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Adolescents' Alcohol Use: Does the Type of Leisure Activity Matter? A Cross-National Study.

Int J Environ Res Public Health 2021 10 31;18(21). Epub 2021 Oct 31.

Institute for Culture and Society (ICS), 31009 Pamplona, Spain.

The main objective of this study was to analyze the relationship between structured, unstructured, and family leisure activities on the frequency of adolescent alcohol intake across three different countries (Spain, Peru, and The Netherlands). The self-control of adolescents was also investigated as a moderator in the relationship between leisure activities and alcohol consumption.

Methodology: This research involved 4608 adolescents aged between 12 and 17 from three countries (Spain, Peru, and The Netherlands). Read More

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October 2021

Timing and Cost of Wound Complications After Colorectal Resection.

Dis Colon Rectum 2021 Dec;64(12):1551-1558

Stanford-Surgery Policy Improvement Research and Education Center (S-SPIRE), Department of Surgery, Stanford University, Stanford, California.

Background: More than 50% of postoperative wound complications occur after discharge. They are the most common postoperative complication and the most common reason for readmission after a surgical procedure. Little is known about the long-term costs of postdischarge wound complications after surgery. Read More

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December 2021

Palliative Care Coverage across European National Health Systems: Proposal of a Synthetic Indicator.

Int J Environ Res Public Health 2021 10 13;18(20). Epub 2021 Oct 13.

ATLANTES Global Palliative Care Observatory, Institute for Culture and Society, University of Navarra, 31001 Pamplona, Spain.

Background: The coverage of palliative care (PC) may be understood as a country's capacity to offer prevention and relief from serious health-related suffering in relation to an existing need. The aim of this study is to estimate European countries´ coverage capacities.

Method: Secondary analysis of three indicators, including the number of specialized services (SSPC), integration capacity scores (ICS) and the PC needs. Read More

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October 2021

The Impact of Chronic Kidney Disease in Patients With Locally Advanced Rectal Cancer Treated With Neoadjuvant Chemoradiation.

Dis Colon Rectum 2021 Dec;64(12):1471-1478

The Ottawa Hospital Cancer Centre/University of Ottawa, Ottawa, Ontario, Canada.

Background: Patients with chronic kidney disease are commonly excluded from clinical trials. The impact of chronic kidney disease on outcomes in patients with locally advanced rectal cancer has not been previously studied.

Objective: This study aimed to investigate the impact of chronic kidney disease on outcomes in patients with locally advanced rectal cancer. Read More

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December 2021

The Fate of Unifocal Versus Multifocal Low-Grade Dysplasia at the Time of Colonoscopy in Patients With IBD.

Dis Colon Rectum 2021 Nov;64(11):1364-1373

Department of Colorectal Surgery, Digestive Disease Surgical Institute, Cleveland Clinic, Cleveland, Ohio.

Background: Recommendations regarding management of colorectal dysplasia in the setting of IBD continue to evolve.

Objective: This study aimed to determine the rate of progression from dysplasia to adenocarcinoma, specifically focusing on the differences in unifocal and multifocal low-grade dysplasia and dysplasia found on random biopsy versus targeted biopsies.

Design: This is a retrospective review. Read More

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November 2021

Lymphocyte-to-C-Reactive Protein Ratio Is the Most Sensitive Inflammation-Based Prognostic Score in Patients With Unresectable Metastatic Colorectal Cancer.

Dis Colon Rectum 2021 Nov;64(11):1331-1341

Department of Colorectal Surgery, National Cancer Center Hospital, Tokyo, Japan.

Background: Systemic inflammation contributes to the progression of malignancies. The preoperative lymphocyte-to-C-reactive protein ratio has recently been shown to predict survival of patients with colorectal cancer who undergo surgery, but its prognostic value remains unclear in patients with unresectable metastatic colorectal cancer.

Objective: This study aimed to examine the prognostic values of inflammation-based prognostic scores in patients with metastatic colorectal cancer, focusing on the lymphocyte-to-C-reactive protein ratio. Read More

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November 2021

[Incidencia, impacto funcional y factores predictores para la presentación de complicaciones asociadas al acceso radial para coronariografía evaluadas por medio de ultrasonografía, cohorte hospitalaria].

Arch Cardiol Mex 2021 Sep 20. Epub 2021 Sep 20.

Servicio de Hemodinamia, Hospital Universitario San Vicente Fundación, Medellín, Antioquia, Colombia.

Introducción: El acceso arterial radial es una de las principales vías para la realización de cateterismo cardiaco izquierdo y coronariografía en diferentes contextos clínicos, por su menor tasa de complicaciones locales y similares resultados clínicos a cuando se usa el acceso femoral. Objetivo: Determinar la incidencia de complicaciones del acceso radial en procedimientos de cardiología intervencionista de un servicio de hemodinamia, así como el impacto en la funcionalidad y los factores predictores para la presentación. Metodología: Estudio tipo cohorte observacional prospectivo en pacientes llevados a coronariografía por acceso radial en un hospital universitario con recolección de datos demográficos, clínicos y ecográficos previo al procedimiento y a las 24 horas de este; se aplicó el modelo estadístico de regresión logística para evaluar la asociación entre las variables y las complicaciones. Read More

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September 2021

Preoperative Serum Vedolizumab Levels Do Not Impact Postoperative Outcomes in Inflammatory Bowel Disease.

Dis Colon Rectum 2021 Oct;64(10):1259-1266

Division of Colorectal Surgery, Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles California.

Background: Vedolizumab has been proposed to lead to fewer postoperative complications because of its gut specificity. Studies, however, suggest an increased risk of surgical site infections, yet the data are conflicting.

Objective: This study aimed to assess the effect of vedolizumab drug levels on postoperative outcomes in patients undergoing major abdominal surgery for IBD. Read More

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October 2021

A Mixed-Methods Evaluation of Patient Education Materials for Colorectal Cancer.

Dis Colon Rectum 2021 Oct;64(10):1249-1258

Department of Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.

Background: Patient education materials are created by professional organizations to inform patients about their disease and its treatment. However, it remains unclear if these materials are appropriate for patients.

Objective: This study aims to broadly evaluate the education materials for patients with colorectal cancer. Read More

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October 2021

Neoadjuvant Therapy in Stage II/III Rectal Cancer: A Retrospective Study in a Disparate Population and the Effect on Survival.

Dis Colon Rectum 2021 Oct;64(10):1212-1221

Department of Surgery, Lexington, Kentucky.

Background: Kentucky has one of the highest rectal cancer incidences in the United States. High poverty rates have led to poor insurance coverage and inadequate access to care. The treatment of locally advanced rectal cancer utilizes a multimodal regimen requiring regular access to expert care. Read More

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October 2021

Organ Preservation in Patients with Rectal Cancer Treated with Total Neoadjuvant Therapy.

Dis Colon Rectum 2021 Dec;64(12):1463-1470

Department of Surgery, Memorial Sloan Kettering Cancer Center, New York.

Background: Retrospective studies suggest that watch-and-wait is a safe alternative to total mesorectal excision in selected patients with a clinical complete response after chemoradiotherapy.

Objective: This study aimed to determine the proportion of patients with rectal cancer who may benefit from watch-and-wait.

Design: This study is a retrospective analysis of data from prospectively maintained databases. Read More

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December 2021

Genomic analysis revealed conserved acid tolerance mechanisms from native micro-organisms in fermented feed.

J Appl Microbiol 2021 Sep 6. Epub 2021 Sep 6.

Laboratorio de Fisiología y Genética de Bacterias Lácticas, Instituto de Biología Molecular y Celular de Rosario (IBR), sede Facultad de Ciencias Bioquímicas y Farmacéuticas (FBioyF), Universidad Nacional de Rosario (UNR), Consejo Nacional de Ciencia y Tecnología (CONICET), Rosario, Argentina.

Aims: Fermented feed is an agricultural practice used in many regions of the world to improve the growth performance of farm animals. This study aimed to identify and evaluate the lactic acid bacteria and yeast involved in the production of fermented feed.

Methods And Results: We isolated and described two micro-organisms from autochthonous microbiota origin present in a regional feed product, Lactobacillus paracasei IBR07 (Lacticaseibacillus paracasei) and Kazachstania unispora IBR014 (Saccharomyces unisporum). Read More

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September 2021

Primary Tumor-Related Complications Among Patients With Unresectable Stage IV Colorectal Cancer in the Era of Targeted Therapy: A Competing Risk Regression Analysis.

Dis Colon Rectum 2021 Sep;64(9):1074-1082

Department of Colorectal Surgery, National Cancer Center Hospital, Tokyo, Japan.

Background: Whether prolonged survival with current chemotherapy using molecular target agents has changed the rate of primary tumor-related complications in patients with unresectable stage IV colorectal cancer is unclear.

Objective: This study aimed to investigate the rate of primary tumor-related complications among patients receiving targeted therapy as compared with patients receiving chemotherapy without molecular target agents.

Design: This was a retrospective review of data from a prospectively maintained database. Read More

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September 2021

Rectal Cancer in Adolescent and Young Adult Patients: Pattern of Clinical Presentation and Case-Matched Comparison of Outcomes.

Dis Colon Rectum 2021 Sep;64(9):1064-1073

IRCCS Humanitas Research Hospital, Division of Colon and Rectal Surgery, Rozzano, Milan, Italy.

Background: Rectal cancer in adolescents and young adults (age ≤39) is increasing. Early diagnosis is a challenge in this subset of patients.

Objective: This study aims to analyze the presentation pattern and outcomes of sporadic rectal cancer in adolescents and young adults. Read More

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September 2021

When is it worth performing lymphadenectomy in patients with melanoma micrometastases? A 20-year experience retrospective analysis.

Cir Cir 2021 ;89(4):457-460

Department of Dermatology and Venereology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

IntroducciÓn: Actualmente existe controversia respecto a los beneficios de realizar linfadenectomía en pacientes de melanoma con una biopsia selectiva de ganglio centinela (BSGC) positiva. La carga tumoral > 1 mm se ha propuesto como el parámetro mas relevante asociado a una linfadenectomía positiva y un deterioro de la supervivencia libre de enfermedad.

Material Y Métodos: Se analizaron los datos de 119 pacientes de melanoma con BSGC positiva atendidos en el periodo entre Junio de 1997 y Junio de 2017. Read More

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September 2021

Plasma colloid osmotic pressure in preeclampsia. Review of the Mexican literature 1997-2018.

Cir Cir 2021 ;89(4):547-552

Unit of Intensve Care, Unidad Médica de Alta Especialida, Hospital de Ginecología y Obstetricia No. 3, Centro Médico Nacional "La Raza," Instituto Mexicano del Seguro Social (IMSS), México City, Mexico.

En México, la presión coloidosmótica del plasma ha sido un tema clave del estudio de la mujer embarazada por más de dos décadas. Las investigaciones clínicas han permitido conocer sus valores en población abierta, mujeres con embarazo normal, puerperio fisiológico, preeclampsia severa, síndrome HELLP y eclampsia. También se ha reportado la relación de la presión coloidosmótica del plasma con la presión sanguínea (índice de Briones), síndrome de fuga capilar y la acumulación de líquido en cavidades serosas (derrame pleural, ascitis). Read More

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September 2021

Recurrence rate of localized prostate cancer after radical prostatectomy according to D'amico risk classification in a tertiary referral hospital: association study.

Cir Cir 2021 ;89(4):520-527

Department of Urology, Hospital Regional de Alta Especialidad del Bajío, León, Guanajuato, Mexico.

Objetivo: Determinar la tasa de recurrencia del cáncer de próstata localizado después de la prostatectomía radical según la clasificación D'Amico.

MÉtodos: Estudio de cohorte retrospectivo comparativo de 5 años. Se obtuvieron datos de registros clínicos de pacientes con cáncer de próstata localizado, que se sometieron a prostatectomía radical y se evaluó la tasa de recurrencia de la enfermedad. Read More

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September 2021

Risk factors associated with SARS-CoV-2 pneumonia in the pediatric population.

Bol Med Hosp Infant Mex 2021 ;78(4):251-258

Hospital de Especialidades Pediátricas, Centro Regional de Alta Especialidad Chiapas, Secretaría de Salud, Tuxtla Gutiérrez, Chiapas. Mexico.

IntroducciÓn: Hasta ahora existen pocos estudios sobre las características clínicas de la población pediátrica con neumonía por COVID-19. El objetivo de este estudio fue analizar los datos que se asocian con el desarrollo de neumonía en niños y adolescentes con infección por SARS-CoV-2 en México.

MÉtodos: Se llevó a cabo un análisis secundario de la base de datos de la Dirección General de Epidemiología del Gobierno Mexicano. Read More

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Closure of Temporary Ileostomy 2 Versus 12 Weeks After Rectal Resection for Cancer: A Word of Caution From a Prospective, Randomized Controlled Multicenter Trial.

Dis Colon Rectum 2021 Nov;64(11):1398-1406

Department of Surgery, Hospital of Baselland-Liestal, Liestal, Switzerland.

Background: The optimum timing for temporary ileostomy closure after low anterior resection is still open.

Objective: This trial aimed to compare early (2 wk) versus late (12 wk) stoma closure.

Design: The study included 2 parallel groups in a multicenter, randomized controlled clinical trial. Read More

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November 2021

[Interobserver agreement in using a checklist for the safe administration of enteral nutrition].

Nutr Hosp 2021 Oct;38(5):903-910

Programa de Pós-Graduação em Enfermagem da Universidade Federal do Rio Grande do Sul (PPGENF/UFRGS).

Introduction: Objective: to describe an evaluation of interobserver agreement in the use of a checklist related to the use of nasoenteral tube (NSS) as a presupposition for quality in obtaining data. Method: a methodological study conducted in 2018 in a Brazilian hospital, preceding the data collection of an open-label clinical trial. Independent observers, blinded to the evaluation of their peers, evaluated patients with NSS through a 25-item checklist. Read More

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October 2021

Further validation and psychometric properties of the Spanish adaptation of the Genetic Counseling Outcome Scale.

J Genet Couns 2021 Jul 3. Epub 2021 Jul 3.

Sección de Genética Clínica, Instituto de Genética Médica y Molecular (INGEMM), Hospital Universitario La Paz, Madrid, Spain.

Evaluation of clinical genetic services is challenging due to the nature of their interventions. The Genetic Counseling Outcome Scale (GCOS-24), a patient-reported outcome measure, was developed to measure empowerment, an important patient-reported outcome from genetic counseling. Previously, we translated and adapted GCOS-24 for use in Spain, but neither test-retest reliability nor structural and construct validity were assessed at that time. Read More

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Plasma Gelsolin Reinforces the Diagnostic Value of FGF-21 and GDF-15 for Mitochondrial Disorders.

Int J Mol Sci 2021 Jun 15;22(12). Epub 2021 Jun 15.

Mitochondrial and Neuromuscular Disorders Research Group, Hospital 12 de Octubre Research Institute (imas12), 28041 Madrid, Spain.

Mitochondrial disorders (MD) comprise a group of heterogeneous clinical disorders for which non-invasive diagnosis remains a challenge. Two protein biomarkers have so far emerged for MD detection, FGF-21 and GDF-15, but the identification of additional biomarkers capable of improving their diagnostic accuracy is highly relevant. Previous studies identified Gelsolin as a regulator of cell survival adaptations triggered by mitochondrial defects. Read More

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A US Rectal Cancer Consortium Study of Inferior Mesenteric Artery Versus Superior Rectal Artery Ligation: How High Do We Need to Go?

Dis Colon Rectum 2021 Oct;64(10):1198-1211

Division of Colon and Rectal Surgery, Department of Surgery, Emory University, Atlanta, Georgia.

Background: The optimal level of pedicle ligation during proctectomy for rectal cancer, either at the origin of the inferior mesenteric artery or the superior rectal artery, is still debated.

Objective: The objective was to determine whether superior rectal artery ligation portends equivalent technical or oncologic outcomes.

Design: This was a retrospective analysis of a rectal cancer database (2007-2017). Read More

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October 2021

Preventable Emergency Department Visits After Colorectal Surgery.

Dis Colon Rectum 2021 Nov;64(11):1417-1425

Department of Surgery, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

Background: The emergency department plays a common and critical role in the treatment of postoperative patients. However, many quality improvement databases fail to record these interactions. As such, our understanding of the prevalence and etiology of postoperative emergency department visits in contemporary colorectal surgery is limited. Read More

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November 2021

Evaluation of Bowel Function After Surgical Treatment for Intestinal Endometriosis: A Prospective Study.

Dis Colon Rectum 2021 Oct;64(10):1267-1275

Cambridge Endometriosis & Endoscopic Surgery Unit (CEESU) and Cambridge Colorectal Unit, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, United Kingdom.

Background: Defecation symptoms related to intestinal deep infiltrative endometriosis are caused by anatomical and functional disorders and are probably linked to the course of the disease and surgical treatment.

Objective: The primary aim of this study was to assess bowel function before and after intestinal deep infiltrative endometriosis surgery. Secondarily, we sought to correlate defecatory symptoms with preoperative risk factors. Read More

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October 2021

Asociación entre mortalidad por Covid-19 y contaminación atmosférica en ciudades mexicanas.

Salud Publica Mex 2021 May 19:1-8. Epub 2021 May 19.

Dirección de Salud Ambiental, Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública. Cuernavaca, Morelos, México..

Objetivo. Analizar la asociación entre la exposición crónica a contaminantes atmosféricos y la tasa de mortalidad por Covid-19 en ciudades mexicanas. Material y métodos. Read More

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High World Heath Organization Performance Status Is Associated With Short- and Long-term Outcomes After Colorectal Cancer Surgery: A Nationwide Population-Based Study.

Dis Colon Rectum 2021 07;64(7):851-860

Enhanced Perioperative Oncology Consortium, Centre for Surgical Science, Zealand University Hospital, Køge/Roskilde, Denmark.

Background: The value of performance status is widely used in medical oncology, but the association with surgical outcomes in colorectal cancer has not been described.

Objective: The aim of this study was to investigate the association between World Heath Organization performance status and 90-day mortality, 30-day mortality, complications, and overall survival after elective colorectal cancer surgery.

Design: The study was conducted as a nationwide population-based cohort study with prospectively collected data. Read More

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The Association Between Modifiable Lifestyle Factors and Postoperative Complications of Elective Surgery in Patients With Colorectal Cancer.

Dis Colon Rectum 2021 Nov;64(11):1342-1353

Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.

Background: Research has demonstrated a possible relation between patients' preoperative lifestyle and postoperative complications.

Objective: This study aimed to assess associations between modifiable preoperative lifestyle factors and postoperative complications in patients undergoing elective surgery for colorectal cancer.

Design: This is a retrospective study of a prospectively maintained database. Read More

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November 2021