43,298 results match your criteria low malignant


Computed tomography (CT) features of pelvic rhabdomyosarcoma (RMS) in children.

Curr Med Imaging 2021 Aug 26. Epub 2021 Aug 26.

Department of Radiology, Children's Hospital, Chongqing Medical University and Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders and Key Laboratory of Pediatrics in Chongqing, Chongqing 400014. China.

Background: Currently, there are few literature reports on the CT features of pelvic rhabdomyosarcoma, most of which exist in the form of case reports, and some literature reports have suggested that CT features of pelvic rhabdomyosarcoma lack specificity. This study was designed to investigate the CT features of pelvic RMS in children to provide imaging evidence for clinical diagnosis.

Methods: We retrospectively reviewed radiographic and clinical data of all paediatric patients with pelvic neoplastic lesions pathologically proven to be malignant in our hospitals from January 2012 through March 2021. Read More

View Article and Full-Text PDF

Enzyme-responsive micellar JQ1 induces enhanced BET protein inhibition and immunotherapy of malignant tumors.

Biomater Sci 2021 Sep 15. Epub 2021 Sep 15.

Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China.

Bromodomain and extra-terminal (BET) proteins are attractive targets for treating various malignancies including melanoma. The inhibition of BET bromodomains, with JQ1, is found to downregulate the expression of both c-MYC oncoprotein and programmed cell death ligand 1 (PD-L1), which play a crucial role in tumor growth and the immunosuppressive tumor microenvironment, respectively. The BET bromodomain inhibitors like JQ1 though exhibiting high selectivity and affinity show usually low bioavailability and efficacy due to fast clearance and inferior uptake by tumor cells. Read More

View Article and Full-Text PDF
September 2021

[Update and interpretation of 2021 National Comprehensive Cancer Network (NCCN) "Clinical Practice Guidelines for Bone Tumors"].

Authors:
Ming Ni

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Sep;35(9):1186-1191

Department of Orthopaedics, Pudong New Area People's Hospital Affiliated to Shanghai University of Medicine and Health Sciences, Shanghai, 201299, P.R.China.

The incidence of primary malignant bone tumors is low, and clinical cognition is insufficient. The establishment of diagnostic criteria is of great significance for prognosis of tumors. National Comprehensive Cancer Network (NCCN) regularly publishes "Clinical Practice Guidelines for Bone Tumors" to summarize the latest treatment progress of bone tumors. Read More

View Article and Full-Text PDF
September 2021

Retrospective Diagnosis of Malignant Struma Ovarii After Discovery of Pulmonary Metastasis.

AACE Clin Case Rep 2021 Sep-Oct;7(5):320-322. Epub 2021 Apr 9.

Department of Medicine, Albert Einstein College of Medicine, Bronx, New York.

Objective: Malignant struma ovarii diagnosis is challenging due to its benign histologic appearance and rarity. We present a case of struma ovarii determined malignant after pulmonary metastases were incidentally discovered.

Methods: A 29-year-old female with a history of benign struma ovarii presented to the emergency room with right lower abdominal pain. Read More

View Article and Full-Text PDF

13q14 Deletion and Its Effect on Prognosis of Chronic Lymphocytic Leukemia.

Cureus 2021 Aug 2;13(8):e16839. Epub 2021 Aug 2.

Internal Medicine, Advent Health and Orlando Health Hospital/JC Medical Center, Orlando, USA.

Chronic lymphocytic leukemia (CLL) is the most common leukemia affecting adults. CLL results due to uncontrolled accumulation of B lymphocytes in the body with the clinical spectrum ranging from comparatively benign disease to an aggressive form. The disease pathogenesis lies in molecular genetics, the most common alteration being the deletion in the long arm of chromosome 13, at position 14 (13q14) region. Read More

View Article and Full-Text PDF

Overexpression of microRNA-130a represses uveal melanoma cell migration and invasion through inactivation of the Wnt/β-catenin signaling pathway by downregulating USP6.

Cancer Gene Ther 2021 Sep 14. Epub 2021 Sep 14.

Department of Strabismus and Pediatric Ophthalmology, The Second Hospital of Jilin University, Changchun, China.

Uveal melanoma (UM) is a neoplasm arising from melanocytes of the ciliary body, choroid, and iris of the eye, which is the most common primary malignant intraocular tumor. microRNA-130a (miR-130a) has been confirmed to be underexpressed in many types of cancers. Here we aimed to investigate the mechanism whereby miR-130a affects the Wnt/β-catenin signaling pathway by targeting ubiquitin-specific protease 6 (USP6) in UM. Read More

View Article and Full-Text PDF
September 2021

Down-regulation of lncRNA MEG3 promotes chronic low dose cadmium exposure-induced cell transformation and cancer stem cell-like property.

Toxicol Appl Pharmacol 2021 Sep 11;430:115724. Epub 2021 Sep 11.

Division of Cancer Biology, Department of Medicine, MetroHealth Medical Center, Case Western University School of Medicine, Cleveland, OH 44109, United States of America. Electronic address:

Cadmium (Cd) is a toxic heavy metal and one of carcinogens that cause lung cancer. However, the exact mechanism of Cd carcinogenesis remains unclear. To investigate the mechanism of Cd carcinogenesis, we exposed human bronchial epithelial cells (BEAS-2B) to a low dose of Cd (2. Read More

View Article and Full-Text PDF
September 2021

Transcriptome-based identification of molecular markers related to the development and prognosis of Colon cancer.

Nucleosides Nucleotides Nucleic Acids 2021 Sep 14:1-11. Epub 2021 Sep 14.

Laboratory Department, Longyan people's Hospital, Fujian, China.

Colon cancer is one of the most common malignant tumors of the digestive system that seriously threaten human health and whose pathogenesis has not been completely elucidated. The purpose of this study was to investigate genes related to colon cancer and explore their potential values in colon cancer prognosis. Clinical information and transcriptome data of patients with colon cancer were obtained from UCSC Xena. Read More

View Article and Full-Text PDF
September 2021

Evidence for marked underutilization of insurance billing in malignant pleural mesothelioma in Finland.

Thorac Cancer 2021 Sep 13. Epub 2021 Sep 13.

Heart and Lung Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Background: Substantial variation in health care costs for malignant pleural mesothelioma (MPM) has previously been identified.

Materials And Methods: We analyzed the changes in health care costs in MPM in Finland during 2002-2012. Finland has low-threshold public health care and a mandatory Workers' Compensation scheme that covers all occupational-related disease expenses. Read More

View Article and Full-Text PDF
September 2021

lncRNA HCG11 suppresses human osteosarcoma growth through upregulating p27 Kip1.

Aging (Albany NY) 2021 Sep 13;13(undefined). Epub 2021 Sep 13.

The Precision Medicine Laboratory, Beilun People's Hospital, Ningbo, Zhejiang, China.

Osteosarcoma (OS) is a common malignant bone cancer threatening children and young adults. Emerging evidence indicates that long non-coding RNAs (lncRNAs) play crucial roles in the progression of OS. Herein, we want to clarify the roles of lncRNA human leukocyte antigen complex group 11 (HCG11) in OS. Read More

View Article and Full-Text PDF
September 2021

Matter of TIME: the tumor-immune microenvironment of mesothelioma and implications for checkpoint blockade efficacy.

J Immunother Cancer 2021 Sep;9(9)

Cancer Research Centre, University of Leicester College of Life Sciences, Leicester, UK

Malignant pleural mesothelioma (MPM) is an incurable cancer with a dismal prognosis and few effective treatment options. Nonetheless, recent positive phase III trial results for immune checkpoint blockade (ICB) in MPM herald a new dawn in the fight to advance effective treatments for this cancer. Tumor mutation burden (TMB) has been widely reported to predict ICB in other cancers, but MPM is considered a low-TMB tumor. Read More

View Article and Full-Text PDF
September 2021

Diagnostic approach to thyroid cancer based on amino acid metabolomics in saliva by ultra-performance liquid chromatography with high resolution mass spectrometry.

Talanta 2021 Dec 24;235:122729. Epub 2021 Jul 24.

Research Center of Analytical Instrumentation, Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an, Shaanxi, 710069, China. Electronic address:

Thyroid cancer is a malignant disease with dramatically low advanced-stage 10-year survival. Meanwhile, the metabolites in saliva are becoming a wealthy source of disease biomarkers. However, there is a lack of non-invasive analytical methods for the identification of biomarkers in saliva for the preoperative diagnosis of thyroid cancer. Read More

View Article and Full-Text PDF
December 2021

Alternation of brain intrinsic activity in patients with hypertensive retinopathy: a resting-state fMRI study.

Aging (Albany NY) 2021 Sep 13;13(undefined). Epub 2021 Sep 13.

Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Ocular Disease Clinical Research Center, Nanchang 330006, Jiangxi, People's Republic of China.

Objective: To investigate the changes of amplitude of low-frequency fluctuation (ALFF) in brain regions of patients with hypertensive retinopathy by using resting-state functional magnetic resonance imaging (rs-fMRI) and change in the relationship of ALFF value with potential emotional and psychological changes.

Methods: Thirty-one patients with hypertensive retinopathy (HR) (16 men and 15 women) and 31 healthy controls (HCs; 16 men and 15 women) matched for age, sex, and weight were enrolled in the research. The changes in mean ALFF values could reflect brain activity between HR patients and HCs. Read More

View Article and Full-Text PDF
September 2021

Detection of Neoplasms by Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid.

JAMA Neurol 2021 Sep 13. Epub 2021 Sep 13.

Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco.

Importance: Cerebrospinal fluid (CSF) cytologic testing and flow cytometry are insensitive for diagnosing neoplasms of the central nervous system (CNS). Such clinical phenotypes can mimic infectious and autoimmune causes of meningoencephalitis.

Objective: To ascertain whether CSF metagenomic next-generation sequencing (mNGS) can identify aneuploidy, a hallmark of malignant neoplasms, in difficult-to-diagnose cases of CNS malignant neoplasm. Read More

View Article and Full-Text PDF
September 2021

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells.

J Vis Exp 2021 Aug 25(174). Epub 2021 Aug 25.

Department of Pathology and Laboratory Medicine, Medical University of South Carolina;

The development of new drugs that precisely target key proteins in human cancers is fundamentally altering cancer therapeutics. However, before these drugs can be used, their target proteins must be validated as therapeutic targets in specific cancer types. This validation is often performed by knocking out the gene encoding the candidate therapeutic target in a genetically engineered mouse (GEM) model of cancer and determining what effect this has on tumor growth. Read More

View Article and Full-Text PDF

Rab6c is a new target of miR‑218 that can promote the progression of bladder cancer.

Mol Med Rep 2021 Nov 13;24(5). Epub 2021 Sep 13.

Department of The Second Cadre Ward, General Hospital of Northern Theater Command, National Center for Clinical Research of Geriatric Diseases, Shenyang, Liaoning 157099, P.R. China.

Bladder cancer has high morbidity and mortality rates among the male genitourinary system tumor types. MicroRNA‑218 (miR‑218) is associated with the development of a variety of cancer types, including bladder cancer. Rab6c is a member of the Rab family and is involved in drug resistance in MCF7 cells. Read More

View Article and Full-Text PDF
November 2021

Pulsed low-dose rate radiotherapy has an improved therapeutic effect on abdominal and pelvic malignancies.

J Zhejiang Univ Sci B 2021 Sept 15;22(9):774-781

Cancer Institute of Xuzhou Medical University, Xuzhou 221000, China.

Until now, there has been a lack of standard and effective treatments for patients with recurrent malignant tumors or abdominal and pelvic malignancies with extensive invasion (Morris, 2000). Generally, these patients face problems such as inability to undergo surgery or chemotherapy resistance (Combs et al., 2016). Read More

View Article and Full-Text PDF
September 2021

Recent Development of Graphene Based Electrochemical Sensor for Detecting Hematological Malignancies-Associated Biomarkers: A Mini-Review.

Front Chem 2021 25;9:735668. Epub 2021 Aug 25.

Key Laboratory of Biopharmaceuticals, Engineering Laboratory of Polysaccharide Drugs, Shandong Academy of Pharmaceutical Sciences, Jinan, China.

Hematologic malignancies are a group of malignant diseases of the hematologic system that seriously endanger human health, mainly involving bone marrow, blood and lymphatic tissues. However, among the available treatments for malignant hematologic diseases, low detection rates and high recurrence rates are major problems in the treatment process. The quantitative detection of hematologic malignancies-related biomarkers is the key to refine the pathological typing of the disease to implement targeted therapy and thus improve the prognosis. Read More

View Article and Full-Text PDF

5'-tiRNA-Cys-GCA regulates VSMC proliferation and phenotypic transition by targeting STAT4 in aortic dissection.

Mol Ther Nucleic Acids 2021 Dec 29;26:295-306. Epub 2021 Jul 29.

Department of Cardiac Ultrasound, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao 266000, People's Republic of China.

Accumulating evidence shows that tRNA-derived fragments are a novel class of functional small non-coding RNA; however, their roles in aortic dissection (AD) are still unknown. In this study, we found that 5'-tiRNA-Cys-GCA was significantly downregulated in human and mouse models of aortic dissection. The abnormal proliferation, migration, and phenotypic transition of vascular smooth muscle cells (VSMCs) played a crucial role in the initiation and progression of aortic dissection, with 5'-tiRNA-Cys-GCA as a potential phenotypic switching regulator, because its overexpression inhibited the proliferation and migration of VSMCs and increased the expression of contractile markers. Read More

View Article and Full-Text PDF
December 2021

WNK3 promotes the invasiveness of glioma cell lines under hypoxia by inducing the epithelial-to-mesenchymal transition.

Transl Neurosci 2021 Jan 25;12(1):320-329. Epub 2021 Aug 25.

Department of Neurosurgery, First Affiliated Hospital of China Medical University, Shenyang 110001, China.

Background: The primary features of malignant glioma include high rates of mortality and recurrence, uncontrollable invasiveness, strong angiogenesis, and widespread hypoxia. The hypoxic microenvironment is an important factor affecting the malignant progression of glioma. However, the molecular mechanisms underlying glioma adaption in hypoxic microenvironments are poorly understood. Read More

View Article and Full-Text PDF
January 2021

Construction of a Novel Immune-Related lncRNA Pair Signature with Prognostic Significance for Kidney Clear Cell Renal Cell Carcinoma.

Dis Markers 2021 1;2021:8800358. Epub 2021 Sep 1.

Department and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, 430030 Wuhan, China.

Background: Renal cell carcinoma (RCC) is one of the most common aggressive malignant tumors in the urinary system, among which the clear cell renal cell carcinoma (ccRCC) is the most common subtype. The immune-related long noncoding ribonucleic acids (irlncRNAs) which are abundant in immune cells and immune microenvironment (IME) have potential significance in evaluating the prognosis and effects of immunotherapy. The signature based on irlncRNA pairs and independent of the exact expression level seems to have a latent predictive significance for the prognosis of patients with malignant tumors but has not been applied in ccRCC yet. Read More

View Article and Full-Text PDF
September 2021

Tumor Expression Profile Analysis Developed and Validated a Prognostic Model Based on Immune-Related Genes in Bladder Cancer.

Front Genet 2021 27;12:696912. Epub 2021 Aug 27.

Department of Urology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China.

: Bladder cancer (BLCA) ranks 10th in incidence among malignant tumors and 6th in incidence among malignant tumors in males. With the application of immune therapy, the overall survival (OS) rate of BLCA patients has greatly improved, but the 5-year survival rate of BLCA patients is still low. Furthermore, not every BLCA patient benefits from immunotherapy, and there are a limited number of biomarkers for predicting the immunotherapy response. Read More

View Article and Full-Text PDF

ESPL1 Is a Novel Prognostic Biomarker Associated With the Malignant Features of Glioma.

Front Genet 2021 26;12:666106. Epub 2021 Aug 26.

Department of Surgery of Spine and Spinal Cord, Henan Provincial People's Hospital, Henan International Joint Laboratory of Intelligentized Orthopedics Innovation and Transformation, Henan Key Laboratory for Intelligent Precision Orthopedics, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, China.

Research has confirmed that extra spindle pole bodies-like 1 (ESPL1), an etiological factor, promotes the malignant progression of cancers. However, the relationship between ESPL1 and glioma has not yet been demonstrated. The purpose of this study was to reveal the potential mechanisms of ESPL1-mediated malignant glioma progression. Read More

View Article and Full-Text PDF

Comprehensive Analysis of the Expression and Prognosis for Laminin Genes in Ovarian Cancer.

Pathol Oncol Res 2021 25;27:1609855. Epub 2021 Aug 25.

Department of Gynecology, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, China.

Survival is low in ovarian cancer (OC). Most OC patients demonstrate advanced metastases, and recurrence is common. Dysregulation of laminin interactions is associated with cancer development. Read More

View Article and Full-Text PDF

Identification of a Five-Gene Prognostic Signature Related to B Cells Infiltration in Pancreatic Adenocarcinoma.

Int J Gen Med 2021 30;14:5051-5068. Epub 2021 Aug 30.

Department of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Nanning, People's Republic of China.

Background: Pancreatic adenocarcinoma (PAAD) is an extremely malignant cancer. Immunotherapy is a promising avenue to increase the survival time of patients with PAAD.

Methods: RNA sequencing and clinical data for PAAD were downloaded from the TCGA database. Read More

View Article and Full-Text PDF

MOLECULAR CHARACTERISTICS OF THE HETEROGENEITY OF NON-INVASIVE PAPILLARY UROTHELIAL CARCINOMAS AND THE MARKERS OF THEIR RECURRENCE.

Georgian Med News 2021 Jul-Aug(316-317):178-184

Tbilisi State Medical University, Georgia.

Urothelial carcinoma represents the most common type of bladder cancer (>90%) and is the most frequent malignancy of the urinary tract. Most of the urothelial carcinomas are non-invasive at the time of diagnosis, however they are characterised with the risk of recurrence after surgical treatment. The aim of our study was to investigate the characteristics of tumor heterogeneity and markers of its progression in urothelial papillary carcinomas. Read More

View Article and Full-Text PDF
September 2021

Orthokeratinized odontogenic cyst: A large series and comprehensive literature review with emphasis on synchronous multiple occurrence and neoplastic transformation.

Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Jul 21. Epub 2021 Jul 21.

Department of Oral Pathology, Seoul National University Dental Hospital, Seoul, Republic of Korea; Department of Oral Pathology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea. Electronic address:

Objectives: The objective of this study was to demonstrate the clinical, radiologic, and histologic features of orthokeratinized odontogenic cyst (OOC); determine the characteristics of multiple OOCs; and present rare but significant manifestations of OOC.

Study Design: A clinical, radiologic, and histopathologic study of 65 primary and 2 recurrent OOC cases was performed retrospectively along with a comprehensive literature review.

Results: OOCs shared similar radiologic findings with odontogenic keratocyst, yet some showed features that have not been previously described: root resorption and radiopaque foci. Read More

View Article and Full-Text PDF

Effectiveness of TI-RADS and ATA classifications for predicting malignancy of thyroid nodules.

Adv Clin Exp Med 2021 Sep 9. Epub 2021 Sep 9.

Department of Endocrinology and Metabolism, Gaziantep Liv Hospital, Turkey.

Background: Thyroid cancer is one of the most common cancers and is especially common in young patients. Therefore, effective recognition and treatment of thyroid cancer are essential for patient survival.

Objectives: To compare the effectiveness of standard guidelines for predicting thyroid malignancy. Read More

View Article and Full-Text PDF
September 2021

Follow-up of small & diminutive colonic polyps - how to balance the risks in the COVID-19 era.

Colorectal Dis 2021 Sep 12. Epub 2021 Sep 12.

The COVID-19 pandemic has led to a reduced colonoscopy capacity in the UK resulting in increased waiting times for investigation. To increase diagnostic capacity and reduce the risk of diagnostic delay, CT colonography (CTC) and colon capsule endoscopy (CCE) are increasingly being relied upon. Endoscopic assessment and treatment will be required for those patients with large colonic polyps or malignant tumours detected by CTC or CCE, provided they are fit enough to undergo further investigation. Read More

View Article and Full-Text PDF
September 2021

Clinicopathologic features and BRAF mutation status of tracheal glomus tumors - Characterization of 4 cases and the distinction from low-grade neuroendocrine tumors.

Ann Diagn Pathol 2021 Jul 31;55:151797. Epub 2021 Jul 31.

Departments of Pathology, China-Japan Friendship Hospital, Beijing, China. Electronic address:

Background: Glomus tumors are uncommon and mostly benign mesenchymal neoplasms of the perivascular family. To date, only a few cases of glomus tumors occurring in the trachea have been reported. Tracheal glomus tumors simulated low-grade neuroendocrine tumors on clinical and histomorphological examination, so the differential diagnosis between these two entities is very necessary. Read More

View Article and Full-Text PDF