1,016,219 results match your criteria loss


Chronical rhino-orbital mucormycosis in an immunocompetent host: A case report.

Int J Surg Case Rep 2021 Apr 10;82:105882. Epub 2021 Apr 10.

Faculté de Médecine et Pharmacie, Hassan II University of Casablanca, B.P 5696, Casablanca, Morocco; Service de Stomatologie et chirurgie Maxillo-faciale, Hôpital 20 Août, CHU Ibn Rochd, B.P 2698, Casablanca, Morocco.

Mucormycosis is an opportunistic fungal infection caused by molds within the order Mucorales. The rhino-orbital-cerebral localization is the most frequent. It is a destructive, necrotizing and potentially fatal disease. Read More

View Article and Full-Text PDF

Stunting, IQ, and final school attainment in the Cebu Longitudinal Health and Nutrition Survey birth cohort.

Econ Hum Biol 2021 Apr 7;42:100999. Epub 2021 Apr 7.

USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City, Philippines.

School attainment is an important aspect of human capital, and a key determinant of long-term health and well-being. Early life deprivation and poor nutritional status are well known predictors of school entry and progression. We examine the persistence of early life influences and subsequent socioeconomic disadvantage (SED) across the multiple school continuation decisions that lead to final school attainment. Read More

View Article and Full-Text PDF

Impact of PTRIA (Patient Test Result Information Act) on patient follow up management.

Clin Imaging 2021 Mar 22;79:20-23. Epub 2021 Mar 22.

Hospital of the University of Pennsylvania, Department of Radiology, 3400 Spruce Street, 1, Silverstein Ste. 130, Philadelphia, PA 19104, United States of America. Electronic address: https://twitter.com/asset25.

Objective: We aim to study if direct patient notification in accordance with the Patient Test Results Information Act (Act 112) in Pennsylvania leads to decreased loss to follow up and prompt management of actionable imaging findings.

Methods: For this IRB-approved study, radiology reports were randomly identified using the Nuance mPower™ search engine. The actionable finding group (prior to Act-112) contained 300 patients for which a voice notification was sent by radiologists to alert ordering physicians about significant imaging findings. Read More

View Article and Full-Text PDF

LRRc17 controls BMSC senescence via mitophagy and inhibits the therapeutic effect of BMSCs on ovariectomy-induced bone loss.

Redox Biol 2021 Apr 1;43:101963. Epub 2021 Apr 1.

Key Laboratory of Transplant Engineering and Immunology, NHFPC; Regenerative Medicine Research Center; National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, PR China. Electronic address:

Senescence of bone marrow-derived mesenchymal stem cells (BMSCs) has been widely reported to be closely correlated with aging-related diseases, including osteoporosis (OP). Moreover, the beneficial functions of BMSCs decline with age, limiting their therapeutic efficacy in OP. In the present study, using RNA sequencing (RNA-Seq), we found that leucine-rich repeat containing 17 (LRRc17) expression in BMSCs was highly positively correlated with age. Read More

View Article and Full-Text PDF

Influence of sedimentary organic matter sources on the distribution characteristics and preservation status of organic carbon, nitrogen, phosphorus, and biogenic silica in the Daya Bay, northern South China Sea.

Sci Total Environ 2021 Apr 5;783:146899. Epub 2021 Apr 5.

Research Center for Coastal Environment Engineering Technology of Shandong Province, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.

Surface sediment samples were collected from Daya Bay in October 2018, and analyzed for total organic carbon (OC), total nitrogen (TN) and their stable isotopes (δC and δN), total phosphorus (TP), biogenic silica (BSi), sediment textures and specific surface area (SSA). The primary objective was to evaluate the influence of mariculture/aquaculture on the distribution characteristics of organic matter (OM), and preservation status of OC, TN, TP, and BSi in sediments. The average δC and δN values, and OC/TN ratios were -21. Read More

View Article and Full-Text PDF

Does Ostmann's fat pad size correlate with development of chronic otitis media in children?

Int J Pediatr Otorhinolaryngol 2021 Apr 14;145:110710. Epub 2021 Apr 14.

Department of Otorhinolaryngology - Head and Neck Surgery, Meir Medical Center, Kfar Saba, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Objective: To compare Ostmann's fat pad (OFP) size between healthy ears and ears with chronic otitis media with cholesteatoma (COMwC) in children, to assess its role in the disease.

Methods: MRI scans of 29 children with unilateral COMwC with conductive hearing loss were used to measure OFP, represented by the maximal diameter of the high intensity area medial to the tensor veli palatini muscle (TVP): M1. A reference diameter was defined from the medial border of OFP reaching the medial border of the medial pterygoid muscle: M2. Read More

View Article and Full-Text PDF

A de novo mutation of the SOX10 gene associated with inner ear malformation in a Guangxi family with Waardenburg syndrome type II.

Int J Pediatr Otorhinolaryngol 2021 Apr 14;145:110711. Epub 2021 Apr 14.

Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China; Regional Key Laboratory of Early Prevention and Treatment of High-Rise Tumors, Nanning, 530021, China. Electronic address:

Objective: Waardenburg syndrome type 2 (WS2) is a rare neural-crest disorder, characterized by heterochromic irides or blue eyes and sensorineural hearing loss. The aim of this study was to analyze the clinical features and investigate the genetic cause of WS2 in a small family from Guangxi Zhuang Autonomous region.

Methods: Whole-exome sequencing and mutational analysis were used to identify disease-causing genes in this family. Read More

View Article and Full-Text PDF

Can thermal intensification be considered a sustainable way for greening Fenton processes?

J Environ Manage 2021 Apr 14;289:112551. Epub 2021 Apr 14.

Universidad Nacional de Colombia-Sede Palmira-Facultad de Ingeniería y Administración. Carrera 32 No. 12-00, Chapinero, Vía Candelaria, Palmira, Colombia. Electronic address:

Life cycle assessment and kinetic modeling were used to elucidate the impact of thermal intensification (TI) on resource consumption and the techno-economic feasibility of a Fenton process at laboratory scale. Increasing temperature from 25 to 55 °C lowers treatment time (96.5%) and electricity use (67. Read More

View Article and Full-Text PDF

Neonatal exposure to monosodium glutamate results in impaired auditory brainstem structure and function.

Hear Res 2021 Apr 8;405:108243. Epub 2021 Apr 8.

Department of Anatomy, Lake Erie College of Osteopathic Medicine, 1858 West Grandview Blvd, Erie, PA 16504, United States. Electronic address:

Excitotoxic injury during the neonatal period has been shown to result in neurodegenerative changes in several different brain regions. Exposure to monosodium glutamate (MSG) during the first two postnatal weeks results in glutamate neurotoxicity in the cochlea and has been shown to result in damage to cochlear hair cells and fewer neurons in the spiral ganglion. Further, we have shown that such exposure results in fewer neurons in the cochlear nucleus and superior olivary complex and abnormal expression of the calcium binding proteins calbindin and calretinin. Read More

View Article and Full-Text PDF

Characteristic thermal denaturation profile of myosin in the longitudinal retractor muscle of sea cucumber (Stichoupus japonicas).

Food Chem 2021 Mar 18;357:129606. Epub 2021 Mar 18.

National Engineering Research Center of Seafood, Collaborative Innovation Center of Provincial and Ministerial Co-construction for Seafood Deep Processing, Liaoning Province Collaborative Innovation Center for Marine Food Deep Processing, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR China. Electronic address:

This study elucidated thermal denaturation profile of myosin in sea cucumber longitudinal muscle. Sea cucumber myosin structure was different from fish at its head/tail junction which could not be cleaved by EDTA. However, sea cucumber myosin in salt-dissolved form could be cleaved into heavy meromyosin (HMM) and light meromyosin (LMM) segments. Read More

View Article and Full-Text PDF

Safety of surgical fertility preservation procedures in children prior to Hematopoietic Stem Cell Transplant.

Transplant Cell Ther 2021 Apr 14. Epub 2021 Apr 14.

Division of Pediatric Oncology, Dana Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA; Department of Pediatrics, Harvard University Medical School, Boston, MA.

Background: Long-term survival following hematopoietic stem cell transplant (HSCT) in childhood continues to improve and patients are thus increasingly faced with the late effects of treatment. Infertility is very common for both males and females following HSCT and is one of the most distressing sequelae. Adoption and surrogate egg or sperm donation are possibilities for some patients but post-HSCT reversal of gonadal failure is not possible. Read More

View Article and Full-Text PDF

An examination of reciprocal effects between cardiovascular morbidity, depressive symptoms and loneliness over time in a longitudinal cohort of Dutch older adults.

J Affect Disord 2021 Mar 31;288:122-128. Epub 2021 Mar 31.

Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands; GGZ inGeest Specialized Mental Health Care, Amsterdam, The Netherlands.

Background: Unidirectional studies suggest that the effects between cardiovascular disease, depressive symptoms and loneliness are reciprocal, but this has not been tested empirically. The aim was to study how cardiovascular morbidity, depressive symptoms and loneliness influence each other longitudinally.

Methods: Data from 2979 older adults from the Longitudinal Aging Study Amsterdam were analysed. Read More

View Article and Full-Text PDF

Transcriptional regulator BOB.1: Molecular mechanisms and emerging role in chronic inflammation and autoimmunity.

Autoimmun Rev 2021 Apr 14:102833. Epub 2021 Apr 14.

Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes, France.

Lymphocytes constitute an essential and potent effector compartment of the immune system. Therefore, their development and functions must be strictly regulated to avoid inappropriate immune responses, such as autoimmune reactions. Several lines of evidence from genetics (e. Read More

View Article and Full-Text PDF

Relationship between ambient temperature and severe acute poisoning by alcohol and drugs.

Alcohol 2021 Apr 14. Epub 2021 Apr 14.

Department of Anesthesiology, Intensive Care Medicine, Emergency Medicine and Pain Therapy, Asklepios Klinikum Harburg, Eißendorfer Pferdeweg 52, 21075 Hamburg, Germany. Electronic address:

Aim: To test the hypothesis that severe acute poisoning by alcohol and drugs is more frequent at higher rather than at lower ambient temperatures.

Method: This was a prospective observational study performed in a prehospital setting under marine west coast climate conditions. Data from the Emergency Medical Service in Hamburg (Germany) and data from the local weather station were evaluated over a 5-year period. Read More

View Article and Full-Text PDF

The transcriptional regulator GON4L is required for viability and hematopoiesis in mice.

Exp Hematol 2021 Apr 14. Epub 2021 Apr 14.

Departments of Internal MedicineCarver College of Medicine, University of Iowa, 375 Newton Road, Iowa City, IA, 52242, USA; Anatomy and Cell BiologyCarver College of Medicine, University of Iowa, 375 Newton Road, Iowa City, IA, 52242, USA; Interdisciplinary Graduate Program in Immunology, Carver College of Medicine, University of Iowa, 375 Newton Road, Iowa City, IA, 52242, USA. Electronic address:

The Gon4l gene encodes a putative transcriptional regulator implicated in the control of both cell differentiation and proliferation. Previously, we described a mutant mouse strain called Justy in which splicing of pre-mRNA generated from Gon4l is disrupted. This defect severely reduces, but does not abolish, GON4L protein expression, and blocks the formation of early B-lineage progenitors, suggesting Gon4l is required for B cell development in vertebrates. Read More

View Article and Full-Text PDF

Sleep disturbance in adult dermatological patients: A cross-sectional study on prevalence, burden and associated factors.

J Am Acad Dermatol 2021 Apr 13. Epub 2021 Apr 13.

Dermatological Allergology, Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Germany. Electronic address:

Background: Sleep disturbance remains insufficiently characterized in many dermatoses.

Objective: To investigate the prevalence, burden and factors associated with sleep disturbance in dermatological patients.

Methods: We recruited 800 patients and recorded pruritus characteristics, sociodemographic and clinical parameters. Read More

View Article and Full-Text PDF

SAGA and SAGA-like SLIK transcriptional coactivators are structurally and biochemically equivalent.

J Biol Chem 2021 Apr 14:100671. Epub 2021 Apr 14.

Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia. Electronic address:

The SAGA-like complex SLIK is a modified version of the Spt-Ada-Gcn5-Acetyltransferase (SAGA) complex. SLIK is formed through C-terminal truncation of the Spt7 SAGA subunit, causing loss of Spt8, one of the subunits that interacts with the TATA-binding protein (TBP). SLIK and SAGA are both coactivators of RNA polymerase II transcription in yeast and both SAGA and SLIK perform chromatin modifications. Read More

View Article and Full-Text PDF

Molecular mechanisms of hearing loss in Nager syndrome.

Dev Biol 2021 Apr 14. Epub 2021 Apr 14.

Department of Molecular Pathobiology, New York University, College of Dentistry, New York, USA. Electronic address:

Nager syndrome is a rare human developmental disorder characterized by hypoplastic neural crest-derived craniofacial bones and limb defects. Mutations in SF3B4 gene, which encodes a component of the spliceosome, are a major cause for Nager. A review of the literature indicates that 45% of confirmed cases are also affected by conductive, sensorineural or mixed hearing loss. Read More

View Article and Full-Text PDF

Hearing loss in childhood cancer survivors.

Lancet Child Adolesc Health 2021 May;5(5):e17

Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland; Division of Pediatric Hematology/Oncology, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

View Article and Full-Text PDF

Characterization of chronic active multiple sclerosis lesions with sodium ( Na) MRI - preliminary observations.

Eur J Neurol 2021 Apr 17. Epub 2021 Apr 17.

Department of Neurology, Medical Faculty Mannheim and Mannheim Center for Translational Neurosciences (MCTN), University of Heidelberg, 68167, Mannheim, Germany.

Background: There has been an increasing interest in chronic active multiple sclerosis (MS) lesions as a new magnetic resonance imaging (MRI) marker of disease progression. Chronic active lesions are characterized by progressive tissue matrix damage, axonal loss and chronic inflammation. Sodium ( Na) MRI provides a biochemical marker of cell integrity and tissue viability in a quantitative manner. Read More

View Article and Full-Text PDF

Psychometric properties of the brief version of the questionnaire of olfactory disorders in patients with chronic rhinosinusitis.

Int Forum Allergy Rhinol 2021 Apr 17. Epub 2021 Apr 17.

Division of Rhinology and Sinus Surgery, Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.

Background: The Questionnaire of Olfactory Disorders-Negative Statements (QOD-NS) is a 17-item instrument measuring olfactory-specific quality of life (QOL). However, in clinical research patients can be overwhelmed with multiple questionnaires. We recently developed the 7-item brief QOD-NS (B-QOD). Read More

View Article and Full-Text PDF

Risk factors and characteristics associated with persistent smell loss in coronavirus disease 2019 (COVID-19) patients.

Int Forum Allergy Rhinol 2021 Apr 17. Epub 2021 Apr 17.

Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of California San Diego, San Diego, California, USA.

View Article and Full-Text PDF

Subsequent pregnancy outcome after uterine compression suture placement for postpartum hemorrhage.

Int J Gynaecol Obstet 2021 Apr 17. Epub 2021 Apr 17.

Department of Obstetrics and Gynaecology, JIPMER, Pondicherry, India.

Objective: To evaluate the subsequent obstetric outcome in women who received uterine compression suture.

Methods: This is a retrospective cohort study of women who received uterine compression suture for postpartum hemorrhage (PPH) between January 2009 and December 2018 and had a subsequent pregnancy at a tertiary care hospital in India. Women who had PPH but did not receive uterine compression suture and had a subsequent pregnancy were taken as controls. Read More

View Article and Full-Text PDF

Megaprosthesis Versus Allograft Prosthesis Composite for the Management of Massive Skeletal Defects: A Meta-Analysis of Comparative Studies.

Curr Rev Musculoskelet Med 2021 Apr 17. Epub 2021 Apr 17.

Department of Orthopedics, All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, India.

Purpose Of Review: Megaprosthesis and Allograft Prosthesis Composite (APC) are the established treatment modalities for massive skeletal defects. There are a handful of studies comparing the use of megaprosthesis and APC in the management of substantial bone loss and it has always been a topic of debate regarding the superiority of one modality over the other. Therefore, we aim to compare the functional outcome and implant survivorship of each modality including complications, revision rates, amputation rate and mortality. Read More

View Article and Full-Text PDF

Circ_03955 promotes pancreatic cancer tumorigenesis and Warburg effect by targeting the miR-3662/HIF-1α axis.

Authors:
A Liu J Xu

Clin Transl Oncol 2021 Apr 17. Epub 2021 Apr 17.

Department of Gastrointestinal Surgery, The First People's Hospital of Yueyang, Yueyang Avenue, Yueyang Tower District, Yueyang City, 414000, Hunan Province, China.

Objectives: Former studies found that circRNAs play an important part in the occurrence of a variety of malignant biological characteristics that are critical for cancer progression. It has been shown that circ_03955 is highly expressed and implicated with quantities of biological processes in solid tumor. However, whether circ_03955 regulates the tumorigenesis and Warburg effect of pancreatic cancer (PC) remains largely unknown. Read More

View Article and Full-Text PDF

Changes in white adipose tissue gene expression in a randomized control trial of dieting obese men with lowered serum testosterone alone or in combination with testosterone treatment.

Endocrine 2021 Apr 17. Epub 2021 Apr 17.

Department of Medicine Austin Health, University of Melbourne, Heidelberg, Victoria, Australia.

Purpose: The aim of this study was to determine early weight loss-associated changes in subcutaneous abdominal white adipose tissue (WAT) gene expression in obese men with lowered serum testosterone by RNA next-generation sequencing.

Methods: Fourteen men, mean age (IQR) 51.6 years (43. Read More

View Article and Full-Text PDF

An energetics perspective on geroscience: mitochondrial protonmotive force and aging.

Geroscience 2021 Apr 17. Epub 2021 Apr 17.

Department of Laboratory Medicine and Pathology, University of Washington Medical Center, 1959 NE Pacific St, Seattle, WA, 98195, USA.

Mitochondria are organelles that provide energy to cells through ATP production. Mitochondrial dysfunction has long been postulated to mediate cellular declines that drive biological aging. Many well-characterized hallmarks of aging may involve underlying energetic defects that stem from loss of mitochondrial function with age. Read More

View Article and Full-Text PDF

Gaseous environment modulates volatile emission and viability loss during seed artificial ageing.

Planta 2021 Apr 17;253(5):106. Epub 2021 Apr 17.

Department of Comparative Plant and Fungal Biology, Royal Botanic Gardens, Kew, Wakehurst Place, Ardingly, UK.

Main Conclusion: Modulation of the gaseous environment using oxygen absorbers and/or silica gel shows potential for enhancing seed longevity through trapping toxic volatiles emitted by seeds during artificial ageing. Volatile profiling using non-invasive gas chromatography-mass spectrometry provides insight into the specific processes occurring during seed ageing. Production of alcohols, aldehydes and ketones, derived from processes such as alcoholic fermentation, lipid peroxidation and Maillard reactions, are known to be dependent on storage temperature and relative humidity, but little is known about the potential modulating role of the gaseous environment, which also affects seed lifespan, on volatile production. Read More

View Article and Full-Text PDF

Efficacy of phloroglucinol for acceleration of labour: a systematic review and meta‑analysis.

Arch Gynecol Obstet 2021 Apr 17. Epub 2021 Apr 17.

Department of Pharmacy, School of Medicine, Women's Hospital, Zhejiang University, Hangzhou, 310006, China.

Purpose: To assess the efficacy of phloroglucinol for acceleration of labour.

Methods: Randomized controlled trials (RCTs) comparing phloroglucinol with placebo were searched in PubMed, Embase and the Cochrane Library. Literatures were collected up to April 2020. Read More

View Article and Full-Text PDF

The feasibility and safety of same-day surgery for diaphragmatic eventration by minithoracotomy in children.

Pediatr Surg Int 2021 Apr 17. Epub 2021 Apr 17.

Department of Pediatric Thoracic Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, Guangdong, China.

Purpose: The diaphragmatic plication procedure by thoracoscopy has gradually become standard treatment for diaphragmatic eventration (DE). However, thoracoscopic diaphragmatic plication is difficult to manipulate and the surgical learning curve is long. This study aimed to demonstrate the feasibility and safety of same-day surgery for DE by minithoracotomy in children. Read More

View Article and Full-Text PDF