1,036,984 results match your criteria loss perianal

Post-chemotherapy alopecia: what the dermatologist needs to know.

Int J Dermatol 2021 Aug 4. Epub 2021 Aug 4.

Department of Dermatology, Ramón Y Cajal Hospital, Madrid, Spain.

It is estimated that chemotherapy-induced alopecia (CIA) occurs in 65% of chemotherapeutic patients. Forty-seven percent of cancer patients consider hair loss to be the most traumatic aspect of therapy. CIA can be anticipated, depending on the regimen used, and doctors should be aware of the treatments that can minimize it. Read More

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Weight Change and the Onset of Cardiovascular Diseases: Emulating Trials Using Electronic Health Records.

Epidemiology 2021 Sep;32(5):744-755

From the Institute of Health Informatics, University College London (UCL), London, United Kingdom.

Background: Cross-sectional measures of body mass index (BMI) are associated with cardiovascular disease (CVD) incidence, but less is known about whether weight change affects the risk of CVD.

Methods: We estimated the effect of 2-y weight change interventions on 7-y risk of CVD (CVD death, myocardial infarction, stroke, hospitalization from coronary heart disease, and heart failure) by emulating hypothetical interventions using electronic health records. We identified 138,567 individuals with 45-69 years of age without chronic disease in England from 1998 to 2016. Read More

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September 2021

Vision Loss Associated With Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy.

J Neuroophthalmol 2021 Jul 27. Epub 2021 Jul 27.

Department of Medicine (MMH), University of California Irvine Medical Center, Orange, California; and Gavin Herbert Eye Institute (CRS, RWC), University of California, Irvine, California.

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Therapeutic effects of vitamin D and IL-22 on methotrexate-induced mucositis in mice.

Anticancer Drugs 2021 Aug 3. Epub 2021 Aug 3.

Division of Pediatric Hematology and Oncology, Department of Pediatrics, Erciyes University School of Medicine Molecular Biology and Genetics, Betül-Ziya Eren Genome and Stem Cell Center (GENKOK) Department of Medical Biology, Erciyes University, School of Medicine Department of Histology and Embryology, Erciyes University, School of Medicine Department of Pathology, Erciyes University, School of Medicine Department of Biology, Erciyes University, Faculty of Science Department of Chemistry and Chemical Processing Technologies, Kayseri University, Mustafa Çikrikçioğlu Vocational School Department of Biology, Faculty of Arts and Science, Yozgat Bozok University, Yozgat, Turkey.

Mucositis is a common side effect of cancer therapies and transplant conditioning regimens. Management of mucositis involves multiple approaches from oral hygiene, anti-inflammatory, anti-apoptotic, cytoprotective, and antioxidant agents, to cryo-therapy, physical therapy, and growth factors. There is room for novel, affordable treatment options, or improvement of currently available therapies. Read More

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The Environmental Role of Hydration in Kidney Health and Disease.

Contrib Nephrol 2021 Aug 4;199:1-14. Epub 2021 Aug 4.

Research Department, Fundação Pró-Rim, Joinville, Brazil.

Clinical Background: Hydration status, which is influenced by environment and self-behavior is associated with kidney health and disease. Epidemiology: Lack of safe water, sanitation, and high temperatures are environmental issues that affect a significant part of the worldwide population. Occupational factors that discourage proper hydration, as well as low water intake in favorable environment conditions, are also highly prevalent. Read More

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Gait Risk Factors for Disease Progression Differ Between Non-traumatic and Post-traumatic Knee Osteoarthritis.

Osteoarthritis Cartilage 2021 Aug 1. Epub 2021 Aug 1.

Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, Canada. Electronic address:

Objective: To examine if relationships between knee osteoarthritis (OA) progression with knee moments and muscle activation during gait vary between patients with non-traumatic and post-traumatic knee OA.

Design: This longitudinal study included participants with non-traumatic (n=17) and post-traumatic (n=18) knee OA; the latter group had a previous anterior cruciate ligament rupture. Motion capture cameras, force plates, and surface electromyography measured knee moments and lower extremity muscle activation during gait. Read More

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SMC complexes are guarded by the SUMO protease Ulp2 against SUMO-chain-mediated turnover.

Cell Rep 2021 Aug;36(5):109485

IFOM, the FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy; Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche (IGM-CNR), Via Abbiategrasso 207, 27100 Pavia, Italy. Electronic address:

Structural maintenance of chromosomes (SMCs) complexes, cohesin, condensin, and Smc5/6, are essential for viability and participate in multiple processes, including sister chromatid cohesion, chromosome condensation, and DNA repair. Here we show that SUMO chains target all three SMC complexes and are antagonized by the SUMO protease Ulp2 to prevent their turnover. We uncover that the essential role of the cohesin-associated subunit Pds5 is to counteract SUMO chains jointly with Ulp2. Read More

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Paradoxical hyperexcitability from Na1.2 sodium channel loss in neocortical pyramidal cells.

Cell Rep 2021 Aug;36(5):109483

Neuroscience Graduate Program, Kavli Institute for Fundamental Neuroscience, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Department of Neurology, Kavli Institute for Fundamental Neuroscience, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA. Electronic address:

Loss-of-function variants in the gene SCN2A, which encodes the sodium channel Na1.2, are strongly associated with autism spectrum disorder and intellectual disability. An estimated 20%-30% of children with these variants also suffer from epilepsy, with altered neuronal activity originating in neocortex, a region where Na1. Read More

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Disassembly and rewiring of a mature converging excitatory circuit following injury.

Cell Rep 2021 Aug;36(5):109463

Department of Ophthalmology, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address:

Specificity and timing of synapse disassembly in the CNS are essential to learning how individual circuits react to neurodegeneration of the postsynaptic neuron. In sensory systems such as the mammalian retina, synaptic connections of second-order neurons are known to remodel and reconnect in the face of sensory cell loss. Here we analyzed whether degenerating third-order neurons can remodel their local presynaptic connectivity. Read More

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Stimulation of α7 nAChR leads to regeneration of damaged neurons in adult mammalian retinal disease models.

Exp Eye Res 2021 Aug 1:108717. Epub 2021 Aug 1.

Western Michigan University, Department of Biological Sciences, Kalamazoo, MI, United States. Electronic address:

The adult mammal lacks the ability to regenerate neurons lost to retinal damage or disease in a meaningful capacity. However, previous studies from this laboratory have demonstrated that PNU-282987, an α7 nicotinic acetylcholine receptor agonist, elicits a robust neurogenic response in the adult murine retina. With eye drop application of PNU-282987, Müller glia cells re-enter the cell cycle and produce progenitor-like cells that can differentiate into various types of retinal neurons. Read More

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Transmission of SARS-CoV-2 in the household setting: a prospective cohort study in children and adults in England.

J Infect 2021 Aug 1. Epub 2021 Aug 1.

Immunisation and Countermeasures Division, Public Health England, 61 Colindale Avenue, NW9 5EQ, London, United Kingdom. Electronic address:

Objectives: To measure secondary attack rates (SARs) in prospectively followed household contacts of paediatric and adult cases of SARS-CoV-2 infection in England.

Methods: Self-taken nasal swabs from household contacts of PCR confirmed cases of COVID-19 and blood samples on day 35 were tested for evidence of infection with SARS-CoV-2 virus.

Results: The secondary attack rate (SAR) among 431 contacts of 172 symptomatic index cases was 33% (95% confidence intervals [CI] 25-40) and was lower from primary cases without respiratory symptoms, 6% (CI 0-14) vs 37% (CI 29-45), p=0. Read More

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Melanocortin 4 receptor mutations become common.

Cell Metab 2021 Aug;33(8):1512-1513

Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin und Humboldt-Universität zu Berlin, Institute for Experimental Pediatric Endocrinology, Augustenburger Platz 1, 13353 Berlin, Germany. Electronic address:

In a new paper, Wade et al. (2021) analyzed the frequency of MC4R loss-of-function (LoF) mutations in a population-based Avon Longitudinal Study of Parents and Children. The frequency was 1 in 337 and the authors showed that MC4R LoF variants significantly correlated with increased body weight and fat mass in children and adults (cumulating in additional 17. Read More

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Association between Family Caregivers' Satisfaction with Care for Terminal Cancer Patients and Quality of Life of the Bereaved Family: A Prospective Pre- and Postloss Study.

J Palliat Med 2021 Aug 4. Epub 2021 Aug 4.

Clinical Research Promotion Center, The University of Tokyo Hospital, Tokyo, Japan.

The quality of life (QOL) of family caregivers often deteriorates after the death of patients with terminal cancer. Although previous retrospective cross-sectional studies of the bereaved family caregivers of cancer patients have suggested that lower satisfaction with care given to terminal cancer patients was related to lower QOL of the bereaved family caregivers, the retrospective cross-sectional study design has limitations. To clarify family caregivers' satisfaction with the care of terminal cancer patients and bereaved family caregivers' QOL. Read More

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Relation between Bone Density and Primary Stability in the Posterior Mandibular Region in Patients Undergoing Dental Implant Treatment: A Retrospective Study.

J Long Term Eff Med Implants 2021 ;31(2):71-79

Department of Prosthodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai-600077, Tamil Nadu, India.

Tooth loss has become one of the most raising issues to be brought up in dentistry, by both patients and dentists. Teeth are considered to be important in case of function and esthetics. Compromise to the dentition would raise social disturbances for the individual. Read More

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January 2021

Retrospective Analysis of Immediate Implants: A Prism with a Different Dimension.

J Long Term Eff Med Implants 2021 ;31(2):51-54

Department of Prosthodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.

Any tooth loss can be addressed for rehabilitation by different types of prosthesis. But, for certain conditions patients and dentists expect immediate results. An immediate implant falls into such a category: The implant is placed immediately into the extracted socket with the expectation of a quick fix. Read More

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January 2021

Survival of Implant-Supported Full-Mouth Rehabilitation among Patients Reporting to a Private Dental Institution.

J Long Term Eff Med Implants 2021 ;31(2):19-25

Department of Oral and Maxillofacial Surgery, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai-77, India.

Full-mouth rehabilitation (FMR) is of increasing importance, as it is through this procedure that patients with dentitions which are in different stages of degeneration or loss can be restored to functional dental health. To identify the survival of implant supported fmr among Chennai population. The participants were the patients who reported for FMR procedure between June 2019 and March 2020 to Saveetha Dental College and Hospital Chennai, the patients were recalled at regular intervals and the survival of the treatment was assessed. Read More

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January 2021

Could Harnessing Natural Killer Cell Activity Be a Promising Therapy for Prostate Cancer?

Jennifer Wu

Crit Rev Immunol 2021 ;41(2):101-106

Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

Harnessing natural killer (NK) cell activity, either endogenous NK or NK-cell-based therapy, is in the forefront development for many tumor types. There are compelling clinical evidence demonstrating the significant relevance of loss of NK cell activity with prostate cancer (PCa) disease progression to the lethal phenotype, metastatic castration-resistant PCa (mCRPC). Given that mCRPC is generally regarded as a "cold" tumor and has only elicited marginal response to immune checkpoint blockade therapy to revive CD8 T cell activity, NK cell targeted therapy may present a viable opportunity not only to directly target mCRPC and also to "fire up" the cold mCRPC tumor. Read More

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January 2021

Bone Bioelectricity and Bone-Cell Response to Electrical Stimulation: A Review.

Crit Rev Biomed Eng 2021 ;49(1):1-19

McMaster School of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada; Department of Mechanical Engineering, McMaster University, Hamilton, Ontario, Canada.

It is hypothesized that bone cells can sense mechanical force in the extracellular network via an electrical signal. This has led to the use of electrical stimulation (ES) to improve fracture repair and mitigate bone loss. Although overlap exists in bone maintenance and fracture healing mechanics, the processes involved in both are very different, resulting in dissimilar behaviors from the cells. Read More

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January 2021

Tranexamic Acid for the Prevention of Blood Loss after Cesarean Delivery.

Michele Bibas

N Engl J Med 2021 Aug;385(6):574-575

Lazzaro Spallanzani National Institute for Infectious Diseases, Rome, Italy

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Healthy Weight Loss Maintenance with Exercise, Liraglutide, or Both Combined.

N Engl J Med 2021 Aug;385(6):572-573

Sapienza University of Rome, Rome, Italy

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The conserved C2 phospholipid-binding domain in Delta contributes to robust Notch signalling.

EMBO Rep 2021 Aug 4:e52729. Epub 2021 Aug 4.

Department of Physiology Development and Neuroscience, University of Cambridge, Cambridge, UK.

Accurate Notch signalling is critical for development and homeostasis. Fine-tuning of Notch-ligand interactions has substantial impact on signalling outputs. Recent structural studies have identified a conserved N-terminal C2 domain in human Notch ligands which confers phospholipid binding in vitro. Read More

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The AMP-Dependent Kinase Pathway is Upregulated in BAP1 Mutant Uveal Melanoma.

Pigment Cell Melanoma Res 2021 Aug 4. Epub 2021 Aug 4.

Department of Cancer Biology, Thomas Jefferson University.

Metastatic uveal melanoma (UM) responds poorly to targeted therapies and immune checkpoint inhibitors. Loss of BRCA1-associated protein 1 (BAP1) via inactivating mutations in the BAP1 gene is associated with UM progression. Thus, molecular alterations caused by BAP1 dysfunction may be novel therapeutic targets for metastatic UM. Read More

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Prepubertal Pattern Hair Loss.

Clin Exp Dermatol 2021 Aug 4. Epub 2021 Aug 4.

Department of Dermatology, Cantonal Hospital Aarau, Switzerland.

Barth et al originally proposed the term "prepubertal hypertrichosis" to denote a relatively common condition of androgen-independent generalized terminal hair hypertrichosis with prepubertal onset, and absence of endocrinological abnormalities [1]. The importance of the observation was founded in the fact that the condition was formerly frequently confused in the literature with other causes of hypertrichosis, particularly hypertrichosis lanuginosa and hirsutism. In analogy to Barth et al's introduction of the term prepubertal hypertrichosis into dermatologic nomenclature for clarification, we propose naming the condition described herein and by our forerunners "prepubertal pattern hair loss". Read More

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A qualitative study on retailer experiences with Philadelphia's sweetened beverage tax.

Transl Behav Med 2021 Aug 4. Epub 2021 Aug 4.

Department of Medical Ethics and Health Policy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

The Philadelphia Beverage Tax was implemented on January 1, 2017 for some sugar- and artificially-sweetened beverages. Few qualitative studies have assessed retailers' reactions to beverage taxes. We aimed to understand food retailers' knowledge and attitudes about the Philadelphia beverage tax and how they responded to it with the goal of informing the framing and implementation of beverage taxes in other interested jurisdictions. Read More

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Economic analysis of the costs associated with Hidradenitis suppurativa at a German University Hospital.

PLoS One 2021 4;16(8):e0255560. Epub 2021 Aug 4.

Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Bavaria, Germany.

Background And Objectives: Hidradenitis suppurativa (HS) significantly affects the patient`s quality of life and leads to multiple medical consultations. Aim of this study was to assess the utilization of medical care of HS patients.

Patients And Methods: All patients presenting in 2017 for an outpatient, day patient and / or inpatient treatment with leading claim type HS at the Department of Dermatology, University Hospital Würzburg, were included. Read More

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The witchweed Striga gesnerioides and the cultivated cowpea: A geographical and historical analysis of their West African distribution points to the prevalence of agro-ecological factors and the parasite's multilocal evolution potential.

PLoS One 2021 4;16(8):e0254803. Epub 2021 Aug 4.

IRD, UMR IEES-Paris, SU/IRD/CNRS/INRA/UPEC/Univ. Paris Diderot, Centre IRD de France Nord, Bondy Cedex, France.

The increasing severity of Striga gesnerioides attacks on cowpea across West Africa has been related to its prolificity, seed mobility and longevity, and adaptation to aridity, in a context of agricultural intensification. To understand this fast extension, we analyzed (1) the distributions of the crop and the witchweed with ecological niche modeling and multivariate climate analysis, and (2) the chronological information available from collections and the literature. The ecoclimatic envelope of S. Read More

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