24,946 results match your criteria long arm


Short- and long-term effects of different exercise programs on the gait performance of older adults with subjective cognitive decline: A randomized controlled trial.

Exp Gerontol 2021 Oct 11:111590. Epub 2021 Oct 11.

Institute of Innovation for Future Society, Nagoya University, Nagoya, Japan; Department of Community Healthcare and Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan. Electronic address:

Background: Older adults, especially those with cognitive decline, often have poor gait performance, which results in poor clinical outcomes due to falls or decreased daily physical activity. The effects of various exercises on gait performance have been studied, whereas the short-term and long-term effects of different exercise modalities remain unknown.

Objective: To compare the short- and long-term effects of aerobic training (AT), resistance training (RT), and combined training (CT) on the gait performance of community-dwelling older adults with subjective cognitive decline (SCD). Read More

View Article and Full-Text PDF
October 2021

Treatment Outcomes and Safety of Mobocertinib in Platinum-Pretreated Patients With EGFR Exon 20 Insertion-Positive Metastatic Non-Small Cell Lung Cancer: A Phase 1/2 Open-label Nonrandomized Clinical Trial.

JAMA Oncol 2021 Oct 14:e214761. Epub 2021 Oct 14.

Dana-Farber Cancer Institute, Boston, Massachusetts.

Importance: Metastatic non-small cell lung cancer (mNSCLC) with EGFR exon 20 insertion (EGFRex20ins) mutations is associated with a poor prognosis. Mobocertinib is an oral tyrosine kinase inhibitor designed to selectively target EGFRex20ins mutations.

Objective: To evaluate treatment outcomes and safety of mobocertinib in patients with previously treated EGFRex20ins-positive mNSCLC. Read More

View Article and Full-Text PDF
October 2021

Randomized controlled trial testing a video-text tobacco cessation intervention among economically disadvantaged African American adults.

Psychol Addict Behav 2021 Oct 14. Epub 2021 Oct 14.

Case School of Engineering.

Objective: This pilot study tested the acceptability and short-term outcomes of a culturally specific mobile health (mHealth) intervention () in a sample of economically disadvantaged African American adults. We hypothesized that would demonstrate greater acceptability, biochemically verified abstinence, and promote nicotine replacement therapy (NRT) use compared with a standard text-messaging program.

Method: In a 2-arm pilot randomized trial, adults who sought to quit smoking ( = 119) received either or the National Cancer Institute's (NCI) SmokefreeTXT, both combined with a brief behavioral counseling session plus 2 weeks of NRT. Read More

View Article and Full-Text PDF
October 2021

A Reference Database of Standardised Continuous Lumbar Intervertebral Motion Analysis for Conducting Patient-Specific Comparisons.

Front Bioeng Biotechnol 2021 27;9:745837. Epub 2021 Sep 27.

AECC University College, Bournemouth, United Kingdom.

Lumbar instability has long been thought of as the failure of lumbar vertebrae to maintain their normal patterns of displacement. However, it is unknown what these patterns consist of. Research using quantitative fluoroscopy (QF) has shown that continuous lumbar intervertebral patterns of rotational displacement can be reliably measured during standing flexion and return motion using standardised protocols and can be used to assess patients with suspected lumbar spine motion disorders. Read More

View Article and Full-Text PDF
September 2021

Long-term outcomes of maxillary single-tooth implants in relation to timing protocols of implant placement and loading: Systematic review and meta-analysis.

Clin Oral Implants Res 2021 Oct;32 Suppl 21:56-66

Academy for Oral Implantology, Vienna, Austria.

Objectives: The aim of the present systematic literature review was to determine whether long-term treatment results with single-tooth implants may differ depending on the timing of implant placement in relation to tooth extraction (immediate IP/early EP/delayed DP) and the timing of prosthetic loading (immediate IL/early EL/delayed DL).

Material And Methods: Electronic and manual searches were performed to identify studies reporting on long-term results (survival rate and/or marginal bone resorption after ≥3 years) of maxillary single-tooth implants in the aesthetic zone using defined placement and loading protocols. Comparative trials were subjected to meta-analyses whilst data from single-arm studies were pooled to evaluate differences between timing protocols. Read More

View Article and Full-Text PDF
October 2021

Selection of Essential Neural Activity Timesteps for Intracortical Brain-Computer Interface Based on Recurrent Neural Network.

Sensors (Basel) 2021 Sep 24;21(19). Epub 2021 Sep 24.

Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.

Intracortical brain-computer interfaces (iBCIs) translate neural activity into control commands, thereby allowing paralyzed persons to control devices via their brain signals. Recurrent neural networks (RNNs) are widely used as neural decoders because they can learn neural response dynamics from continuous neural activity. Nevertheless, excessively long or short input neural activity for an RNN may decrease its decoding performance. Read More

View Article and Full-Text PDF
September 2021

Ergonomic Risk Assessment of Dental Students-RULA Applied to Objective Kinematic Data.

Int J Environ Res Public Health 2021 Oct 8;18(19). Epub 2021 Oct 8.

Institute of Occupational Medicine, Social Medicine and Environmental Medicine, Goethe University, 60596 Frankfurt am Main, Germany.

Musculoskeletal disorder (MSD) is already prevalent in dental students despite their young age and the short duration of dental practice. The current findings state that the causes of MSD are related to posture during dental work. This study aims to investigate the ergonomic risk of dental students. Read More

View Article and Full-Text PDF
October 2021

The CADM1 tumor suppressor gene is a major candidate gene in MDS with deletion of the long arm of chromosome 11.

Blood Adv 2021 Oct 12. Epub 2021 Oct 12.

Belgian Cancer Registry, Brussels, Belgium.

Myelodysplastic syndromes (MDS) represent a heterogeneous group of clonal hematopoietic stem-cell disorders characterized by ineffective hematopoiesis leading to peripheral cytopenias and in a substantial proportion of cases to acute myeloid leukemia. The deletion of the long arm of chromosome 11, del(11q), is a rare but recurrent clonal event in MDS. Here, we detail the largest series of 113 cases of MDS and myelodysplastic syndromes/myeloproliferative neoplasms (MDS/MPN) harboring a del(11q) analyzed at clinical, cytological, cytogenetic and molecular levels. Read More

View Article and Full-Text PDF
October 2021

Therapeutic acute intermittent hypoxia: A translational roadmap for spinal cord injury and neuromuscular disease.

Exp Neurol 2021 Oct 9:113891. Epub 2021 Oct 9.

Breathing Research and Therapeutics Center, Department of Physical Therapy and McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA. Electronic address:

We review progress towards greater mechanistic understanding and clinical translation of a strategy to improve respiratory and non-respiratory motor function in people with neuromuscular disorders, therapeutic acute intermittent hypoxia (tAIH). In 2016 and 2020, workshops to create and update a "road map to clinical translation" were held to help guide future research and development of tAIH to restore movement in people living with chronic, incomplete spinal cord injuries. After briefly discussing the pioneering, non-targeted basic research inspiring this novel therapeutic approach, we then summarize workshop recommendations, emphasizing critical knowledge gaps, priorities for future research effort, and steps needed to accelerate progress as we evaluate the potential of tAIH for routine clinical use. Read More

View Article and Full-Text PDF
October 2021

-Sirolimus for Patients With Malignant Perivascular Epithelioid Cell Tumors.

J Clin Oncol 2021 Oct 12:JCO2101728. Epub 2021 Oct 12.

Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY.

Purpose: Malignant perivascular epithelioid cell tumor (PEComa) is a rare aggressive sarcoma, with no approved treatment. To our knowledge, this phase II, single-arm, registration trial is the first prospective clinical trial in this disease, investigating the safety and efficacy of the mammalian target of rapamycin inhibitor -sirolimus (AMPECT, NCT02494570).

Patients And Methods: Patients with malignant PEComa were treated with -sirolimus 100 mg/m intravenously once weekly for 2 weeks in 3-week cycles. Read More

View Article and Full-Text PDF
October 2021

ARISE-a prospective, non-interventional, single-arm study assessing clinical parameters associated with the use of insulin degludec/insulin aspart in patients with type 2 diabetes in real-world settings: rationale and design.

Endocrine 2021 Oct 12. Epub 2021 Oct 12.

Union and Clinton Hospitals in Alberton, Gauteng, South Africa.

Purpose: IDegAsp, a co-formulation of long-acting basal (insulin degludec) and rapid-acting bolus (insulin aspart) insulin, provides separate prandial and basal glucose-lowering effects with relatively low risk of hypoglycaemia. Its efficacy and safety have been investigated in a large clinical trial programme (BOOST). We present the rationale and design of the ARISE study, which aims to assess glycaemic control and other clinical parameters associated with IDegAsp use in real world. Read More

View Article and Full-Text PDF
October 2021

The use of patient-reported outcome measures in primary care: applications, benefits and challenges.

J Patient Rep Outcomes 2021 Oct 12;5(Suppl 2):84. Epub 2021 Oct 12.

Alberta PROMs and EQ-5D Research and Support Unit (APERSU), 2-040 Li Ka Shing Center for Health Research Innovation, University of Alberta, Edmonton, AB, T6G 2E1, Canada.

PROMs use in primary care has expanded from simply describing patient populations to contributing to decision-making, in response to the increasingly complex, ever-changing healthcare environment. In Alberta, primary care is organized into primary care networks (PCNs), where family physicians are grouped geographically and supported by allied health professionals. PCNs implement programs and services in response to local population health needs with frequent evaluation, often incorporating PROMs for this purpose. Read More

View Article and Full-Text PDF
October 2021

Cognitions That Support Concussion Reporting in Collegiate Athletes: An Analysis of a Worksheet Activity.

Health Educ Behav 2021 Oct 12:10901981211046535. Epub 2021 Oct 12.

Department of Professional Psychology, Chestnut Hill College, Philadelphia, PA, USA.

Background: Sports related concussions continue to be a public health concern and improving reporting behavior a focus of educational programs. While educational programs have addressed changes in knowledge of concussion symptoms, it has been challenging to design educational programs which have lasting effects on reporting behavior.

Aims: The current analysis describes an intervention in which thoughts about reporting behavior are actively written down in a worksheet exercise to "pre-arm" athletes with cognitions designed to enhance reporting behavior prior to the injury event. Read More

View Article and Full-Text PDF
October 2021

Long-term effectiveness of carglumic acid in patients with propionic acidemia (PA) and methylmalonic acidemia (MMA): a randomized clinical trial.

Orphanet J Rare Dis 2021 Oct 11;16(1):422. Epub 2021 Oct 11.

Medical Genetics Section, King Fahad Medical City, Children's Hospital, Riyadh, Kingdom of Saudi Arabia.

Background: Propionic acidemia (PA) and methylmalonic acidemia (MMA) are rare, autosomal recessive inborn errors of metabolism that require life-long medical treatment. The trial aimed to evaluate the effectiveness of the administration of carglumic acid with the standard treatment compared to the standard treatment alone in the management of these organic acidemias.

Methods: The study was a prospective, multicenter, randomized, parallel-group, open-label, controlled clinical trial. Read More

View Article and Full-Text PDF
October 2021

Time-dependent changes in hippocampal and striatal glycogen long after maze training in male rats.

Neurobiol Learn Mem 2021 Oct 8:107537. Epub 2021 Oct 8.

Biology Department, Syracuse University, Syracuse, New York, 13244 USA. Electronic address:

Long-lasting biological changes reflecting past experience have been studied in and typically attributed to neurons in the brain. Astrocytes, which are also present in large number in the brain, have recently been found to contribute critically to learning and memory processing. In the brain, glycogen is primarily found in astrocytes and is metabolized to lactate, which can be released from astrocytes. Read More

View Article and Full-Text PDF
October 2021

Structural basis of ubiquitin recognition by a bacterial OTU deubiquitinase LotA.

J Bacteriol 2021 Oct 11:JB0037621. Epub 2021 Oct 11.

Department of Macromolecular Science, Graduate School of Science, Osaka University, 1-1 Machikaneyama-cho, Toyonaka, Osaka 560-0043, Japan.

Pathogenic bacteria have acquired a vast array of eukaryotic-like proteins via intimate interaction with host cells. Bacterial effector proteins that function as ubiquitin ligases and deubiquitinases (DUBs) are remarkable examples of such molecular mimicry. LotA, a effector, belongs to the ovarian tumor (OTU) superfamily, which regulates diverse ubiquitin signals by their DUB activities. Read More

View Article and Full-Text PDF
October 2021

Prognostic Factors Affecting Long-Term Outcomes After Elbow Dislocation: A Longitudinal Cohort Study.

J Hand Surg Glob Online 2021 Sep 24;3(5):260-265. Epub 2021 Jun 24.

Department of Orthopaedic Surgery, University of Utah, Salt Lake City, UT.

Purpose: To describe patient-reported outcomes following simple elbow dislocation and to identify the baseline factors that predict outcomes.

Methods: Adult patients treated with a closed reduction for a simple elbow dislocation with or without minor fracture (coronoid avulsion, radial head fracture, or epicondyle avulsion) from 2000 to 2018 completed outcome instruments including Disabilities of the Arm, Shoulder and Hand (DASH) via Research Electronic Data Capture. Descriptive statistics were calculated. Read More

View Article and Full-Text PDF
September 2021

Energy-restricted interventions are effective for the remission of newly diagnosed type 2 diabetes: A systematic review of the evidence base.

Obes Sci Pract 2021 Oct 15;7(5):606-618. Epub 2021 May 15.

Faculty of Science The University of Nottingham Nottingham UK.

Background: Type 2 diabetes (T2D) is a chronic, progressive disease. Caloric restriction and subsequent weight loss have been associated with both improvements and, in some cases, remission of T2D.

Aim: To systematically review the safety and effectiveness of calorie-restricted diets on weight change and the remission of T2D. Read More

View Article and Full-Text PDF
October 2021

Case Report: Candidate Genes Associated With Prenatal Ultrasound Anomalies in a Fetus With Prenatally Detected 1q23.3q31.2 Deletion.

Front Genet 2021 23;12:696624. Epub 2021 Sep 23.

Center for Medical Ultrasound, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China.

Patients with deletions involving the long arm of chromosome 1 are rare, and the main aim of this study was to refine the genotype-phenotype correlation. In this report, a 28-year-old pregnant woman, gravida 2 para 1, at 25 weeks of gestation underwent ultrasound examination in our institute. The ultrasonographic findings of the fetus were as follows: (1) fetal growth restriction; (2) cleft lip and palate; (3) bilateral renal hypoplasia; (4) lateral ventriculomegaly; (5) single umbilical artery; (6) absent stomach; (7) coronary sinus dilatation with persistent left superior vena cava, ventricular septal defect and unroofed coronary sinus syndrome. Read More

View Article and Full-Text PDF
September 2021

Co-existing bipolar disease and 17q12 deletion: a rare case report.

Psychiatr Genet 2021 Oct 7. Epub 2021 Oct 7.

Department of Psychiatry Department of Medical Genetics, Cerrahpaşa School of Medicine, Istanbul University-Cerrahpaşa, Istanbul, Turkey.

Background: 17q12 microdeletion syndrome is a rare autosomal dominant chromosomal anomaly, caused by the deletion of a 1.4 Mb-spanning DNA sequence on the long arm of chromosome 17. Herein, we report the first bipolar disease (BPD) case with a 1. Read More

View Article and Full-Text PDF
October 2021

Effect of a Video-Assisted Advance Care Planning Intervention on End-of-Life Health Care Transitions Among Long-Stay Nursing Home Residents.

J Am Med Dir Assoc 2021 Oct 8. Epub 2021 Oct 8.

Department of Health Services, Policy, and Practice, Brown University School of Public Health, Providence, RI, USA; Long Term Services and Supports Center of Innovation, Providence VA Medical Center, Providence, RI, USA.

Objective: To determine the relationship between an advance care planning (ACP) video intervention, Pragmatic Trial of Video Education in Nursing Homes (PROVEN), and end-of-life health care transitions among long-stay nursing home residents with advanced illness.

Design: Pragmatic cluster randomized clinical trial. Five ACP videos were available on tablets or online at intervention facilities. Read More

View Article and Full-Text PDF
October 2021

Clinical effectiveness and safety of baricitinib for the treatment of juvenile idiopathic arthritis-associated uveitis or chronic anterior antinuclear antibody-positive uveitis: study protocol for an open-label, adalimumab active-controlled phase 3 clinical trial (JUVE-BRIGHT).

Trials 2021 Oct 9;22(1):689. Epub 2021 Oct 9.

Pediatric Immunology-Hematology and Rheumatology Unit, RAISE reference centre for rare diseases, Necker-Enfants Malades University Hospital, Assistance Publique-Hopitaux de Paris, IMAGINE Institute, Université de Paris, Paris, France.

Background: Juvenile idiopathic arthritis (JIA) is the most common pediatric rheumatic disease and the most common systemic disorder associated with uveitis in childhood. Uveitis is more common in JIA patients who are antinuclear antibody (ANA)-positive, have an early-onset disease, and have oligoarticular arthritis. JIA-associated uveitis (JIA-uveitis) is typically anterior, chronic, bilateral, nongranulomatous, and asymptomatic. Read More

View Article and Full-Text PDF
October 2021

Discontinuation and remission rates and social functioning in patients with schizophrenia receiving second-generation antipsychotics: 52-week evaluation of JUMPs, a randomized, open-label study.

Psychiatry Clin Neurosci 2021 Oct 9. Epub 2021 Oct 9.

Sekiyama Psychiatric Clinic, 3-32-13, Aoto, Katsushika-ku, Tokyo, 125-0062, Japan.

Aim: Globally, evidence from short-term studies is insufficient for the guidelines to uniformly recommend a particular antipsychotic(s) for the maintenance treatment of schizophrenia. Therefore, long-term comprehensive evaluation of antipsychotics is required from a social rehabilitation perspective, especially for drugs that have not yet been studied. The Japan Useful Medication Program for Schizophrenia (JUMPs) is a large-scale, long-term naturalistic study to present pivotal 52-week data on the continuity of second-generation antipsychotics (SGA: aripiprazole, blonanserin, and paliperidone). Read More

View Article and Full-Text PDF
October 2021

6q deletion is frequent but unrelated to patient prognosis in breast cancer.

Breast Cancer 2021 Oct 8. Epub 2021 Oct 8.

Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.

Background: Deletions involving the long arm of chromosome 6 have been reported to occur in breast cancer, but little is known about the clinical relevance of this alteration.

Methods: We made use of a pre-existing tissue microarray with 2197 breast cancers and employed a 6q15/centromere 6 dual-labeling probe for fluorescence in situ (FISH) analysis RESULTS: Heterozygous 6q15 deletions were found in 202 (18%) of 1099 interpretable cancers, including 19% of 804 cancers of no special type (NST), 3% of 29 lobular cancers, 7% of 41 cribriform cancers, and 28% of 18 cancers with papillary features. Homozygous deletions were not detected. Read More

View Article and Full-Text PDF
October 2021

Acute coronary syndrome and transient global amnesia with sumatriptan.

Am J Emerg Med 2021 Sep 11. Epub 2021 Sep 11.

Department of Emergency Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA; New Jersey Poison Information and Education System, Newark, NJ, USA. Electronic address:

Triptans are potent serotoninergic vasoconstrictors. They are generally avoided in elderly patients age greater than 65 or in patients with a history of CAD. Although there are reported cases of Acute Coronary Syndrome (ACS) or Transient Global Amnesia (TGA) in patients after ingesting therapeutic doses of triptan or dihydroergotamine, this is the first case report, up to our knowledge, of a patient, who had no previous cardiac history, that was diagnosed with both ACS and TGA. Read More

View Article and Full-Text PDF
September 2021

Triceps and cutaneous radial nerve branches investigated via an axillary anterior arm approach: new findings in a fresh-cadaver anatomical study.

J Neurosurg 2021 Oct 8:1-10. Epub 2021 Oct 8.

4Department of Anatomy, Federal University of Santa Catarina, Florianópolisz, Santa Catarina, Brazil.

Objective: The authors sought to describe the anatomy of the radial nerve and its branches when exposed through an axillary anterior arm approach.

Methods: Bilateral upper limbs of 10 fresh cadavers were dissected after dyed latex was injected into the axillary artery.

Results: Via the anterior arm approach, all triceps muscle heads could be dissected and individualized. Read More

View Article and Full-Text PDF
October 2021

Clinical outcomes of ultrathin biodegradable polymer-coated sirolimus-eluting stents in an all-comer population: One-year results from the T-FLEX registry including high-risk subgroups.

Anatol J Cardiol 2021 10;25(10):706-715

Department of Cardiology, Malla Reddy Narayana Multispeciality Hospital; Telangana-India.

Objective: T-Flex registry was designed to investigate the safety and clinical performance of the ultrathin (60 µm) strut biodegradable polymer-coated sirolimus-eluting stent (SES) with a unique long dual Z (LDZ) link design on a cobalt-chromium stent platform (Sahajanand Medical Technologies Pvt. Ltd., Surat, India) in a real-world all-comer population including high-risk subgroups. Read More

View Article and Full-Text PDF
October 2021

Comparative Propensity Matched Outcomes in Severe COVID-19 Respiratory Failure-Extracorporeal Membrane Oxygenation or Maximum Ventilation Alone.

Ann Surg 2021 11;274(5):e388-e394

Cardiothoracic and Vascular Surgical Associates, S.C., Advocate Christ Medical Center, Oak Lawn, IL.

Objective: Does extracorporeal membrane oxygenation (ECMO) improve outcomes in ECMO-eligible patients with COVID-19 respiratory failure compared to maximum ventilation alone (MVA)?

Summary Background Data: ECMO is beneficial in severe cases of respiratory failure when mechanical ventilation is inadequate. Outcomes for ECMO-eligible COVID-19 patients on MVA have not been reported. Consequently, a direct comparison between COVID-19 patients on ECMO and those on MVA has not been established. Read More

View Article and Full-Text PDF
November 2021

Hemorrhagic transformation after acute ischemic stroke caused by polycythemia vera: Report of two case.

World J Clin Cases 2021 Sep;9(25):7551-7557

Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei Province, China.

Background: Polycythemia vera (PV) is a chronic myeloproliferative disorder characterized by an increase in red blood cells in the peripheral blood. Previous work has reported the occurrence of thrombosis or hemorrhage arising in the cerebral vasculature secondary to PV. However, hemorrhagic transformation after PV-associated acute ischemic stroke has not been previously described. Read More

View Article and Full-Text PDF
September 2021

Fatigue and endocrine symptoms among women with early breast cancer randomized to endocrine versus chemoendocrine therapy: Results from the TAILORx patient-reported outcomes substudy.

Cancer 2021 Oct 6. Epub 2021 Oct 6.

Wake Forest University Health Sciences, Winston-Salem, North Carolina.

Background: TAILORx (Trial Assigning Individualized Options for Treatment) prospectively assessed fatigue and endocrine symptoms among women with early-stage hormone receptor-positive breast cancer and a midrange risk of recurrence who were randomized to endocrine therapy (E) or chemotherapy followed by endocrine therapy (CT+E).

Methods: Participants completed the Functional Assessment of Chronic Illness Therapy-Fatigue, the Patient-Reported Outcomes Measurement Information System-Fatigue Short Form, and the Functional Assessment of Cancer Therapy-Endocrine Symptoms at the baseline and at 3, 6, 12, 24, and 36 months. Linear regression was used to model outcomes on baseline symptoms, treatment, and other factors. Read More

View Article and Full-Text PDF
October 2021