59,582 results match your criteria loss muscle

Leveraging insights from behavioral economics to improve mobility for adults with stroke: Design and rationale of the BE Mobile clinical trial.

Contemp Clin Trials 2021 Jun 12:106483. Epub 2021 Jun 12.

Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Physical inactivity post-stroke can negatively impact long-term health outcomes and contribute to cardiovascular deconditioning, muscle loss, and increased risk for recurrent stroke. The limited number of interventions designed to improve daily physical activity post-stroke have lacked precision in step goals, are resource intensive, and difficult to scale. The purpose of the Leveraging Insights from Behavioral Economics to Improve Mobility for Adults with Stroke (BE Mobile) trial is to examine the preliminary effectiveness of a novel gamification with social incentives intervention for improving physical activity post-stroke. Read More

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Distinct glycolytic pathway regulation in liver, tumour and skeletal muscle of mice with cancer cachexia.

Cell Biochem Funct 2021 Jun 15. Epub 2021 Jun 15.

Department of Exercise Science and Health Promotion, Florida Atlantic University, Boca Raton, Florida, USA.

Energetically inefficient inter-organ substrate shuttles are proposed contributors to cachexia-related weight loss. Here, we examined glycolytic pathway metabolites, enzyme activity and transport proteins in skeletal muscle, liver and tumours of mice with cachexia-related weight loss induced by colon-26 cancer cells. Skeletal muscle of cachexic mice had increased [L-lactate]/[pyruvate], LDH activity and lactate transporter MCT1. Read More

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Influence of Muscle Mass Area and Visceral Obesity on 30-day Mortality After Colorectal Surgery with Primary Anastomosis.

Rev Invest Clin 2021 Jun 15. Epub 2021 Jun 15.

Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Background: Muscle mass and visceral fat may be assessed at the level of the third lumbar vertebra (L3) in computed tomography (CT). Both variables have been related with adverse surgical outcomes.

Objective: The objective of the study was to study the association of skeletal muscle index (SMI) and visceral fat area (VFA) with 30-day mortality in colorectal surgery. Read More

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GADD45A is a protective modifier of neurogenic skeletal muscle atrophy.

JCI Insight 2021 Jun 15. Epub 2021 Jun 15.

Department of Neurology, Johns Hopkins School of Medicine, Baltimore, United States of America.

Neurogenic muscle atrophy is the loss of skeletal muscle mass and function that occurs with nerve injury and in denervating diseases such as amyotrophic lateral sclerosis. Aside from prompt restoration of innervation and exercise where feasible, there are currently no effective strategies for maintaining skeletal muscle mass in the setting of denervation. We conducted a longitudinal analysis of gene expression changes occurring in atrophying skeletal muscle, and identified Gadd45a as a gene that shows one of the earliest and most sustained increases in expression in skeletal muscle after denervation. Read More

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Cross sectional study of the clinical characteristics of French primary care patients with COVID-19.

Sci Rep 2021 Jun 14;11(1):12492. Epub 2021 Jun 14.

Primary Care Unit, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

The early identification of patients suffering from SARS-CoV-2 infection in primary care is of outmost importance in the current pandemic. The objective of this study was to describe the clinical characteristics of primary care patients who tested positive for SARS-CoV-2. We conducted a cross-sectional study between March 24 and May 7, 2020, involving consecutive patients undergoing RT-PCR testing in two community-based laboratories in Lyon (France) for a suspicion of COVID-19. Read More

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Symptoms reported by SARS-CoV-2 seropositive and seronegative healthcare and administrative employees in Denmark from May to August 2020.

Int J Infect Dis 2021 Jun 11. Epub 2021 Jun 11.

Department of Clinical Immunology, Aarhus University Hospital, DK-8200 Aarhus N, Denmark; Department of Clinical Medicine, Aarhus University, DK-8000 Aarhus C, Denmark.

Background: The distribution and nature of symptoms among SARS-CoV-2 infected individuals need to be clarified.

Methods: Between May and August 2020, 11,138 healthcare and administrative personnel from Central Denmark Region were tested for SARS-CoV-2 antibodies and subsequently completed a questionnaire. Symptom prevalence and overall duration for symptoms persisting for more than 30 days were calculated. Read More

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Active airflow of the paranasal sinuses in extinct crocodyliforms: Evidence from a natural cast of the thalattosuchian Dakosaurus andiniensis.

Anat Rec (Hoboken) 2021 Jun 14. Epub 2021 Jun 14.

CONICET, División Paleontología Vertebrados, Museo de La Plata, Facultad de Ciencias Naturales y Museo, Universidad Nacional de La Plata, La Plata, Argentina.

The evolution of Thalattosuchia documents the unique shift among Crocodylomorpha from aquatic continental/coastal habitats to a fully pelagic lifestyle. This transition was coupled with deep modification of their skeletons, such as hydrofoil forelimbs, hypocercal tail, and loss of osteoderms. The natural snout casts of the rhacheosaurin Cricosaurus araucanensis showed that it also included changes in the internal anatomy of the snout like the enlargement of nasal glands (probably for salt excretion) and the rearrangement of the paranasal sinus system, including the internalization of the antorbital sinus. Read More

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A Novel Stable Isotope Approach Demonstrates Surprising Degree of Age-Related Decline in Skeletal Muscle Collagen Proteostasis.

Function (Oxf) 2021 10;2(4):zqab028. Epub 2021 May 10.

Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.

Age-related deterioration in turnover of collagen proteins accelerates extracellular matrix fibrosis and hinders adaptation to external stimuli. This project sought to understand factors that increase skeletal muscle fibrosis with age by studying what we term the dynamic protein pool. We hypothesized that the dynamic protein pool size of muscle collagen decreases with age, thus indicating a decrease in proteostatic maintenance (ie, ability to maintain proteostasis), and that failure to account for these changes impacts the interpretation of tracer-measured synthesis rates. Read More

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Complex Revision Glenoid Reconstruction with Use of a Distal Tibial Allograft.

JBJS Essent Surg Tech 2021 Jan-Mar;11(1). Epub 2021 Jan 20.

The Steadman Clinic, Vail, Colorado.

Background: Coracoid transfer procedures have been increasingly utilized for anterior shoulder instability with associated glenoid bone loss. Unfortunately, in a young, high-risk patient population, these procedures can fail secondary to traumatic causes but also because of bone graft resorption or malposition or hardware prominence, among other reasons. In active patients, revision glenoid reconstruction may be indicated. Read More

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January 2021

Exercise-induced benefits on glucose handling in a model of diet-induced obesity are reduced by concurrent nicotinamide mononucleotide.

Am J Physiol Endocrinol Metab 2021 06 14. Epub 2021 Jun 14.

School of Medical Sciences, UNSW Sydney, Australia.

Almost 40% of adults worldwide are classified as overweight or obese. Exercise is a beneficial intervention in obesity, partly due to increases in mitochondrial activity, and subsequent increases in nicotinamide adenine dinucleotide (NAD), an important metabolic cofactor. Recent studies have shown that increasing NAD levels through pharmacological supplementation with precursors such as nicotinamide mononucleotide (NMN) improved metabolic health in high fat diet (HFD) fed mice. Read More

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Diagnosing sarcopenia: functional perspectives and a new algorithm from the ISPRM special interest group on sarcopenia.

J Rehabil Med 2021 Jun 14. Epub 2021 Jun 14.

Physical and Rehabilitation Medicine, Hacettepe University Medical School, Ankara, Turkey. E-mail:

Sarcopenia is an important public health problem, characterized by age-related loss of muscle mass and muscle function. It is a precursor of physical frailty, mobility limitation, and premature death. Although muscle loss is mainly due to the loss of type II muscle fibres, progressive loss of motor neurones is thought to be the primary underlying factor. Read More

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Excessive alcohol intake and liver fibrosis are associated with skeletal muscle mass reduction in elderly men: the Wakayama study.

Aging Clin Exp Res 2021 Jun 12. Epub 2021 Jun 12.

Department of Cardiology, Sumiya Rehabilitation Hospital, Wakayama, Japan.

Background: Excessive alcohol intake complicated by liver dysfunction has been presumed to affect skeletal muscles. This study aimed to examine the association between excessive alcohol intake, liver fibrosis, and loss of skeletal muscle mass in elderly men.

Methods: The study participants comprised 799 community-dwelling elderly men (age, 71 ± 3 years) with no history of treatment for liver disease. Read More

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HDAC4 induces the development of asthma by increasing Slug-upregulated CXCL12 expression through KLF5 deacetylation.

J Transl Med 2021 Jun 12;19(1):258. Epub 2021 Jun 12.

School of Health, Shandong University of Traditional Chinese Medicine, Jinan, 250355, Shandong, People's Republic of China.

Background: Asthma is a frequently occurring respiratory disease with an increasing incidence around the world. Airway inflammation and remodeling are important contributors to the occurrence of asthma. We conducted this study aiming at exploring the effect of Histone deacetylase 4 (HDAC4)-mediated Kruppel-like factor 5 (KLF5)/Slug/CXC chemokine ligand-12 (CXCL12) axis on the development of asthma in regulation of airway inflammation and remodeling. Read More

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Carvacrol, citral and α-terpineol essential oil incorporated biodegradable films for functional active packaging of Pacific white shrimp.

Food Chem 2021 May 30;363:130252. Epub 2021 May 30.

Department of Packaging and Materials Technology, Faculty of Agro-Industry, Kasetsart University, 50 Ngam Wong Wan Rd., Latyao, Chatuchak, Bangkok 10900, Thailand; Center for Advanced Studies for Agriculture and Food, Kasetsart University, 50 Ngam Wong Wan Rd., Latyao, Chatuchak, Bangkok 10900, Thailand. Electronic address:

Biodegradable poly(butylene adipate terephthalate) and poly(lactic acid) (PBAT/PLA) blend films compounded with carvacrol, citral and α-terpineol essential oils (EOs) were produced for food packaging via blown-film extrusion. PBAT/PLA interacted with citral and α-terpineol via hydrogen bonding and carbonyl groups. Microstructures and barrier properties against water vapor and oxygen were modified depending on types and concentrations (3% and 6%) of EOs. Read More

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Exploring the alternative: fish, flies and worms as preclinical models for ALS.

Neurosci Lett 2021 Jun 9:136041. Epub 2021 Jun 9.

KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology, and Leuven Brain Institute (LBI), Leuven, Belgium; VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium. Electronic address:

Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disorder characterized by the loss of upper and lower motor neurons. In general, patients succumb to respiratory insufficiency due to respiratory muscle weakness. Despite many promising therapeutic strategies primarily identified in rodent models, patient trials remain rather unsuccessful. Read More

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Efficacy of aqua-based plyometric exercises in the rehabilitation of patients with juvenile dermatomyositis: A randomized crossover pilot study.

Int J Rheum Dis 2021 Jun 12. Epub 2021 Jun 12.

Department of Physical Therapy for Pediatrics, Faculty of Physical Therapy, Cairo University, Giza, Egypt.

Background: Patients with juvenile dermatomyositis (JDM) experience muscle weakness, tiredness, and loss of energy, which restrict their abilities in performance of their daily living activities.

Objective: To explore the effect of aquatic-based plyometric (Aqua-PLYO) exercises on muscle strength, fatigue, and functional ability in patients with JDM.

Methods: This was a randomized, single-blind, crossover pilot study that included 16 patients with JDM (age 13. Read More

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Kindlin-2 in Sertoli cells is essential for testis development and male fertility in mice.

Cell Death Dis 2021 Jun 11;12(6):604. Epub 2021 Jun 11.

Department of Human Anatomy, Histology and Embryology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) and State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing, 100191, China.

Kindlin-2 is known to play important roles in the development of mesoderm-derived tissues including myocardium, smooth muscle, cartilage and blood vessels. However, nothing is known for the role of Kindlin-2 in mesoderm-derived reproductive organs. Here, we report that loss of Kindlin-2 in Sertoli cells caused severe testis hypoplasia, abnormal germ cell development and complete infertility in male mice. Read More

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Effects of Different Velocity Loss Thresholds on Passive Contractile Properties and Muscle Oxygenation in the Squat Exercise Using Free Weights.

J Strength Cond Res 2021 May 4. Epub 2021 May 4.

Department of Human Motricity and Sports Performance, University of Seville, Spain; MOVE-IT Research Group and Department of Physical Education, Faculty of Education Sciences, University of Cádiz, Cádiz, Spain; Biomedical Research and Innovation Institute of Cádiz (INiBICA) Research Unit, Puerta del Mar University Hospital, University of Cádiz, Cádiz, Spain; Department of Sport, CEU Cardenal Spinola University, Spain; and Department of Physical Education and Sport, University of Sevilla, Spain.

Abstract: Muñoz-López, A, Marín-Galindo, A, Corral-Pérez, J, Costilla, M, Sánchez-Sixto, A, Sañudo, B, Casals, C, and Ponce-González, JG. Effects of different velocity loss thresholds on passive contractile properties and muscle oxygenation in the squat exercise using free weights. J Strength Cond Res XX(X): 000-000, 2021-The current study assessed the impact between different velocity loss thresholds on changes in the muscle contractile properties and muscle oxygenation after a single resistance training (RT) session. Read More

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Survival motor neuron deficiency slows myoblast fusion through reduced myomaker and myomixer expression.

J Cachexia Sarcopenia Muscle 2021 Jun 11. Epub 2021 Jun 11.

Department of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, F. Edward Hébert School of Medicine, Bethesda, MD, USA.

Background: Spinal muscular atrophy is an inherited neurodegenerative disease caused by insufficient levels of the survival motor neuron (SMN) protein. Recently approved treatments aimed at increasing SMN protein levels have dramatically improved patient survival and have altered the disease landscape. While restoring SMN levels slows motor neuron loss, many patients continue to have smaller muscles and do not achieve normal motor milestones. Read More

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Type 2 diabetes impairs vascular responsiveness to nitric oxide, but not the venoarteriolar reflex or post-occlusive reactive hyperaemia in forearm skin.

Exp Dermatol 2021 Jun 11. Epub 2021 Jun 11.

Human and Environmental Physiology Research Unit, University of Ottawa, Ottawa, Canada.

The venoarteriolar reflex (VAR) is a local mechanism by which vasoconstriction is mediated in response to venous congestion. This response may minimize tissue overperfusion, preventing capillary damage and edema. Post-occlusive reactive hyperaemia (PORH) is used to appraise microvascular function performed by a brief local arterial occlusion resulting in a subsequent rapid transient vasodilation. Read More

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Early efficacy of teprotumumab for the treatment of dysthyroid optic neuropathy: A multicenter study.

Am J Ophthalmol Case Rep 2021 Sep 14;23:101111. Epub 2021 May 14.

Department of Ophthalmology, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.

Purpose: To study post-interventional findings in patients with dysthyroid optic neuropathy (DON) treated with teprotumumab.

Observations: In this multicenter observational Case series patients with DON were treated with teprotumumab, an insulin-like growth factor I receptor inhibitor (10 mg/kg for the first infusion then 20 mg/kg for subsequent infusions, every three weeks for a total 8 infusions). This study included patients with acute and chronic thyroid eye disease (TED) with DON who had failed conventional therapies and were not candidates for surgical decompression. Read More

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September 2021

Combination Model of Thyrotrophin Receptor Antibody and Volumetric Orbital Apex Crowding Index as an Indicator of Dysthyroid Optic Neuropathy.

Dis Markers 2021 18;2021:9964232. Epub 2021 May 18.

Eye Center of Xiangya Hospital, Central South University, Changsha, Hunan, China.

Background: Dysthyroid optic neuropathy (DON) is one of the most serious vision-threatening complications of thyroid eye disease (TED); however, accurate and established diagnostic tools for DON are yet lacking. The present study was aimed at identifying new diagnostic factors for the accurate diagnosis of DON.

Methods: This retrospective cross-sectional study included 25 TED patients (50 eyes) with enlarged extraocular muscles, no previous anti-inflammatory therapy, and the absence of other vision-affecting diseases between May 2017 and August 2019. Read More

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Screening for Sarcopenia (Physical Frailty) in the COVID-19 Era.

Int J Endocrinol 2021 21;2021:5563960. Epub 2021 May 21.

Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan.

Although the numbers of aged populations have risen considerably in the last few decades, the current coronavirus disease 2019 (COVID-19) has revealed an extensive vulnerability among these populations. Sarcopenia is an age-related disorder that increases hospitalization, dependencies, and mortality in older adults. It starts to develop in midlife or even earlier as a result of unbalanced diet/poor nutrition and low levels of physical activity, in addition to chronic disorders such as obesity and diabetes mellitus. Read More

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Identifying molecular targets for reverse aging using integrated network analysis of transcriptomic and epigenomic changes during aging.

Sci Rep 2021 Jun 10;11(1):12317. Epub 2021 Jun 10.

Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea.

Aging is associated with widespread physiological changes, including skeletal muscle weakening, neuron system degeneration, hair loss, and skin wrinkling. Previous studies have identified numerous molecular biomarkers involved in these changes, but their regulatory mechanisms and functional repercussions remain elusive. In this study, we conducted next-generation sequencing of DNA methylation and RNA sequencing of blood samples from 51 healthy adults between 20 and 74 years of age and identified aging-related epigenetic and transcriptomic biomarkers. Read More

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Extra-skeletal effects of dietary calcium: Impact on the cardiovascular system, obesity, and cancer.

Adv Food Nutr Res 2021 18;96:1-25. Epub 2021 Mar 18.

Department of Food and Human Nutritional Sciences, Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, MB, Canada. Electronic address:

Calcium is well known to be integral to bone and muscle health, with deleterious effects such as osteoporosis associated with inadequate calcium intake. Recent studies have also highlighted the significant effects of calcium in extra-musculoskeletal functioning, including the cardiovascular system, obesity, and cancer. Calcium impacts the cardiovascular system as an antagonist associated with a reduction in hypertension, increase vasodilation, and improvement in blood vessel function when obtained in the diet as an organic source, through food. Read More

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Plasma high-resolution metabolomic phenotyping of lean mass in a US adult cohort.

JPEN J Parenter Enteral Nutr 2021 Jun 10. Epub 2021 Jun 10.

Emory Center for Clinical and Molecular Nutrition, Emory University, Atlanta, GA, USA.

Background: Rapid loss of lean mass during catabolic states is associated with impaired convalescence and increased mortality rates. Understanding metabolic pathways related to lean mass is needed to enable future interventions designed to combat malnutrition. This study assessed the plasma metabolome in relation to lean mass in clinically stable working adults in a US cohort. Read More

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Altered tryptophan absorption and metabolism could underlie long-term symptoms in survivors of coronavirus disease 2019 (COVID-19).

Nutrition 2021 May 1;90:111308. Epub 2021 May 1.

Department of General Internal Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

The global pandemic of COVID-19 has been lasting for more than one year and there is little known about the long-term health effects of the disease. Long-COVID is a new term that is used to describe the enduring symptoms of COVID-19 survivors. Huang et al. Read More

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Primary high-grade myoepithelial carcinoma of the lung: A study of three cases illustrating frequent SMARCB1-deficiency and review of the literature.

Ann Diagn Pathol 2021 May 8;53:151759. Epub 2021 May 8.

Department of Pathology, Rambam Health Care Campus, 31096 Haifa, Israel.

Primary myoepithelial carcinoma of the lung is exceptionally rare and, hence, remained poorly characterized. We present 3 tumors affecting 2 males and 1 female aged 60 to 84 years. Tumor size ranged from 4 to 10 cm. Read More

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Exogenous parathyroid hormone attenuates ovariectomy-induced skeletal muscle weakness in vivo.

Bone 2021 Jun 7;151:116029. Epub 2021 Jun 7.

Department of Orthopaedic Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.

Osteoporosis commonly affects the elderly and is associated with significant morbidity and mortality. Loss of bone mineral density induces muscle atrophy and increases fracture risk. However, muscle lipid content and droplet size are increased by aging and mobility impairments, inversely correlated with muscle function, and a cause of reduced motor function. Read More

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Skeletal muscle loss and body composition in progressive supranuclear palsy: A retrospective cross-sectional study.

PLoS One 2021 10;16(6):e0253079. Epub 2021 Jun 10.

Department of Neurology, National Hospital Organization, Higashinagoya National Hospital, Nagoya, Japan.

Introduction: Skeletal muscle mass loss has been associated with decreased physical performance; however, the body composition characteristics in progressive supranuclear palsy (PSP) are not well understood. We investigated body composition parameters, focusing on skeletal muscle mass, in patients with PSP and compared them with those of healthy older adults.

Methods: This retrospective cross-sectional study included 39 patients with PSP and 30 healthy older adults (control group). Read More

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