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Rapid Inhibition Accuracy and Leg Strength Are Required for Community-Dwelling Older People to Recover Balance From Induced Trips and Slips: An Experimental Prospective Study.

J Geriatr Phys Ther 2021 Jul 26. Epub 2021 Jul 26.

Falls, Balance and Injury Research Centre, Neuroscience Research Australia, Sydney, New South Wales, Australia. UNSW Medicine, Sydney, New South Wales, Australia. Department of Human Movement Sciences, Amsterdam Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor.

Background And Purpose: Falls can result in bone fractures and disability, presenting a serious threat to quality of life and independence in older adults. The majority of falls in community-living older adults occur while walking and are often caused by trips and slips. The study aimed to identify the specific sensorimotor and psychological factors required for older adults to recover balance from trips and slips. Read More

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First Report of Fruit Rot of Grapes (Vitis vinifera) Caused by Cladosporium cladosporioides in Xinjiang, China.

Plant Dis 2021 Jul 28. Epub 2021 Jul 28.

Shihezi University, Plant protection, Shihezi, Xinjiang, China;

Xinjiang Province accounts for nearly 20% of the total grape (Vitis Vinifera L.), proles orientalis) (wine, table and raisin combined) production, being the largest production area in China. Fruit rot is the most common disease that impacts grape quality and yield. Read More

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Neurosurgical management of petrous bone lesions: classification system and selection of surgical approaches.

Acta Neurochir (Wien) 2021 Jul 27. Epub 2021 Jul 27.

Division of Neurosurgery, Duke University Medical Center, Durham, NC, USA.

Background: Surgery of petrous bone lesions (PBLs) is challenging for neurosurgeons. Selection of the surgical approach is an important key for success. In this study, the authors present an anatomical classification for PBLs that has been used by our group for over the past 26 years. Read More

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Effective Model of Food Allergy in Mice Sensitized with Ovalbumin and Freud's Adjuvant.

Bull Exp Biol Med 2021 Jul 23. Epub 2021 Jul 23.

Key Lab for Immunology, Universities of Shandong Province, School of Basic Medical Sciences, Weifang Medical University, Weifang, China.

To better explore the pathophysiology of FA and its therapy, we aimed to establish a simple and practicable FA model with Freund's adjuvant and introduce an easy and reliable laboratory evaluation method for assessment of inflammation in intestinal segments at different anatomical locations. BALB/c mice were sensitized with ovalbumin combined with Freund's adjuvant. Complete Freund's adjuvant was chosen for the first sensitization and two weeks later incomplete Freund's adjuvant was used for a second sensitization. Read More

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Distribution of polycyclic aromatic hydrocarbons and heavy metals in soil following a large tire fire incident: A case study.

Chemosphere 2021 Jul 13;286(Pt 1):131556. Epub 2021 Jul 13.

Institute of Chemistry, Vilnius University, Naugarduko 24, LT-03225, Vilnius, Lithuania.

In October 2019, a fire occurred in a tire-recycling facility in Alytus (Lithuania), where around 5000 t of tires had been stored. Only after 10 days was the fire completely extinguished, and the potential contamination of the surrounding environment has raised a large public concern. With an aim to assess the pollution level and pollutants distribution in the surrounding area, we conducted a study on polycyclic aromatic hydrocarbons (PAHs) and heavy metals. Read More

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Risk factors of medical device-related pressure injury in intensive care units.

J Clin Nurs 2021 Jul 26. Epub 2021 Jul 26.

The Third Affilated Hospital of Sun Yat-sen University, Lingnan Hospital, Guangzhou, China.

Objectives: Intensive care unit (ICU) patients are at high risk of medical device related pressure injury (MDRPI). This study aims to ascertain the MDRPI prevalence in ICU patients and analyse the risk factors of MDRPI.

Background: The occurrence of MDRPI not only increases hospitalisation time with pain and economic burden, but also causes medical disputes. Read More

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COVID-19: a closer look at the pathology in two autopsied cases. Is the pericyte at the center of the pathological process in COVID-19?

Autops Case Rep 2021 6;11:e2021262. Epub 2021 May 6.

University of the West Indies, St. Augustine, Trinidad, West Indies.

We performed autopsies on two cases of COVID-19. The microcirculations of all organs were the site of the pathological findings. Thrombotic microangiopathy was found in the brain and also the kidneys. Read More

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Localized Atrial Tachycardia and Dispersion Regions in Atrial Fibrillation: Evidence of Spatial Concordance.

J Clin Med 2021 Jul 18;10(14). Epub 2021 Jul 18.

Hôpital Saint Joseph, 26 bd de Louvain, 13008 Marseille, France.

Introduction: During atrial fibrillation (AF) ablation, it is generally considered that atrial tachycardia (AT) episodes are a consequence of ablation. Objective: To investigate the spatial relationship between localized AT episodes and dispersion/ablation regions during persistent AF ablation procedures. Methods: We analyzed 72 consecutive patients who presented for an index persistent AF ablation procedure guided by the presence of spatiotemporal dispersion of multipolar electrograms. Read More

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Articular cartilage thickness changes differ between males and females four years following anterior cruciate ligament reconstruction.

J Orthop Res 2021 Jul 20. Epub 2021 Jul 20.

Department of Rehabilitation and Movement Science, College of Nursing and Health Sciences, Univ of Vermont.

Anterior cruciate ligament injury and reconstruction (ACLR) affects articular cartilage thickness profiles about the tibial, femoral, and patellar surfaces; however, it's unclear whether the magnitudes of change in cartilage thickness, as well as the locations and areas over which these changes occur, differ between males and females. This is important to consider as differences exist between the sexes with regard to knee biomechanics, patellofemoral pain, and anatomic alignment, which influence risk of an index and repeated injury. Subjects underwent ACLR with a bone-patella tendon-bone autograft. Read More

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Quality of referrals to a rheumatology service before and after implementation of a triage system with telemedicine support.

Adv Rheumatol 2021 Jul 20;61(1):47. Epub 2021 Jul 20.

Rheumatology Service at Hospital Nossa Senhora da Conceição (HNSC), Grupo Hospitalar Nossa Senhora da Conceição (GHC), Avenida Francisco Trein, 596, 3 Andar, Porto Alegre, Rio Grande do Sul, Brazil.

Purpose: To evaluate the quality of referrals for a first Rheumatology consultation at a tertiary care center in a southern Brazilian capital (Porto Alegre, RS), having as background findings from a similar survey performed in 2007/2008. Since then, our state has implemented referral protocols and a triage system with teleconsulting support exclusively for referrals from locations outside the capital, permitting a comparison between patients screened and not screened by the new system.

Methods: Physicians of the Rheumatology Service at Hospital Nossa Senhora da Conceição prospectively collected information regarding first visits over a 6-month period (Oct 2017 to March 2018). Read More

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Impact of Surgical Resection and Reasons for Poor Prognosis of Pelvic Osteosarcoma Based on the Bone Tumor Registry in Japan.

Cancers (Basel) 2021 Jul 1;13(13). Epub 2021 Jul 1.

Musculoskeletal Oncology and Rehabilitation Medicine, National Cancer Center, Tokyo 104-0045, Japan.

Pelvic osteosarcoma has a poor prognosis compared to osteosarcomas in other locations, and the reasons for this remain unknown. Surgical resection of pelvic osteosarcoma is technically demanding and often results in dysfunction and complications. In this study, we investigated the reasons underlying the poor prognosis of pelvic osteosarcoma by comparing it to femoral osteosarcoma using data from the Bone Tumor Registry in Japan. Read More

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Remembering nothing: Encoding and memory processes involved in representing empty locations.

Mem Cognit 2021 Jul 19. Epub 2021 Jul 19.

Department of Psychological Sciences, Birkbeck University of London, Malet St, Bloomsbury, London, WC1E 7HX, UK.

Previous research has provided rich evidence that a set of visual objects can be encoded in isolation along with their exact coordinate positions as well as a global configuration that provides a network of interrelated spatial information. However, much less data is available on how unoccupied locations are encoded and maintained in memory. We tested this ability in adults using a novel paradigm that involved both empty and filled locations and required participants to monitor the addition or deletion of an item, which occurred 50% of the time. Read More

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First Report of Downy Mildew on Sweet Basil Caused By Peronospora belbahrii in India.

Plant Dis 2021 Jul 19. Epub 2021 Jul 19.

CSIR-CIMAP, 30083, Plant Pathology, Lucknow, Uttar Pradesh, India;

Sweet basil (Ocimum basilicum L.; Family Lamiaceae) is an annual aromatic and medicinal plant grown in tropical and subtropical regions of the world. In India, it is cultivated as a commercial crop on ~8,000 ha. Read More

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Acetabular Edge Loading During Gait Is Elevated by the Anatomical Deformities of Hip Dysplasia.

Front Sports Act Living 2021 1;3:687419. Epub 2021 Jul 1.

Program in Physical Therapy, Movement Science Research Center, Washington University in St. Louis School of Medicine, St. Louis, MO, United States.

Developmental dysplasia of the hip (DDH) is a known risk factor for articular tissue damage and secondary hip osteoarthritis. Acetabular labral tears are prevalent in hips with DDH and may result from excessive loading at the edge of the shallow acetabulum. Location-specific risks for labral tears may also depend on neuromuscular factors such as movement patterns and muscle-induced hip joint reaction forces (JRFs). Read More

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Cardiopulmonary Resuscitation-Induced Hardware Failure After Surgical Stabilization of Flail Chest.

Cureus 2021 Jun 9;13(6):e15549. Epub 2021 Jun 9.

Department of Surgery, Division of Trauma and Acute Care Surgery, Medical University of South Carolina, Charleston, USA.

Flail chest occurs when three or more ribs have concurrent fractures in two or more places. Flail chest is a marker of injury severity and is associated with increased morbidity and mortality. The management of flail chest includes multiple nonoperative components in addition to surgical stabilization, which has been shown to lower mortality rates to those of multiple rib fractures with a stable chest wall (i. Read More

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Pattern of local recurrence after mastectomy and reconstruction in breast cancer patients: a systematic review.

Gland Surg 2021 Jun;10(6):2037-2046

Department of Plastic and Reconstructive Surgery, Pusan National University School of Medicine, Yangsan, Korea.

Background: This study aimed to describe the locations of local recurrences based on the mastectomy and reconstruction type in breast cancer patients.

Methods: In November 2020, a systematic literature review was performed through MEDLINE/PubMed and the Cochrane Centre Register of Controlled Trials. Publications that included skin-sparing or nipple-sparing mastectomy followed by breast reconstruction and described the location of local recurrences were analyzed. Read More

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Head Impact Biomechanics in Youth Flag Football: A Prospective Cohort Study.

Am J Sports Med 2021 Jul 15:3635465211026643. Epub 2021 Jul 15.

UGA Concussion Research Laboratory, Department of Kinesiology, University of Georgia, Athens, Georgia, USA.

Background: Youth flag football participation has rapidly grown and is a potentially safer alternative to tackle football. However, limited research has quantitatively assessed youth flag football head impact biomechanics.

Purpose: To describe head impact biomechanics outcomes in youth flag football and explore factors associated with head impact magnitudes. Read More

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Hemorrhagic Shock and Resuscitation Causes Glycocalyx Shedding and Endothelial Oxidative Stress Preferentially in the Lung and Intestinal Vasculature.

Shock 2021 Feb 19. Epub 2021 Feb 19.

*Department of Surgery †Tulane University School of Medicine, New Orleans, LA ‡Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN.

Introduction: Hemorrhagic shock has recently been shown to cause shedding of a carbohydrate surface layer of endothelial cells known as the glycocalyx. This shedding of the glycocalyx is thought to be a mediator of the coagulopathy seen in trauma patients. Clinical studies have demonstrated increases in shed glycocalyx in the blood after trauma, and animal studies have measured glycocalyx disruption in blood vessels in the lung, skeletal muscle, and mesentery. Read More

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February 2021

Abnormalities in cortical pattern of coherence in migraine detected using ultra high-density EEG.

Brain Commun 2021 2;3(2):fcab061. Epub 2021 Apr 2.

Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA 15213, USA.

Individuals with migraine generally experience photophobia and/or phonophobia during and between migraine attacks. Many different mechanisms have been postulated to explain these migraine phenomena including abnormal patterns of connectivity across the cortex. The results, however, remain contradictory and there is no clear consensus on the nature of the cortical abnormalities in migraine. Read More

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Relevant SARS-CoV-2 Genome Variation through Six Months of Worldwide Monitoring.

Biomed Res Int 2021 29;2021:5553173. Epub 2021 Jun 29.

Center of Clinical Research, University Hospital Mohammed VI, Marrakech, Morocco.

Real-time genome monitoring of the SARS-CoV-2 pandemic outbreak is of utmost importance for designing diagnostic tools, guiding antiviral treatment and vaccination strategies. In this study, we present an accurate method for temporal and geographical comparison of mutational events based on GISAID database genome sequencing. Among 42523 SARS-CoV-2 genomes analyzed, we found 23202 variants compared to the reference genome. Read More

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Global, regional, and national burden of mortality associated with non-optimal ambient temperatures from 2000 to 2019: a three-stage modelling study.

Lancet Planet Health 2021 Jul;5(7):e415-e425

Department of Earth Sciences, University of Turin, Turin, Italy.

Background: Exposure to cold or hot temperatures is associated with premature deaths. We aimed to evaluate the global, regional, and national mortality burden associated with non-optimal ambient temperatures.

Methods: In this modelling study, we collected time-series data on mortality and ambient temperatures from 750 locations in 43 countries and five meta-predictors at a grid size of 0·5° × 0·5° across the globe. Read More

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Is Weekend Presentation Associated With Odontogenic Infection Severity?

J Oral Maxillofac Surg 2021 Jun 12. Epub 2021 Jun 12.

Director, Beau Visage Med Spa and Greater Waterbury OMS, Cheshire, CT; Associate Clinical Professor, Division of Oral and Maxillofacial Surgery, University of Connecticut, Farmington, CT. Electronic address:

Purpose: Many dental infections that otherwise could be treated in-office are directly referred to emergency departments (ED) outside of normal business hours. This study sought to determine if odontogenic infections presenting to EDs were less severe on the weekends.

Materials And Methods: This was a retrospective cohort study of the 2014 Nationwide Emergency Department Sample. Read More

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Venous Injury in Patients with Blunt Traumatic Brain Injury: Retrospective Analysis of a National Cohort.

Neurocrit Care 2021 Jul 9. Epub 2021 Jul 9.

Department of Neurosurgery, State University of New York Upstate Medical University, 750 E. Adams St., Syracuse, NY, 13210, USA.

Background: Cerebral venous injury (CVI) includes injury to a dural venous sinus or major vein and leads to poorer outcomes for patients with blunt traumatic brain injury (TBI). We sought to identify the incidence, associated factors, and outcomes associated with CVI in a large national cohort.

Methods: Adult patients with blunt TBI were identified from the National Trauma Databank (2013-2017). Read More

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Longitudinal cohort study of injury type, settings, treatment and costs in British Columbia youth, 2003-2013.

Inj Prev 2021 Jul 8. Epub 2021 Jul 8.

BC Injury Research and Prevention Unit, Vancouver, British Columbia, Canada.

Background: In 2010 in British Columbia (BC), Canada, total injury costs per capita were higher among youth aged 15-24 years than in any other age group. Injury prevention efforts have targeted injuries with high mortality (transportation injuries) or morbidity (concussions). However, the profile and health costs of common youth injuries (types, locations, treatment choices and prevention strategies) and how these change from adolescence to young adulthood is not known. Read More

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Occurrence and dynamics of potentially pathogenic vibrios in the wet-dry tropics of northern Australia.

Mar Environ Res 2021 Jul 29;169:105405. Epub 2021 Jun 29.

Research Institute for the Environment and Livelihoods, Charles Darwin University, Darwin, NT, Australia.

Bacteria from the Vibrio genus are a ubiquitous component of coastal and estuarine ecosystems with several pathogenic Vibrio species displaying preferences for warm tropical waters. We studied the spatial and temporal abundance of three key human potential pathogens V. parahaemolyticus, V. Read More

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Sudden out-of-hospital cardiac arrest in pediatric patients in Kyushu area in Japan.

Pediatr Int 2021 Jul 8. Epub 2021 Jul 8.

Kagoshima Medical Association, Kagoshima, Japan.

Background: It is well-known that a neurologically favorable outcome of out-of-hospital cardiac arrest (OHCA) is associated with the presence of bystander-initiated cardiopulmonary resuscitation (bystander CPR) and use of an automated external defibrillator. However, little is known about the effect of the presence of pre-existing conditions, prior activity, and locations on the outcome of pediatric OHCA.

Methods: We analyzed the data from questionnaires about pediatric patients with OHCA aged from 3 days to 19 years in the Kyushu area in Japan between 2012 and 2016. Read More

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A Target-Based In Vivo Test System to Identify Novel Fungicides with Mode of Action in the HOG Pathway.

Methods Mol Biol 2021 ;2356:121-127

Institute of Biotechnology and Drug Research gGmbH (IBWF), Mainz, Germany.

Resistance management plays a key role in modern plant protection. There is a growing need to identify new fungicide targets and new modes of action. In this context, it is also mandatory to find new compounds acting on successful target locations. Read More

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January 2021

Spontaneous and targeted mutations in the decapping enzyme enhance replication of modified vaccinia virus Ankara (MVA) in monkey cells.

J Virol 2021 Jul 7:JVI0110421. Epub 2021 Jul 7.

Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Modified vaccinia virus Ankara (MVA) was derived by repeated passaging in chick fibroblasts, during which deletions and mutations rendered the virus unable to replicate in most mammalian cells. Marker rescue experiments demonstrated that the host range defect could be overcome by replacing DNA that had been deleted from near the left end of the genome. One virus isolate, however, recovered the ability to replicate in monkey BS-C-1 cells but not human cells without added DNA suggesting it arose from a spontaneous mutation. Read More

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Eur J Endocrinol 2021 Jul 1. Epub 2021 Jul 1.

L Giovanella, Thyroid Committee, European Association of Nuclear Medicine, EANM, Wien, Austria.

Aim: The risk of differentiated thyroid cancer (DTC) recurrence is widely evaluated according to the 2015 ATA Risk Stratification System. Topography of malignant nodules has been previously reported as an additional risk factor but is not included in the ATA system. Thus, our study aimed to evaluate the relationship between DTC topography and response to initial therapy. Read More

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It is everywhere-A survey on the presence of carp edema virus in carp populations in Germany.

Transbound Emerg Dis 2021 Jul 7. Epub 2021 Jul 7.

Fish Disease Research Unit, Institute for Parasitology, University of Veterinary Medicine, Hannover, Germany.

Carp edema virus (CEV) is the causative agent of koi sleepy disease (KSD), a serious gill disease affecting common carp, Cyprinus carpio, and its ornamental variety, koi. After recent detections of the virus in various countries around the world, KSD has emerged as a new global disease in carp. However, the prevalence of the infection in carp populations in a given geographical region has not been studied thoroughly. Read More

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