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Preliminary evaluation of two bathing methods for the management of Malassezia overgrowth in dogs with atopic dermatitis.

Vet Dermatol 2021 Apr 12. Epub 2021 Apr 12.

Vet Derm Tokyo, Dermatological and Laboratory Service for Animals, 910 Shoubusawa, Fujisawa-shi, Kanagawa, 252-0823, Japan.

Background: Antifungal shampoos are widely used for canine Malassezia dermatitis. Few studies have evaluated effective bathing methods for atopic dogs with Malassezia overgrowth.

Objectives: To evaluate the efficacy of an emollient bathing product (AFLOAT VET) and 2% miconazole/2% chlorhexidine shampoo (2% MIC/CHX) in atopic dogs, and to evaluate the influence on skin barrier function of both products in healthy dogs. Read More

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Irisin Regulating Skeletal Response to Endurance Exercise in Ovariectomized Mice by Promoting Akt/β-Catenin Pathway.

Front Physiol 2021 25;12:639066. Epub 2021 Mar 25.

College of Physical Education, Yangzhou University, Yangzhou, China.

Thought irisin is recognized as a pivotal modulator for bone formation, its role in regulating skeletal response to exercise training remains unknown. Therefore, we aimed to determine the change of irisin in response to 8-week exercise training and its role in regulating the effects of exercise on bone loss in ovariectomized (Ovx) mice. Forty 3-month old female C57BL/6 mic were randomly allocated into four groups: (1) Sham-operated (Sham); (2) ovariectomized; (3) Ovx plus 8-week downhill running exercise (Ex); (4) Ovx plus exercise and received twice weekly injection of cyclo RGDyk protein (a putative anti-irisin receptor agents) (ExRg). Read More

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A novel murine model of pulmonary fibrosis: the role of platelets in chronic changes induced by bleomycin.

J Pharmacol Toxicol Methods 2021 Apr 2;109:107057. Epub 2021 Apr 2.

Sackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King's College London, London SE1 9NH, United Kingdom.

Idiopathic pulmonary fibrosis (IPF) is a disease that causes scarring and destruction of lung tissue that is ultimately fatal. There is a need to develop improved treatments for IPF. One problem with identifying novel treatments of IPF is the poor predictability of current preclinical models. Read More

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Vitamin D supplementation does not enhance the effects of resistance training in older adults.

J Cachexia Sarcopenia Muscle 2021 Mar 31. Epub 2021 Mar 31.

Section for Health and Exercise Physiology, Inland Norway University of Applied Sciences, P.O. Box. 422, Lillehammer, 2604, Norway.

Background: Lifestyle therapy with resistance training is a potent measure to counteract age-related loss in muscle strength and mass. Unfortunately, many individuals fail to respond in the expected manner. This phenomenon is particularly common among older adults and those with chronic diseases (e. Read More

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Emicizumab in tolerized patients with hemophilia A with inhibitors: A single-institution pediatric cohort assessing inhibitor status.

Res Pract Thromb Haemost 2021 Feb 8;5(2):342-348. Epub 2021 Feb 8.

Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta Atlanta GA USA.

Background: The majority of patients with hemophilia A with inhibitors who undergo immune tolerance induction (ITI) achieve successful tolerance and transition to factor VIII (FVIII) prophylaxis. A portion of these patients have switched to emicizumab for bleeding prevention. However, the risk of inhibitor relapse on emicizumab is unclear. Read More

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February 2021

Effects of Biofeedback-Guided Pelvic Floor Muscle Training With and Without Extracorporeal Magnetic Innervation Therapy on Stress Incontinence: A Randomized Controlled Trial.

J Wound Ostomy Continence Nurs 2021 Mar-Apr 01;48(2):153-161

Sureyya Gumussoy, PhD, MSN, Atatürk Health Care Vocational School, Ege University, Bornova, Izmir, Turkey.

Purpose: We evaluated the effects of biofeedback-guided pelvic floor muscle training (EMG-BF), with and without extracorporeal magnetic innervation (EMG-BF+ExMI) therapy on lower urinary tract symptoms based on frequency of stress urinary incontinence (SUI) and grams of urine loss, health-related quality of life, and sexual function in women with SUI.

Design: This was a randomized controlled trial.

Subjects And Setting: The sample comprised 51 adult women with SUI. Read More

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Long-term health-related quality of life in patients treated with subcutaneous C1-inhibitor replacement therapy for the prevention of hereditary angioedema attacks: findings from the COMPACT open-label extension study.

Orphanet J Rare Dis 2021 Feb 15;16(1):86. Epub 2021 Feb 15.

University College Hospital, London, UK.

Background: Long-term prophylaxis with subcutaneous C1-inhibitor (C1-INH[SC]; HAEGARDA, CSL Behring) in patients with hereditary angioedema (HAE) due to C1-INH deficiency (C1-INH-HAE) was evaluated in an open-label extension follow-up study to the international, double-blind, placebo-controlled COMPACT study. The current analysis evaluated patient-reported health-related quality of life (HRQoL) data from 126 patients in the open-label extension study randomized to treatment with C1-INH(SC) 40 IU/kg (n = 63) or 60 IU/kg (n = 63) twice weekly for 52 weeks. HRQoL was evaluated at the beginning of the open-label study and at various time points using the European Quality of Life-5 Dimensions Questionnaire (EQ-5D), the Hospital Anxiety and Depression Scale (HADS), the Work Productivity and Activity Impairment Questionnaire (WPAI), and the Treatment Satisfaction Questionnaire for Medication. Read More

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February 2021

Strength training and gross-motor skill exercise as interventions to improve postural control, dynamic functional balance and strength in older individuals.

J Sports Med Phys Fitness 2021 Jan 22. Epub 2021 Jan 22.

Institute for Sport and Health, University College Dublin, Belfield Dublin 4, Ireland.

Background: Loss of balance control is commonly experienced by older individuals. Despite the large amount of research on the effects of exercise on balance the optimal exercise regime is yet to be identified. Most studies have concentrated on strength training due to associations between muscle weakness, balance disfunction and fall risk. Read More

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January 2021

Feasibility and acceptability of a technology-based, rural weight management intervention in older adults with obesity.

BMC Geriatr 2021 Jan 12;21(1):44. Epub 2021 Jan 12.

Dartmouth College, Hanover, NH, USA.

Background: Older adults with obesity residing in rural areas have reduced access to weight management programs. We determined the feasibility, acceptability and preliminary outcomes of an integrated technology-based health promotion intervention in rural-living, older adults using remote monitoring and synchronous video-based technology.

Methods: A 6-month, non-randomized, non-blinded, single-arm study was conducted from October 2018 to May 2020 at a community-based aging center of adults aged ≥65 years with a body mass index (BMI) ≥30 kg/m. Read More

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January 2021

What the forks? A longitudinal quality improvement study tracking cutlery numbers in a public teaching and research hospital staff tearoom.

Med J Aust 2020 12;213(11):521-523

Royal Brisbane and Women's Hospital, Brisbane, QLD.

Objectives: To evaluate the circulation lifespan of forks and teaspoons in an institutional tearoom.

Design: Longitudinal quality improvement study, based on prospective tracking of marked teaspoons and forks.

Setting: Staff tearoom in a public teaching and research hospital, Brisbane. Read More

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December 2020

Soy-tomato enriched diet reduces inflammation and disease severity in a pre-clinical model of chronic pancreatitis.

Sci Rep 2020 12 11;10(1):21824. Epub 2020 Dec 11.

James Comprehensive Cancer Center, The Ohio State University, Columbus, USA.

Chronic pancreatitis (CP) is a fibro-inflammatory syndrome in individuals who develop persistent pathological responses to parenchymal injury or stress. Novel therapeutic or dietary interventions that could lessen inflammation in this disease could significantly improve quality of life in patients with CP. Complex dietary foods like soy and tomatoes are composed of active metabolites with anti-inflammatory effects. Read More

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December 2020

The role of self-efficacy and information processing in weight loss during an mHealth behavioral intervention.

Digit Health 2020 Jan-Dec;6:2055207620976755. Epub 2020 Nov 30.

Holcombe Department of Electrical and Computer Engineering, Clemson University, Clemson, USA.

Self-efficacy (SE) and information processing (IP) may be important constructs to target when designing mHealth interventions for weight loss. The goal of this study was to examine the relationship between SE and IP with weight loss at six-months as part of the Dietary Interventions Examining Tracking with mobile study, a six-month randomized trial with content delivered remotely via twice-weekly podcasts. Participants were randomized to self-monitor their diet with either a mobile app (n = 42) or wearable Bite Counter device (n = 39). Read More

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November 2020

Intensive nutrition counseling as part of a multi-component weight loss intervention improves diet quality and anthropometrics in older adults with obesity.

Clin Nutr ESPEN 2020 Dec 19;40:293-299. Epub 2020 Sep 19.

The Geisel School of Medicine at Dartmouth, 1 Rope Ferry Road Hanover, NH, 03755, USA; Department of Internal Medicine, Dartmouth-Hitchcock Medical Center, 1 Medical Center Drive Lebanon, NH, 03766, USA; The Dartmouth Institute for Health Policy,1 Medical Center Drive, Lebanon, NH, 03766, USA; Division of Geriatric Medicine, Center for Aging and Health, Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, HC, 27517, USA. Electronic address:

Background And Aims: Obesity significantly impacts older adults. Intensive nutrition counseling can aid in weight reduction and improve diet quality, but data are sparse in this population. The objective of this intervention is to determine how intensive nutrition counseling affects diet quality and anthropometric measures during a multi-component weight loss intervention in rural older adults with obesity. Read More

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December 2020

Case Study: Rapid Complete Recovery From An Autism Spectrum Disorder After Treatment of Aspergillus With The Antifungal Drugs Itraconazole And Sporanox.

Integr Med (Encinitas) 2020 Aug;19(4):20-27

The Great Plains Laboratory in Lenexa, Kansas.

Context: A child with symptoms placing him within the autism spectrum and with urine biochemical markers consistent with fungal () colonization of the gastrointestinal tract was first treated with the antifungal probiotic A dramatic Herxheimer reaction provided strong clinical indications that mold colonization might be a factor in causing autism in this child.

Objective: The child's physician (Baker) wished to try a more potent antifungal therapy, itraconazole, in an attempt to reverse the child's autism since itraconazole is an especially effective agent against species.

Setting: The child was treated as an outpatient by the physician who had first diagnosed the child with an autism spectrum disorder. Read More

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Incidence of influenza during pregnancy and association with pregnancy and perinatal outcomes in three middle-income countries: a multisite prospective longitudinal cohort study.

Lancet Infect Dis 2021 01 29;21(1):97-106. Epub 2020 Oct 29.

US Naval Medical Research Unit No 6, Bellavista, Peru.

Background: Influenza vaccination during pregnancy prevents influenza among women and their infants but remains underused among pregnant women. We aimed to quantify the risk of antenatal influenza and examine its association with perinatal outcomes.

Methods: We did a prospective cohort study in pregnant women in India, Peru, and Thailand. Read More

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January 2021

Seasonal heat load is more potent than the degree of body weight loss in dysregulating immune function by reducing white blood cell populations and increasing inflammation in Holstein dairy cows.

J Dairy Sci 2020 Nov 28;103(11):10809-10822. Epub 2020 Sep 28.

Department of Ruminant Science, Institute of Animal Sciences, Agricultural Research Organization, Volcani Center, Rishon Lezion, 7505101, Israel.

We investigated the effects of seasonal heat stress and the degree of body weight (BW) loss postpartum (PP) on immune and inflammatory markers in transition dairy cows. Blood sampled twice weekly during the transition period (3 wk prepartum to 3 wk PP) from 12 peripartum Holstein cows in summer and 12 in winter was analyzed for plasma nonesterified fatty acids, the oxidative stress marker malondialdehyde (MDA), haptoglobin, and tumor necrosis factor-α (TNF-α). Complete blood counts and white blood cell (WBC) subpopulations (CD4, CD8, CD25, WC1, and CD335) were examined weekly during the transition period. Read More

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November 2020

Is Dietary Nonadherence Unique to Obesity and Weight Loss? Results From a Randomized Clinical Trial.

Obesity (Silver Spring) 2020 11;28(11):2020-2027

Obesity and Diabetes Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA.

Objective: Weight stigma is associated with poor dietary adherence, yet adherence is essential for weight loss and maintenance. This study aimed to determine differences in dietary adherence and perceived hunger between lean individuals and two groups of individuals with obesity.

Methods: In a 6-week outpatient dietary intervention (23 males; aged 48  [SD 14] years), lean participants (n = 23; BMI 23  [SD 2] kg/m ) received a weight-maintaining energy needs (WMEN) diet, and participants with obesity (BMI 36  [SD 7]) were randomized to either WMEN (n = 18) or a 35% calorie-reduced (CR) diet (n = 19). Read More

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November 2020

Phase I Trial of First-in-Class ATR Inhibitor M6620 (VX-970) as Monotherapy or in Combination With Carboplatin in Patients With Advanced Solid Tumors.

J Clin Oncol 2020 09 22;38(27):3195-3204. Epub 2020 Jun 22.

Drug Development Unit, Royal Marsden Hospital, London, United Kingdom.

Purpose: Preclinical studies demonstrated that ATR inhibition can exploit synthetic lethality (eg, in cancer cells with impaired compensatory DNA damage responses through ATM loss) as monotherapy and combined with DNA-damaging drugs such as carboplatin.

Patients And Methods: This phase I trial assessed the ATR inhibitor M6620 (VX-970) as monotherapy (once or twice weekly) and combined with carboplatin (carboplatin on day 1 and M6620 on days 2 and 9 in 21-day cycles). Primary objectives were safety, tolerability, and maximum tolerated dose; secondary objectives included pharmacokinetics and antitumor activity; exploratory objectives included pharmacodynamics in timed paired tumor biopsies. Read More

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September 2020

Coccidioidal Endophthalmitis: Excellent Recovery of Vision with Aggressive Use of Intravitreal Antifungals and Vitrectomy.

Retin Cases Brief Rep 2020 Jun 8. Epub 2020 Jun 8.

Retina Service, Department of Ophthalmology, University of California, San Francisco, San Francisco, California, USA.

Purpose: To report a case of Coccidioides immitis endophthalmitis with severe vision loss and a return to excellent vision following aggressive intervention.

Methods: Case report.

Results: A 41-year-old male with a history of solid organ transplantation who complained of floaters and decreased vision in the setting of disseminated Coccidioides infection was found to have presumed coccidioidal endophthalmitis with visual acuities (VA) of 20/20 in the right eye and 20/200 in the left eye. Read More

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Interleukin-2 Therapy of Autoimmunity in Diabetes (ITAD): a phase 2, multicentre, double-blind, randomized, placebo-controlled trial.

Wellcome Open Res 2020 20;5:49. Epub 2020 Mar 20.

Islet Transplant Research Group, Nuffield Department of Surgical Sciences, Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Oxford, OX3 9DU, UK.

Type 1 diabetes is a common autoimmune disease due to destruction of pancreatic β cells, resulting in lifelong need for insulin. Evidence suggest that maintaining residual β-cell function can improve glucose control and reduce risk of hypoglycaemia and vascular complications. Non-clinical, preclinical and some preliminary clinical data suggest that low-dose interleukin-2 (IL-2) therapy could block pancreatic β cells destruction by increasing the number of functional regulatory T cells (Tregs) that inhibit islet-specific autoreactive effector T cells (Teffs). Read More

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A Weight Loss Intervention Augmented by a Wearable Device in Rural Older Adults With Obesity: A Feasibility Study.

J Gerontol A Biol Sci Med Sci 2021 Jan;76(1):95-100

Massachusetts General Hospital, Boston.

Background: Older persons with obesity aged 65+ residing in rural areas have reduced access to weight management programs due to geographic isolation. The ability to integrate technology into health promotion interventions shows a potential to reach this underserved population.

Methods: A 12-week pilot in 28 older rural adults with obesity (body mass index [BMI] ≥ 30 kg/m2) was conducted at a community aging center. Read More

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January 2021

Comparison of various treatment options for canine atopic dermatitis: a blinded, randomized, controlled study in a colony of research atopic beagle dogs.

Vet Dermatol 2020 Aug 17;31(4):284-e69. Epub 2020 Apr 17.

Blanche Saunders Dermatology Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, 2015 SW 16th Avenue, Gainesville, FL, 32610, USA.

Background: No study has directly compared the various treatment options for canine atopic dermatitis and their effects on skin barrier.

Hypothesis/objectives: To compare prednisone, oclacitinib, ciclosporin and lokivetmab treatment of atopic dermatitis.

Animals: Nineteen atopic beagle dogs. Read More

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Effects of supervised high-intensity resistance and impact training or machine-based isometric training on regional bone geometry and strength in middle-aged and older men with low bone mass: The LIFTMOR-M semi-randomised controlled trial.

Bone 2020 07 11;136:115362. Epub 2020 Apr 11.

Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia; School of Allied Health Sciences, Griffith University, Gold Coast, Queensland, Australia; The Bone Clinic, Brisbane, Queensland, Australia. Electronic address:

Introduction: Few data exist on the effects of bone-targeted exercise on geometric and biomechanical indices of bone strength in men. The Lifting Intervention For Training Muscle and Osteoporosis Rehabilitation for Men (LIFTMOR-M) trial was designed to compare the efficacy and safety of two novel, supervised, twice-weekly, high-intensity exercise programs in middle-aged and older men with osteopenia and osteoporosis on musculoskeletal health and risk factors related to falls and fractures. The current report includes secondary outcomes of the LIFTMOR-M exercise intervention trial. Read More

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PROTECT VIII Kids: BAY 94-9027 (PEGylated Recombinant Factor VIII) safety and efficacy in previously treated children with severe haemophilia A.

Haemophilia 2020 May 25;26(3):e55-e65. Epub 2020 Mar 25.

Cumming School of Medicine, Alberta Children's Hospital, University of Calgary, Calgary, AB, Canada.

Introduction: BAY 94-9027, a site-specifically PEGylated, B-domain-deleted recombinant factor VIII (FVIII) with extended half-life, demonstrated efficacy for bleed prevention and treatment in previously treated adolescents and adults with severe haemophilia A.

Aim: To assess BAY 94-9027 in children with severe haemophilia A.

Methods: In the two-part PROTECT VIII Kids study, boys <12 years with <1% FVIII and >50 exposure days (EDs) to FVIII were enrolled in two cohorts (<6 years; 6-<12 years) and treated with BAY 94-9027 prophylaxis twice-weekly, every 5 days, or every 7 days at physician discretion for ≥50 EDs (Part 1) or twice-weekly for 12-weeks (Part 2). Read More

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Topical treatment with SPHINGOLIPIDS and GLYCOSAMINOGLYCANS for canine atopic dermatitis.

BMC Vet Res 2020 Mar 20;16(1):92. Epub 2020 Mar 20.

Department of Medicine and Surgery, Veterinary School, Universitat Autònoma de Barcelona, Edifici V Campus UAB, 08290, Cerdanyola del Vallès, Spain.

Background: Skin barrier dysfunction plays a key role in atopic dermatitis (AD). This impairment is related to altered composition and metabolism of epidermal sphingolipids and a deficiency of ceramides. Glycosaminoglycans (GAGs), and especially hyaluronic acid, could be useful in the management of AD. Read More

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Narrative Review of Incremental Hemodialysis.

Kidney Int Rep 2020 Feb 6;5(2):135-148. Epub 2019 Dec 6.

Department of Internal Medicine, Section on Nephrology, University of California Irvine School of Medicine, Orange, California, USA.

The prescription of hemodialysis (HD) in patients with incident end-stage kidney disease (ESKD) is fundamentally empirical. The abrupt transition from nondialysis chronic kidney disease (CKD) to thrice-weekly in-center HD of much the same dialysis intensity as in those with prevalent ESKD underappreciates the progressive nature of kidney disease whereby the decline in renal function has been gradual and ongoing-including at the time of HD initiation. Adjuvant pharmacologic treatment (i. Read More

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February 2020

Evaluating differences in the clinical impact of a free online weight loss programme, a resource-intensive commercial weight loss programme and an active control condition: a parallel randomised controlled trial.

BMC Public Health 2019 Dec 23;19(1):1732. Epub 2019 Dec 23.

Nuffield Health Research Group, Nuffield Health, Ashley Avenue, Epsom, Surrey, KT18 5AL, UK.

Background: Finding effective intervention strategies to combat rising obesity levels could significantly reduce the burden that obesity and associated non-communicable diseases places on both individuals and the National Health Service.

Methods: In this parallel randomised-controlled trial, 76 participants who are overweight or obese (50 female) were given free access to a fitness centre for the duration of the 12-week intervention and randomised to one of three interventions. The commercial intervention, the Healthy Weight Programme, (HWP, n = 25, 10/15 men/women) consisted of twelve 1-h nutrition coaching sessions with a nutritionist delivered as a mixture of group and 1 to 1 sessions. Read More

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December 2019

Ultrafiltration Rate, Residual Kidney Function, and Survival Among Patients Treated With Reduced-Frequency Hemodialysis.

Am J Kidney Dis 2020 03 6;75(3):342-350. Epub 2019 Dec 6.

Harold Simmons Center for Kidney Disease Research and Epidemiology, Division of Nephrology & Hypertension, University of California Irvine Medical Center, Orange, CA. Electronic address:

Rationale & Objective: Patients receiving twice-weekly or less-frequent hemodialysis (HD) may need to undergo higher ultrafiltration rates (UFRs) to maintain acceptable fluid balance. We hypothesized that higher UFRs are associated with faster decline in residual kidney function (RKF) and a higher rate of mortality.

Study Design: Retrospective cohort study. Read More

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Cognitive remediation-enabled cognitive behaviour therapy for obesity: a case series.

Eat Weight Disord 2021 Feb 3;26(1):103-114. Epub 2019 Dec 3.

University of New South Wales, Level 3, Samuel Building, UNSW, Kensington, NSW, 2052, Australia.

Purpose: Despite varied treatment effects, weight recidivism is common and typically associated with the abandonment of prescribed weight management strategies. Literature suggests that difficulty with weight management is associated with deficits in executive functioning, in particular cognitive flexibility and response inhibition, the neurocognitive processes that are involved in goal-directed behaviours, such as dietary adherence. These processes are overlooked by mainstream weight loss programmes. Read More

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February 2021

Case Report of Exercise to Attenuate Side Effects of Treatment for Pancreatic Cancer.

Case Rep Oncol 2019 Sep-Dec;12(3):845-854. Epub 2019 Nov 1.

Edinburgh Napier University, Edinburgh, United Kingdom.

Treatments for pancreatic cancer can have debilitating side effects including fatigue, weight loss, and cardiac toxicity, resulting in functional loss and psychological distress. Exercise has been proposed as a therapy to counteract physical and psychological detriments. The case: A 47-year-old male undergoing chemotherapy for stage 3 locally advanced pancreatic cancer. Read More

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November 2019