330,818 results match your criteria longitudinal vascular

Exome sequence association study of levels and longitudinal change of cardiovascular risk factor phenotypes in European Americans and African Americans from the Atherosclerosis Risk in Communities Study.

Genet Epidemiol 2021 Jun 24. Epub 2021 Jun 24.

Department of Epidemiology, Human Genetics, and Environmental Sciences, Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

Cardiovascular disease (CVD) is responsible for 31% of all deaths worldwide. Among CVD risk factors are age, race, increased systolic blood pressure (BP), and dyslipidemia. Both BP and blood lipids levels change with age, with a dose-dependent relationship between the cumulative exposure to hyperlipidemia and the risk of CVD. Read More

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Longitudinal Timed Up and Go Assessment in Amyotrophic Lateral Sclerosis: A Pilot Study.

Eur Neurol 2021 Jun 24:1-5. Epub 2021 Jun 24.

Division of Cognitive and Motor Aging, Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York, USA.

Progressive loss of walking ability in amyotrophic lateral sclerosis (ALS) has been scarcely studied as a potential predictive factor for survival in motor neuron disease. We aimed to assess the progression of gait decline and its association with mortality in ALS using the Timed Up and Go test (TUG). Patients were followed up prospectively at the Centre for ALS and Related Disorders in Geneva University Hospitals between 2012 and 2016. Read More

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First assessment of bone mineral density in healthy pregnant women by means of Radiofrequency Echographic Multi Spectrometry (REMS) technology.

Eur J Obstet Gynecol Reprod Biol 2021 Jun 15;263:44-49. Epub 2021 Jun 15.

Department of Medicine and Surgery, Obstetrics and Gynaecology Unit, University of Parma, Parma, Italy. Electronic address:

Objective: The maternal bone structure is the largest calcium reserve for the fetus during pregnancy, and this is claimed to lead to a bone mineral density (BMD) reduction in pregnant women. The primary outcome of the present work was to assess the BMD in a group of healthy pregnant women.

Study Design: In this prospective case - control observational study, a non-consecutive group of pregnant women with uncomplicated pregnancy at or >37 weeks were enrolled at the unit of Obstetrics and Gynecology, University of Parma, from February to December 2020. Read More

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Early differentiation of memory retrieval processes for newly learned voices and phonemes as indexed by the MMN.

Brain Lang 2021 Jun 21;220:104981. Epub 2021 Jun 21.

Dipartimento di Psicologia, Università degli Studi di Milano-Bicocca, Piazza dell'Ateneo Nuovo 1, 20126 Milano (MI), Italy; Milan Center for Neuroscience (NeuroMi), Università degli Studi di Milano-Bicocca, Piazza dell'Ateneo Nuovo 1, 20126 Milano (MI), Italy. Electronic address:

Linguistic and vocal information are thought to be differentially processed since the early stages of speech perception, but it remains unclear if this differentiation also concerns automatic processes of memory retrieval. The aim of this ERP study was to compare the automatic retrieval processes for newly learned voices vs phonemes. In a longitudinal experiment, two groups of participants were trained in learning either a new phoneme or a new voice. Read More

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The antenatal risk questionnaire-revised: Development, use and test-retest reliability in a community sample of pregnant women in Australia.

J Affect Disord 2021 Jun 5;293:43-50. Epub 2021 Jun 5.

School of Nursing and Midwifery, University of Newcastle, NSW, Australia; Black Dog Institute, NSW, Australia; Royal Hospital for Women, NSW, Australia.

Background: Routine psychosocial assessment during pregnancy and the first postnatal year is a public health strategy that prioritises early identification of known risk factors for poor perinatal mental health. We aimed to report on the development and use of the Antenatal Risk Questionnaire-Revised (ANRQ-R), contribute normative data for a community sample of pregnant women and examine its test-retest reliability.

Methods: The ANRQ-R was developed in consultation with an expert advisory group. Read More

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Annual changes in appendicular skeletal muscle mass and quality in adults over 50 y of age, assessed using bioelectrical impedance analysis.

Nutrition 2021 May 16;90:111342. Epub 2021 May 16.

The Karkonosze State University of Applied Sciences, Jelenia Góra, Poland.

Objectives: It is essential to monitor changes in skeletal muscles to control healthy aging. The aim of this study was to assess changes in muscle mass, strength, and functional quality taking place in the course of aging and to analyze their correlations with recorded changes in impedance.

Methods: The study, carried out in two stages at a 1-y interval, covered 313 subjectively healthy adults ages 50 to 83 y. Read More

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Variability in urinary biomarkers of human exposure to polycyclic aromatic hydrocarbons and its association with oxidative stress.

Environ Int 2021 Jun 21;156:106720. Epub 2021 Jun 21.

Department of Pediatrics and Department of Environmental Medicine, New York University, School of Medicine, New York, NY 10016, United States. Electronic address:

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants. Urinary concentrations of mono-hydroxylated metabolites of PAHs (OH-PAHs) have been used as biomarkers of these chemicals' exposure in humans. Little is known, however, with regard to intra- and inter-individual variability in OH-PAH concentrations and their association with oxidative stress. Read More

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Trajectories of Adiposity Indicators and Association with Asthma and Lung Function in Urban Minority Children.

J Allergy Clin Immunol 2021 Jun 21. Epub 2021 Jun 21.

Division of Pediatric Pulmonology, Columbia University Irving Medical Center, Vagelos College of Physicians and Surgeons, New York, NY.

Background: A relationship between adiposity and asthma has been described in some cohort studies, yet little is known about trajectories of adiposity throughout early childhood among children at high-risk for developing asthma in urban United States cities. Moreover, early life trajectories of adipokines that have metabolic and immunologic properties have not been comprehensively investigated.

Objective: Our objective was to characterize trajectories of adiposity in a longitudinal birth cohort of predominately Black and Latinx children (n=418) using several different repeated measures including body mass index (BMI) z-score, bio-impedance analysis (BIA), leptin and adiponectin in the first 10 years of life. Read More

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Perturbation of amino acid metabolism mediates air pollution associated vascular dysfunction in healthy adults.

Environ Res 2021 Jun 21:111512. Epub 2021 Jun 21.

Department of Occupational and Environmental Health, Peking University School of Public Health, And Peking University Institute of Environmental Medicine, Beijing, China; Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education, Peking University, Beijing, China. Electronic address:

The molecular mechanisms of air pollution-associated adverse cardiovascular effects remain largely unknown. In the present study, we investigated the impacts of ambient air pollution on vascular function and the potential mediation effects of amino acids in a longitudinal follow-up of 73 healthy adults living in Beijing, China, between 2014 and 2016. We estimated associations between air pollutants and serum soluble intercellular adhesion molecule 1 (sICAM-1) and plasma levels of amino acids using linear mixed-effects models, and elucidated the biological pathways involved using mediation analyses. Read More

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Sex-specific longitudinal association between baseline physical activity level and cognitive decline in Chinese over 45 years old: Evidence from the China health and retirement longitudinal study.

Aging Ment Health 2021 Jun 24:1-9. Epub 2021 Jun 24.

School of Public Health, Medical College of Soochow University, Suzhou, China.

Objectives: To examine whether sex-specific associations between baseline PA level and follow up cognitive performance in Chinese subjects exist from the China Health and Retirement Longitudinal study (CHARLS).

Method: A total of 3395 adults aged 45 or old from the CHARLS were used for analysis. The combined scores of measurements of mental status and verbal episodic memory were utilized for assessing cognitive function at baseline in 2011 and the follow-up survey in 2015. Read More

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Role of received social support in the physical activity of coronary heart patients: The Health Action Process Approach.

Appl Psychol Health Well Being 2021 Jun 24. Epub 2021 Jun 24.

Department of Behavioural Sciences, Medical School, University of Pécs, Pécs, Hungary.

Physical activity (PA) plays a crucial role in the management of coronary artery disease (CAD). The Health Action Process Approach provides a useful framework for understanding and predicting the process of health behaviors. The aim of the current study was to unveil the role of received social support in the HAPA model, concerning the physical activity of CAD patients. Read More

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Occult primary white matter impairment in Leber's hereditary optic neuropathy.

Eur J Neurol 2021 Jun 24. Epub 2021 Jun 24.

Department of Radiology & Tianjin Key Lab of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, 300052, China.

Background: Leber's hereditary optic neuropathy (LHON) is a disease maternally inherited from mitochondria that predominantly impairs the retinal ganglion cells and their axons. To identify whether occult brain white matter (WM) impairment is involved, a voxel-based analysis (VBA) of diffusion metrics was carried out in LHON patients with normal-appearing brain parenchyma.

Methods: Fifty-four symptomatic LHON patients (including 22 acute LHON with vision loss <= 12 months, and 32 chronic LHON) without any visible brain lesions and 36 healthy controls (HC) were enrolled in this study. Read More

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Breeding responses to environmental variation are age- and trait-dependent in female Nazca boobies.

Ecology 2021 Jun 24:e03457. Epub 2021 Jun 24.

Biology Department, Wake Forest University, Winston-Salem, USA.

Age and environment are important determinants of reproductive parameters in long-lived organisms. These factors may interact to determine breeding responses to environmental change, yet few studies have examined the environmental dependence of aging patterns across the entire lifespan. We do so, using a 20-year longitudinal dataset of reproductive phenotypes in long-lived female Nazca boobies (Sula granti), a monogamous seabird breeding in the eastern tropical Pacific. Read More

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Longitudinal changes in epigenetic age acceleration in aviremic HIV-infected recipients of long-term antiretroviral treatment.

J Infect Dis 2021 Jun 24. Epub 2021 Jun 24.

HIV/AIDS and Infectious Diseases Research Group, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid 28046, Spain.

Background: HIV infection induces epigenetic age acceleration (EAA), but it remains unclear whether epigenetic aging continues to accelerate during successful ART and prolonged virological suppression.

Methods: We longitudinally analyzed 63 long-term aviremic HIV-infected adults. Using blood DNA methylation patterns, we calculated EAA measures based on three epigenetic clocks (Horvath´s clock, PhenoAge and GrimAge). Read More

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Delineating sociodemographic, medical and quality of life factors associated with psychological distress in individuals with endometriosis.

Hum Reprod 2021 Jun 24. Epub 2021 Jun 24.

Department of Obstetrics and Gynaecology, The University of Sydney, Sydney, NSW, Australia.

Study Question: What is the relationship between specific quality of life domains and depression, anxiety and stress in the endometriosis population?

Summary Answer: Psychosocial domains of quality of life, such as a perception of social support and self-image, are more strongly associated with depression, anxiety and stress than pain and medical factors.

What Is Known Already: Prior research indicates a high prevalence of anxiety and depression in individuals with endometriosis. Pain is thought to be critical in the development of psychological distress, however prior research has investigated this association without consideration of psychosocial quality of life domains such as social functioning, perceived social support and self-image. Read More

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Mechanisms of parental distress during and after the first COVID-19 lockdown phase: A two-wave longitudinal study.

PLoS One 2021 24;16(6):e0253087. Epub 2021 Jun 24.

Department of Psychology, University of Oslo, Oslo, Norway.

Background: In these unpredictable times of the global coronavirus disease 2019 (COVID-19) pandemic, parents worldwide are affected by the stress and strain caused by the physical distancing protocols that have been put in place.

Objective: In a two-wave longitudinal survey, we investigated the levels of parental stress and symptoms of anxiety and depression in a sample of parents at two time points; during the implementation of the strictest physical distancing protocols following the onset of the COVID-19 pandemic (T1, N = 2,868) and three months after the discontinuation of the protocols (T2, N = 1,489). Further, we investigated the relationships between parental stress and anxiety and depression relative to relationship quality and anger toward their children at the two aforementioned time points, including subgroups based on age, parental role, cultural background, relationship status, education level, number of children, employment status and pre-existing psychiatric diagnosis. Read More

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Balancing fertility and livelihood diversity in mixed economies.

PLoS One 2021 24;16(6):e0253535. Epub 2021 Jun 24.

Department of Anthropology, University of Utah, Salt Lake City, Utah, United States of America.

Mixed economies provide a unique context for testing theories of fertility change. Because they have a stake in two traditions, mixed-economy households balance the demands of both a labor-based subsistence economy, which benefits from a large family, and a wage-labor economy, which benefits from reduced fertility. Additionally, household size changes over the course of its life-cycle and shapes available economic opportunities. Read More

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Musical instrument engagement across the life course and episodic memory in late life: An analysis of 60 years of longitudinal data from the Wisconsin Longitudinal Study.

PLoS One 2021 24;16(6):e0253053. Epub 2021 Jun 24.

Program in Public Health, Department of Family, Population, and Preventive Medicine, Stony Brook University, Stony Brook, NY, United States of America.

Background: As the global burden of dementia increases, the absence of treatment underscores the need for identification of factors that may improve cognitive reserve-the ability to stave off cognitive decline in old age. The beneficial association between musical instrument engagement and episodic memory has been identified in children, young adults, and older adults. Yet, previous studies in musical instrument engagement have rarely examined the potential for adolescence and adulthood exposures to independently improve cognition, nor have they been linked with the rate of memory decline over time in older adults. Read More

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Gross anatomy of the longitudinal fascicle of Sapajus sp.

PLoS One 2021 24;16(6):e0252178. Epub 2021 Jun 24.

Department of Behavioral Neurology, Clinical Hospital, Federal University of Goias, Goiânia, Goiás, Brazil.

Opposing genetic and cultural-social explanations for the origin of language are currently the focus of much discussion. One of the functions linked to the longitudinal fascicle is language, which links Wernicke's area and Broca's area in the brain, and its size should indicate the brain increase in the evolution. Sapajus is a New World primate genus with high cognition and advanced tool use similar to that of chimpanzees. Read More

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The Goto Kakizaki rat: Impact of age upon changes in cardiac and renal structure, function.

PLoS One 2021 24;16(6):e0252711. Epub 2021 Jun 24.

St. Michael's Hospital, Keenan Research Centre, Li Ka Shing Knowledge Institute, Toronto, Canada.

Background: Patients with diabetes are at a high risk for developing cardiac dysfunction in the absence of coronary artery disease or hypertension, a condition known as diabetic cardiomyopathy. Contributing to heart failure is the presence of diabetic kidney disease. The Goto-Kakizaki (GK) rat is a non-obese, non-hypertensive model of type 2 diabetes that, like humans, shares a susceptibility locus on chromosome 10. Read More

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Development and validation of the CHIME simulation model to assess lifetime health outcomes of prediabetes and type 2 diabetes in Chinese populations: A modeling study.

PLoS Med 2021 Jun 24;18(6):e1003692. Epub 2021 Jun 24.

School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.

Background: Existing predictive outcomes models for type 2 diabetes developed and validated in historical European populations may not be applicable for East Asian populations due to differences in the epidemiology and complications. Despite the continuum of risk across the spectrum of risk factor values, existing models are typically limited to diabetes alone and ignore the progression from prediabetes to diabetes. The objective of this study is to develop and externally validate a patient-level simulation model for prediabetes and type 2 diabetes in the East Asian population for predicting lifetime health outcomes. Read More

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Remote and adjacent psychological predictors of early-adulthood resilience: Role of early-life trauma, extraversion, life-events, depression, and social-support.

PLoS One 2021 24;16(6):e0251859. Epub 2021 Jun 24.

Department of Nursing Psychology, Army Medical University, Chongqing, China.

Resilience is important for people to maintain mental health after negative life-events. However, its longitudinal psychological and social predictors are poorly revealed. Based on the ecological system theory model, the current study aimed to determine the longitudinal temporal mechanism underlying the development of early-adulthood resilience using long-term (early-life trauma and personality), medium-term and short-term (life-events, social support, and depression) psychosocial predictors. Read More

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Exposure to traffic-related air pollution and bacterial diversity in the lower respiratory tract of children.

PLoS One 2021 24;16(6):e0244341. Epub 2021 Jun 24.

Department of Environmental Health, University of Cincinnati, Cincinnati, OH, United States of America.

Background: Exposure to particulate matter has been shown to increase the adhesion of bacteria to human airway epithelial cells. However, the impact of traffic-related air pollution (TRAP) on the respiratory microbiome is unknown.

Methods: Forty children were recruited through the Cincinnati Childhood Allergy and Air Pollution Study, a longitudinal cohort followed from birth through early adolescence. Read More

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Physical Restraints in Critically Ill Children: A Multicenter Longitudinal Point Prevalence Study.

Crit Care Med 2021 Jun 25. Epub 2021 Jun 25.

Department of Nursing, Osaka Women's and Children's Hospital, Osaka, Japan. Department of Pediatrics, CHU Sainte-Justine Research Center, University of Montreal, Montreal, QC, Canada. Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada. Department of Intensive Care Medicine, Tokyo Women's Medical University, Tokyo, Japan. Department of Pediatric Critical Care, Shizuoka Children's Hospital, Shizuoka, Japan. Department of Nursing, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan. Department of Nursing, University of Tsukuba Hospital, Ibaraki, Japan. Department of Intensive Care Medicine, Osaka Women's and Children's Hospital, Osaka, Japan. Department of Critical Care Medicine, Saitama Children's Medical Center, Saitama, Japan. Department of Pediatric Intensive Care, Okinawa Prefectural Nanbu Children's Medical Center, Okinawa, Japan. Department of Cardiology, Gunma Children's Medical Center, Gunma, Japan. Department of Critical Care Medicine, Toyama Prefectural Central Hospital, Toyama, Japan. Department of Pediatrics, Kanazawa Medical University, Ishikawa, Japan. Department of Nursing, Sakakibara Heart Institute, Tokyo, Japan. Department of Nursing, Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Japan. Department of Nursing, Miyagi Children's Hospital, Miyagi, Japan. Department of Nursing, Hyogo Prefectural Kobe Children's Hospital, Kobe, Japan. Emergency and Critical Care Center, Kyushu University Hospital, Fukuoka, Japan.

Objectives: We elucidate to investigate the prevalence of and factors associated with the use of physical restraints among critically ill or injured children in PICUs.

Design: This was a multicenter, longitudinal point prevalence study.

Setting: We included 26 PICUs in Japan. Read More

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Long-Term Functional Outcome and Quality of Life Following In-Hospital Cardiac Arrest-A Longitudinal Cohort Study.

Crit Care Med 2021 Jun 24. Epub 2021 Jun 24.

Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia. Department of Physiotherapy, St. Vincent's Hospital, Melbourne, VIC, Australia. Department of Intensive Care, The Austin Hospital, Melbourne, VIC, Australia. Department of Physiotherapy, The Alfred Hospital, Melbourne,VIC, Australia.

Objectives: To evaluate the functional outcome and health-related quality of life of in-hospital cardiac arrest survivors at 6 and 12 months.

Design: A longitudinal cohort study.

Setting: Seven metropolitan hospitals in Australia. Read More

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Experimental Manipulation of Corticosterone Does Not Affect Venom Composition or Functional Activity in Free-Ranging Rattlesnakes.

Physiol Biochem Zool 2021 Sep-Oct;94(5):286-301

AbstractVenom is an integral feeding trait in many animal species. Although venom often varies ontogenetically, little is known about the proximate physiological mediators of venom variation within individuals. The glucocorticoid hormone corticosterone (CORT) can alter the transcription and activation of proteins, including homologues of snake venom components such as snake venom metalloproteinases (SVMPs) and phospholipase A (PLA). Read More

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Exploring ADHD Symptoms and Associated Impairment across Development.

J Atten Disord 2021 Jun 24:10870547211025612. Epub 2021 Jun 24.

Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, UK.

Objective: ADHD symptoms typically decline with age, but less is known about whether the presentation of specific ADHD symptoms differs across development. This study aimed to examine the frequency and associated impairment of specific ADHD symptoms in childhood, adolescence, and young adulthood.

Method: A prospective, longitudinal cohort, the Avon Longitudinal Study of Parents and Children, was utilized ( = 2,327). Read More

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Case Studies in Physiology: Temporal Variations of the Lung Parenchyma and Vasculature in Asymptomatic COVID-19 Pneumonia: A Multi-Spectral CT Assessment.

J Appl Physiol (1985) 2021 Jun 24. Epub 2021 Jun 24.

Department of Radiology, grid.214572.7University of Iowa Carver College of Medicine, Iowa City, IA, United States.

This study reports systematic longitudinal pathophysiology of lung parenchymal and vascular effects of asymptomatic COVID-19 pneumonia in a young, healthy never-smoking male. Inspiratory and Expiratory non-contrast along with contrast Dual-energy computed tomography (DECT) scans of the chest were performed at baseline on the day of acute COVID-19 diagnosis (Day 0), and across a 90 day period. Despite normal vital signs and pulmonary function tests on the day of diagnosis, the CT scans and corresponding quantification metrics detected abnormalities in parenchymal expansion based on image registration, ground glass (GGO) texture (inflammation) as well as DECT-derived pulmonary blood volume (PBV). Read More

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SARS-CoV-2 Serologic Assays Dependent on Dual-Antigen Binding Demonstrate Diverging Kinetics Relative to Other Antibody Detection Methods.

J Clin Microbiol 2021 Jun 24:JCM0123121. Epub 2021 Jun 24.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.

Longitudinal studies assessing durability of the anti-SARS-CoV-2 humoral immune response have generated conflicting results. This has been proposed to be due to differences in patient populations, the lack of standardized methodologies, and the use of assays that measure distinct aspects of the humoral response. SARS-CoV-2 antibodies were serially measured in sera from a cohort of 44 well-characterized convalescent plasma donors over 120 days post-COVID-19 symptom onset, utilizing eight assays, which varied according to antigen source, the detected antibody isotype, and the activity measured ( binding, blocking, or neutralizing). Read More

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A daily diary study of minority stress and negative and positive affect among racially diverse sexual minority adolescents.

J Couns Psychol 2021 Jun 24. Epub 2021 Jun 24.

Department of Behavioral and Community Health, University of Maryland School of Public Health.

We conducted an intensive longitudinal study of sexual minority adolescents to address gaps in the literature, limitations in retrospective reporting, and test tenets of the minority stress model. We examined the frequency of daily minority stressors and their within-person associations with negative and positive affect. We also tested the moderating effects of depressive symptomology on these associations. Read More

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