7,035 results match your criteria loss incorporation

The Clinical Relevance and Tumor Promoting Function of C19orf10 in Kidney Renal Clear Cell Carcinoma.

Front Oncol 2021 6;11:725959. Epub 2021 Sep 6.

Guangdong Provincial Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Department of Urology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital (Shenzhen Institute of Translational Medicine), Shenzhen, China.

Kidney renal clear cell carcinoma (KIRC) is the most common primary renal neoplasms. Currently, there are few molecular indicators and therapeutic targets that can be used in diagnostic and prognostic assessment. In this study, we identified the C19orf10 expression in KIRC specimens and explored the diagnostic and prognostic value of C19orf10 in KIRC using TCGA and CPTAC database. Read More

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September 2021

Development of growth factor-incorporating liposomes for integration into scaffolds as a method to improve tissue regeneration.

Int J Dev Biol 2021 Aug 9. Epub 2021 Aug 9.

Laboratory of Pharmaceutical Technology, Dept. of Pharmacy, School of Health Sciences, University of Patras, 26504 Rio Patras, Greece.

This review is an update about the efforts to develop liposomal carriers for growth factor delivery. It is well known that growth factors have the potential to enhance/accelerate tissue regeneration, however their poor stability which results in rapid loss of their activity, together with their rapid clearance from defected tissues (when applied as free molecules) is a serious drawback for their use; their highly hydrophilic nature and low capability to permeate through biological barriers (cell membranes) are additional factors that limit their applicability. In the last years, the advantages of liposomal drug delivery systems have motivated efforts to deliver growth factors (GFs) in liposomal form. Read More

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Incorporation of electroendocytosis and nanosecond pulsed electric field in electrochemotherapy of breast cancer cells.

Electromagn Biol Med 2021 Sep 20:1-10. Epub 2021 Sep 20.

Radiology and Medical Imaging Department, College of Applied Medical Sciences, Prince Sattam Bin Abdul-Aziz University, Alkharj, KSA.

The study aimed to evaluate the possibility to perform electrochemotherapy using nanosecond pulsed electric field (nsPEF) and low electric field (LEF) monopolar electrical impulses to alleviate the problems of conventional electroporation. Two types of pulses have been used to treat MCF-7 human breast carcinoma cell line: very low voltage (electric field strength) long trains of short unipolar electric pulses, and low frequencies of extremely intense (40kV/cm), ultra-short (10ns) electric pulses. The electropermeabilization efficiency of the formed endocytotic vesicles was measured using the cloning efficacy test. Read More

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September 2021

Discontinuation of antiviral therapy in chronic hepatitis B patients.

World J Clin Cases 2021 Aug;9(24):6979-6986

Department of Gastroenterology and Hepatology, Centro Hospitalar Universitário de São João, Porto 4200-319, Portugal.

Nucleos(t)ide analogs (NUC) are the first-line therapy for patients with chronic hepatitis B (CHB) recommended by most current guidelines. NUC therapy decreases progression of liver disease, reduces the risk of liver-related complications, and improves the quality of life of patients with CHB. Although indefinite or long-term NUC therapy is usually recommended, this strategy raises several concerns, such as side-effects, adherence, costs, and patient willingness to stop therapy. Read More

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Endoplasmic Reticulum Stress Induced Proliferation Remains Intact in Aging Mouse β-Cells.

Front Endocrinol (Lausanne) 2021 31;12:734079. Epub 2021 Aug 31.

Division of Endocrinology, Diabetes and Metabolism and the Weill Center for Metabolic Health, Weill Cornell Medicine, New York, NY, United States.

Aging is associated with loss of proliferation of the insulin-secreting β-cell, a possible contributing factor to the increased prevalence of type 2 diabetes in the elderly. Our group previously discovered that moderate endoplasmic reticulum (ER) stress occurring during glucose exposure increases the adaptive β-cell proliferation response. Specifically, the ATF6α arm of the tripartite Unfolded Protein Response (UPR) promotes β-cell replication in glucose excess conditions. Read More

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R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells.

Cell Commun Signal 2021 Sep 16;19(1):95. Epub 2021 Sep 16.

Department of Pathology and Laboratory Medicine (SMW, AP, JFL, SLC), MUSC Medical Scientist Training Program (SMW), Medical University of South Carolina, 171 Ashley Avenue, MSC 908, Charleston, SC, 29425-9080, USA.

Background: Loss of the Ras GTPase-activating protein neurofibromin promotes nervous system tumor pathogenesis in patients with neurofibromatosis type 1 (NF1). Neurofibromin loss potentially hyperactivates classic Ras (H-Ras, N-Ras, K-Ras), M-Ras, and R-Ras (R-Ras, R-Ras2/TC21) subfamily proteins. We have shown that classic Ras proteins promote proliferation and survival, but not migration, in malignant peripheral nerve sheath tumor (MPNST) cells. Read More

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September 2021

A Study on Prevalence and Factors Associated with Depression among Elderly Residing in Tenements Under Resettlement Scheme, Kancheepuram District, Tamil Nadu.

J Midlife Health 2021 Apr-Jun;12(2):137-143. Epub 2021 Jul 27.

Department of Community Medicine, Shri Sathya Sai Medical College and Research Institute, Sri Balaji Vidyapeeth - Deemed to be University, Kancheepuram, Tamil Nadu, India.

Background: Mental disorders have got high prevalence and low priority among the elderly in most of the countries worldwide, of which depression being the most common treatable condition. The causes for elderly depression are multifactorial and preventable.

Objective: The aim of this study is to estimate the prevalence of depression and to assess the factors associated with depression among the elderly age. Read More

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Combined Metabolic and Chemical (CoMetChem) Labeling Using Stable Isotopes-a Strategy to Reveal Site-Specific Histone Acetylation and Deacetylation Rates by LC-MS.

Anal Chem 2021 Sep 14. Epub 2021 Sep 14.

Institute of Biochemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innsbruck 6020, Austria.

Histone acetylation is an important, reversible post-translational protein modification and a hallmark of epigenetic regulation. However, little is known about the dynamics of this process, due to the lack of analytical methods that can capture site-specific acetylation and deacetylation reactions. We present a new approach that combines metabolic and chemical labeling (CoMetChem) using uniformly 13C-labeled glucose and stable isotope-labeled acetic anhydride. Read More

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September 2021

A retrospective study examining the adverse effect of childhood abuse among adult psychiatric service users in Britain.

Int J Ment Health Nurs 2021 Oct 15;30(5):1093-1105. Epub 2021 Mar 15.

St George's University London, Population Health Research Institute, London, UK.

The long-term effects of childhood abuse have been well studied though the effects of abuse of specific types in adult psychiatric service users are less known. This study aimed to assess the association between childhood abuse and the development of harmful social and behavioural outcomes among adult psychiatric service users. Adult psychiatric service users were accessed from secondary mental health services in South London. Read More

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October 2021

Meeting the challenges and clinical requirements for dental regeneration; the New Zealand experience.

Bone 2021 Sep 10;154:116181. Epub 2021 Sep 10.

Sir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, New Zealand. Electronic address:

Disease and trauma leading to tooth loss and destruction of supporting bone is a significant oral handicap, which may be addressed through surgical therapies that aim to regenerate the lost tissue. Whilst complete regeneration of teeth is still aspirational, regeneration of supporting structures (dental pulp, cementum, periodontal ligament, bone) is becoming commonplace, both for teeth and for titanium dental implants that are used to replace teeth. Most grafting materials are essentially passive, however the next generation of oral regenerative devices will combine non-antibiotic antimicrobials and/or osteogenic or inductive factors and/or appropriate multipotential stem cells. Read More

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September 2021

Combining Automated Organoid Workflows With Artificial Intelligence-Based Analyses: Opportunities to Build a New Generation of Interdisciplinary High-Throughput Screens for Parkinson's Disease and Beyond.

Mov Disord 2021 Sep 8. Epub 2021 Sep 8.

Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Münster, Germany.

Parkinson's disease (PD) is the second most common neurodegenerative disease and primarily characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain. Despite decades of research and the development of various disease model systems, there is no curative treatment. This could be due to current model systems, including cell culture and animal models, not adequately recapitulating human PD etiology. Read More

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September 2021

How good is the evidence that cellular senescence causes skin ageing?

Ageing Res Rev 2021 Sep 3;71:101456. Epub 2021 Sep 3.

Ageing Biology Laboratories, Newcastle University Biosciences Institute, Newcastle University, Newcastle upon Tyne NE4 5PL, UK.

Skin is the largest organ of the body with important protective functions, which become compromised with time due to both intrinsic and extrinsic ageing processes. Cellular senescence is the primary ageing process at cell level, associated with loss of proliferative capacity, mitochondrial dysfunction and significantly altered patterns of expression and secretion of bioactive molecules. Intervention experiments have proven cell senescence as a relevant cause of ageing in many organs. Read More

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September 2021

Evaluation of Pathological Findings of COVID-19 by Minimally Invasive Autopsies: A Single Tertiary Care Center Experience from India.

J Lab Physicians 2021 Jun 28;13(2):97-106. Epub 2021 Jun 28.

Department of Surgical Oncology, All India Institute of Medical Sciences (AIIMS), Jodhpur, Rajasthan, India.

 The 2019 novel coronavirus (2019-nCoV) has spread across the globe with more than 6 lakh deaths. Clinical autopsies are important to understand the pathobiology of the disease.  Autopsy techniques have been modified to be minimally invasive autopsies in all COVID-19 positive cases, and tissue biopsies were sampled from lungs, liver, and bone marrow within an hour after death. Read More

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The role of biomaterials for the energy transition from the lens of a national integrated assessment model.

Clim Change 2021 28;167(3-4):57. Epub 2021 Aug 28.

Centre for Energy and Environmental Economics (CENERGIA), Energy Planning Program (PPE), Graduate School of Engineering (COPPE), Universidade Federal do Rio de Janeiro (UFRJ), Centro de Tecnologia, Bloco C, Sala 211 Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ 21941-972 Brazil.

Integrated assessment models (IAMs) indicate biomass as an essential energy carrier to reduce GHG emissions in the global energy system. However, few IAMs represent the possibility of co-producing final energy carriers and feedstock. This study fills this gap by developing an integrated analysis of energy, land, and materials. Read More

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Functional characterization of novel rare CYP2A6 variants and potential implications for clinical outcomes.

Clin Transl Sci 2021 Sep 3. Epub 2021 Sep 3.

Department of Pharmacology & Toxicology, University of Toronto, Toronto, ON, Canada.

CYP2A6 activity, phenotyped by the nicotine metabolite ratio (NMR), is a predictor of several smoking behaviors, including cessation and smoking-related disease risk. The heritability of the NMR is 60-80%, yet weighted genetic risk scores (wGRSs) based on common variants explain only 30-35%. Rare variants (minor allele frequency <1%) are hypothesized to explain some of this missing heritability. Read More

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September 2021

Correlating the Active Layer Structure and Composition with the Device Performance and Lifetime of Amino-Acid-Modified Perovskite Solar Cells.

ACS Appl Mater Interfaces 2021 Sep 2;13(36):43505-43515. Epub 2021 Sep 2.

Department of Materials and Centre for Processable Electronics, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, U.K.

Additive engineering is emerging as a powerful strategy to further enhance the performance of perovskite solar cells (PSCs), with the incorporation of bulky cations and amino acid (AA) derivatives being shown as a promising strategy for enhanced device stability. However, the incorporation of such additives typically results in photocurrent losses owing to their saturated carbon backbones, hindering charge transport and collection. Here, we investigate the use of AAs with varying carbon chain lengths as zwitterionic additives to enhance the PSC device stability, in air and nitrogen, under illumination. Read More

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September 2021

Unilateral vocal nerve resection alters neurogenesis in the avian song system in a region-specific manner.

PLoS One 2021 31;16(8):e0256709. Epub 2021 Aug 31.

Psychology Department, Queens College, City University of New York, Flushing, NY, United States of America.

New neurons born in the adult brain undergo a critical period soon after migration to their site of incorporation. During this time, the behavior of the animal may influence the survival or culling of these cells. In the songbird song system, earlier work suggested that adult-born neurons may be retained in the song motor pathway nucleus HVC with respect to motor progression toward a target song during juvenile song learning, seasonal song restructuring, and experimentally manipulated song variability. Read More

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Impact of calorie restriction and intermittent fasting on periodontal health.

Sameena Parveen

Periodontol 2000 2021 Oct;87(1):315-324

Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan, Saudi Arabia.

The scientific evidence indicates that calorie restriction and intermittent fasting are among the appropriate strategies targeting factual causative factors of various inflammatory and lifestyle-related disorders. Periodontitis is a common oral inflammatory disease leading to bone loss that is associated with various systemic problems. Previous studies suggest that calorie restriction may dampen inflammation and concomitant tissue damage under inflammatory conditions, such as periodontal diseases in nonhuman primates. Read More

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October 2021

Incorporation of Low Molecular Weight Chitosan in a Low-Fat Beef Burger: Assessment of Technological Quality and Oxidative Stability.

Foods 2021 Aug 23;10(8). Epub 2021 Aug 23.

Centro Tecnológico de la Carne de Galicia, Rúa Galicia No 4, Parque Tecnológico de Galicia, San Cibrao das Viñas, 32900 Ourense, Spain.

In the present work, incorporating low molecular weight chitosan (LMWCH) (0, 0.5, 1, and 2%) as a fat replacer into low-fat beef burgers and technological, textural, and oxidative stability were investigated. The weight loss and shrinkage of samples decreased with the increase of LMWCH concentration. Read More

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Bidirectional Differentiation of Human-Derived Stem Cells Induced by Biomimetic Calcium Silicate-Reinforced Gelatin Methacrylate Bioink for Odontogenic Regeneration.

Biomedicines 2021 Jul 31;9(8). Epub 2021 Jul 31.

School of Dentistry, Chung Shan Medical University, Taichung 40201, Taiwan.

Tooth loss or damage is a common problem affecting millions of people worldwide, and it results in significant impacts on one's quality of life. Dental regeneration with the support of stem cell-containing scaffolds has emerged as an alternative treatment strategy for such cases. With this concept in mind, we developed various concentrations of calcium silicate (CS) in a gelatin methacryloyl (GelMa) matrix and fabricated human dental pulp stem cells (hDPSCs)-laden scaffolds via the use of a bioprinting technology in order to determine their feasibility in promoting odontogenesis. Read More

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Alginate enriched with phytic acid for hydrogels preparation. Therapeutic applications.

Int J Biol Macromol 2021 Aug 20;189:335-345. Epub 2021 Aug 20.

"Gr .T. Popa" University of Medicine and Pharmacy, Str. Universitatii No11, Iasi, Romania.

In the last decade, numerous innovative strategies have been used to obtain highly efficient synthetic or semi-synthetic biomaterials. Between these innovative biomaterials, hydrogels occupy a distinct place due to their superior biological and physico-chemical characteristics. Alginate is a natural linear polysaccharide with important physico-chemical and biological properties. Read More

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Incorporation of ascorbic acid in chitosan-based edible coating improves postharvest quality and storability of strawberry fruits.

Int J Biol Macromol 2021 Aug 17;189:160-169. Epub 2021 Aug 17.

Department of Horticulture, Bahauddin Zakariya University, Multan 60800, Pakistan. Electronic address:

Recent postharvest studies have shown that adding an antioxidative agent in a polysaccharide-based edible coating reduces postharvest losses and extends the shelf life of a coated fruit. Therefore, the effect of addition of ascorbic acid (AA, 1%) in chitosan-based coating (CH, 1%) on strawberry fruits under cold storage conditions at 4 ± 1 °C and 85 ± 5% RH was investigated for 15 days. It was observed that addition of AA in CH coating reduced weight loss, decay percentage, malondialdehyde content and hydrogen peroxide compared to CH alone. Read More

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A case of trichotillomania and trichophagy: Fantasies of cannibalism.

Int J Psychoanal 2021 Aug 17:1-21. Epub 2021 Aug 17.

St. Louis Psychoanalytic Institute, Saint Louis, MO, USA.

Cannibalistic fantasies underlie some core mechanisms in psychoanalysis: identification, incorporation, introjection, and internalization. Freud (1917) saw melancholia as an incorporation of the object by devouring it, and Julia Kristeva (1989) takes the melancholic cannibalistic imagination to be a repudiation of loss, a destruction in order to possess the object. The author argues that cannibalism is a useful concept for understanding the double dynamics of trichotillomania and trichophagy - as destructive disconnection followed by incorporation of the hair; both suggest a magical reconnection with what was disconnected in order to establish a bond with the mother/analyst. Read More

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Microencapsulation of carotenoid-rich materials: A review.

Food Res Int 2021 09 1;147:110571. Epub 2021 Jul 1.

Universidade de São Paulo, Faculdade de Zootecnia e Engenharia de Alimentos, Departamento de Engenharia de Alimentos, Avenida Duque de Caxias Norte, 225 - 13635-900 Pirassununga, SP, Brazil. Electronic address:

Carotenoids are natural pigments that present several bioactive properties, including antioxidant, anticarcinogenic and provitamin A activities. However, these compounds are susceptible to degradation when exposed to a number of conditions (e.g. Read More

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September 2021

Promoting Energy Transfer via Manipulation of Crystallization Kinetics of Quasi-2D Perovskites for Efficient Green Light-Emitting Diodes.

Adv Mater 2021 Aug 15:e2102246. Epub 2021 Aug 15.

Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, Beijing Key Laboratory for Theory and Technology of Advanced Battery Materials, School of Materials Science and Engineering, Peking University, Beijing, 100871, China.

Quasi-2D (Q-2D) perovskites are promising materials applied in light-emitting diodes (LEDs) due to their high exciton binding energy and quantum confinement effects. However, Q-2D perovskites feature a multiphase structure with abundant grain boundaries and interfaces, leading to nonradiative loss during the energy-transfer process. Here, a more efficient energy transfer in Q-2D perovskites is achieved by manipulating the crystallization kinetics of different-n phases. Read More

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Incorporation of quantitative MRI in a model to predict temporal lobe epilepsy surgery outcome.

Brain Commun 2021 16;3(3):fcab164. Epub 2021 Jul 16.

Department of Neurology, Epilepsy Center, Cleveland Clinic, Cleveland, OH, USA.

Quantitative volumetric brain MRI measurement is important in research applications, but translating it into patient care is challenging. We explore the incorporation of clinical automated quantitative MRI measurements in statistical models predicting outcomes of surgery for temporal lobe epilepsy. Four hundred and thirty-five patients with drug-resistant epilepsy who underwent temporal lobe surgery at Cleveland Clinic, Mayo Clinic and University of Campinas were studied. Read More

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Succession of fungal community and enzyme activity during the co-decomposition process of rice (Oryza sativa L.) straw and milk vetch (Astragalus sinicus L.).

Waste Manag 2021 Oct 12;134:1-10. Epub 2021 Aug 12.

Key Laboratory of Plant Nutrition and Fertilizer, Ministry of Agriculture and Rural Affairs/Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences, Beijing 100081, PR China. Electronic address:

The co-incorporation of rice straw (RS) and milk vetch (MV) into paddy fields has been increasingly applied as a sustainable farming practice in southern China. Our previous study revealed the contribution of bacteria to the co-decomposition of the RS and MV mixture, although additional underlying factors driving the co-decomposition process need to be clarified. The present study further determined the succession of fungal communities and enzyme activity in the co-decomposition process of the RS and MV mixture. Read More

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October 2021

Domain knowledge augmentation of parallel MR image reconstruction using deep learning.

Comput Med Imaging Graph 2021 09 2;92:101968. Epub 2021 Aug 2.

Monash Biomedical Imaging, Monash University, Melbourne, Australia; Department of Electrical and Computer Systems Engineering, Monash University, Melbourne, Australia.

A deep learning (DL) method for accelerated magnetic resonance (MR) imaging is presented that incorporates domain knowledge of parallel MR imaging to augment the DL networks for accurate and stable image reconstruction. The proposed DL method employs a novel loss function consisting of a combination of mean absolute error, structural similarity, and sobel edge loss. The DL model takes both original measurements and images reconstructed by the parallel imaging method as inputs to the network. Read More

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September 2021

Characterisation of putative lactate synthetic pathways of Coxiella burnetii.

PLoS One 2021 13;16(8):e0255925. Epub 2021 Aug 13.

Faculty of Veterinary and Agricultural Sciences, Asia-Pacific Centre for Animal Health, Melbourne Veterinary School, University of Melbourne, Parkville, Victoria, Australia.

The zoonotic pathogen Coxiella burnetii, the causative agent of the human disease Q fever, is an ever-present danger to global public health. Investigating novel metabolic pathways necessary for C. burnetii to replicate within its unusual intracellular niche may identify new therapeutic targets. Read More

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Fabrication, physico-chemical characterization, and bioactivity evaluation of chitosan-linalool composite nano-matrix as innovative controlled release delivery system for food preservation.

Int J Biol Macromol 2021 Oct 10;188:751-763. Epub 2021 Aug 10.

Laboratory of Herbal Pesticides, Centre of Advanced Study in Botany, Institute of Science, Banaras Hindu University, Varanasi 221005, India. Electronic address:

The aim of the present study was to encapsulate linalool into chitosan nanocomposite (Nm-linalool) for developing novel controlled release delivery system in order to protect stored rice against fungal infestation, aflatoxin B (AFB) contamination, and lipid peroxidation. The chitosan-linalool nanocomposite showed spherical shapes, smooth surface with monomodal distribution as revealed by SEM and AFM investigation. FTIR and XRD represented peak shifting and changes in degree of crystallinity after incorporation of linalool into chitosan nanocomposite. Read More

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October 2021