10,261 results match your criteria loss iron

Synthesis of SPIO Nanoparticles and the Subsequent Applications in Stem Cell Labeling for Parkinson's Disease.

Nanoscale Res Lett 2021 Jun 14;16(1):107. Epub 2021 Jun 14.

Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, No. 88 Keling Road, Suzhou New District, Suzhou, 215163, China.

Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons in the midbrain, and the stem cell transplantation method provides a promising strategy for the treatment. In these studies, tracking the biological behaviors of the transplanted cells in vivo is essential for a basic understanding of stem cell function and evaluation of clinical effectiveness. In the present study, we developed a novel ultrasmall superparamagnetic iron oxide nanoparticles coating with the polyacrylic acid (PAA) and methoxypolyethylene glycol amine (PEG) by thermal decomposition method and a two-step modification. Read More

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Loss of SDHB Promotes Dysregulated Iron Homeostasis, Oxidative Stress, and Sensitivity to Ascorbate.

Cancer Res 2021 Jun 14. Epub 2021 Jun 14.

PARCC, INSERM UMR970, Equipe Labellisée par la Ligue Contre le Cancer, Paris, France.

Succinate dehydrogenase is a key enzyme in the tricarboxylic acid cycle and the electron transport chain. All four subunits of succinate dehydrogenase are tumor suppressor genes predisposing to paraganglioma, but only mutations in the SDHB subunit are associated with increased risk of metastasis. Here we generated an knockout chromaffin cell line and compared it with deficient cells. Read More

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Superior removal of As(III) and As(V) from water with Mn-doped β-FeOOH nanospindles on carbon foam.

J Hazard Mater 2021 Jun 7;418:126347. Epub 2021 Jun 7.

Department of Civil and Environmental Engineering, University of California, Berkeley, CA 94720-1710, USA. Electronic address:

Arsenic pollution of water is one of the severest environmental challenges threatening human health. Iron-based nanomaterials have been demonstrated effective in arsenic removal. However, they generally suffer from low removal efficiency towards highly toxic As(III), loss of active sites owing to agglomeration, and poor reusability. Read More

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A new approach on synergistic effect and chemical stability of graphene oxide-magnetic nanocomposite in the heterogeneous Fenton degradation of caffeine.

Environ Sci Pollut Res Int 2021 Jun 14. Epub 2021 Jun 14.

Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, 14800-900, Brazil.

Two compositions of graphene oxide-magnetite nanocomposites were studied as catalysts in the heterogeneous Fenton process. Transmission electron microscopy and X-ray diffraction revealed that the graphene oxide sheets were covered with nanoparticles of magnetite, with an average crystallite size of 7 nm. Infrared spectroscopy analysis indicated that the phases interacted through covalent Fe-O-C bonds. Read More

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Estimation of Health-Related Quality of Life Losses Owing to a Technological Disaster in Brazil Using EQ-5D-3L: A Cross-Sectional Study.

Value Health Reg Issues 2021 Jun 10;26:66-74. Epub 2021 Jun 10.

School of Medicine, University of Leeds, Leeds, England, UK.

Objectives: In 2015, a dam collapsed at Samarco iron ore mine in the municipality of Mariana, Brazil, and contaminated more than 600 km of watercourses and destroyed almost 1600 acres of vegetation. Nineteen people died and more than 600 families lost their homes. This study aimed to estimate health-related quality of life (HRQoL) losses owing to this disaster. Read More

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A novel nZVI-bentonite nanocomposite to remove trichloroethene (TCE) from solution.

Chemosphere 2021 Jun 7;282:131018. Epub 2021 Jun 7.

Institute of Applied Geosciences, Graz University of Technology, Rechbauerstraße 12, A-97.9, Graz, Austria. Electronic address:

Nanoscale zero-valent iron (nZVI) based (nano)composites supported by clay mineral substrates are a promising technology for the in-situ remediation of groundwater and (sub)soils contaminated with chlorinated hydrocarbons, such as trichloroethene (TCE). However, the physicochemical processes and interaction mechanisms between nZVI particles, clay minerals and TCE are poorly understood, yet. We immobilized nZVI particles on a commercial bentonite substrate to prepare a novel nZVI-B nanocomposite and tested its performance for TCE removal from solution against pure nZVI in batch reactors. Read More

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Restriction of Iron Loading into Developing Seeds by A YABBY Transcription Factor Safeguards Successful Reproduction in Arabidopsis.

Mol Plant 2021 Jun 8. Epub 2021 Jun 8.

State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou 310058, China;. Electronic address:

Iron (Fe) storage in plant seeds is not only necessary for seedling establishment following germination, but also a major source of dietary Fe for human and animal life. Seed Fe accumulation was known to be low during early seed development. However, the underlying mechanism and biological significance remain elusive. Read More

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Isotopic measurement of iron requirements in sub-Saharan African children.

Am J Clin Nutr 2021 Jun 10. Epub 2021 Jun 10.

Laboratory of Human Nutrition, Institute of Food, Nutrition and Health, ETH Zürich, Zurich, Switzerland.

Background: Prevention of iron deficiency in African children is a public health priority. Current WHO/FAO estimations of iron requirements are derived from factorial estimates based on healthy, iron-sufficient "model" children using data derived mainly from adults.

Objectives: In this study, we aimed to quantify iron absorption, loss, and balance in apparently healthy 5- to 7-y-old children living in rural Africa. Read More

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Yield Response and Physiological Adaptation of Green Bean to Photovoltaic Greenhouses.

Front Plant Sci 2021 24;12:655851. Epub 2021 May 24.

Department of Agricultural, Food and Environmental Sciences, Polytechnic University of Marche, Ancona, Italy.

The cultivation of the horticultural crops inside photovoltaic greenhouses (PVG) should be studied in relation to the shading cast by the photovoltaic (PV) panels on the roof. This work evaluated the green bean cultivation inside PVGs with a percentage of the greenhouse area covered with PV panels (PV cover ratio, ) ranging from 25 to 100%. Three dwarf green bean cycles ( L. Read More

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Hepcidin contributes to Swedish mutant APP-induced osteoclastogenesis and trabecular bone loss.

Bone Res 2021 Jun 9;9(1):31. Epub 2021 Jun 9.

Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.

Patients with Alzheimer's disease (AD) often have lower bone mass than healthy individuals. However, the mechanisms underlying this change remain elusive. Previously, we found that Tg2576 mice, an AD animal model that ubiquitously expresses Swedish mutant amyloid precursor protein (APP), shows osteoporotic changes, reduced bone formation, and increased bone resorption. Read More

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Imaging the Substantia Nigra in Parkinson Disease and Other Parkinsonian Syndromes.

Radiology 2021 Jun 8:203341. Epub 2021 Jun 8.

From the Departments of Radiology (Y.J.B., B.S.C., S.J.C., J.H.K.), Neurology (J.M.K., J.H.C.), and Nuclear Medicine (Y.S.S.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, 173-82 Gumi-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 463-707, Republic of Korea; Departments of Radiology (C.H.S.) and Neurology (B.J.), Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea; and Division of Biomedical Engineering, Hankuk University of Foreign Studies, Yongin, Republic of Korea (Y.N.).

Parkinson disease is characterized by dopaminergic cell loss in the substantia nigra of the midbrain. There are various imaging markers for Parkinson disease. Recent advances in MRI have enabled elucidation of the underlying pathophysiologic changes in the nigral structure. Read More

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Long-Term Results of One Anastomosis Gastric Bypass: a Single Center Experience with a Minimum Follow-Up of 10 Years.

Obes Surg 2021 Jun 7. Epub 2021 Jun 7.

Department of Digestive and Bariatric Surgery, Clinique Geoffroy-Saint Hilaire, Générale de Santé (GDS), 75005, Paris, France.

Purpose: The purpose of this study was to evaluate the efficacy and safety of the OAGB at least 10 years after surgery.

Material And Methods: We retrospectively reviewed our prospectively collected data on consecutive morbid patients with obesity receiving OAGB from January 2005 to December 2007.

Results: A total of 385 patients met the inclusion criteria. Read More

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Supraoptimal Iron Nutrition of Plants Suppresses the Iron Uptake of Chloroplasts by Down-Regulating Chloroplast Ferric Chelate Reductase.

Front Plant Sci 2021 20;12:658987. Epub 2021 May 20.

Department of Plant Physiology and Molecular Plant Biology, Institute of Biology, ELTE Eötvös Loránd University, Budapest, Hungary.

Iron (Fe) is an essential micronutrient for plants. Due to the requirement for Fe of the photosynthetic apparatus, the majority of shoot Fe content is localised in the chloroplasts of mesophyll cells. The reduction-based mechanism has prime importance in the Fe uptake of chloroplasts operated by Ferric Reductase Oxidase 7 (FRO7) in the inner chloroplast envelope membrane. Read More

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Approaches to Understanding Mechanisms of Dentilisin Protease Complex Expression in .

Front Cell Infect Microbiol 2021 18;11:668287. Epub 2021 May 18.

Department of Biologic and Materials Sciences & Prosthodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, United States.

The oral spirochete is a keystone periodontal pathogen that, in association with members of a complex polymicrobial oral biofilm, contributes to tissue damage and alveolar bone loss in periodontal disease. Virulence-associated behaviors attributed to include disruption of the host cell extracellular matrix, tissue penetration and disruption of host cell membranes accompanied by dysregulation of host immunoregulatory factors. dentilisin is associated with several of these behaviors. Read More

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Alpha-synuclein increases in rodent and human spinal cord injury and promotes inflammation and tissue loss.

Sci Rep 2021 Jun 3;11(1):11720. Epub 2021 Jun 3.

Center for Brain and Spinal Cord Repair and Department of Neuroscience, The Ohio State University, 692 Biomedical Research Tower, 460 W 12th Ave, Columbus, OH, 43210, USA.

Synucleinopathies are neurodegenerative diseases in which α-synuclein protein accumulates in neurons and glia. In these diseases, α-synuclein forms dense intracellular aggregates that are disease hallmarks and actively contribute to tissue pathology. Interestingly, many pathological mechanisms, including iron accumulation and lipid peroxidation, are shared between classical synucleinopathies such as Alzheimer's disease, Parkinson's disease and traumatic spinal cord injury (SCI). Read More

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Impact of chronic kidney disease on hemoglobin among patients with peripheral artery disease treated with P2Y inhibitors: Insights from the EUCLID trial.

Vasc Med 2021 Jun 3:1358863X211017641. Epub 2021 Jun 3.

CPC Clinical Research, Aurora, CO, USA.

Patients with chronic kidney disease may develop new or more severe anemia when treated with antiplatelet agents due to blood loss in conjunction with impaired erythropoiesis. Because anemia independently predicts limb amputation and mortality among patients with peripheral artery disease (PAD), we evaluated the relationship between estimated glomerular filtration rate (eGFR) and hemoglobin (Hb) levels in the EUCLID trial in which patients with symptomatic PAD were randomized to ticagrelor or clopidogrel. At baseline, 9025, 1870, and 1000 patients had eGFR ⩾ 60, 45-59, and < 45 mL/min/1. Read More

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Sciatic Nerve Regeneration After Traumatic Injury Using Magnetic Targeted Adipose-derived Mesenchymal Stem Cells.

Acta Biomater 2021 May 31. Epub 2021 May 31.

Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica. Cátedra de Química Biológica Patológica. Junín 956, Buenos Aires, Argentina.; CONICET. Universidad de Buenos Aires. Instituto de Química y Fisicoquímica Biológicas (IQUIFIB). Junín 956, Buenos Aires, Argentina.. Electronic address:

Traumatic peripheral nerve injuries constitute a huge concern to public health. Nerve damage leads to a decrease or even loss of mobility of the innervated area. Adult stem cell therapies have shown some encouraging results and have been identified as promising treatment candidates for nerve regeneration. Read More

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HO-1: A new potential therapeutic target to combat osteoporosis.

Eur J Pharmacol 2021 May 31;906:174219. Epub 2021 May 31.

Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen, Guangdong, 518057, China; Key Laboratory for Space Bioscience and Biotechnology, Northwestern Polytechnical University, Xi'an, Shaanxi, 710072, China. Electronic address:

Heme oxygenase-1 (HO-1) exerts a protective effect against cell damage and induces the activity of many enzymes involved in the treatment of many human diseases, including osteoporosis. The increasing prevalence of osteoporosis and the limitations of the current treatments available led to a continuous occurrence of bone loss and osteoporotic fractures, highlighting the need of a better understanding of the mechanism and function of HO-1. Many factors cause osteoporosis, including lack of estrogen, aging, and iron overload, and they either cause the increase in inflammatory factors or the increase in reactive oxygen species to break bone reconstruction balance. Read More

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Iron-loaded transferrin potentiates erythropoietin effects on erythroblast proliferation and survival: A novel role through transferrin receptors.

Exp Hematol 2021 May 30. Epub 2021 May 30.

Institut Hospitalo-Universitaire (IHU) Imagine, Université Sorbonne Paris cité, Assistance Publique-Hôpitaux de Paris, Hôpital Necker, Paris, France; INSERM U1163, Université Paris Descartes, Faculté de Médecine, Hôpital Necker, Paris, France; Laboratory of Excellence GReX, Paris, France; Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand. Electronic address:

Red blood cell production, or erythropoiesis, is a proliferative process that requires a tight regulation. Erythropoietin (Epo) is a glycoprotein cytokine that plays a major actor in erythropoiesis by triggering erythroid progenitors/precursors of various sensitivities. The concentration of Epo in bone marrow is hypothesized to be suboptimal, and the survival of erythroid cells has been suggested to depend on Epo sensitivity. Read More

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Femtosecond Laser Trimming with Simultaneous Nanostructuring to Fine Piercing Punch to Electrical Amorphous Steel Sheets.

Micromachines (Basel) 2021 May 17;12(5). Epub 2021 May 17.

Komatsu-Seiki Kosakusho, Co., Ltd., Suwa-City 392-0012, Japan.

A CVD (Chemical Vapor Deposition) diamond coated tungsten carbide (WC) and cobalt (Co) sintered alloy punch was trimmed by the femtosecond laser machining to sharpen its edge with about 2 μm and to simultaneously make nanostructuring to its side surface. In addition to the sharpened edge, its edge profile was formed to be homogeneous enough to reduce the damage layer width by piercing the electrical amorphous steel sheet stack. Each brittle sheet in the stacked work was damaged to have three kinds of defects by piercing; e. Read More

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Nutritional Support for Bariatric Surgery Patients: The Skin beyond the Fat.

Nutrients 2021 May 6;13(5). Epub 2021 May 6.

Department of Biomedical Sciences, University of Padova, 35122 Padua, Italy.

Body contouring surgery after the massive weight loss due to bariatric surgery deals with different kinds of complications. The aim of this review is to analyze the role that some nutrients may play in tissue healing after surgery, thus helping plastic surgeons to improve the aesthetic and health outcomes in massive weight loss patients under a multidisciplinary approach. As a matter of fact, preoperative nutritional deficiencies have been shown for vitamins and minerals in a large percentage of post-bariatric patients. Read More

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Flowability of Gel-Matrix and Magnetorheological Response for Carrageenan Magnetic Hydrogels.

Gels 2021 May 6;7(2). Epub 2021 May 6.

Graduate School of Science and Technology, Niigata University, Niigata 950-2181, Japan.

The relationship between rheological features in the absence of a magnetic field and magnetic response was investigated for κ-carrageenan magnetic hydrogels containing carbonyl iron particles. The concentration of carrageenan was varied from 1.0 to 5. Read More

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Loss of PKGIβ/IRAG1 Signaling Causes Anemia-Associated Splenomegaly.

Int J Mol Sci 2021 May 21;22(11). Epub 2021 May 21.

Department of Pharmacology and Toxicology, Institute of Pharmacy, University of Regensburg, 93040 Regensburg, Germany.

Inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate 1 (IRAG1) is a substrate protein of the NO/cGMP-signaling pathway and forms a ternary complex with the cGMP-dependent protein kinase Iβ (PKGIβ) and the inositol triphosphate receptor I (IPR-I). Functional studies about IRAG1 exhibited that IRAG1 is specifically phosphorylated by the PKGIβ, regulating cGMP-mediated IP-dependent Ca-release. IRAG1 is widely distributed in murine tissues, e. Read More

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Electromagnetic Wave-Absorbing and Bending Properties of Three-Dimensional Honeycomb Woven Composites.

Polymers (Basel) 2021 May 5;13(9). Epub 2021 May 5.

Key Laboratory of High Performance Fibers & Products, Ministry of Education, Donghua University, Shanghai 201620, China.

To avoid the delamination of the traditional three-dimensional (3-D) honeycomb electromagnetic (EM) absorbing composites and improving the defects of low mechanical properties, the 3-D honeycomb woven fabrics were woven on the ordinary loom by practical design. The fabrication of 3-D honeycomb woven EM absorbing composites was based on carbon black/carbonyl iron powder/basalt fiber/carbon fiber/epoxy resin (CB/CIP/BF/CF/EP) by the vacuum-assisted resin transfer molding (VARTM) process. A CB/CIP composite absorbent study showed that CB/CIP composite absorbent belongs to a magnetic loss type absorbent. Read More

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Changes in Cerebral Gray and White Matter in Patients with Pantothenate Kinase-Associated Neurodegeneration: A Long-Term Magnetic Resonance Imaging Follow-Up Study.

J Mov Disord 2021 May 26;14(2):148-152. Epub 2021 May 26.

Department of Radiology, CEDIMAT, Santo Domingo, Dominican Republic.

Objective: To determine the volume changes in gray and white matter during a long-term follow-up in patients suffering from pantothenate kinase-associated neurodegeneration (PKAN).

Methods: Magnetic resonance imaging was repeated in 13 patients and 14 age-matched controls after a mean interval of more than 7 years. T1-weighted sequences were evaluated by fully automated atlas-based volumetry, compared between groups and correlated with disease progression. Read More

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Melatonin-induced DNA demethylation of metal transporters and antioxidant genes alleviates lead stress in radish plants.

Hortic Res 2021 Jun 1;8(1):124. Epub 2021 Jun 1.

National Key Laboratory of Crop Genetics and Germplasm Enhancement, Key Laboratory of Horticultural Crop Biology and Genetic Improvement (East China) of MOAR, College of Horticulture, Nanjing Agricultural University, Nanjing, 210095, P.R. China.

Melatonin (MT) is a tryptophan-derived natural product that plays a vital role in plant response to abiotic stresses, including heavy metals (HMs). However, it remains elusive how exogenous MT mediates lead (Pb) accumulation and detoxification at the methylation and transcriptional levels in radish. In this study, decreased Pb accumulation and increased antioxidant enzyme activity were detected under MT treatment in radish. Read More

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A Win-Loss Interaction on Fe Between Methanogens and Acetogens From a Climate Lake.

Front Microbiol 2021 13;12:638282. Epub 2021 May 13.

Nordcee, Department of Biology, University of Southern Denmark, Odense, Denmark.

Diverse physiological groups congregate into environmental corrosive biofilms, yet the interspecies interactions between these corrosive physiological groups are seldom examined. We, therefore, explored Fe-dependent cross-group interactions between acetogens and methanogens from lake sediments. On Fe, acetogens were more corrosive and metabolically active when decoupled from methanogens, whereas methanogens were more metabolically active when coupled with acetogens. Read More

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Genome-resolved metagenomics reveals role of iron metabolism in drought-induced rhizosphere microbiome dynamics.

Nat Commun 2021 05 28;12(1):3209. Epub 2021 May 28.

Department of Plant and Microbial Biology, University of California, Berkeley, CA, USA.

Recent studies have demonstrated that drought leads to dramatic, highly conserved shifts in the root microbiome. At present, the molecular mechanisms underlying these responses remain largely uncharacterized. Here we employ genome-resolved metagenomics and comparative genomics to demonstrate that carbohydrate and secondary metabolite transport functionalities are overrepresented within drought-enriched taxa. Read More

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Declining diversity of wild-caught species puts dietary nutrient supplies at risk.

Sci Adv 2021 May 28;7(22). Epub 2021 May 28.

Department of Ecology, Evolution, and Environmental Biology, Columbia University, New York, NY, USA.

Although biodiversity loss adversely influences a variety of ecosystem functions, how declining wild food diversity affects nutrient supplies for people is poorly understood. Here, we analyze the impact of declining biodiversity on nutrients supplied by fish using detailed information from the Peruvian Amazon, where inland fisheries provide a critical source of nutrition for many of the region's 800,000 people. We found that the impacts of biodiversity loss on nutrient supplies depended on compensation, trophic dynamics, and functional diversity. Read More

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Gastrointestinal Endoscopic Outcome in Late Adolescent Women With Iron-Deficiency Anemia in Basrah-Iraq: A Multicenter Study.

Cureus 2021 Apr 22;13(4):e14630. Epub 2021 Apr 22.

Internal Medicine, College of Medicine, University of Basrah, Basrah, IRQ.

Background Iron deficiency anemia (IDA) in late adolescent women has multiple pathophysiologies. Silent blood loss, celiac disease (CD), malignancies, and other gastrointestinal (GI) lesions receive much attention during IDA management. There is no consensus about endoscopic screening. Read More

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