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Chronobiological evaluation and an intervention study on timing of food intake in the treatment of obesity.

Int J Clin Pract 2021 Jun 12:e14502. Epub 2021 Jun 12.

Department of Family Medicine, Düzce University Medical Faculty, Duzce, Turkey.

Background: The chronotype of patients who cannot reach their ideal weight despite diet and exercise may play a role in this resistance. In this study, the relationship between BMI and chronobiological preferences was examined and a weight loss program was applied to refractory obese patients with evening type (ET).

Method: The study included 50 obese (BMI≥30 kg/m ), 50 overweight (BMI=25-29 kg/m ), and 50 normal normal-weight (BMI<25 kg/m ). Read More

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Swallowing Exercise During Head and Neck Cancer Treatment: Results of a Randomized Trial.

Dysphagia 2021 Jun 11. Epub 2021 Jun 11.

Cancer Late Effects Research Unit (CASTLE), Department of Oncology, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.

The diagnosis and treatment of head and neck cancer (HNC) can have substantial impact on swallowing function, nutritional balance, physical function and quality of life (QoL). Early initiated swallowing exercises are hypothesized to improve swallowing function in HNC patients. The aim was to investigate the effects of swallowing exercises and progressive resistance training (PRT) during radiotherapy on swallowing function, physical function and QoL in patients with pharynx-, larynx-, oral cavity cancer or unknown primary compared to usual care. Read More

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Real-world outcomes with extended-release buprenorphine (XR-BUP) in a low threshold bridge clinic: A retrospective case series.

J Subst Abuse Treat 2021 Jul 2;126:108316. Epub 2021 Feb 2.

Department of Medicine, Massachusetts General Hospital, 55 Fruit St, Boston, MA, United States of America. Electronic address:

Background: In clinical trial settings, extended-release buprenorphine (XR-BUP) is noninferior to sublingual buprenorphine and may offer some advantages. However, real-world experiences of XR-BUP are limited and outcomes are unknown for low-threshold clinics with high-risk populations. Practical guidance is lacking on overcoming treatment challenges, such as inability for some to stabilize on sublingual (SL) BUP for seven days prior to XR-BUP and ongoing craving/withdrawal symptoms during treatment. Read More

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Prospective, Randomized, Double-Blinded Clinical Trial Comparing PEEK and Allograft Spacers in Patients Undergoing Transforaminal Lumbar Interbody Fusion Surgeries.

Spine J 2021 Jun 8. Epub 2021 Jun 8.

Boulder Neurosurgical Associates, Boulder, Colorado, USA; Justin Parker Neurological Institute, Boulder, Colorado, USA. Electronic address:

Background Context: Allograft and polyether-ether-ketone (PEEK) radiographic, biomechanical, histological properties have been extensively studied and both spacers have their advantages and shortcomings. There are no comparative randomized or double-blinded spinal fusion clinical trials reported to date.

Purpose: The study's primary objective was to prospectively investigate clinical and radiological outcomes in patients undergoing lumbar interbody fusions and randomized to receive either PEEK or structural bone allografts. Read More

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High rate of completion for weekly rifapentine plus isoniazid treatment in Chinese children with latent tuberculosis infection-A single center study.

PLoS One 2021 11;16(6):e0253159. Epub 2021 Jun 11.

Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

Three months of weekly rifapentine plus isoniazid (3HP) is a short course regimen for latent tuberculosis infection treatment with satisfied safety and efficacy. However, research on its use in children is limited. In this study, we evaluated the completion rate and safety of the 3HP regimen among children in China. Read More

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Comparison of hepatitis C treatment outcomes between primary care and specialty care.

J Am Assoc Nurse Pract 2021 Jun 9. Epub 2021 Jun 9.

Integrated Health Services, Colorado Coalition for the Homeless, Denver, Colorado, Seattle University College of Nursing, Seattle, Washington.

Background: Hepatitis C virus (HCV) infections have increased significantly in the United States recently, having tripled by 2014. Seventy-five percent of those with HCV are aging baby boomers, which places increased pressure on the medical system to provide treatment. There are not enough specialists available to treat everyone infected with HCV. Read More

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Implants Placed in Adolescents Followed for Up to 15.5 Years: A Retrospective Case Series.

Int J Oral Maxillofac Implants 2021 May-Jun;36(3):561-568

Purpose: To evaluate the clinical outcomes of unsplinted implant-supported single crowns placed in adolescents, ages 10 to 19 years, and followed up from 5 to 15 years.

Materials And Methods: This retrospective case series evaluated the outcomes of implant-supported single crowns placed in adolescents between June 2002 and January 2015. The patients were treated with locking-taper connection implants under a two-stage rehabilitation technique. Read More

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Influential factors of subacromial impingement syndrome after hook plate fixation for acromioclavicular joint dislocation: A retrospective study.

Medicine (Baltimore) 2021 Jun;100(23):e26333

Department of Orthopedic Trauma Surgery, Ningbo No.6 Hospital.

Abstract: Subacromial impingement syndrome (SIS) after hook plate fixation for acromioclavicular joint (AC) dislocation was the most common complication. However, the researches on its' influential factors were rare. The purpose of this study was to identify the risk factors by analyzing the influencing factors of postoperative SIS and minimize the incidence of SIS in clinical surgery. Read More

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Postoperative incision scars and cosmetic satisfaction of living liver donors.

Medicine (Baltimore) 2021 Jun;100(23):e26187

Department of General Surgery, Changhua Christian Hospital, Changhua.

Abstract: Cosmetic appearance is a major concern for living donors. However, little is known about the impact of a surgical scar on body image changes in living liver donors. The aim of this study was to identify potential factors that cause displeasing upper midline incision scar, and to evaluate the overall satisfaction regarding body image and scarring after living donor hepatectomy. Read More

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Cannabis Use Is Associated With Recurrence After Primary Spontaneous Pneumothorax.

Front Surg 2021 25;8:668588. Epub 2021 May 25.

Department of Cardiovascular and Thoracic Surgery, Rush University Medical Center, Chicago, IL, United States.

Primary spontaneous pneumothorax (PSP) is a frequently encountered entity that carries a high rate of recurrence. The current study aims to investigate if cannabis use at time of initial PSP is associated with disease recurrence. Patients presenting with PSP between 2010 and 2018 at a single institution were identified. Read More

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Cardiac Tamponade Unmasking Recurrent Ovarian Cancer.

Cureus 2021 Jun 5;13(6):e15464. Epub 2021 Jun 5.

Gynecologic Oncology, State University of New York (SUNY) Downstate Medical Center, Brooklyn, USA.

Pericardial disease is a common manifestation of malignancy. Gynecologic malignancies such as ovarian cancer rarely present with cardiac involvement. Cardiac tamponade may be the initial presentation of malignancy in as many as half of pericardial disease cases. Read More

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Cost of Illness of Epilepsy and Associated Factors in Patients Attending Adult Outpatient Department of University of Gondar Referral Hospital, Northwest Ethiopia.

Risk Manag Healthc Policy 2021 4;14:2385-2394. Epub 2021 Jun 4.

Department of Health Systems and Policy, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: Epilepsy has significant economic implications on health care needs, premature death, and lost work productivity. Therefore, this study aimed to assess the cost of illness of epilepsy and its associated factors in the Outpatient Department of University of Gondar Referral Hospital, Northwest Ethiopia.

Methods: We conducted an institution-based cross-sectional study from March 2018 to April 2018. Read More

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Seven-year follow-up of posterior chamber phakic intraocular lens with central port design.

Eye Vis (Lond) 2021 Jun 11;8(1):23. Epub 2021 Jun 11.

Fernández-Vega Ophthalmological Institute, Avda. Dres. Fernández-Vega 114, 33012, Oviedo, Spain.

Background: To assess the clinical outcomes of the Visian Implantable Collamer Lens (ICL) with a central port throughout 7 years of follow-up.

Methods: Eighty-four eyes of 52 patients were evaluated over a follow-up period of 7 years after V4c ICL implantation. Uncorrected (UDVA) and corrected (CDVA) distance visual acuities, refraction, intraocular pressure (IOP), endothelial cell density (ECD) and vault were analysed. Read More

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Primary high-grade myoepithelial carcinoma of the lung: A study of three cases illustrating frequent SMARCB1-deficiency and review of the literature.

Ann Diagn Pathol 2021 May 8;53:151759. Epub 2021 May 8.

Department of Pathology, Rambam Health Care Campus, 31096 Haifa, Israel.

Primary myoepithelial carcinoma of the lung is exceptionally rare and, hence, remained poorly characterized. We present 3 tumors affecting 2 males and 1 female aged 60 to 84 years. Tumor size ranged from 4 to 10 cm. Read More

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Prospective Comparison of Pediatric Endoscopic Lateral Graft and Interlay Tympanoplasty.

Otol Neurotol 2021 Jul;42(6):867-875

Department of Otolaryngology, Head and Neck Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada.

Objective: To compare outcomes and complications of endoscopic lateral graft (LGT) and interlay (IT) tympanoplasty.

Study Design: Prospective observational cohort study of totally endoscopic ear surgery (TEES) tympanoplasty.

Setting: Pediatric tertiary referral center. Read More

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Impact of a personalized mHealth program for type 2 diabetes mellitus during the COVID-19 pandemic: single-group pre-post retrospective analysis.

JMIR Diabetes 2021 Jun 6. Epub 2021 Jun 6.

NOVI Health, Singapore, SG.

Background: With increasing type 2 diabetes mellitus (T2DM) prevalence, there is a need for effective programs that support diabetes management and improve T2DM outcomes. Mobile health (mHealth) interventions have shown promising results. With advances in wearable sensors and improved integration, mHealth programs could become more accessible and personalized. Read More

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Radiographic Outcomes of Cotton Osteotomy in Treatment of Adult-Acquired Flatfoot Deformity.

Foot Ankle Int 2021 Jun 10:10711007211015175. Epub 2021 Jun 10.

Department of Orthopaedic Surgery, MedStar Union Memorial Hospital, Baltimore, MD, USA.

Background: We investigated the long-term radiographic outcomes of the Cotton osteotomy performed at our institution by the 2 senior authors in conjunction with other reconstruction procedures to correct adult-acquired flatfoot deformity (AAFD).

Methods: We retrospectively studied patients who underwent Cotton osteotomy between 2005 and 2010 with minimum 4-year follow-up. Radiographic assessment was made on weightbearing radiographs taken at 4 different time intervals: preoperative, early (first postoperative full weightbearing), intermediate (between 1 and 4 years postoperatively), and final (over 4 years postoperatively). Read More

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An Optimal Surgical Plane for Laparoscopic Functional Total Mesorectal Excision in Rectal Cancer.

J Gastrointest Surg 2021 Jun 9. Epub 2021 Jun 9.

Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, People's Republic of China.

Background: Intraoperative damage of pelvic autonomic nerves is the primary reason for postoperative sexual and urinary dysfunction after rectal cancer surgery,1,2 especially in patients with low rectal cancer. In the present study, we developed the nerve plane as a novel concept in rectal cancer surgery, which served as a landmark for better preservation of pelvic autonomic nerves in standardized total mesorectal excision (TME) surgery. The nerves never exist alone, and are always surrounded by tiny capillaries and adipose tissue, which are covered by a thin layer of membranous tissue, leading to a continuous plane, which we defined as the nerve plane. Read More

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Intraoperative Neuromonitoring Auxiliary Significance of DNEP for MEP-positive Event During Severe Spinal Deformity Surgery.

Clin Spine Surg 2021 Jun 9. Epub 2021 Jun 9.

Spine Center, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai Department of Orthopaedic Surgery, the 1st Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.

Study Design: This was a retrospective analysis.

Objective: The objective of this study was to assess the intraoperative neuromonitoring auxiliary significance of descending neurogenic-evoked potential (DNEP) for motor-evoked potential (MEP) during severe spinal deformity surgery when MEP-positive event occurs.

Summary Of Background Data: MEP detection is the most widely applied neurological monitoring technique in spinal deformity surgery. Read More

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Evaluation of Adherence Rates following Ectopic Pregnancy to Inform Management Decisions in a Public Hospital System.

J Gynecol Obstet Hum Reprod 2021 Jun 6:102180. Epub 2021 Jun 6.

Northwestern University Feinberg School of Medicine, Department of Obstetrics & Gynecology; John H. Stroger Hospital, Department of Obstetrics & Gynecology, Division of Family Planning. Electronic address:

Introduction: Adherence to follow-up is an important consideration when treating non-emergent ectopic pregnancy. Our aim was to evaluate the management of ectopic pregnancy among patients in a public hospital system and to identify factors related to adherence of medical management in this population.

Material And Methods: A retrospective review to evaluate the management of ectopic pregnancy among women in a public hospital system, including all women undergoing treatment for ectopic pregnancy from 2012 to 2017. Read More

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Treatment outcomes in HIV infected patients older than 50 years attending an HIV clinic in Harare, Zimbabwe: A cohort study.

PLoS One 2021 9;16(6):e0253000. Epub 2021 Jun 9.

Newlands Clinic, Newlands, Harare, Zimbabwe.

There is a growing number of older people living with HIV (OPLHIV). While a significant proportion of this population are adults growing into old age with HIV, there are also new infections among OPLHIV. There is a lack of data describing the outcomes of OPLHIV who commenced antiretroviral therapy (ART) after the age of 50 years in sub-Saharan Africa. Read More

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Mentalization-Based Treatment in a Naturalistic Setting in Ireland: A Cohort Study.

Psychiatr Serv 2021 Jun 9:appips202000810. Epub 2021 Jun 9.

East Blanchardstown Mental Health Service, Dublin (Tong); Department of Psychiatry, University Hospital Galway, Galway, Ireland (Costello, McCabe); School of Medicine, University College Dublin, and Liaison Psychiatry, Mater Misericordiae University Hospital, Dublin (Doherty).

Objective: This study evaluated the real-world effectiveness of mentalization-based treatment by assessing the clinical status of patients before and after completing the treatment program, which was nested within a general adult community mental health service, and by comparing these patients with a treatment-as-usual group.

Methods: In this retrospective longitudinal naturalistic study, patients with a primary diagnosis of borderline personality disorder received either mentalization-based treatment (N=34) or treatment as usual (N=51). Data were collected from clinical charts and hospital databases. Read More

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Predictors of mortality for acute vertebrobasilar artery occlusion receiving endovascular treatment.

Acta Neurol Scand 2021 Jun 8. Epub 2021 Jun 8.

Department of Neurology, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Nanjing, China.

Objectives: Acute vertebrobasilar artery occlusion (VBAO) is a devastating type of stroke with a high mortality rate. This study aimed to investigate the predictors of 3-month and 1-year mortality in VBAO patients receiving endovascular treatment (EVT).

Materials & Methods: Consecutive acute VBAO patients undergoing EVT between January 2014 and December 2019 were retrospectively analyzed in a prospectively maintained database. Read More

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Dental implant placement with inferior alveolar nerve repositioning in severely resorbed mandibles: a retrospective multicenter study of implant success and survival rates, and lower lip sensory disturbances.

Int J Implant Dent 2021 Jun 9;7(1):44. Epub 2021 Jun 9.

S'OS Orthognathic Surgery, Vytenio 22-201, Vilnius, Lithuania.

Background: The purpose of this study was to analyze medium-to-long-term implant success and survival rates, and lower lip sensory disturbance after placement of dental implants with simultaneous inferior alveolar nerve (IAN) repositioning.

Methods: Fifteen patients (3 men, 12 women) treated in two centers were included in this retrospective study. The ages of the participants ranged from 19 to 68. Read More

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Application and comparison of Fuhrman nuclear grading system with the novel tumor grading system for chromophobe renal cell carcinoma and its correlation with disease-specific events.

Indian J Urol 2021 Apr-Jun;37(2):147-152. Epub 2021 Apr 1.

Department of Pathology, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India.

Introduction: The grading system of chromophobe renal cell carcinoma (ChRCC) is not well established. In this study, we aimed to compare the application of Fuhrman nuclear grade (FNG) with the novel chromophobe tumor grade (CTG). We also evaluated the correlation of these two grading systems with the clinical outcome. Read More

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A Call for a Standardized Approach to Reporting Patient-Reported Outcome Measures: Clinical Relevance Ratio.

J Bone Joint Surg Am 2021 Jun 8. Epub 2021 Jun 8.

Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio.

Abstract: A shift toward a value-driven health-care model has made prospective collection of patient-reported outcome measures (PROMs) inextricably tied to measuring the success of orthopaedic surgery and patient satisfaction. While progress has been made in optimizing the utilization of PROM data, including establishing appropriate PROMs for a procedure and determining the clinical importance of unique tools, if these PROMs are not accurately analyzed and reported, a proportion of patients who do not reach the clinical thresholds may go unnoticed. Furthermore, parameters are unclear for setting a statistically and clinically important PROM threshold along with a minimum period for follow-up data collection. Read More

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Ultra-short versus standard-length dental implants in conjunction with osteotome-mediated sinus floor elevation: A randomized controlled clinical trial.

Clin Implant Dent Relat Res 2021 Jun 8. Epub 2021 Jun 8.

Faculty of Dentistry, Department of Oral Medicine and Periodontology, Cairo University, Cairo, Egypt.

Background: The ability to restore missing teeth with dental implants is dictated by the available bone and by the presence of anatomical structures. The potential to insert ultrashort implants avoids additional surgical procedures and its inherent complications. The last European Association of Dental Implantologists consensus in 2016 defined ultrashort implants and standard-length dental implants as <6 and >8 mm, respectively. Read More

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Revisional Adjustable Gastric Band in Roux-en-Y Gastric Bypass-Is It Worth It?

J Gastrointest Surg 2021 Jun 7. Epub 2021 Jun 7.

Clarunis, Department of Visceral Surgery, University Centre for Gastrointestinal and Liver Diseases, St. Clara Hospital and University Hospital Basel, 4002, Basel, Switzerland.

Purpose: A subset of patients undergoing Roux-en-Y gastric bypass (RYGB) presents with either insufficient weight loss or weight regain. Data on the revisional restrictive options including laparoscopic adjustable gastric band (LAGB) is scarce. This study analyzes the mid-term efficacy and safety of LAGB as a revisional procedure after RYGB. Read More

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Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID-19 and elevated D-dimer concentration (ACTION): an open-label, multicentre, randomised, controlled trial.

Lancet 2021 Jun 4;397(10291):2253-2263. Epub 2021 Jun 4.

Brazilian Research in Intensive Care Network, São Paulo, Brazil; BP-A Beneficência Portuguesa de São Paulo, São Paulo, Brazil.

Background: COVID-19 is associated with a prothrombotic state leading to adverse clinical outcomes. Whether therapeutic anticoagulation improves outcomes in patients hospitalised with COVID-19 is unknown. We aimed to compare the efficacy and safety of therapeutic versus prophylactic anticoagulation in this population. Read More

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Impact of the diagnostic test Xpert MTB/RIF on patient outcomes for tuberculosis.

Cochrane Database Syst Rev 2021 05 6;5:CD012972. Epub 2021 May 6.

University of Basel, Basel, Switzerland.

Background: The World Health Organization (WHO) recommends Xpert MTB/RIF in place of smear microscopy to diagnose tuberculosis (TB), and many countries have adopted it into their diagnostic algorithms. However, it is not clear whether the greater accuracy of the test translates into improved health outcomes.

Objectives: To assess the impact of Xpert MTB/RIF on patient outcomes in people being investigated for tuberculosis. Read More

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