82,908 results match your criteria low movement

[Function-based tests to determine the return-to-activity state in patients with non-specific low back pain].

Sportverletz Sportschaden 2021 May 12. Epub 2021 May 12.

Hochschule Furtwangen, Germany.

Background:  Most people with back pain suffer from non-specific low back pain, for which no specific reasons can be found. Two out of three have recurrent pain episodes. To reduce the likelihood of recurrence and long-lasting pain, functional tests are increasingly used to determine the current functional status. Read More

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Tracking changes in behavioural dynamics using prediction error.

PLoS One 2021 12;16(5):e0251053. Epub 2021 May 12.

Section of Ecology, Behavior, and Evolution, Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America.

Automated analysis of video can now generate extensive time series of pose and motion in freely-moving organisms. This requires new quantitative tools to characterise behavioural dynamics. For the model roundworm Caenorhabditis elegans, body pose can be accurately quantified from video as coordinates in a single low-dimensional space. Read More

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The impact of mass drug administration expansion to low onchocerciasis prevalence settings in case of connected villages.

PLoS Negl Trop Dis 2021 May 12;15(5):e0009011. Epub 2021 May 12.

Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Background: The existence of locations with low but stable onchocerciasis prevalence is not well understood. An often suggested yet poorly investigated explanation is that the infection spills over from neighbouring locations with higher infection densities.

Methodology: We adapted the stochastic individual based model ONCHOSIM to enable the simulation of multiple villages, with separate blackfly (intermediate host) and human populations, which are connected through the regular movement of the villagers and/or the flies. Read More

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Romidepsin (FK228) fails in counteracting the transformed phenotype of rhabdomyosarcoma cells but efficiently radiosensitizes, and , the alveolar phenotype subtype.

Int J Radiat Biol 2021 May 12:1-32. Epub 2021 May 12.

Department of Radiotherapy, Policlinico Umberto I, "Sapienza" University of Rome, 00161 Rome, Italy.

Herein we describe the and activity of FK228 (Romidepsin), an inhibitor of class I HDACs, in counteracting and radiosensitizing embryonal (ERMS, fusion-negative) and alveolar (ARMS, fusion-positive) rhabdomyosarcoma (RMS). RH30 (ARMS, fusion-positive) and RD (ERMS, fusion-negative) cell lines and human multipotent mesenchymal stromal cells (HMSC) were used. Flow cytometry analysis, RT-qPCR, western blotting and enzymatic assays were performed. Read More

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Kinematic and Acoustic Changes to Vowels and Diphthongs in Bite Block Speech.

J Speech Lang Hear Res 2021 May 12:1-8. Epub 2021 May 12.

Department of Communication Disorders, Brigham Young University, Provo, UT.

Purpose We examined the effect of bite block insertion (BBI) on lingual movements and formant frequencies in corner vowel and diphthong production in a sentence context. Method Twenty young adults produced the corner vowels (/u/, /ɑ/, /æ/, /i/) and the diphthong /ɑɪ/ in sentence contexts before and after BBI. An electromagnetic articulograph measured the movements of the tongue back, middle, and front. Read More

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Multi-scale assessment of functional connectivity: Landscape genetics of eastern indigo snakes in an anthropogenically fragmented landscape in central Florida.

Mol Ecol 2021 May 12. Epub 2021 May 12.

Department of Environmental Conservation, University of Massachusetts, Amherst, Massachusetts, USA.

Landscape features can strongly influence gene flow and the strength and direction of these effects may vary across spatial scales. However, few studies have evaluated methodological approaches for selecting spatial scales in landscape genetics analyses, in part because of computational challenges associated with optimizing landscape resistance surfaces (LRS). We used the federally threatened eastern indigo snake (Drymarchon couperi) in central Florida as a case study with which to compare the importance of landscape features and their scales-of-effect in influencing gene flow. Read More

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Home physical exercise improves functional mobility and quality of life in elderly. A CONSORT-prospective, randomized controlled clinical trial.

Int J Clin Pract 2021 May 11:e14347. Epub 2021 May 11.

Master Degree and PhD Post Graduate Program in Human Movement and Rehabilitation, University Center of Anapolis - UniEVANGELICA, Anapolis, GO, Brazil.

Aims: To test the hypothesis of a semi-supervised home physical exercise program that is likely to improve the functional mobility and quality of life (QOL) of elderly in the community.

Methods: This trial included elderly adults (88% female) aged 60 years or older and who were sedentary and without cognitive decline. The participants were randomly assigned to an intervention group (IG, home physical exercise and sleep hygiene) and a control group (CG, sleep hygiene). Read More

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Fine-scale foraging behavior reveals differences in the functional roles of herbivorous reef fishes.

Ecol Evol 2021 May 18;11(9):4898-4908. Epub 2021 Mar 18.

ARC Centre of Excellence for Coral Reef Studies James Cook University Townsville QLD Australia.

Efforts to understand and protect ecosystem functioning have put considerable emphasis on classifying species according to the functions they perform. However, coarse classifications based on diet or feeding mode often oversimplify species' contributions to ecological processes. Behavioral variation among superficially similar species is easily missed but could indicate important differences in competitive interactions and the spatial scale at which species deliver their functions. Read More

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Socio-Demographics, Pain Characteristics, Quality of Life and Treatment Values Before and After Specialized Interdisciplinary Pain Treatment: Results from the Danish Clinical Pain Registry (PainData).

J Pain Res 2021 4;14:1215-1230. Epub 2021 May 4.

Interdisciplinary Research Unit, Elective Surgery Center, Silkeborg Regional Hospital, Silkeborg, Denmark.

Background And Aims: PainData is an electronic internet-based clinical pain registry established to improve the understanding and treatment of high-impact chronic pain. The primary aim of this paper is to describe socio-demographics, pain characteristics, quality of life, and treatment values at baseline and follow-up in individuals referred to public and private interdisciplinary pain centers in Denmark between 2018 and 2020.

Methods: Self-reported patient-reported outcomes collected through PainData before (n=12,257) and after (n=4,111) treatment across 13 public and private interdisciplinary specialized pain centers in Denmark (87% of all pain centers in Denmark) are described. Read More

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Understanding regional activation of thoraco-lumbar muscles in chronic low back pain and its relationship to clinically relevant domains.

BMC Musculoskelet Disord 2021 May 11;22(1):432. Epub 2021 May 11.

Centre of Precision Rehabilitation for Spinal Pain, School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom.

Background: Altered regional activation of the lumbar extensors has been previously observed in individuals with low back pain (LBP) performing high-effort and fatiguing tasks. It is currently unknown whether similar alterations can be observed during low-effort functional tasks. Similarly, previous studies did not investigate whether side differences in regional activation are present in individuals with LBP. Read More

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Leadership Through Influence: What Mechanisms Allow Leaders to Steer a Swarm?

Bull Math Biol 2021 May 10;83(6):69. Epub 2021 May 10.

Dipartimento Interateneo di Scienze, Progetto e Politiche del Territorio (DIST), Politecnico di Torino, Viale Pier Andrea Mattioli, 39, 10125, Turin, Italy.

Collective migration of cells and animals often relies on a specialised set of "leaders", whose role is to steer a population of naive followers towards some target. We formulate a continuous model to understand the dynamics and structure of such groups, splitting a population into separate follower and leader types with distinct orientation responses. We incorporate leader influence via three principal mechanisms: a bias in the orientation of leaders towards the destination (orientation-bias), a faster movement of leaders when moving towards the target (speed-bias), and leaders making themselves more clear to followers when moving towards the target (conspicuousness-bias). Read More

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Temporal summation of mechanical pain prospectively predicts movement-evoked pain severity in adults with chronic low back pain.

BMC Musculoskelet Disord 2021 May 10;22(1):429. Epub 2021 May 10.

Department of Psychology, University of Alabama at Birmingham, 1300 University Boulevard, Campbell Hall, Suite 237, Birmingham, AL, 35294, USA.

Background: Biopsychosocial factors above and beyond pathoanatomical changes likely contribute to the severity of chronic low back pain. A pro-nociceptive endogenous pain modulatory balance (↓inhibition and ↑facilitation) may be an important contributor to chronic low back pain severity and physical function; however, additional research is needed to address this possibility. The objective of this study was to determine whether quantitative sensory tests of endogenous pain inhibition and facilitation prospectively predict movement-evoked pain and cLBP severity self-reported on a validated questionnaire. Read More

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Risk of Infection after Deep Brain Stimulation Surgery with Externalization and Local-Field Potential Recordings: Twelve-Year Experience from a Single Institution.

Stereotact Funct Neurosurg 2021 May 10:1-9. Epub 2021 May 10.

Department of Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Introduction: Deep brain stimulation (DBS) has been an established surgical procedure in the field of functional neurosurgery for many years. The experimental electrophysiological method of local field potential (LFP) recordings in postsurgically externalized patients has made substantial contributions to the better understanding of pathophysiologies underlying movement disorders. As interest in LFP recordings for the development of improved stimulation strategies increases, this study's aim was to provide evidence concerning safety of this research method, in a major DBS center. Read More

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Genetic Testing for Parkinson Disease: Are We Ready?

Neurol Clin Pract 2021 Feb;11(1):69-77

Department of Medical and Molecular Genetics (LC, JS, TF), Indiana University School of Medicine, Indianapolis; The Michael J. Fox Foundation for Parkinson's Research (CK, TH), New York; Parkinson's Foundation (AN), Miami, FL; Department of Neurology (JW, KP), Indiana University School of Medicine, Indianapolis; Department of Neurology (RNA), Columbia University Irving Medical Center, New York; Institute of Neurogenetics (CK), University of Lübeck, Germany; Department of Neurology (RS-P), Mount Sinai Beth Israel, New York; and Parkinson's Disease and Movement Disorders Center (TS), Northwestern University Feinberg School of Medicine, Chicago IL.

Purpose Of Review: With the advent of precision medicine and demand for genomic testing information, we may question whether it is time to offer genetic testing to our patients with Parkinson disease (PD). This review updates the current genetic landscape of PD, describes what genetic testing may offer, provides strategies for evaluating whom to test, and provides resources for the busy clinician.

Recent Findings: Patients with PD and their relatives, in various settings, have expressed an interest in learning their PD genetic status; however, physicians may be hesitant to widely offer testing due to the perceived low clinical utility of PD genetic test results. Read More

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February 2021

Post-stroke gait training practices in a low resource setting: A cross-sectional survey among Indian physiotherapists.

NeuroRehabilitation 2021 May 3. Epub 2021 May 3.

Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, India.

Background: Independent mobility is the most important determinant of quality of life after stroke and it is vital that training aimed at restoration of gait is based on contemporary evidence. Despite several practice guidelines for gait rehabilitation after stroke existing globally, their feasibility of application in low-resource settings is often questionable.

Objective: To investigate the current practices in gait training among Indian physiotherapists involved in the rehabilitation of stroke survivors. Read More

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Six-Month Community-Based Brisk Walking and Balance Exercise Alleviates Motor Symptoms and Promotes Functions in People with Parkinson's Disease: A Randomized Controlled Trial.

J Parkinsons Dis 2021 May 3. Epub 2021 May 3.

Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, China.

Background: In Parkinson's disease (PD), sustained aerobic exercise is a promising therapy in delaying motor disability. Brisk walking is a moderate intensity aerobic training, which could be translated to community practice at low cost, but its effects on motor symptoms remains unclear.

Objective: To determine the effectiveness of a six-month brisk walking and balance program in alleviating motor symptoms, and promoting functional, gait, and balance performance in people with PD. Read More

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Nonvascularized Free Toe Phalangeal Transfers in Congenital Hand Differences : Radiological, Functional, and Patient/Parent-Reported Outcomes.

J Hand Surg Am 2021 May 6. Epub 2021 May 6.

Department of Plastic, Hand and Reconstructive Microsurgery, Ganga Hospital, Coimbatore, Tamil Nadu, India.

Purpose: To evaluate radiologically, functionally and by patient-reported outcome measures, nonvascularized free toe phalangeal transfer (NVFTT) in the reconstruction of congenital short fingers with redundant soft tissue.

Methods: Nineteen children who underwent NVFTT in 40 digits were studied. Of these, 13 patients with a mean follow-up of 5. Read More

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Natural abundance isotope ratios to differentiate sources of carbon used during tumor growth in vivo.

BMC Biol 2021 May 10;19(1):85. Epub 2021 May 10.

Centre for Cancer Cell Reprogramming, Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Montebello, N-0379, Oslo, Norway.

Background: Radioactive or stable isotopic labeling of metabolites is a strategy that is routinely used to map the cellular fate of a selected labeled metabolite after it is added to cell culture or to the circulation of an animal. However, a labeled metabolite can be enzymatically changed in cellular metabolism, complicating the use of this experimental strategy to understand how a labeled metabolite moves between organs. These methods are also technically demanding, expensive and potentially toxic. Read More

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The Addition of AçaÍ Palm Fruit Extract in the Cryopreservation Diluent of Bull's Semen with Low Performance on Freezing.

Cryo Letters 2019 Sep-Oct;40(5):299-304

Laboratory of Biotechnology in Animal Reproduction of Carajas, Federal Rural University of Amazonia, Parauapebas-PA, Brazil.

Background: Semen freezing is of great importance for animal production because it allows the use and the rapid diffusion of the genetic material from economically important animals.

Objective: To evaluate the effect of açai (Euterpe oleracea; Arecaceae family) extract addition to the semen cryopreservation diluent on the morphology, sperm motility parameters, and plasma membrane integrity of spermatozoa.

Materials And Methods: The ejaculates, obtained from five bulls with low performance on semen freezing, were fractionated and distributed according to the experimental group. Read More

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The accuracy of the Ishii score chart in predicting sarcopenia in the elderly community in Chengdu.

BMC Geriatr 2021 May 8;21(1):296. Epub 2021 May 8.

National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang Renmin Nan Lu Chengdu, Sichuan, China.

Background: Sarcopenia is a disorder associated with age that reduces the mass of skeletal muscles, the strength of muscles, and/or physical activity. It increases the risk of fall incidence which can result in fractures, hospitalizations, limited movement, and considerably decreased quality of life. Hence, it is needed to explore candidate screening tools to evaluate sarcopenia in the initial phases. Read More

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Parasympathetic Nervous Activity Associated with Discoordination Between Physical Acceleration and Heart Rate Variability in Patients with Sleep Apnea.

Adv Exp Med Biol 2021 ;1269:229-234

Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Sleep apnea syndrome (SAS) often accompanies alterations in heart rate variability (HRV). The severity of SAS is sometimes evaluated using the oxygen desaturation index (ODI). We hypothesized that effects of the autonomic nervous system could be involved in the coordination between HRV and physical acceleration during free movement in patients with SAS. Read More

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Functional Impact of Acidosis-Regulated MicroRNAs on the Migration and Adhesion of Tumor Cells.

Adv Exp Med Biol 2021 ;1269:151-155

Julius-Bernstein-Institute of Physiology, University of Halle-Wittenberg, Halle (Saale), Germany.

Tumor tissue shows special features in metabolism in contrast to healthy tissue. Besides a distinctive oxygen deficiency, tumors often show a reduced extracellular pH (acidosis) resulting from an intensified glycolysis not only under hypoxic but also under normoxic conditions (Warburg effect). As shown in previous studies, cell migration is increased in AT1 prostate carcinoma cells after incubation at pH 6. Read More

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Shield and sword nano-soldiers ameliorate rheumatoid arthritis by multi-stage manipulation of neutrophils.

J Control Release 2021 May 6. Epub 2021 May 6.

Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, People's Republic of China. Electronic address:

Rheumatoid arthritis (RA) is characterized by the outbreak of inflammation. Neutrophils, the main culprit of the outbreak of inflammation, are the first inflammatory cells to be recruited to inflamed joints and facilitate the recruitment of themselves by stimulating the release of chemokines. Here, based on neutrophils, a novel anti-inflammatory "shield and sword soldiers" strategy is established with LMWH-TOS nanoparticles (LT NPs). Read More

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Role of sleep on respiratory failure after extubation in the ICU.

Ann Intensive Care 2021 May 8;11(1):71. Epub 2021 May 8.

INSERM CIC 1402, ALIVE Research Group, University of Poitiers, Poitiers, France.

Background: Sleep had never been assessed immediately after extubation in patients still in the ICU. However, sleep deprivation may alter respiratory function and may promote respiratory failure. We hypothesized that sleep alterations after extubation could be associated with an increased risk of post-extubation respiratory failure and reintubation. Read More

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Recent Advances in the Development of Stem-Cell-Derived Dopaminergic Neuronal Transplant Therapies for Parkinson's Disease.

Mov Disord 2021 May 8. Epub 2021 May 8.

Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan.

The last decade has seen exciting advances in the development of potential stem cell-based therapies for Parkinson's disease (PD), which have used different types of stem cells as starting material. These cells have been developed primarily to replace dopamine-producing neurons in the substantia nigra that are progressively lost in the disease process. The aim is to largely restore lost motor functions, whilst not ever being curative. Read More

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Older-onset levodopa-responsive parkinsonism with normal DAT-SPECT and pterin hypometabolism.

BMJ Case Rep 2021 May 7;14(5). Epub 2021 May 7.

Department of Neurology, National Hospital Organization Utano National Hospital, Kyoto, Japan.

Pterin species participate in dopamine biosynthesis, and abnormal pteridine metabolism contributes to reduced dopamine. GTP cyclohydrolase 1 (GCH-1) deficiency, which triggers pteridine hypometabolism and normally develops in childhood, can mediate an adult-onset decrease in levodopa production and dopa-responsive dystonia (DRD), with normal dopamine transporter single-photon emission computed tomography (DAT-SPECT). A recent study described normal DAT-SPECT in adult-onset cases with GCH-1 mutations, clinically diagnosed with Parkinson's disease, which raises the possibility that the abnormal metabolism of pteridine may be a differential diagnosis for adult-onset parkinsonism. Read More

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Enhanced Recovery After Surgery strategies for elective craniotomy: a systematic review.

J Neurosurg 2021 May 7:1-25. Epub 2021 May 7.

1Machine Intelligence in Clinical Neuroscience (MICN) Laboratory, Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Switzerland.

Objective: Enhanced Recovery After Surgery (ERAS) has led to a paradigm shift in perioperative care through multimodal interventions. Still, ERAS remains a relatively new concept in neurosurgery, and there is no summary of evidence on ERAS applications in cranial neurosurgery.

Methods: The authors systematically reviewed the literature using the PubMed/MEDLINE, Embase, Scopus, and Cochrane Library databases for ERAS protocols and elements. Read More

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Prevalence and associated factors of anxiety and depression in students at a Greek university during COVID-19 lockdown.

J Public Health Res 2021 May 7. Epub 2021 May 7.

Lab of Public Health, Medical School, University of Patras.

Background: Restrictions on movement and lockdown are measures taken in many nations, in response to the COVID-19 pandemic. University students are additionally burdened by the transition to distance e-learning. The aims of the study were to investigate the prevalence of anxiety and depression in university students and to identify associated risk factors. Read More

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Cognitive deficit is correlated with sleep stability in insomnia: A cardiopulmonary coupling study.

Brain Behav 2021 May 7:e02068. Epub 2021 May 7.

Department of Neurology, Tianjin Medical University General Hospital Airport Site, Tianjin, China.

Objectives: To assess the correlation of cognitive function with sleep stability and depressive-anxious symptoms in insomnia patients.

Methods: Twenty-two insomnia patients with cognitive impairment (insomnia-CI), 21 insomnia patients with normal cognition (insomnia-CN), and 15 matched healthy control subjects (HCs) were enrolled and completed neuropsychological tests, the Hamilton Depression and Anxiety Scales (HAMD and HAMA), the Epworth Sleepiness Scale, the Pittsburgh Sleep Quality Index (PSQI),the Insomnia Severity Index (ISI), and the cardiopulmonary coupling (CPC) examination. Ratios of high-frequency coupling (HFC), low-frequency coupling (LFC), and very low-frequency coupling (VLFC) measured by CPC analysis represent stable sleep, unstable sleep, and wake/rapid eye movement (REM) sleep, respectively. Read More

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What is the current clinico-radiological diagnostic accuracy for intracranial tumours?

Acta Neurol Scand 2021 May 7. Epub 2021 May 7.

Department of Neurosurgery, St. Olav's University Hospital, Trondheim, Norway.

Objective: To determine the diagnostic accuracy of routine clinico-radiological workup for a population-based selection of intracranial tumours.

Methods: In this prospective cohort study, we included consecutive adult patients who underwent a primary surgical intervention for a suspected intracranial tumour between 2015 and 2019 at a single-neurosurgical centre. The treating team estimated the expected diagnosis prior to surgery using predefined groups. Read More

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