290,981 results match your criteria longitudinal study

Pain and mortality among older adults in Korea.

Epidemiol Health 2021 Sep 7:e2021058. Epub 2021 Sep 7.

Graduated School of Public Health, Seoul National University, Seoul, Korea.

Objectives: With the rising elderly population subject to chronic disease, pain becomes crucial to understand and design an appropriate approach to it. While pain is a noted mortality risk factor, limited studies exists due to various causes of pain and subjectivity of pain expression. This study aims to examine the relationship between pain and mortality, controlling for other disease and socio-cultural factors. Read More

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September 2021

Association between body temperature and leukocyte telomere length in middle-aged and older adults.

Epidemiol Health 2021 Sep 8:e2021063. Epub 2021 Sep 8.

Department of Foods and Nutrition, College of Natural Sciences, Kookmin University, 02707 Seoul, Republic of Korea.

Objectives: Data on the association between body temperature (BT) and leukocyte telomere length (LTL), which has been widely used as a biomarker of cellular senescence in recent epidemiological studies, are limited. Aims: The present study aimed to explore the association between a normal BT range (35.0 to 37. Read More

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September 2021

Sonographic and ophthalmic assessment of optic nerve in patients with idiopathic intracranial hypertension: A longitudinal study.

J Neurol Sci 2021 Sep 4;430:118069. Epub 2021 Sep 4.

Department of Neurology, Saarland University Medical Center, Homburg, Germany.

Background: To assess the validity of neurosonological parameters (transorbital sonography (TOS)) for detection and monitoring of patients with idiopathic intracranial hypertension (IIH).

Methods: Prospective, single-center, case-controlled study in 25 patients with IIH and 19 controls. Visual parameters of papilledema, visual acuity, computerized static threshold perimetry, fundus examination, and neurosonological parameters of papilledema/optic disc elevation (ODE), optic nerve sheath diameter (ONSD) and optic nerve diameter (OND) were recorded at baseline and only for patients with IIH again within 6 months. Read More

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September 2021

Modelling the relationship between poor sleep and problem anger in veterans: A dynamic structural equation modelling approach.

J Psychosom Res 2021 Sep 8;150:110615. Epub 2021 Sep 8.

Phoenix Australia - Centre for Posttraumatic Mental Health, Centenary of Anzac Centre, Department of Psychiatry, University of Melbourne, Australia.

Objective: Problem anger and poor sleep are common, particularly in military and veteran populations, but the nature of the relationship is poorly understood, and treatment approaches would benefit from improved understanding of how these constructs interact. Ecological momentary assessment (EMA) is suitable for monitoring day-to-day fluctuations in symptoms, and modelling dynamic relationships between variables.

Methods: This study aimed to examine these fluctuations and relationships involving sleep quality and anger experiences among veterans. Read More

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September 2021

Longitudinal Genomic Characterization of Carbapenemase-producing Enterobacteriaceae (CPE) Reveals Changing Pattern of CPEs Isolated in Hong Kong Hospitals.

Int J Antimicrob Agents 2021 Sep 12:106430. Epub 2021 Sep 12.

Department of Microbiology, the Chinese University of Hong Kong, Hong Kong, China; Prince of Wales Hospital, Hong Kong, China. Electronic address:

A rising trend of carbapenemase-producing Enterobacteriaceae (CPE) isolated from patients was observed after implementing an active CPE surveillance programme in Hong Kong hospitals from 2011. We described the molecular epidemiology of 567 CPE from patients of three of seven public hospital clusters in Hong Kong. During a 7-year period, the incidence of CPE isolation increased from 0. Read More

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September 2021

The exposome in practice: an exploratory panel study of biomarkers of air pollutant exposure in Chinese people aged 60-69 years (China BAPE Study).

Environ Int 2021 Sep 12;157:106866. Epub 2021 Sep 12.

China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China; Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China. Electronic address:

The exposome overhauls conventional environmental health impact research paradigms and provides a novel methodological framework that comprehensively addresses the complex, highly dynamic interplays of exogenous exposures, endogenous exposures, and modifiable factors in humans. Holistic assessments of the adverse health effects and systematic elucidation of the mechanisms underlying environmental exposures are major scientific challenges with widespread societal implications. However, to date, few studies have comprehensively and simultaneously measured airborne pollutant exposures and explored the associated biomarkers in susceptible healthy elderly subjects, potentially resulting in the suboptimal assessment and management of health risks. Read More

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September 2021

Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging.

Cell Rep 2021 Sep;36(11):109689

The Garvan Institute of Medical Research, St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW 2010, Australia.

Assessing drug response within live native tissue provides increased fidelity with regards to optimizing efficacy while minimizing off-target effects. Here, using longitudinal intravital imaging of a Rac1-Förster resonance energy transfer (FRET) biosensor mouse coupled with in vivo photoswitching to track intratumoral movement, we help guide treatment scheduling in a live breast cancer setting to impair metastatic progression. We uncover altered Rac1 activity at the center versus invasive border of tumors and demonstrate enhanced Rac1 activity of cells in close proximity to live tumor vasculature using optical window imaging. Read More

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September 2021

Using an implementation science approach to build leader facilitation capability in healthcare: a novel approach for enhancing action learning set facilitation.

J Health Organ Manag 2021 Sep;ahead-of-print(ahead-of-print)

Faculty of Health and Medical Sciences, School of Psychology, The University of Adelaide, Adelaide, Australia.

Purpose: The study describes the implementation of a novel strategy, entitled the Action Learning Set Facilitation Model, to develop internal facilitation capability to lead change. The Model incorporated the Novice-Experienced-Expert pathway, a facilitation development approach underpinning the integrated-Promoting Action on Research Implementation in Health Services Implementation Framework, with action learning methodology.

Design/methodology/approach: A mixed-methods descriptive approach reports the results of 22 interviews, 182 Action Learning Sets and 159 post program survey data sets to explore facilitator experiences, strengths and potential application of the Model. Read More

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September 2021

Adiponectin, leptin and resistin and the risk of dementia.

J Gerontol A Biol Sci Med Sci 2021 Sep 15. Epub 2021 Sep 15.

Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.

Background: Adipokines are hormones secreted by adipose tissue with roles in energy homeostasis and regulation of metabolism. Their dysregulation is suggested to contribute to the increased risk of dementia seen with midlife obesity, but longitudinal studies investigating this are scarce. We determined the association between plasma levels of adiponectin, leptin and resistin with the risk of dementia. Read More

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September 2021

Genome-wide analysis of thyroid function in Australian adolescents highlights SERPINA7 and NCOA3.

Eur J Endocrinol 2021 Sep 1. Epub 2021 Sep 1.

S Wilson, Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Australia.

Objective Genetic factors underpin the narrow intraindividual variability of thyroid function, although precise contributions of environmental versus genetic factors remain uncertain. We sought to clarify the heritability of thyroid function traits and thyroid peroxidase antibody (TPOAb) positivity and identify single nucleotide polymorphisms (SNPs) contributing to the trait variance. Methods Heritability of thyroid stimulating hormone (TSH), free T4 (fT4), free T3 (fT3) and TPOAb in a cohort of 2854 euthyroid, dizygous and monozygous twins (age range 11. Read More

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September 2021

Adverse Childhood Experiences and Depressive Symptoms among Young Adult Hispanic Immigrants: Moderating and Mediating Effects of Distinct Facets of Acculturation Stress.

Issues Ment Health Nurs 2021 Sep 15:1-11. Epub 2021 Sep 15.

School of Nursing, Duke University, Durham, North Carolina, USA.

Hispanic immigrants experience more adverse childhood experiences (ACEs) and depressive symptom chronicity/severity than non-Hispanic peers. Acculturation stress relates to both depressive symptoms and ACEs, but the mechanism is not well-understood. We conducted a secondary data analysis of baseline data, from an ongoing longitudinal study to test theoretically-based mediating and moderating effects of acculturation stress on the relationship between ACEs and depression in a sample of young adult Hispanic immigrants ( = 391). Read More

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September 2021

The Assessment of Functional Movement in Children and Adolescents: A Systematic Review and Meta-Analysis.

Sports Med 2021 Sep 15. Epub 2021 Sep 15.

School of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, Ireland.

Background: The Functional Movement Screen™ (FMS™) is an assessment of human movement that may signal potential deficits that could predispose an otherwise healthy person to injury risk. FMS™ scores are well reported in both athletic and adult samples. However, to date, there has been no comprehensive systematic review and meta-analysis of FMS™ data among school-aged children and adolescents. Read More

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September 2021

Perceived quality of life (QOLIE-31-P), depression (NDDI-E), anxiety (GAD-7), and insomnia in patients with epilepsy attended at a refractory epilepsy unit in real-life clinical practice.

Neurol Sci 2021 Sep 15. Epub 2021 Sep 15.

Epilepsy Unit, Neurology Department, Hospital Universitario de La Princesa & Instituto de Investigación Sanitaria La Princesa, Madrid, Spain.

Objectives: This study aims to evaluate the relationship between psychiatric comorbidity (anxiety and depression), somnolence, and quality of life, using validated scales in patients with epilepsy in real-life clinical practice and clinical and demographic variables.

Methods: A cross-sectional observational study was conducted. Self-administered scales of anxiety disorders (GAD-7), depression (NDDI-E), somnolence (Epworth Sleepiness Scale (ESS)), and quality of life (QOLIE-31-P) in patients with epilepsy treated in the refractory epilepsy unit of a tertiary hospital were employed. Read More

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September 2021

Comparison between cystic biliary atresia and choledochal cyst: a clinical controlled study.

Pediatr Surg Int 2021 Sep 15. Epub 2021 Sep 15.

Department of General Surgery, Capital Institute of Pediatrics, Beijing, China.

Purpose: It is difficult to distinguish cystic biliary atresia (CBA) from choledochal cyst (CC) before intraoperative cholangiography in neonates or young infants because of the similar ultrasonographic patterns and clinical manifestations. This study is to investigate the difference of clinical parameters between CBA and CC.

Methods: 96 patients with cyst at hepatic hilum whose ages were less than 120 days during the period from Jan'2013 to Nov'2015 were retrospectively studied, they were divided into CBA group and CC group by intraoperative cholangiography, there were 29 cases of CBA and 67 cases of CC. Read More

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September 2021

Associations of dietary glycemic index and load during pregnancy with blood pressure, placental hemodynamic parameters and the risk of gestational hypertensive disorders.

Eur J Nutr 2021 Sep 15. Epub 2021 Sep 15.

The Generation R Study Group, Erasmus MC, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.

Purpose: The aim of this study was to examine the associations of dietary glycemic index and load with gestational blood pressure, placental hemodynamic parameters and the risk of gestational hypertensive disorders.

Methods: In a population-based cohort among 3378 pregnant Dutch women, dietary glycemic index and load were assessed from food frequency questionnaires at median 13.4 (95% range 9. Read More

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September 2021

Association of Myocardial Blood Flow Reserve With Adverse Left Ventricular Remodeling in Patients With Aortic Stenosis: The Microvascular Disease in Aortic Stenosis (MIDAS) Study.

JAMA Cardiol 2021 Sep 15. Epub 2021 Sep 15.

Cardiovascular Imaging Program, Division of Cardiovascular Medicine, Division of Cardiac Surgery, Heart and Vascular Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Importance: Impaired myocardial flow reserve (MFR) and stress myocardial blood flow (MBF) on positron emission tomography (PET) myocardial perfusion imaging may identify adverse myocardial characteristics, including myocardial stress and injury in aortic stenosis (AS).

Objective: To investigate whether MFR and stress MBF are associated with LV structure and function derangements, and whether these parameters improve after aortic valve replacement (AVR).

Design, Setting, And Participants: In this single-center prospective observational study in Boston, Massachusetts, from 2018 to 2020, patients with predominantly moderate to severe AS underwent ammonia N13 PET myocardial perfusion imaging for myocardial blood flow (MBF) quantification, resting transthoracic echocardiography (TTE) for assessment of myocardial structure and function, and measurement of circulating biomarkers for myocardial injury and wall stress. Read More

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September 2021

Comparative Effectiveness and Functional Outcome of C2 Dome-like Expansive Versus C2 Expansive Open-door Laminoplasty for Upper Cervical Ossification of the Posterior Longitudinal Ligament: A Retrospective Cohort Study.

Spine (Phila Pa 1976) 2021 Sep 14. Epub 2021 Sep 14.

Department of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou City, Zhejiang Province, PR China Orthopedics Research Institute of Zhejiang University, Hangzhou City, Zhejiang Province, PR China Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, P.R. China.

Study Design: Retrospective Cohort Study.

Objectives: This study compared the function and radiographical outcomes of the patients who underwent C2 dome-like expansive laminoplasty to those C2 expansive open-door laminoplasty for the treatment of OPLL with C2 involved.

Summary Of Background Data: There are few comparative studies of these two surgical methods. Read More

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September 2021

Legacy effect on neuropsychological function in HIV-infected men on combination antiretroviral therapy.

AIDS 2021 Sep 13. Epub 2021 Sep 13.

Departments of Statistics, University of Pittsburgh Departments of Psychiatry, University of Pittsburgh Departments of Biostatistics, University of Pittsburgh Departments of Epidemiology, Graduate School of Public Health, University of Pittsburgh Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh Department of Neurology, David Geffen School of Medicine, UCLA Department of Psychiatry, Rush University School of Medicine Departments of Psychiatry, The Johns Hopkins University School of Medicine Department of Radiology, Northwestern University Neurology, The Johns Hopkins University School of Medicine Department of Epidemiology, Bloomberg School of Public Health, The Johns Hopkins University Departments of Neurology, University of Pittsburgh Departments of Psychology, University of Pittsburgh.

Objective: To determine whether cART initiation alters the trajectory of cognitive performance in HIV+ men, and whether cognition prior to cART predicts post-cART function.

Design: Longitudinal cohort study. Multicenter AIDS Cohort Study. Read More

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September 2021

Young Sexual Minority Adolescent Experiences of Self-expression and Isolation on Social Media: Cross-sectional Survey Study.

JMIR Ment Health 2021 Sep 15;8(9):e26207. Epub 2021 Sep 15.

Wellesley Centers for Women, Wellesley College, Wellesley, MA, United States.

Background: Early adolescent years are marked by pervasive self- and peer-regulation regarding gender and sexuality norms, which can affect the mental well-being of sexual minority youth. During this developmental period, social media use is also emerging as a dominant mode of communication with peers, allowing for both risk and resilient behaviors that can impact well-being.

Objective: This exploratory study aims to examine how sexual minorities in middle school use social media, who they are connected to and for what purposes, and the associations between these behaviors and mental well-being compared with their heterosexual peers. Read More

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September 2021

A Cyberbullying Media-Based Prevention Intervention for Adolescents on Instagram: Pilot Randomized Controlled Trial.

JMIR Ment Health 2021 Sep 15;8(9):e26029. Epub 2021 Sep 15.

Brown-Lifespan Center for Digital Health, Providence, RI, United States.

Background: Between 15% and 70% of adolescents report experiencing cybervictimization. Cybervictimization is associated with multiple negative consequences, including depressed mood. Few validated, easily disseminated interventions exist to prevent cybervictimization and its consequences. Read More

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September 2021

Mobile App for Parental Empowerment for Caregivers of Children With Autism Spectrum Disorders: Prospective Open Trial.

JMIR Ment Health 2021 Sep 15;8(9):e27803. Epub 2021 Sep 15.

Department of Psychiatry, Hôpital St Antoine, Assistance Publique Hôpitaux de Paris, Paris, France.

Background: Conflicting data emerge from literature regarding the actual use of smartphone apps in medicine; some considered the introduction of smartphone apps in medicine to be a breakthrough, while others suggested that, in real-life, the use of smartphone apps in medicine is disappointingly low. Yet, digital tools become more present in medicine daily. To empower parents of a child with autism spectrum disorder, we developed the Smartautism smartphone app, which asks questions and provides feedback, using a screen with simple curves. Read More

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September 2021

Shift in Social Media App Usage During COVID-19 Lockdown and Clinical Anxiety Symptoms: Machine Learning-Based Ecological Momentary Assessment Study.

JMIR Ment Health 2021 Sep 15;8(9):e30833. Epub 2021 Sep 15.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

Background: Anxiety symptoms during public health crises are associated with adverse psychiatric outcomes and impaired health decision-making. The interaction between real-time social media use patterns and clinical anxiety during infectious disease outbreaks is underexplored.

Objective: We aimed to evaluate the usage pattern of 2 types of social media apps (communication and social networking) among patients in outpatient psychiatric treatment during the COVID-19 surge and lockdown in Madrid, Spain and their short-term anxiety symptoms (7-item General Anxiety Disorder scale) at clinical follow-up. Read More

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September 2021

Collaboration of a detrimental HLA-B*35:01 allele with HLA-A*24:02 in co-evolution of HIV-1 with T-cells leading to poorer clinical outcomes.

J Virol 2021 Sep 15:JVI0125921. Epub 2021 Sep 15.

Tokyo Laboratory and Division of International Collaboration Research, Joint Research Center for Human Retrovirus Infection.

Although mutant-specific T-cells are elicited in some individuals infected with HIV-1 mutant viruses, the detailed characteristics of these T-cells remain unknown. A recent study showed that the accumulation of strains expressing Nef135F, which were selected by HLA-A*24:02-restricted T-cells, was associated with poor outcomes in individuals with the detrimental HLA-B*35:01 allele, and that HLA-B*35:01-restricted NefYF9(Nef135-143)-specific T-cells failed to recognize target cells infected with Nef135F mutant viruses. Here we investigated HLA-B*35:01-restricted T-cells specific for the NefFF9 epitope incorporating the Nef135F mutation. Read More

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September 2021

All-cause acute care hospitalization rates of immigrants and the Canadian-born population: A linkage study.

Health Rep 2021 Sep;32(9):3-13

Health Analysis Division, Statistics Canada, Ottawa, Ontario.

Background: As Canadian immigration levels increase, knowledge concerning immigrant health becomes increasingly important for health system policy and planning. This study compares the rate of all-cause hospitalization among immigrants with that of their Canadian-born counterparts.

Data And Methods: Using records from the Discharge Abstract Database (2004/2005 to 2016/2017) and the Ontario Mental Health Reporting System (2006/2007 to 2017/2018) linked to the 2016 Longitudinal Immigration Database, this study compared the age-standardized hospitalization rates (ASHRs) among immigrants with those of the Canadian-born population; the latter were obtained from a linkage based on the 2011 National Household Survey. Read More

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September 2021

Effect of Health Shocks on Poverty Status in South Korea: Exploring the Mechanism of Medical Impoverishment.

Chang-O Kim

Int J Health Policy Manag 2021 Sep 5. Epub 2021 Sep 5.

Visiting Doctors Program of Medical Home, Seoul, Republic of Korea.

Background: South Korea has the highest out-of-pocket burden for medical expenses among the Organisation for Economic Co-operation and Development (OECD) member countries and has no formal sickness benefit system, along with United States and Switzerland, greatly increasing the risk of poverty due to a sudden illness.

Methods: We identify the causal effect of health shocks on poverty status and explore the mechanisms of medical impoverishment by analyzing longitudinal data from 13 670 households that participated in the representative Korean Welfare Panel Study (KOWEPS) from 2007 to 2016. In this study, we define a as a case in which no household members were hospitalized in the previous year, but together they had more than 30 days of hospitalization in this year. Read More

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September 2021

Genetic variation in genes regulating skeletal muscle regeneration and tissue remodelling associated with weight loss in chronic obstructive pulmonary disease.

J Cachexia Sarcopenia Muscle 2021 Sep 15. Epub 2021 Sep 15.

Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

Background: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death globally. COPD patients with cachexia or weight loss have increased risk of death independent of body mass index (BMI) and lung function. We tested the hypothesis genetic variation is associated with weight loss in COPD using a genome-wide association study approach. Read More

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September 2021

Patient Empowerment and Associations with Disease Activity and Pain-Related and Lifestyle Factors in Patients With Rheumatoid Arthritis.

ACR Open Rheumatol 2021 Sep 15. Epub 2021 Sep 15.

Spenshult Research and Development Centre, Halmstad, Sweden, and Lund University, Lund, Sweden.

Background: Empowerment is important to patients with rheumatoid arthritis (RA) because most care is in the form of self-management. The aim was to study levels of empowerment and associated variables in patients with RA and to investigate longitudinal clinical data in patients with low and high empowerment.

Methods: A postal survey was sent in 2017 to patients with RA from the BARFOT (Better Anti-Rheumatic Pharmacotherapy) cohort that included questions about disease activity, pain-related factors, lifestyle habits, and contained the Swedish Rheumatic Disease Empowerment Scale (SWE-RES-23). Read More

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September 2021

Child growth faltering dynamics in food insecure districts in rural Ethiopia.

Matern Child Nutr 2021 Sep 15:e13262. Epub 2021 Sep 15.

Center for Food Science and Nutrition. College of Natural Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Child undernutrition disproportionally affects children in low- and middle-income countries. In Ethiopia, both wasting and stunting are serious public health concerns, with high human and economic costs. Understanding the dynamics in ponderal and linear growth faltering is critical to inform the design of innovative interventions that can prevent both wasting and stunting in poor and complex settings. Read More

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September 2021

Isolated diastolic hypertension and target organ damage: Findings from the STANISLAS cohort.

Clin Cardiol 2021 Sep 15. Epub 2021 Sep 15.

Université de Lorraine, Inserm, Centre d'Investigations Cliniques, - Plurithématique 14-33, and Inserm U1116, CHRU Nancy, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France.

Background: Isolated diastolic hypertension (IDH) is defined as diastolic blood pressure (DBP) ≥80 mmHg and systolic blood pressure (SBP) <130 mmHg according to 2017 ACC/AHA guidelines. The effective cardiovascular risk linked to IDH is debated.

Hypothesis: IDH might contribute marginally to hypertension-related target organ damage (TOD) development. Read More

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September 2021