124,158 results match your criteria long-term outcomes

Simulation Modeling for the Economic Evaluation of Population-Based Dietary Policies: A Systematic Scoping Review.

Adv Nutr 2021 Apr 19. Epub 2021 Apr 19.

Institute of Health Economics and Health Care Management, Helmholtz Zentrum München, Neuherberg, Germany.

Simulation modeling can be useful to estimate the long-term health and economic impacts of population-based dietary policies. We conducted a systematic scoping review following the PRISMA-ScR (Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews) guideline to map and critically appraise economic evaluations of population-based dietary policies using simulation models. We searched Medline, Embase, and EconLit for studies published in English after 2005. Read More

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The utility and cultural specificity of cognitive-based interventions in preventing cognitive decline among healthy older adults in Asia: A systematic review.

Asian J Psychiatr 2021 Apr 6;60:102646. Epub 2021 Apr 6.

Clinical Psychology and Behavioural Health Program, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia; Centre for Healthy Ageing and Wellness (H-CARE), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

Background: The effects of aging and its associated cognitive decline is particularly acute in Asia given the exponential growth of older adults as a proportion of the population as a whole. Many structured cognitive interventions have been proposed to prevent the cognitive decline typically seen in older age, but their utility as a viable means of achieving these goals is questionable.

Objectives: To summarize and synthesize evidence on the utility and methodological quality of cognitive-based interventions on cognitive performance and associated secondary outcomes among healthy older adults in Asia, as well as novel, culture-specific components of cognitive interventions across the region. Read More

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Prognostic factors in patients with advanced non-small cell lung cancer after long-term Anti-PD-1 therapy (HOT1902).

Lung Cancer 2021 Apr 15;156:12-19. Epub 2021 Apr 15.

Department of Respiratory Medicine, KKR Sapporo Medical Center, Sapporo, Japan.

Objectives: Limited information is available on the appropriate treatment duration of immune checkpoint inhibitors (ICIs). We aimed to identify candidates who would benefit from ICI discontinuation after one year of treatment for metastatic non-small cell lung cancer (NSCLC).

Materials And Methods: This retrospective multi-institutional observational study examined medical records of all consecutive patients with advanced or recurrent NSCLC, who started ICI monotherapy at 15 institutions in Japan between December 2015 and December 2017. Read More

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Stereoelectroencephalography-guided radiofrequency thermocoagulation for hypothalamic hamartoma: Electroclinical patterns and the relationship with surgical prognosis.

Epilepsy Behav 2021 Apr 16;118:107957. Epub 2021 Apr 16.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Department of Stereotactic and Functional Neurosurgery, Beijing Neurosurgical Institute, Beijing, China. Electronic address:

Background: Radiofrequency thermocoagulation (RFTC) guided by stereo-electroencephalography (SEEG) has been proved to be a safe method to reduce seizure frequency in patients with drug-resistant epilepsy. However, there are few reports addressing the value and safety of this procedure in hypothalamic hamartoma (HH).

Objective: To present the results of our experience using SEEG-guided RFTC in HH patients with drug-resistant epilepsy, and identify outcome predictors. Read More

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Nursing staff member experiences with household model implementation in a nursing home setting.

Geriatr Nurs 2021 Apr 16;42(3):748-755. Epub 2021 Apr 16.

School of Health Sciences, Central Michigan University, Mount Pleasant, MI 48859, USA.

This qualitative study used conventional content analysis of interview data to examine nursing staff members' experiences with Household Model implementation in a nursing home setting. Staff members were recruited from the skilled nursing center post implementation and completed individual interviews (N=16). Participants described the impact of implementation in relation to three categories: antecedents, explicit reactions and change consequences. Read More

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Burden of Pre-operative Opioid Use and Its Impact on Healthcare Utilization After Primary Single Level Lumbar Discectomy.

Spine J 2021 Apr 16. Epub 2021 Apr 16.

Department of Neurosurgery, University of Louisville, 200 Abraham Flexner Hwy, Louisville, KY, U.S.A. 40202. Electronic address:

Background Context: The complication profile and higher cost of care associated with pre-operative opioid use and spinal fusion is well described. However, the burden of opioid use and its impact in patients undergoing lumbar discectomy is not known. Knowledge of this, especially for a relatively benign and predictable procedure will be important in bundled and value-based payment models. Read More

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Recipient Obesity and Kidney Transplant Outcomes: A Mate-Kidney Analysis.

Am J Kidney Dis 2021 Apr 16. Epub 2021 Apr 16.

Section of Nephrology, Department of Medicine, University of Chicago, IL. Electronic address:

Rationale & Objective: The impact of extreme recipient obesity on long-term kidney transplant outcomes has been controversial. This study sought to evaluate the association of various levels of recipient obesity on kidney transplantation outcomes by comparing mate-kidney recipient pairs to address possible confounding effects of donor characteristics on post-transplant outcomes.

Design: Nationwide observational cohort study, using mate-kidney models. Read More

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Prognostic value of the postoperative neutrophil-lymphocyte ratio in solid tumors: A meta-analysis.

PLoS One 2021 19;16(4):e0250091. Epub 2021 Apr 19.

School of Clinical Medicine, Tsinghua University, Haidian District, Beijing, China.

Purpose: Numerous studies have demonstrated that a variety of systemic inflammatory markers were associated with the survival of different tumors. However, the association between elevated postoperative neutrophil-lymphocyte ratio (postNLR) and long-term outcomes, including overall survival (OS), disease-free survival (DFS), in patients with solid tumors remains controversial. A systematic review was conducted to explore the association between the postNLR and long-term outcomes in solid tumors. Read More

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High willingness to vaccinate against COVID-19 despite safety concerns: a Twitter poll analysis on public health opinion.

J Med Internet Res 2021 Apr 17. Epub 2021 Apr 17.

Ludwig Boltzmann Institute Digital Health and Patient Safety, Medical University of Vienna, Spitalgasse 23, Vienna, AT.

Background: On the 30th of January 2020, the WHO's Emergency Committee declared the rapid worldwide spread of COVID-19, a global health emergency. Since then tireless efforts have been made to mitigate the spread of the disease and its impact, mostly relying on non-pharmaceutical interventions. By December 2020, the safety and efficacy of the first COVID-19 vaccines have been demonstrated. Read More

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The Relationship of the Type of Intracerebral Hemorrhage to Early Disease Evolution and Long-Term Prognosis After r-tPA Thrombolysis.

Clin Appl Thromb Hemost 2021 Jan-Dec;27:1076029621992125

Department of Neurology, 26453The Second Affiliate Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

To investigate the relationship of different subtypes of intracerebral hemorrhage (ICH) to early disease evolution and long-term prognosis in patients with acute cerebral infarction after intravenous recombinant tissue plasminogen activator(r-tPA). Seventy ischemic stroke patients treated with intravenous r-tPA who underwent computed tomography (CT) within 24 hours after thrombolysis were divided into 4 types (hemorrhagic infarction type 1 [HI-1], HI-2, parenchymal hemorrhage type 1 [PH-1], or PH-2 which according to the size of the hematoma and the presence or absence of space-occupying effect). Early evolution of the disease was observed by the change in the National Institutes of Health Stroke Scale (NIHSS) score within 24 hours after thrombolysis. Read More

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Five-Year Outcomes With Pembrolizumab Versus Chemotherapy for Metastatic Non-Small-Cell Lung Cancer With PD-L1 Tumor Proportion Score ≥ 50.

J Clin Oncol 2021 Apr 19:JCO2100174. Epub 2021 Apr 19.

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD.

Purpose: We report the first 5-year follow-up of any first-line phase III immunotherapy trial for non-small-cell lung cancer (NSCLC). KEYNOTE-024 (ClinicalTrials.gov identifier: NCT02142738) is an open-label, randomized controlled trial of pembrolizumab compared with platinum-based chemotherapy in patients with previously untreated NSCLC with a programmed death ligand-1 (PD-L1) tumor proportion score of at least 50% and no sensitizing or alterations. Read More

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Is Comprehensive Geriatric Assessment Admission Avoidance Hospital at Home an Alternative to Hospital Admission for Older Persons? : A Randomized Trial.

Ann Intern Med 2021 Apr 20. Epub 2021 Apr 20.

University of Leeds, Leeds, United Kingdom (J.Y.).

Background: Delivering hospital-level care with comprehensive geriatric assessment (CGA) in the home is one approach to deal with the increased demand for bed-based hospital care, but clinical effectiveness is uncertain.

Objective: To assess the clinical effectiveness of admission avoidance hospital at home (HAH) with CGA for older persons.

Design: Multisite randomized trial. Read More

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Autoantibodies to LG3 are Associated with Poor Long-term Survival after Liver Re-transplantation.

Clin Transplant 2021 Apr 19:e14318. Epub 2021 Apr 19.

Departmnt of Pathology, University of Pittsburgh, Pittsburgh.

Autoantibodies are detrimental to the survival of organ transplantation. We demonstrated that Angiotensin II Type I Receptor agonistic autoantibodies (AT1R-AA) were associated with poor outcomes after liver retransplantation. To examine the effect of other autoantibodies, we studied a retrospective cohort of 93 patients who received a second liver transplant. Read More

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The Impact of Coronavirus (COVID-19) Related Public-Health Measures on Training Behaviours of Individuals Previously Participating in Resistance Training: A Cross-Sectional Survey Study.

Sports Med 2021 Apr 19. Epub 2021 Apr 19.

Solent University, Southampton, UK.

Introduction: Understanding the impact of lockdown upon resistance training (RT), and how people adapted their RT behaviours, has implications for strategies to maintain engagement in similar positive health behaviours. Further, doing so will provide a baseline for investigation of the long-term effects of these public health measures upon behaviours and perceptions, and facilitate future follow-up study.

Objectives: To determine how the onset of coronavirus (COVID-19), and associated 'lockdown', affected RT behaviours, in addition to motivation, perceived effectiveness, enjoyment, and intent to continue, in those who regularly performed RT prior to the pandemic. Read More

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Evolution of Treatment Paradigms in Newly Diagnosed Multiple Myeloma.

Drugs 2021 Apr 19. Epub 2021 Apr 19.

Division of Oncology and Hematology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 68198, USA.

The plasma cell neoplasm multiple myeloma (MM) is currently considered incurable. However, significant advances in treatment options over the past 20 years have led to unprecedented response rates to initial therapy as well as prolonged survival rates. Induction regimens have evolved from alkylator-based therapies to those consisting of immunomodulatory drugs and proteasome inhibitors. Read More

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Duration of response after DEB-TACE compared to lipiodol-TACE in HCC-naïve patients: a propensity score matching analysis.

Eur Radiol 2021 Apr 19. Epub 2021 Apr 19.

Department of Interventional Radiology, Pisa University Hospital, Via Paradisa 2, 56126, Pisa, Italy.

Objectives: To retrospectively compare long-term outcomes of first-line drug-eluting particle (DEB)- transarterial chemoembolization (TACE) and lipiodol-TACE, in patients with unresectable hepatocellular (HCC).

Methods: We retrospectively reviewed our database to identify adult patients with treatment-naïve unresectable HCC, who underwent TACE from 2006 to 2013. Patients were excluded in the absence of complete medical records relative to first TACE, 1-month follow-up, and/or sufficient follow-up data. Read More

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Association of Postoperative Infections After Fractures With Long-term Income Among Adults.

JAMA Netw Open 2021 Apr 1;4(4):e216673. Epub 2021 Apr 1.

Department of Public and Occupational Health, Amsterdam Universitair Medische Centra, University of Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, the Netherlands.

Importance: Postoperative infections after a fracture exert tremendous costs on the health care system. However, the patient economic burden associated with a postoperative infection is unclear.

Objective: To evaluate the association between a postoperative infection and long-term income among patients with surgically treated fractures. Read More

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Propensity score-based analysis of long-term follow-up in patients supported with durable centrifugal left ventricular assist devices: the EUROMACS analysis.

Eur J Cardiothorac Surg 2021 Apr 19. Epub 2021 Apr 19.

Department of Cardiovascular Surgery, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.

Objectives: The HeartWare HVAD (HW) and the HeartMate3 (HM3) are presently the most commonly used continuous-flow left ventricular assist devices worldwide. We compared the outcomes of patients supported with either of these 2 devices based on data from the EUROMACS (European Registry for Patients with Mechanical Circulatory Support).

Methods: A retrospective analysis of the survival and complications profile in propensity score-matched adult patients enrolled in the EUROMACS between 01 January 2016 and 01 September 2020 and supported with either an HW or HM3. Read More

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Association of Oral Corticosteroid Bursts With Severe Adverse Events in Children.

JAMA Pediatr 2021 Apr 19. Epub 2021 Apr 19.

Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.

Importance: The adverse effects from the long-term use of oral corticosteroids are known, but, to our knowledge, few studies have reported the risk of corticosteroid bursts, particularly among children.

Objective: To quantify the associations of corticosteroid bursts with severe adverse events, including gastrointestinal (GI) bleeding, sepsis, pneumonia, and glaucoma, in children.

Design, Setting, And Participants: This cohort study used data derived from the National Health Insurance Research Database in Taiwan from January 1, 2013, to December 31, 2017, on children younger than 18 years of age and used a self-controlled case series design. Read More

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Ketogenic diet therapy in Alzheimer's disease: an updated review.

Curr Opin Clin Nutr Metab Care 2021 Apr 16. Epub 2021 Apr 16.

Université de Paris INSERM UMRS1144 Optimisation Thérapeutique en Neuropsychopharmacologie Centre de Neurologie Cognitive/CMRR Paris Nord Ile de France, APHP Nord Université de Paris, Lariboisière Hospital, Paris, France.

Purpose Of Review: Ketogenic diets (KD) are validated treatments of pharmacoresistant epilepsy. Their interest in neurodegenerative diseases such as Alzheimer's disease (AD) has been suggested, because ketone bodies may reduce neuroinflammation, improve neurotransmitters transport pathway, synaptic maintenance, and reduce brain β-amyloid deposition. In this updated review, we aimed at critically examining the evidence of the past 2 years regarding KD or ketogenic supplements (KS) on cognitive and biological/neuropathological outcomes. Read More

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[The orthognathic surgery so called « early »].

Orthod Fr 2021 Mar;92(1):67-93

Unité Fonctionnelle d'ODF, Hôpital de la Timone, 264 rue Saint-Pierre, 13005 Marseille, France, Hôpitaux Universitaires de Marseille Conception, 147 boulevard Baille, 13005 Marseille, France.

Some young patients with a significant skeletal shift with a strong morpho-aesthetic and psychological impact may require surgical correction during their growth. A good understanding of facial growth, the different treatment options and the effects of surgery on the post-operative growth pattern will allow the practitioner to use the technique most suited to each of his patients and improve long-term treatment outcomes. So-called « interceptive » surgery may therefore be considered in cases of severe skeletal dysmorphism of secondary or functional origin. Read More

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Chronic kidney disease in acute coronary syndromes: real world data of long-term outcomes.

Future Cardiol 2021 Apr 19. Epub 2021 Apr 19.

Serviço de Cardiologia, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Patients with chronic kidney disease (CKD) are at increased cardiovascular risk. Patients with acute coronary syndrome were retrospectively allocated to three groups (stage 3A, stage 3B or stage 4) based on the Kidney Disease Improving Global Outcomes classification formulas: the CKD Epidemiology Collaboration (CKD-EPI; N = 401) and the modification of diet in renal disease (n = 355). The primary end point was all-cause mortality (median follow-up time, 32 months [15-70]). Read More

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Digital interventions for the management of chronic obstructive pulmonary disease.

Cochrane Database Syst Rev 2021 Apr 19;4:CD013246. Epub 2021 Apr 19.

Department of Rural Health, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Australia.

Background: Chronic obstructive pulmonary disease (COPD) is associated with dyspnoea, cough or sputum production (or both) and affects quality of life and functional status. More efficient approaches to alternative management that may include patients themselves managing their condition need further exploration in order to reduce the impact on both patients and healthcare services. Digital interventions may potentially impact on health behaviours and encourage patient engagement. Read More

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Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis.

Cochrane Database Syst Rev 2021 Apr 19;4:CD011535. Epub 2021 Apr 19.

Department of Dermatology, Hôpital Henri Mondor, Créteil, France.

Background: Psoriasis is an immune-mediated disease for which some people have a genetic predisposition. The condition manifests in inflammatory effects on either the skin or joints, or both, and it has a major impact on quality of life. Although there is currently no cure for psoriasis, various treatment strategies allow sustained control of disease signs and symptoms. Read More

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Myelin Oligodendrocyte Glycoprotein Antibody-Associated Optic Neuritis-A Review.

J Neuroophthalmol 2021 Apr 14. Epub 2021 Apr 14.

Neuro-Ophthalmology, Department of Ophthalmology, Queen Elizabeth Hospital, University Hospitals Birmingham, Birmingham, United Kingdom.

Abstract: Our understanding of demyelinating optic neuritis has substantially evolved over the past 2 decades. With advancements in serological testing, antibodies against myelin oligodendrocyte glycoprotein (MOG) have been recently discovered in a distinct subset of demyelinating neuroinflammatory disease. Although MOG-immunoglobulin G (IgG)-associated disorder (MOGAD) has previously been seen as a component of neuromyelitis optica spectrum disorder (NMOSD), evidence increasingly suggests that it should be distinguished as a separate condition. Read More

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Antiresorptive treatment and talar collapse after displaced fractures of the talar neck: a long-term follow-up of 19 patients.

Acta Orthop 2021 Apr 18:1-6. Epub 2021 Apr 18.

Department of Orthopedics and Department of Biomedical and Clinical Sciences, Faculty of Health Science, Linköping University, Linköping.

Background and purpose - Displaced fractures of the talar neck are associated with a high risk of structural collapse. In this observational analysis we hypothesized that pharmacological inhibition of osteoclast function might reduce the risk of structural collapse through a reduction in bone resorption during revascularization of the injured bone.Patients and methods - Between 2002 and 2014 we treated 19 patients with displaced fractures of the talar neck with open reduction and internal fixation. Read More

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Whole genome transcriptome analysis of the stomach resected in human vertical sleeve gastrectomy: cutting more than calories.

Physiol Genomics 2021 Apr 19. Epub 2021 Apr 19.

Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, United States.

Background: Vertical sleeve gastrectomy (VSG) is a surgical weight loss procedure that resects 80% of the stomach, creating a tube linking the esophagus to the duodenum. Because of the efficacy and relative simplicity of VSG, it is preferred in the U.S with VSG currently at >61% of bariatric surgeries performed. Read More

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Predictors of Use and Outcomes of Mechanical Valve Replacement in the United States (2008-2017).

J Am Heart Assoc 2021 Apr 19:e019929. Epub 2021 Apr 19.

Department of Cardiovascular Diseases Mayo Clinic School of Medicine Rochester MN.

Background Contemporary nationwide data on the use, predictors, and outcomes of mechanical valve replacement in patients less than 70 years of age are limited. Methods and Results We identified hospitalizations for aortic valve replacement (AVR) or mitral valve replacement (MVR) in the Nationwide Inpatient Sample between January 1, 2008, and December 31, 2017. The study's end points included predictors of mechanical valve replacement and risk-adjusted in-hospital mortality. Read More

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Functional Outcomes and Post-Discharge Care Sought by Patients with COVID-19 Compared to Matched Controls After Completing Inpatient Acute Rehabilitation.

PM R 2021 Apr 19. Epub 2021 Apr 19.

Department of Physical Medicine and Rehabilitation, Sunnyview Rehabilitation Hospital, 1270 Belmont Avenue, Schenectady, New York, USA.

Introduction: A subset of patients with COVID-19 can develop severe illness, resulting in significant functional and cognitive deficits that require acute inpatient rehabilitation. Guidelines following discharge from acute inpatient rehabilitation have not yet been established. This study seeks to establish outcomes of rehabilitation patients with COVID-19 and characterize their need for long term care. Read More

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Long-term outcomes of pulmonary metastasectomy: a multicentre analysis.

ANZ J Surg 2021 Apr 18. Epub 2021 Apr 18.

Department of Cardiothoracic Surgery, Royal Melbourne Hospital, Melbourne, Victoria, Australia.

Background: Many extrapulmonary neoplasms metastasize to the lungs. We conducted a retrospective review of all patients who underwent pulmonary metastasectomy for oligometastatic disease at two centres in order to determine long-term outcomes.

Methods: The study institutions' thoracic surgery databases were searched for all patients who underwent pulmonary metastasectomy from 2000 to 2017. Read More

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