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Outcomes of surgical and/or medical treatment in patients with prolactinomas during long-term follow-up: a retrospective single-centre study.

Horm Mol Biol Clin Investig 2020 Dec 17;42(2):153-157. Epub 2020 Dec 17.

Division of Endocrinology, Faculty of Medicine, Cukurova University, Adana, Turkey.

Objectives: Prolactinoma is the most common cause of pituitary tumours. Current medical guidelines recommend dopamine agonists (cabergoline or bromocriptine) as the initial therapy for prolactinoma. However, surgical removal can also be considered in selected cases, such as patients with macroadenomas with local complications (bleeding or optic chiasm pressure) or those not responding to medical treatment. Read More

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December 2020

Therapeutic plasma exchange in MS refractory relapses: Long-term outcome.

Mult Scler Relat Disord 2021 Jul 25;55:103168. Epub 2021 Jul 25.

Department of Neurology. Fleni. Buenos Aires, Argentina. Electronic address:

Introduction: Therapeutic plasma exchange (TPE) is considered a treatment option for steroid-refractory multiple sclerosis (MS) relapses. Our objective was to assess long-term clinical response to TPE in MS steroid-refractory exacerbations.

Methods: Retrospective study of relapsing remitting MS (RRMS) patients presenting intravenous methylprednisolone (IVMPS)-refractory relapses, who underwent TPE. Read More

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Combination therapy of curcumin and fecal microbiota transplant: Potential treatment of polycystic ovarian syndrome.

Med Hypotheses 2021 Jul 15;154:110644. Epub 2021 Jul 15.

School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India.

Polycystic ovarian syndrome (PCOS) is a combination of various symptoms like anovulation, hirsutism, chronic amenorrhea, infertility, obesity and polycystic ovaries. It affects over 7 million women worldwide. The current strategy to treat this disorder is based on the use of drugs that provide symptomatic relief. Read More

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Long-term outcome after midline lumbar fusion for the treatment of lumbar spine instability due to degenerative disease.

World Neurosurg 2021 Jul 28. Epub 2021 Jul 28.

Department of Neurosurgery, Tomas Bata Regional Hospital, Zlin, Czech Republic (Havlickovo nabrezi 600, 762 75 Zlin). Electronic address:

Background: New surgical techniques have been developed to minimize perioperative damage to paravertebral stabilizing musculotendinous system. Among them, midline lumbar fusion (MIDLF) shows to be a viable option. With data on MIDLF remaining scarce, we assessed its long-term clinical and radiological effects. Read More

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Gender-linked determinants for utilization of long2 term care in community-dwelling adults 65+ in 3 Germany: Results from the population-based 4 KORA-Age study.

Exp Gerontol 2021 Jul 28:111500. Epub 2021 Jul 28.

Institute of Health Economics and Health Care Management, Helmholtz Zentrum München, Germany; Quality Management and Gender Medicine, München Klinik Schwabing, Kölner Platz 1, 80804 Munich, Germany. Electronic address:

Background: The number of people using long-term care (LTC) is increasing steadily, hence, demand for adequate services is rising. The purpose of this exploratory study was to identify relevant gender-linked determinants for utilization of LTC in community-dwelling older adults.

Methods: We examined 4077 females (52. Read More

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Single-stage tracheal transplantation-From bench to bedside.

Am J Transplant 2021 Jul 31. Epub 2021 Jul 31.

Division of Cardiothoracic Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.

We read with great interest and admiration the manuscript by Genden and colleagues titled "Single-stage long-segment tracheal transplantation" (1). In adult patients, the general limits of safe tracheal resection and direct end to end re-anastomosis has always been considered to be a maximum of 5-6 cm. Long-segment tracheal resection and replacement is a challenge and has led to a century-long search for a means of tracheal replacement. Read More

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A semi-Markov model comparing the lifetime cost-effectiveness of mesh prophylaxis to prevent parastomal hernia in patients undergoing end colostomy creation for rectal cancer.

Colorectal Dis 2021 Jul 31. Epub 2021 Jul 31.

The CIPHER study group investigators.

Aim: Parastomal hernia (PSH) is a common problem following colostomy. Using prophylactic mesh during end colostomy creation may reduce PSH incidence, but concerns exist regarding the optimal type of mesh, potential long-term complications, and cost-effectiveness of its use. We evaluated the cost-effectiveness of mesh prophylaxis to prevent PSH in patients undergoing end colostomy for rectal cancer. Read More

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COVID-19 Preparedness and Response Plans from 106 countries: a review from a health systems resilience perspective.

Health Policy Plan 2021 Jul 31. Epub 2021 Jul 31.

Universal Health Coverage and Life Course, World Health Organization, Geneva, Switzerland.

Coronavirus disease (COVID-19) has exposed long-standing fragmentation in health systems strengthening efforts for health security and universal health coverage while these objectives are largely interdependent and complementary. In this prevailing background, we reviewed countries' COVID-19 Preparedness and Response Plans (CPRPs) to assess the extent of integration of non-COVID-19 essential health service continuity considerations alongside emergency response activities. We searched for COVID-19 planning documents from governments and ministries of health, World Health Organization (WHO) country offices and United Nations (UN) country teams. Read More

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Depiction of the genomic and genetic landscape identifies CCL5 as a protective factor in colorectal neuroendocrine carcinoma.

Br J Cancer 2021 Jul 30. Epub 2021 Jul 30.

Department of Medical Oncology, The First Affiliated Hospital Zhejiang, University School of Medicine, Hangzhou, China.

Background: Colorectal neuroendocrine carcinomas (CRNECs) are highly aggressive tumours with poor prognosis and low incidence. To date, the genomic landscape and molecular pathway alterations have not been elucidated.

Methods: Tissue sections and clinical information of CRNEC (n = 35) and CR neuroendocrine tumours (CRNETs) (n = 25) were collected as an in-house cohort (2010-2020). Read More

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Lithium effects on Hippocampus volumes in patients with bipolar disorder.

J Affect Disord 2021 Jul 18;294:521-526. Epub 2021 Jul 18.

Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. Electronic address:

Background: Lithium is one of the most effective medications for bipolar disorder episode prevention, but its mechanism of action is still largely unknown. The hippocampus is a subcortical cerebral structure involved in the formation of emotional responses, cognition and various primitive functions, altered during affective episodes. Deviations in the anatomy or physiology of the hippocampus would partially explain the symptomatology of bipolar subjects, and restoration may reflect treatment response. Read More

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LINC01559 promotes colorectal cancer via sponging miR-1343-3p to modulate PARP1/PTEN/AKT pathway.

Pathol Res Pract 2021 Jun 8;224:153521. Epub 2021 Jun 8.

Fujian Cancer Hospital & Institute, No 420 Fuma Road, Fuzhou, Fujian, 350014, China. Electronic address:

Background: Colorectal cancer (CRC) is considered as one of the commonest tumors and is the major reason of cancer-related deaths around the world. Plentiful evidences have validated that long non-coding RNAs (lncRNAs) play a significant part in various cancers, including CRC. LINC01559 is implicated in the development of various cancers. Read More

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Comparing Artificial Intelligence and Traditional Methods to Identify Factors Associated with Pediatric Asthma Readmission.

Acad Pediatr 2021 Jul 27. Epub 2021 Jul 27.

Department of Pediatrics, University of Miami Miller School of Medicine, and Holtz Children's Hospital, Jackson Health System, Miami, FL.

Objective: To identify and contrast risk factors for six-month pediatric asthma readmissions using traditional models (Cox proportional-hazards and logistic regression) and artificial neural-network modeling.

Methods: This retrospective cohort study of the 2013 Nationwide Readmissions Database included children 5-18 years old with a primary diagnosis of asthma. The primary outcome was time to asthma readmission in the Cox model, and readmission within 180 days in logistic regression. Read More

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A multi-centre analysis of adjuvant contact x-ray brachytherapy (CXB) in rectal cancer patients treated with local excision - preliminary results of the CONTEM1 study.

Radiother Oncol 2021 Jul 27. Epub 2021 Jul 27.

Service de Radiotherapie, Centre Antoine-Lacassagne, Nice, France.

Introduction: Early rectal cancers are increasingly diagnosed through screening programmes and are often treated using local excision (LE). In the case of adverse pathological features completion total mesorectal excision surgery (TME) is the standard recommendation. The morbidity and mortality risks of TME have stimulated the use of adjunctive treatments following LE to achieve organ preservation. Read More

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Couple oriented counselling improves male partner involvement in sexual and reproductive health of a couple: Evidence from the ANRS PRENAHTEST randomized trial.

PLoS One 2021 30;16(7):e0255330. Epub 2021 Jul 30.

Centre Pasteur Cameroon, Epidemiology and Public Health Service, Yaounde, Cameroon.

Background: Male partner involvement (MPI) has been recognized as a priority area to be strengthened in Prevention of Mother to Child Transmission (PMTCT) of HIV. We explored the impact of Couple Oriented Counselling (COC) in MPI in sexual and reproductive health and associated factors.

Method: From February 2009 to October 2011, pregnant women were enrolled at their first antenatal care visit (ANC-1) and followed up until 6 months after delivery in the Mother and Child Center of the Chantal Biya Foundation within the randomized prenahtest multicentric trial. Read More

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Patient delay and associated factors among tuberculosis patients in Gamo zone public health facilities, Southern Ethiopia: An institution-based cross-sectional study.

PLoS One 2021 30;16(7):e0255327. Epub 2021 Jul 30.

Departments of Public Health, Mizan Tepi University, Mizan Aman, Ethiopia.

Background: Delayed tuberculosis diagnosis and treatment increase morbidity, mortality, expenditure, and transmission in the community. Early diagnosis and initiation of treatment are essential for effective TB control. Therefore, the main objective of this study was to assess the magnitude and factors associated with patient delay among tuberculosis patients in Gamo Zone, Southern Ethiopia. Read More

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Comparison of PROMIS Computerized Adaptive Testing versus Fixed Short Forms in Juvenile Myositis.

Arthritis Care Res (Hoboken) 2021 Jul 30. Epub 2021 Jul 30.

Division of Pediatric Rheumatology, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.

Objective: Patient-Reported Outcomes Measurement Information System (PROMIS ) measures can be administered via computerized adaptive testing (CAT) or fixed short forms (FSF), but the empirical benefits of CAT versus FSF are unknown in juvenile myositis (JM). This study assesses if PROMIS CAT is feasible, precise, correlated with FSF, and less prone to respondent burden and floor/ceiling effects than FSF in JM.

Methods: Patients 8-17 yo (self-report and parent proxy) and parents of patients 5-7 yo (only parent proxy) completed PROMIS Fatigue, Pain Interference, Upper Extremity Function, Mobility, Anxiety and Depressive Symptoms measures. Read More

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Innovative treatment targeting gangliosides aimed at blocking the formation of neurotoxic α-synuclein oligomers in Parkinson's disease.

Glycoconj J 2021 Jul 30. Epub 2021 Jul 30.

INSERM UMR_S 1072, Aix-Marseille Université, 13015, Marseille, France.

Parkinson's disease (PD) is a major neurodegenerative disorder which exhibits many of the characteristics of a pandemic. Current therapeutic strategies are centered on the dopaminergic system, with limited efficacy, so that a treatment that has a direct impact on the underlying disease pathogenesis is urgently needed. Although α-synuclein is a privileged target for such therapies, this protein has been in the past wrongly considered as exclusively intracellular, so that the impact of paracrine neurotoxicity mechanisms in PD have been largely ignored. Read More

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[Intervertebral disc-related occupational diseases of the lumbar and cervical spines].

Internist (Berl) 2021 Jul 30. Epub 2021 Jul 30.

Zentrum für Orthopädie, Unfallchirurgie und Paraplegiologie, Konservative Orthopädie und Gutachtenambulanz, Universitätsklinikum Heidelberg, Schlierbacher Landstr. 200a, 69118, Heidelberg, Deutschland.

Intervertebral disc-related diseases of the cervical and lumbar spine are considered to be occupational diseases, if the occupational and medical prerequisites are fulfilled and the causal connection between the prerequisites is likely. The working conditions include occupational burdens with long-term lifting and carrying of heavy loads or long-term activities in an extremely bent position of the torso, long-term carrying of heavy loads on the shoulders and long-term effects of whole-body vibration in a sitting position. A medical prerequisite is fulfilled by a damage pattern with chronic lower back or neck pain and damage of the cervical or lumbar vertebrae in a conform manner. Read More

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Biologicals for moderate-to-severe plaque type psoriasis in pediatric patients.

Expert Rev Clin Immunol 2021 Jul 30:1-9. Epub 2021 Jul 30.

Department of Dermatology, CHU Du Sart Tilman, University of Liège, Liège, Belgium.

Introduction: Psoriasis affects around 2% of children in Europe. The majority of cases is readily managed with topical treatments using corticosteroids without or with calcipotriol. More resistant and extensive moderate-to-severe cases require UVA or UVB phototherapies or conventional systemic treatment including ciclosporin, acitretin and methotrexate. Read More

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Salt sensitivity of blood pressure in childhood and adolescence.

Coral D Hanevold

Pediatr Nephrol 2021 Jul 29. Epub 2021 Jul 29.

University of Washington School of Medicine, Department of Pediatrics, Division of Nephrology, 4800 Sand Point Way NE, M/S OC.9.820, Seattle, WA, 98105, USA.

Although moderation of sodium intake is recommended population-wide, it remains uncertain who benefits from salt restriction. Salt sensitivity refers to changes in blood pressure in response to sodium intake and may occur with or without hypertension. Unfortunately, there is no practical way to assess salt sensitivity in daily practice. Read More

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Trace metals and metalloids in Andean flamingos (Phoenicoparrus andinus) and Puna flamingos (P. jamesi) at two wetlands with different risk of exposure in the Bolivian Altiplano.

Environ Monit Assess 2021 Jul 29;193(8):535. Epub 2021 Jul 29.

Center for Biodiversity and Conservation, American Museum of Natural History, 200 Central Park West, New York, NY, 10024, USA.

Birds are widely used as bioindicators in monitoring programs in wetlands. We compare concentrations of seven trace metals and metalloids (TMM) As, Cd, Cu, Fe, Hg, Pb, Znin both feathers and blood in two flamingo species in two high-altitude wetlands in Bolivia, with different levels of anthropogenic point source pollution. Lake Uru Uru (LUU) receives discharges from mining operations, and also effluents from the nearby city of Oruro, while Laguna Colorada (LCo) does not receive contaminants from anthropogenic sources. Read More

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Physical activity and sedentary behaviour in secondary prevention of coronary artery disease: A review.

Am J Prev Cardiol 2021 Mar 9;5:100146. Epub 2021 Jan 9.

Heart Center, Kuopio University Hospital (KUH), Kuopio, Finland.

Comprehensive management of coronary artery disease (CAD) includes physical exercise as a part of daily lifestyle therapy. Still CAD patients generally have low physical activity (PA) and high sedentary behaviour (SB). This review summarizes the effect of exercise training and habitual PA and SB on physical fitness and quality of life (QoL) as well as on rehospitalizations and mortality in patients with stable CAD, recent acute coronary syndrome (ACS) or recent revascularization. Read More

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Opportunities to improve cardiovascular health in the new American workplace.

Am J Prev Cardiol 2021 Mar 8;5:100136. Epub 2020 Dec 8.

Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Adult working-class Americans spend on average 50% of their workday awake time at their jobs. The vast majority of these jobs involve mostly physically inactive tasks and frequent exposure to unhealthy food options. Traditionally, the workplace has been a challenging environment for cardiovascular prevention, where cardiovascular guidelines have had limited implementation. Read More

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Performance of neutrophil to lymphocyte ratio for the prediction of long-term morbidity and mortality in coronary slow flow phenomenon patients presented with non-ST segment elevation acute coronary syndrome.

J Cardiovasc Thorac Res 2021 1;13(2):125-130. Epub 2021 Mar 1.

Department of Cardiology, University of Health Scienses, Dr. Siyami Ersek Training and Research Hospital, Istanbul, Turkey.

In this study, we aimed to determine if neutrophil to lymphocyte ratio could predict long term morbidity and mortality in patients who hospitalized for non-ST segment elevation acute coronary syndrome (NSTE-ACS) and had coronary slow flow on coronary angiography. In this observational study, 111 patients who presented with NSTE-ACS and diagnosed with coronary slow flow phenomenon on angiographic examination were included. Neutrophil to lymphocyte ratio (NLR) calculated as the ratio of the number of neutrophils to the number of lymphocytes. Read More

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Current cancer therapies and their influence on glucose control.

World J Diabetes 2021 Jul;12(7):1010-1025

Departments of Anatomy and Cell Biology and Medicine, Division of Endocrinology, University of Saskatchewan, Saskatoon S7N 0W8, Saskatchewan, Canada.

This review focuses on the development of hyperglycemia arising from widely used cancer therapies spanning four drug classes. These groups of medications were selected due to their significant association with new onset hyperglycemia, or of potentially severe clinical consequences when present. These classes include glucocorticoids that are frequently used in addition to chemotherapy treatments, and the antimetabolite class of 5-fluorouracil-related drugs. Read More

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Saponin Momordin Ic Modulates HaCaT Cell Proliferation and Apoptosis via the Wnt/-Catenin Pathway.

Evid Based Complement Alternat Med 2021 16;2021:5522164. Epub 2021 Jul 16.

Department of Dermatology, The Second Affiliated Hospital, The Domestic First-Class Discipline Construction Project of Chinese Medicine of Hunan University of Chinese Medicine, Changsha, Hunan 410005, China.

Psoriasis is a chronic, recurrent, immunoinflammatory disease. For a long period, Traditional Chinese Medicine (TCM) is considered a reliable alternative therapy for patients with psoriasis. Fructus Kochiae (or ) and its principle saponin, Momordin Ic, have been reported to protect against inflammation. Read More

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Predicting One's Turn With Both Body and Mind: Anticipatory Speech Postures During Dyadic Conversation.

Front Psychol 2021 13;12:684248. Epub 2021 Jul 13.

Department of Psychology, University of California, Santa Cruz, Santa Cruz, CA, United States.

In natural conversation, turns are handed off quickly, with the mean downtime commonly ranging from 7 to 423 ms. To achieve this, speakers plan their upcoming speech as their partner's turn unfolds, holding the audible utterance in abeyance until socially appropriate. The role played by prediction is debated, with some researchers claiming that speakers predict upcoming speech opportunities, and others claiming that speakers wait for detection of turn-final cues. Read More

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Regional Ictal Hyperperfusion in the Contralateral Occipital Area May Be a Poor Prognostic Marker of Anterior Temporal Lobectomy: A SISCOM Analysis of MTLE Cases.

Neuropsychiatr Dis Treat 2021 22;17:2421-2427. Epub 2021 Jul 22.

Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background And Objective: Subtraction of ictal SPECT coregistered to MRI (SISCOM) provides complementary information for detecting the ictal onset zone, especially in patients with MRI-negative focal epilepsy, and provides additional useful information for predicting long-term postresection outcomes. This study sought to investigate the relationship between surgical failure and increased cerebral blood flow (CBF) pattern using SPECT in patients with mesial temporal lobe epilepsy with unilateral hippocampal sclerosis (MTLE-HS).

Methods: Among 42 subjects who underwent anterior temporal lobectomy with amygdalohippocampectomy (ATL-AH) for MTLE-HS, 29 (69. Read More

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Yoga for treating low back pain: a systematic review and meta-analysis.

Pain 2021 Jul 28. Epub 2021 Jul 28.

Department of Internal and Integrative Medicine, Evang. Kliniken Essen-Mitte, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany. National Centre for Naturopathic Medicine, Southern Cross University, Lismore, Australia. Australian Research Centre in Complementary and Integrative Medicine (ARCCIM), Faculty of Health, University of Technology Sydney, Sydney, Australia.

Abstract: Yoga is frequently used for back pain relief. However, evidence was judged to be of only low- or moderate. To assess the efficacy and safety of yoga in patients with low back pain a meta-analysis was performed. Read More

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Cost-effectiveness of infant respiratory syncytial virus preventive interventions in Mali: A modeling study to inform policy and investment decisions.

Vaccine 2021 Jul 26. Epub 2021 Jul 26.

Center for Vaccine Development & Global Health, 685 W. Baltimore St., University of Maryland School of Medicine, Baltimore, Maryland 21201, USA. Electronic address:

Importance: Low- and middle-income countries have a high burden of respiratory syncytial virus lower respiratory tract infections. A monoclonal antibody administered monthly is licensed to prevent these infections, but it is cost-prohibitive for most low- and middle-income countries. Long-acting monoclonal antibodies and maternal vaccines against respiratory syncytial virus are under development. Read More

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