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Labeling of liver cells with CdSe/ZnS quantum dot-based fluorescence probe below freezing point.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jul 21;263:120203. Epub 2021 Jul 21.

Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics - Hubei Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, PR China; Key Laboratory of Biomedical Photonics (HUST), Ministry of Education, Huazhong University of Science and Technology, Wuhan, Hubei 430074, PR China. Electronic address:

In this paper, CdSe/ZnS quantum dots (QDs) with particle size of 5.5 ~ 9.3 nm were synthesized, and the fluorescence emission ranged from 545 ~ 616 nm. Read More

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Characteristics, kinetics, thermodynamics and long-term effects of zerovalent iron/pyrite in remediation of Cr(VI)-contaminated soil.

Environ Pollut 2021 Jul 23;289:117830. Epub 2021 Jul 23.

School of Metallurgy and Environment, Central South University, Changsha, 410083, PR China; Chinese National Engineering Research Centre for Control & Treatment of Heavy Metal Pollution, Changsha, 410083, PR China. Electronic address:

Development of efficient, green and low-cost natural mineral-based reductive materials is promising to remediation of hexavalent chromium(Cr(VI))-contaminated soil. Considering the synergetic effect between pyrite and zerovalent iron (ZVI), an activated pyrite supported ZVI(ZVI/FeS) with high reducing activity was developed by ball milling activation of natural pyrite and sulfidation of ZVI. The remediation property of ZVI/FeS for Cr(VI)-contaminated soil was evaluated with different ZVI/FeS dosage, soil-water ratio, initial pH, time and temperature, as well as the stability of Cr. Read More

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The effect of reviewer's review volumes on online consumer reviews' perceived usefulness: An event-related potential study.

Neurosci Lett 2021 Jul 26:136139. Epub 2021 Jul 26.

School of Management, Guangdong University of Technology, Guangzhou, China.

What is the most useful online consumer review? Consumers face the challenge of identifying useful online consumer reviews, some of which might have been manipulated. Reviewer's review volumes is the past behavior of a reviewer. Reviews are used by many online shopping websites. Read More

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Neuroactive steroids, WIN-compounds and cholesterol share a common binding site on muscarinic acetylcholine receptors.

Biochem Pharmacol 2021 Jul 26:114699. Epub 2021 Jul 26.

Institute of Physiology Czech Academy of Sciences, Prague, Czech Republic. Electronic address:

Endogenous neurosteroids and their synthetic analogues - neuroactive steroids - have been found to bind to muscarinic acetylcholine receptors and allosterically modulate acetylcholine binding and function. Using radioligand binding experiments we investigated their binding mode. We show that neuroactive steroids bind to two binding sites on muscarinic receptors. Read More

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Seed-borne fungal endophytes constrain reproductive success of host plants under ozone pollution.

Environ Res 2021 Jul 26:111773. Epub 2021 Jul 26.

IFEVA, Universidad de Buenos Aires, CONICET, Facultad de Agronomía, Buenos Aires, Argentina.

Tropospheric ozone is among the global change factors that pose a threat to plants and microorganisms. Symbiotic microorganisms can assist plants to cope with stress, but their role in the tolerance of plants to ozone is poorly understood. Here, we subjected endophyte-symbiotic and non-symbiotic plants of Lolium multiflorum, an annual species widely distributed in temperate grasslands, to high and low (i. Read More

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Pre-release dietary supplements of methoprene and raspberry ketone increase field abundance of sterile Queensland fruit flies (Diptera: Tephritidae).

J Econ Entomol 2021 Jul 29. Epub 2021 Jul 29.

Applied BioSciences, Macquarie University, Sydney, Australia.

The sterile insect technique (SIT) is a sustainable pest management tool based on the release of millions of sterile insects that suppress reproduction in targeted populations. Success of SIT depends on survival, maturation, dispersal, and mating of released sterile insects. Laboratory and field cage studies have demonstrated that dietary supplements of methoprene and raspberry ketone (RK) promote sexual maturation of adult Queensland fruit fly, Bactrocera tryoni (Froggatt), and may hence shorten the delay between release and maturity in the field. Read More

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An alternative approach for bioanalytical assay optimization for wastewater-based epidemiology of SARS-CoV-2.

Sci Total Environ 2021 May 26;789:148043. Epub 2021 May 26.

Laboratory for Microbiology, Parasitology and Hygiene, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium.

Wastewater-based epidemiology of SARS-CoV-2 could play a role in monitoring the spread of the virus in the population and controlling possible outbreaks. However, sensitive sample preparation and detection methods are necessary to detect trace levels of SARS-CoV-2 RNA in influent wastewater (IWW). Unlike predecessors, method optimization of a SARS-CoV-2 RNA concentration and detection procedure was performed with IWW samples with high viral SARS-CoV-2 RNA loads. Read More

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Impact of biochar on the desiccation cracking behavior of silty clay and its mechanisms.

Sci Total Environ 2021 Jun 24;794:148608. Epub 2021 Jun 24.

School of Earth Sciences and Engineering, Nanjing University, Nanjing, Jiangsu 210023, China.

Biochar has recently been widely used in environmental geotechnical engineering. However, its impact on soil cracking is not fully understood. In this study, the influence of different wood biochar dosages on the desiccation cracking characteristics of silty clay was studied, and the mechanism was elucidated through a combination of image and microstructural analysis. Read More

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Efficient mercury removal in chlorine-free flue gas by doping Cl into CuO nanocrystals.

J Hazard Mater 2021 Jun 22;419:126423. Epub 2021 Jun 22.

School of Chemistry and Environmental Engineering, Jiangsu University of Technology, Changzhou, Jiangsu 213001, PR China. Electronic address:

The low content of hydrogen chloride (HCl) in flue gas is difficult to meet the request of Hg removal. Here, a small amount of Cl was doped into the crystal lattice of CuO nanocrystals (Cl-CuO), presenting excellent Hg removal efficiency in chlorine-free coal combustion flue gas. SEM, XRD, BET, and XPS characterizations revealed well crystal morphology and structure of Cl-CuO catalyst. Read More

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Occurrence, source apportionment, and carcinogenic risk assessment of polycyclic aromatic hydrocarbons in urban road dusts in Shanghai.

Environ Sci Pollut Res Int 2021 Jul 28. Epub 2021 Jul 28.

School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China.

Polycyclic aromatic hydrocarbons (PAHs), as a class of important environmental pollutants, have received considerable concern due to their widespread existence and biological toxicity. The main purpose of this study was to determine concentrations, spatial distribution, possible sources, and potential health risk of PAHs in urban road dust in Shanghai, China. The concentration of ΣPAHs ranged from 53. Read More

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Haemoglobin cut-off values for the diagnosis of anaemia in preschool-age children.

Am J Blood Res 2021 15;11(3):248-254. Epub 2021 Jun 15.

Consultant Family Medicine, Qatar University Health Center, Primary Health Care Corporation Qatar.

Background: The World Health Organisation (WHO) suggests haemoglobin that (Hgb) cut-off levels below 2SD from the population mean to initiate anaemia investigations. In the absence of epidemiological data, Hgb less than 11 g/dL is considered abnormal in children up to the age of 59 months (4 years and eleven months).

Objectives: This study reports on the Hgb cut-off levels among children at 1 and 4 years of age. Read More

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Comparative Repeat Profiling of Two Closely Related Conifers ( and ) Reveals High Genome Similarity With Only Few Fast-Evolving Satellite DNAs.

Front Genet 2021 12;12:683668. Epub 2021 Jul 12.

Institute of Botany, Technische Universität Dresden, Dresden, Germany.

In eukaryotic genomes, cycles of repeat expansion and removal lead to large-scale genomic changes and propel organisms forward in evolution. However, in conifers, active repeat removal is thought to be limited, leading to expansions of their genomes, mostly exceeding 10 giga base pairs. As a result, conifer genomes are largely littered with fragmented and decayed repeats. Read More

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Risk of all-cause mortality associated with chronic obstructive pulmonary disease and the role of healthy ageing trajectories: a population-based study of middle-aged and older adults.

BMJ Open 2021 Jul 28;11(7):e050947. Epub 2021 Jul 28.

Research, Innovation and Teaching Unit, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Catalunya, Spain.

Objectives: The aims were to study the risk of all-cause mortality associated with chronic obstructive pulmonary disease (COPD) and healthy ageing trajectories (HAT) in three birth cohorts and to determine the moderating role of HAT in the association between COPD and all-cause mortality.

Design: Prospective cohort study.

Setting: Data from waves 1 to 5 of The Survey of Health, Ageing and Retirement in Europe. Read More

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Host immunity increases Mycobacterium tuberculosis reliance on cytochrome bd oxidase.

PLoS Pathog 2021 Jul 28;17(7):e1008911. Epub 2021 Jul 28.

Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.

In order to sustain a persistent infection, Mycobacterium tuberculosis (Mtb) must adapt to a changing environment that is shaped by the developing immune response. This necessity to adapt is evident in the flexibility of many aspects of Mtb metabolism, including a respiratory chain that consists of two distinct terminal cytochrome oxidase complexes. Under the conditions tested thus far, the bc1/aa3 complex appears to play a dominant role, while the alternative bd oxidase is largely redundant. Read More

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Temporal and mediation relations of weight loss, and changes in insulin resistance and blood pressure in response to 2-year weight-loss diet interventions: the POUNDS Lost trial.

Eur J Nutr 2021 Jul 28. Epub 2021 Jul 28.

Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, 70112, USA.

Purpose: Body weight and insulin resistance (IR) are closely correlated, and their temporal sequences in affecting blood pressure (BP) remain poorly defined. We examined the temporal sequences of weight loss and IR change, and their relations with BP in the Pounds Lost trial, a randomized weight-loss diet intervention study.

Methods: The present study included overweight/obese adults, who were randomized in a 2 × 2 factorial design to low-calorie diets containing 20 or 40% fat and 15 or 25% protein (diets with 65, 55, 45 and 35% carbohydrate). Read More

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Magnetic Properties and Second Harmonic Generation of Noncentrosymmetric Cyanido-Bridged Ln(III)-W(V) Assemblies.

Inorg Chem 2021 Jul 28. Epub 2021 Jul 28.

Department of Chemistry, School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

One-dimensional zigzag cyanido-bridged coordination polymers have been prepared as a result of self-assembly of lanthanide(III) ions with octacyanidotungstate(V) anions in the presence of ,-dimethylacetamide (dma). All compounds crystallized in noncentrosymmetric space group 2 with a molecular formula of [Ln(dma)][W(CN)] [Ln = Gd (), Tb (), Dy (), Ho (), Er (), Tm (), Yb (), Lu (), or Y ()]. Magnetic studies revealed weak antiferromagnetic interactions through Ln-NC-W bridges and the formation of ferrimagnetically coupled chains at very low temperatures. Read More

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JunD accentuates arecoline-induced disruption of tight junctions and promotes epithelial-to-mesenchymal transition by association with NEAT1 lncRNA.

Oncotarget 2021 Jul 20;12(15):1520-1539. Epub 2021 Jul 20.

Cancer Research Laboratory, Department of Zoology, University of Calcutta, Kolkata 700019, West Bengal, India.

Head and neck cancers are highly prevalent in south-east Asia, primarily due to betel nut chewing. Arecoline, the primary alkaloid is highly carcinogenic; however its role in promoting tumorigenesis by disrupting junctional complexes and increasing risk of metastasis is not well delineated. Subsequently, the effects of low and high concentrations of arecoline on the stability of tight junctions and EMT induction were studied. Read More

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The relationship between CM and CO chondrites: Insights from combined analyses of titanium, chromium, and oxygen isotopes in CM, CO, and ungrouped chondrites.

Geochim Cosmochim Acta 2021 May 10;301:70-90. Epub 2021 Mar 10.

School of Earth and Space Exploration, Arizona State University, Tempe, AZ 85287, USA.

A close relationship between CM and CO chondrites has been suggested by previous petrologic and isotopic studies, leading to the suggestion that they may originate from similar precursor materials or even a common parent body. In this study, we evaluate the genetic relationship between CM and CO chondrites using Ti, Cr, and O isotopes. We first provide additional constraints on the ranges of εTi and εCr values of bulk CM and CO chondrites by reporting the isotopic compositions of CM2 chondrites Murchison, Murray, and Aguas Zarcas and the CO3. Read More

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Unfolding the multiscale structure of networks with dynamical Ollivier-Ricci curvature.

Nat Commun 2021 07 27;12(1):4561. Epub 2021 Jul 27.

Department of Mathematics, Imperial College London, London, UK.

Describing networks geometrically through low-dimensional latent metric spaces has helped design efficient learning algorithms, unveil network symmetries and study dynamical network processes. However, latent space embeddings are limited to specific classes of networks because incompatible metric spaces generally result in information loss. Here, we study arbitrary networks geometrically by defining a dynamic edge curvature measuring the similarity between pairs of dynamical network processes seeded at nearby nodes. Read More

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SARS-CoV-2 infection triggers widespread host mRNA decay leading to an mRNA export block.

RNA 2021 Jul 27. Epub 2021 Jul 27.

University of Colorado Boulder.

The transcriptional induction of interferon (IFN) genes is a key feature of the mammalian antiviral response that limits viral replication and dissemination. A hallmark of severe COVID-19 disease caused by SARS-CoV-2 is the low presence of IFN proteins in patient serum despite elevated levels of IFN-encoding mRNAs, indicative of post-transcriptional inhibition of IFN protein production. Here, we performed single-molecule RNA visualization to examine the expression and localization of host mRNAs during SARS-CoV-2 infection. Read More

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Induction of Apoptosis and Autophagy by Ternary Copper Complex Towards Breast Cancer Cells.

Anticancer Agents Med Chem 2021 Jul 26. Epub 2021 Jul 26.

School of Pharmacy, Taylor's University, Faculty of Health and Medical Sciences, 1, Jalan Taylors, 47500, Subang Jaya, Selangor. Malaysia.

Background: Copper complex has been gaining much attention in anticancer research as targeted agent since cancer cells uptake more copper than non-cancerous cells. Our group has synthesised a ternary copper complex which is composed of 1,10-phenanthroline and tyrosine [Cu(phen)(L-tyr)Cl].3H0. Read More

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Feasibility and acceptability of instructions of daily care in overweight and obese knee osteoarthritis participants.

Curr Rheumatol Rev 2021 Jul 26. Epub 2021 Jul 26.

Department of Physical Medicine and Rehabilitation, Mayo Hospital Lahore. Pakistan.

Introduction: Knee osteoarthritis (OA) is a weight-bearing joint disease and more common in the overweight and obese persons. The objective of the study was to assess the feasibility and acceptability of instructions of daily care (IDC) on pain, mobility and body mass index (BMI) among knee OA participants who are overweight or obese.

Material And Method: The study was an open-label randomized controlled trial of six-weeks. Read More

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Computational study of DMPC liposomes loaded with the N-(2-Hydroxyphenyl)-2-propylpentanamide (HO-AAVPA) and determination of its antiproliferative activity in NIH-3T3 cells.

J Biomol Struct Dyn 2021 Jul 27:1-12. Epub 2021 Jul 27.

Laboratorio de Diseño y Desarrollo de Nuevos Fármacos e Innovación Biotecnológica (Laboratory for the Design and Development of New Drugs and Biotechnological Innovation) SEPI-ESM Instituto Politécnico Nacional, Ciudad de México, Mexico.

-(2-Hydroxyphenyl)-2-propylpentanamide (HO-AAVPA) is a valproic acid (VPA) derivative that has shown promising antiproliferative effects in different cancer cell lines, such as A204, HeLa, and MDA-MB-231. However, its low water solubility could reduce its therapeutic effectiveness. To solve this problem, in this work, we incorporated HO-AAVPA into dimyristoyl-phosphatidylcholine (DMPC) liposomes in the presence or absence of cholesterol (CHOL). Read More

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Inequality and Inequity in the Use of Oral Health Services in Australian Adults.

JDR Clin Trans Res 2021 Jul 27:23800844211027489. Epub 2021 Jul 27.

Australian Research Centre for Population Oral Health, Adelaide Dental School, University of Adelaide, Adelaide, Australia.

Objective: Social determinants drive disparities in dental visiting. This study aimed to measure inequality and inequity in dental visiting among Australian adults.

Methods: Data were obtained from the National Study of Adult Oral Health (2017 to 2018). Read More

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Beyond internalizing and externalizing symptoms: The association between body disconnection and the symptoms of Internet gaming disorder.

Addict Behav 2021 Jul 7;123:107043. Epub 2021 Jul 7.

Faculty of Human and Social Sciences, UKE - Kore University of Enna, Enna, Italy.

As the vast majority of online videogames imply the immersion into an alternative reality where a virtual body is also involved, the current cross-sectional study aims to investigate the contribution of low body awareness (i.e. low attention to sensory cues indicating bodily state) and body dissociation (i. Read More

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Comparison of transcriptomic adjustments to availability of sugar, cellular energy, and oxygen in germinating rice embryos.

J Plant Physiol 2021 Jul 10;264:153471. Epub 2021 Jul 10.

Department of Systems Biotechnology, Konkuk University, Seoul, 143-701, Republic of Korea. Electronic address:

During germination, the availability of sugars, oxygen, or cellular energy fluctuates under dynamic environmental conditions, likely affecting the global RNA profile of rice genes. Most genes that exhibit sugar-regulation in rice embryos under aerobic conditions are responsive to low energy and anaerobic conditions, indicating that sugar regulation is strongly associated with energy and anaerobic signaling. The interference pattern of sugar regulation by either anaerobic or low energy conditions indicates that induction is likely the more prevalent regulatory mechanism than repression for altering the expression of sugar-regulated genes. Read More

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Alginate-azo/chitosan nanocapsules in vitro drug delivery for hepatic carcinoma cells: UV-stimulated decomposition and drug release based on trans-to-cis isomerization.

Int J Biol Macromol 2021 Jul 24;187:214-222. Epub 2021 Jul 24.

College of Chemical and Molecular Engineering, Nanjing Tech University, Nanjing 210000, PR China. Electronic address:

In this study, a nanocapsule (AL-azo/CH) was prepared with the anionic alginate-azo (AL-azo) and cationic chitosan (CH) via layer-by-layer method. Doxorubicin hydrochloride (DOX), an anticancer drug, was entrapped inside the AL-azo nanocapsules to form the DOX-loaded nanocapsules (DOX/AL-azo/CH). When the DOX/AL-azo/CH nanocapsules were irradiated with 365-nm light, the electrostatic attraction between the layers would be weakened as the trans-to-cis isomerization of AL-azo, which would lead to the UV-responsive decomposition and drug-release. Read More

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Exposure to citrinin induces DNA damage, autophagy, and mitochondria dysfunction during first cleavage of mouse embryos.

Environ Toxicol 2021 Jul 27. Epub 2021 Jul 27.

College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.

Citrinin (CTN) is a mycotoxin, which is isolated from Penicillium citrinum and widely existed in the contaminated feeds. It is reported that CTN is toxic to heart, liver, and reproductive system. Previous studies indicated that CTN induced apoptosis in oocytes and embryos. Read More

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High-density DArT-based SilicoDArT and SNP markers for genetic diversity and population structure studies in cassava (Manihot esculenta Crantz).

PLoS One 2021 27;16(7):e0255290. Epub 2021 Jul 27.

Department of Statistics and Actuarial Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Cassava (Manihot esculenta Crantz) is an important industrial and staple crop due to its high starch content, low input requirement, and resilience which makes it an ideal crop for sustainable agricultural systems and marginal lands in the tropics. However, the lack of genomic information on local genetic resources has impeded efficient conservation and improvement of the crop and the exploration of its full agronomic and breeding potential. This work was carried out to obtain information on population structure and extent of genetic variability among some local landraces conserved at the Plant Genetic Resources Research Institute, Ghana and exotic cassava accessions with Diversity Array Technology based SilicoDArT and SNP markers to infer how the relatedness in the genetic materials can be used to enhance germplasm curation and future breeding efforts. Read More

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Adaptation of African swine fever virus to HEK293T cells.

Transbound Emerg Dis 2021 Jul 27. Epub 2021 Jul 27.

State Key Laboratory of Veterinary Biotechnology, National High Containment Facilities for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.

African swine fever (ASF), caused by African swine fever virus (ASFV), is a highly contagious disease with high morbidity and mortality in domestic pigs. Although adaptation of ASFV to Vero cells has been investigated, the phenotypic changes and the corresponding genomic variations during adaptation of ASFV to other cell lines remain unclear. To obtain a cell-adapted ASFV strain, different cell lines were tested to determine whether they support ASFV infection. Read More

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