Epub 2021 Jun 12.

Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan, 430065, China; New Medicine Innovation and Development Institute, Department of Pharmacy, College of Medicine, Wuhan University of Science and Technology, Wuhan, 430065, China. Electronic address:

Obesity is characterized by a condition of low-grade chronic inflammation that facilitates development of numerous comorbidities and dysregulation of brain homeostasis. It is reported that obesity can lead to behavioral alterations such as cognitive decline and depression-like behaviors both in humans and rodents. Saponins from panax japonicus (SPJ) have been reported to exhibit anti-inflammatory action in mouse model of diet-induced obesity. Read More

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Lipoproteins and cancer: The role of HDL-C, LDL-C, and cholesterol-lowering drugs.

Biochem Pharmacol 2021 Jun 12:114654. Epub 2021 Jun 12.

Department of Molecular, Cellular, and Biomedical Sciences, Sophie Davis School of Biomedical Education, City University of New York School of Medicine, New York, NY, USA; Graduate Program in Biology, City University of New York Graduate Center, New York, USA. Electronic address:

Cholesterol is an amphipathic sterol molecule that is vital for maintaining normal physiological homeostasis. It is a relatively complicated molecule with 27 carbons whose synthesis starts with 2-carbon units. This in itself signifies the importance of this molecule. Read More

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"It's Really Like Any Other Study": Rural Radiology Facilities Performing Low-Dose Computed Tomography for Lung Cancer Screening.

Ann Am Thorac Soc 2021 Jun 15. Epub 2021 Jun 15.

Oregon Health & Science University, 6684, Portland, Oregon, United States.

Rationale: The majority of eligible people have not been screened for lung cancer. There is emerging evidence that there are location-based disparities applicable to lung cancer screening.

Objective: Describe lung cancer screening radiologic services in rural Oregon and understand the barriers and facilitators to implementation of lung cancer screening using LDCT. Read More

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Elke Bräuer-Krisch: Dedication, creativity and generosity: May 17, 1961- September 10, 2018.

Jean A Laissue

Int J Radiat Biol 2021 Jun 15:1-24. Epub 2021 Jun 15.

Institute of Pathology, University of Bern, Switzerland.

Purpose: This extraordinary woman worked her professional way from a radiation protection engineer to become the successful principal investigator of a prestigious international European project for a new radiation therapy (ERC Synergy grant, HORIZON 2020). The evaluation of the submitted proposal was very positive. The panel proposed that it be funded. Read More

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Homogeneous Visual and Fluorescence Detection of Circulating Tumor Cells in Clinical Samples Selective Recognition Reaction and Enzyme-Free Amplification.

ACS Nano 2021 Jun 15. Epub 2021 Jun 15.

Department of Laboratory Medicine, State Key Laboratory of Biotherapy and Cancer Center, Med+X Center for Manufacturing, West China Precision Medicine Industrial Technology Institute, Department of Urology, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China.

Here we report a simple all-nucleic-acid enzyme-free catalyzed hairpin assembly assisted amplification strategy with quantum dots (QDs) as the nanoscale signal reporter for homogeneous visual and fluorescent detection of A549 lung cancer cells from clinical blood samples. This work was based on the phenomenon that CdTe QDs can selectively recognize Ag and C-Ag-C and by using mucin 1 as the circulating tumor cells (CTCs) marker and aptamer as the recognition probe. Under optimized conditions, the limits of detections as low as 0. Read More

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Analysis of spatiotemporal variation of formaldehyde column concentration in Qinghai-Tibet Plateau and its influencing factors.

Environ Sci Pollut Res Int 2021 Jun 15. Epub 2021 Jun 15.

College of Geography and Environmental Sciences, Northwest Normal University, Lanzhou, 730070, Gansu, China.

Based on the formaldehyde (HCHO) inversion data of OMI satellite sensor from 2009 to 2019, this paper discusses the spatial and temporal distribution of HCHO column concentration over the Qinghai-Tibet Plateau in the past 11 years and explores the factors affecting the dynamic distribution of atmospheric HCHO column concentration over the Qinghai-Tibet Plateau in combination with meteorological, aerosol, ozone, and other data. The results show that the average concentration of HCHO column in the Qinghai-Tibet Plateau is 8.84 × 10 molec/cm in the past 11 years, which is relatively low, and the annual variation rate of HCHO column is 7. Read More

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Rapid Surface-Enhanced Raman Spectroscopy Detection of Chlorothalonil in Standard Solution and Orange Peels with Pretreatment of Ultraviolet Irradiation.

Bull Environ Contam Toxicol 2021 Jun 15. Epub 2021 Jun 15.

State Key Laboratory of Food Science and Technology, Jiangnan University, No.1800 Lihu Avenue, Wuxi, 214122, Jiangsu, China.

At present, the detection of chlorothalonil is generally based on chromatography and immunoassay; both of which are time-consuming and costly. In this study, Surface-enhanced Raman Spectroscopy (SERS) has been successfully utilized in the detection of chlorothalonil coupled with photochemistry and meanwhile, gold nanoparticles were prepared to enhance the Raman signal. Two Raman peaks (2246 cm and 2140 cm) of chlorothalonil were appeared after ultraviolet (UV) irradiation compared to the original solution. Read More

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Cissus quadrangularis extract attenuates diabetic nephropathy by altering SIRT1/DNMT1 axis.

J Pharm Pharmacol 2021 Jun 15. Epub 2021 Jun 15.

Pharmaceutics & Pharmacokinetics Division, CSIR-Central Drug Research Institute, Lucknow, India.

Objectives: Hyperglycemia-induced SIRT1, DNMT1, SODs, as well as oxidative stress, play a pivotal role in the progression of diabetic nephropathy. Cissus quadrangularis, holds antioxidant and hypoglycemic activity; however, a direct link between its activity and prevention of diabetic nephropathy has not been ascertained yet. Accordingly, we aimed to delineate the protective effect of ethanolic extract of Cissus quadrangularis (EECQ) against high-fat diet/streptozotocin (HFD/STZ) induced diabetic nephropathy rats. Read More

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Absolute Quantification of MicroRNAs in a Single Cell with Chemiluminescence Detection Based on Rolling Circle Amplification on a Microchip Platform.

Anal Chem 2021 Jun 15. Epub 2021 Jun 15.

State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin 541004, China.

The absolute quantification of miRNAs in a single cell allows to better understand the heterogeneity of cells and the relationship between miRNAs and diseases. However, seldom methods for miRNA quantification in a single cell have been reported because the miRNA content in a single cell is very low. Herein, an ultrasensitive chemiluminescence assay strategy based on rolling circle amplification (RCA) on a microchip platform was proposed for the absolute quantification of miRNAs in a single cell. Read More

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Graphene-coated nanoporous nickel towards a metal-catalyzed oxygen evolution reaction.

Nanoscale 2021 Jun 15. Epub 2021 Jun 15.

Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21218, USA. and WPI Advanced Institute for Materials Research, Tohoku University, Sendai 980-8577, Japan.

Developing highly active electrocatalysts with low costs and long durability for oxygen evolution reactions (OERs) is crucial towards the practical implementations of electrocatalytic water-splitting and rechargeable metal-air batteries. Anodized nanostructured 3d transition metals and alloys with the formation of OER-active oxides/hydroxides are known to have high catalytic activity towards OERs but suffer from poor electrical conductivity and electrochemical stability in harsh oxidation environments. Here we report that high OER activity can be achieved from the metallic state of Ni which is passivated by atomically thick graphene in a three-dimensional nanoporous architecture. Read More

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X-chromosome inactivation patterns in females with Fabry disease examined by both ultra-deep RNA sequencing and methylation-dependent assay.

Clin Exp Nephrol 2021 Jun 14. Epub 2021 Jun 14.

Department of Nephrology, Kobe University Graduate School of Medicine, Kobe, Japan.

Background: Fabry disease is an X-linked inherited lysosomal storage disorder caused by mutations in the gene encoding α-galactosidase A. Males are usually severely affected, while females have a wide range of disease severity. This variability has been assumed to be derived from organ-dependent skewed X-chromosome inactivation (XCI) patterns in each female patient. Read More

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MiR-3614-5p Is a Potential Novel Biomarker for Colorectal Cancer.

Front Genet 2021 28;12:666833. Epub 2021 May 28.

Department of General Surgery, The Armed Police Corps Hospital of Anhui, Hefei, China.

MiR-3614-5p has been found in a variety of cancers including colorectal cancer. However, the association of miR-3614-5p with colorectal cancer is still unclear. Based on the Cancer Genome Atlas (TCGA) database, the relationship between miR-3614-5p and colorectal cancer can be proved. Read More

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Design of a miniaturized ultrawideband and low scattering antipodal vivaldi antenna array.

Sci Rep 2021 Jun 14;11(1):12499. Epub 2021 Jun 14.

State Key Laboratory of Media Convergence and Communication, Communication University of China, Beijing, 100024, China.

This paper presents a miniaturized ultra-wideband (UWB) antipodal Vivaldi antenna (AVA) array with low-scattering characteristics integrated a hybrid diffusive-absorptive metasurface. Periodic elliptical slots at the outer edges and a dielectric lens are utilized for antenna element to improve performances including miniaturized size, wide bandwidth, and high gain. The optimized element is fabricated and measured, the results demonstrate that the - 10 dB impedance bandwidth is 4. Read More

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Vaccination with BCGΔBCG1419c protects against pulmonary and extrapulmonary TB and is safer than BCG.

Sci Rep 2021 Jun 14;11(1):12417. Epub 2021 Jun 14.

Biotecnología Médica y Farmacéutica, Centro de Investigación y Asistencia en Tecnología y diseño del Estado de Jalisco, Av. Normalistas 800, Col. Colinas de la Normal, 44270, Guadalajara, Jalisco, Mexico.

A single intradermal vaccination with an antibiotic-less version of BCGΔBCG1419c given to guinea pigs conferred a significant improvement in outcome following a low dose aerosol exposure to M. tuberculosis compared to that provided by a single dose of BCG Pasteur. BCGΔBCG1419c was more attenuated than BCG in murine macrophages, athymic, BALB/c, and C57BL/6 mice. Read More

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Biomechanical Effects of a 6-Week Change-of-Direction Technique Modification Intervention on Anterior Cruciate Ligament Injury Risk.

J Strength Cond Res 2021 Jun 11. Epub 2021 Jun 11.

Human Performance Laboratory, Directorate of Sport, Exercise, and Physiotherapy, University of Salford, Greater Manchester, United Kingdom; Department of Sport and Exercise Sciences, Musculoskeletal Science and Sports Medicine Research Centre, Manchester Metropolitan University, Manchester, United Kingdom; and Edith Cowan University, School of Medical and Health Science, Western Australia, Australia.

Abstract: Dos'Santos, T, Thomas, C, Comfort, P, and Jones, PA. Biomechanical effects of a 6-week change-of-direction technique modification intervention on anterior cruciate ligament injury risk. J Strength Cond Res XX(X): 000-000, 2021-The aim of this study was to evaluate the biomechanical effects of a 6-week change-of-direction (COD) technique modification intervention on anterior cruciate ligament (ACL) injury risk (i. Read More

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The Timing of Obesity Matters: Associations Between Current Versus Chronic Obesity since Adolescence and Romantic Relationship Satisfaction Among Young Adult Women.

Womens Health Issues 2021 Jun 11. Epub 2021 Jun 11.

PolicyLab, Children's Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania.

Background: Although the social consequences of obesity for women are well-documented, its stigmatizing effect on romantic relationships across the life course has seldom been explored. We examined whether having current or chronic obesity since adolescence is associated with romantic relationship satisfaction among women in early adulthood.

Methods: This is a secondary analysis of data from the National Longitudinal Study of Adolescent Health. Read More

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Effect of Surface Nanopatterning on Slip: The Case of Couette Flow of Long-Chain Polyethylene Melt Flowing Past Gold Surfaces.

J Phys Chem B 2021 Jun 15. Epub 2021 Jun 15.

School of Chemical Engineering, National Technical University of Athens (NTUA), Athens, GR-15780, Greece.

The manifestation of slip during flow of a polymer melt past a solid surface depends on several parameters, such as film thickness, the strength of polymer-solid interactions compared to the cohesive energy of the polymer, and the roughness of the surface. Understanding the role of these molecular aspects for slip is crucial in microfluidics, friction-tuning, polymer extrusion, and nanocomposites applications. The present article investigates the effect of surface nanopatterning on slip, via Couette-flow simulations of long chain polyethylene melts past nanopatterned gold surfaces. Read More

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Iron-carbon microelectrolysis for wastewater remediation: Preparation, performance and interaction mechanisms.

Chemosphere 2021 Sep 3;278:130483. Epub 2021 Apr 3.

School of Environment, Key Laboratory for Yellow River and Huai River Water Environment and Pollution Control, Ministry of Education, Henan Key Laboratory for Environmental Pollution Control, Henan Normal University, Xinxiang, 453007, China.

Rapid industrialization and urbanization have produced a lot of hazardous substances in water and wastewater, which has turned into a crucial issue to the environment and the public health. Recently, iron carbon microelectrolysis (IC-ME) has attracted extensive attention in environmental remediation due to its low costs and excellent performance. Nevertheless, there is still a lack of a more systematic review on IC-ME preparation methods, their performance, and the interaction mechanisms of IC-ME in the remediation of wastewater. Read More

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September 2021

Rare earth element migration and impact of Dicranopteris dichotoma at mines in south China.

Chemosphere 2021 Sep 31;278:130433. Epub 2021 Mar 31.

State Key Laboratory for Subtropical Mountain Ecology of the Ministry of Science and Technology and Fujian Province, Fujian Normal University, Fuzhou, Fujian, China; Institute of Geography, Fujian Normal University, Fuzhou, Fujian, China; School of Geographical Sciences, Fujian Normal University, Fuzhou, Fujian, China.

The migration of rare earth elements (REEs) has a major influence on the environment. However, little is known about REEs migration control by Dicranopteris dichotoma at REEs mines. Therefore, this study examined the horizontal and vertical migration of REEs using artificial rainfall and naive soil column experiments, respectively, and the REEs migration control of Dicranopteris dichotoma at REEs mines in south China. Read More

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September 2021

The cross-talk modulation of excited state electron transfer to reduce the false negative background for high fidelity imaging .

Chem Sci 2020 Jan 18;11(7):1964-1974. Epub 2020 Jan 18.

College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institutes of Biomedical Sciences, Shandong Normal University Jinan 250014 P. R. China

In practice, high fidelity fluorescence imaging faces many issues, for example: (1) the fluorescence background of the probe is bleached by the wide intensity scale of fluorescence microscopy, displaying an inherent false negative background (); and (2) the dosage of the probe has to be increased to achieve sufficient intensity for imaging, causing a vicious cycle that exacerbates the . Herein, we constructed a fluorophore ()-electron donor ()-electron regulator () system, and thereby developed a dual modulation strategy for the design of high fidelity probes. Using cross-talk modulation, the probe allows: (1) enhanced (excited state electron transfer) from to , which minimizes the inherent based on synergistic (photo induced electron transfer); and (2) the inhibition of and weakening of from to to maximize the reporting intensity to further reduce the , which is additionally enhanced by an overdose of the probe. Read More

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January 2020

Harpagide, a natural product, promotes synaptic vesicle release as measured by nanoelectrode amperometry.

Chem Sci 2019 Nov 28;11(3):778-785. Epub 2019 Nov 28.

Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University Wuhan 430072 China

Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive loss of dopaminergic (DAergic) neurons and low level of dopamine (DA) in the midbrain. Recent studies suggested that some natural products can protect neurons against injury, but their role on neurotransmitter release and the underlying mechanisms remained unknown. In this work, nanoelectrode electrochemistry was used for the first time to quantify DA release inside single DAergic synapses. Read More

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November 2019

A Newborn Falsely Suspected of Congenital Hypothyroidism due to Mutated Thyroxine-Binding Globulin with Low Binding Affinity.

Horm Res Paediatr 2021 Jun 14:1-5. Epub 2021 Jun 14.

Department of Pediatric Endocrinology, Amsterdam UMC, Emma Children's Hospital, University of Amsterdam, Amsterdam, The Netherlands.

Introduction: Neonatal screening programs for congenital hypothyroidism (CH) have been implemented worldwide to facilitate early diagnosis and treatment. The Dutch neonatal CH screening is primarily based on the measurement of thyroxine (T4). When T4 is low, an additional thyroxine-binding globulin (TBG) measurement is performed to reduce the number of false-positive screening results due to harmless TBG deficiency. Read More

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Preparation of fluorescent bimetallic silver/copper nanoparticles and their utility of dual-mode fluorimetric and colorimetric probe for Hg.

Spectrochim Acta A Mol Biomol Spectrosc 2021 May 29;261:120035. Epub 2021 May 29.

Key Laboratory of Photochemical Biomaterials and Energy Storage Materials, Heilongjiang Province, Key Laboratory for Photonic and Electronic Bandgap Materials, Ministry of Education, College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin, Heilongjiang 150025, China; Department of Chemistry, University of Cambridge, Lensfield Rd, Cambridge CB2 1EW, UK. Electronic address:

A dual-mode colorimetric and fluorimetric probe was successfully established based on silver/copper bimetallic nanoparticles (AgCu-BNPs). The AgCu-BNPs were confirmed as individually bimetallic nanoparticles with a mean size of 7.7 ± 0. Read More

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Design a system for measuring individual cow feed intake in commercial dairies.

Animal 2021 Jun 11;15(7):100277. Epub 2021 Jun 11.

Presicion Livestock Farming (PLF) Lab, Institute of Agricultural Engineering, Agricultural Research Organization (A.R.O.), The Volcani Center, P.O. Box 6, Bet-Dagan 50250, Israel.

Monitoring individual cow feed intake is necessary for calculating the cow individual feed efficiency. The cost and maintenance time necessary for research systems make them impractical for most of the commercial producers. We developed a measurement system with producer convenience and low investment as key design criteria. Read More

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