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Protean Regulation of Leukocyte Function by Nuclear Lamins.

Trends Immunol 2021 Apr 27;42(4):323-335. Epub 2021 Feb 27.

Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases (NIAID), Rockville, MD 20892, USA. Electronic address:

The leukocyte nucleus must be sufficiently elastic to squeeze through tissue barriers during migration, but not so collapsible as to risk damaging chromatin. The proper balance is struck in part by the composition of the nuclear lamina, a flexible meshwork composed mainly of intermediate filaments woven from type A and type B lamin proteins, that is located subjacent to the inner nuclear membrane. There is now increasing evidence that, in addition to influencing nuclear shape and stiffness and cell migration, lamins and lamin-interacting proteins may also interact functionally with chromatin to influence leukocyte gene expression, differentiation, and effector function, including T cell differentiation, B cell somatic hypermutation, and the formation of neutrophil extracellular traps (NETosis). Read More

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Wiad Lek 2020 ;73(12 cz 1):2612-2616


Objective: The aim: Thepaper wasaimedat thestudyof thebiomineralization processesofa permanentdental crown in thepostnatal period of histogenesis.

Patients And Methods: Materials and methods: The study involved 30 culled puppies aged 30-40 days. To study the histogenesis of the germs of the permanent tooth from the cuticular epithelium in the postnatal period microscopic, electron microscopic, immunohistochemical methods of study have been used. Read More

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February 2021

New methods for determination of the keyhole position in the lateral suboccipital approach to avoid transverse-sigmoid sinus injury: Proposition of the groove line as a new surgical landmark.

Neurochirurgie 2021 Jan 12. Epub 2021 Jan 12.

Department of neurosurgery, Showa university school of medicine, 1-5-8 Hatanodai, 142-8555 Tokyo, Shinagawa, Japan.

Purpose: The asterion is frequently used as an anatomical landmark to determine the location of a keyhole in the lateral suboccipital approach used in craniotomies. However, the asterion may not be ideal because of large individual differences among patients. We examined a simple and safe method for determining an optimal keyhole position (KP) using the digastric groove as a new landmark in the lateral suboccipital approach. Read More

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January 2021

The Bacterial Community of the Foliose Macro-lichen Peltigera frigida Is More than a Mere Extension of the Microbiota of the Subjacent Substrate.

Microb Ecol 2021 May 6;81(4):965-976. Epub 2021 Jan 6.

Faculty of Sciences, Department of Ecological Sciences, Universidad de Chile, Santiago, Chile.

Lichens host highly diverse microbial communities, with bacteria being one of the most explored groups in terms of their diversity and functioning. These bacteria could partly originate from symbiotic propagules developed by many lichens and, perhaps more commonly and depending on environmental conditions, from different sources of the surroundings. Using the narrowly distributed species Peltigera frigida as an object of study, we propose that bacterial communities in these lichens are different from those in their subjacent substrates, even if some taxa might be shared. Read More

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Clinical characteristics, treatment, and outcome for cattle that developed retroperitoneal abscesses following paralumbar fossa laparotomy: 32 cases (1995-2017).

J Am Vet Med Assoc 2020 Apr;256(7):814-821

Objective: To describe the clinical and clinicopathologic characteristics, treatment, and outcome for cattle that developed a retroperitoneal abscess (RA) following paralumbar fossa laparotomy (PFL).

Animals: 32 Holstein cows with RA.

Procedures: The record database of a veterinary teaching hospital was searched to identify cattle that were treated for an RA between January 1995 and March 2017. Read More

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Focal adhesion kinase and osmotic responses in ionocytes of Fundulus heteroclitus, a euryhaline teleost fish.

Comp Biochem Physiol A Mol Integr Physiol 2020 03 19;241:110639. Epub 2019 Dec 19.

Department of Biology, St. Francis Xavier University, P.O. Box 5000, Antigonish, Nova Scotia B2G 2W5, Canada. Electronic address:

Cystic Fibrosis Transmembrane conductance Regulator (CFTR) anion channels are the regulated exit pathway in Cl secretion by teleost salt secreting ionocytes of the gill and opercular epithelia of euryhaline teleosts. By confocal light immunocytochemistry using regular and phospho-antibodies directed against conserved sites, we found that killifish CFTR (kfCFTR) and the tyrosine kinase Focal Adhesion Kinase (FAK) phosphorylated at Y407 (FAKpY407) and FAKpY397 are colocalized at the apical membrane and in subjacent membrane vesicles of ionocytes. Hypotonic shock and the α-2 adrenergic agonist clonidine rapidly and reversibly inhibit Cl secretion by isolated opercular epithelia, simultaneous with dephosphorylation of FAKpY407 and increased FAKpY397, located in the apical membrane of ionocytes in the opercular epithelium. Read More

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Subpial Hemorrhage of the Neonate.

Stroke 2020 01 7;51(1):315-318. Epub 2019 Nov 7.

Department of Radiology (N.V.S., D.M.M.), Children's Hospital Colorado, Aurora.

Background and Purpose- Subpial hemorrhage of the neonate is a rare stroke subtype reported in few case series. Birth trauma and coagulopathy are commonly proposed etiologies. We evaluated our subpial hemorrhage of the neonate patient cohort to expand current understanding Methods- Cases of subpial hemorrhage of the neonate were identified by keyword searches of the institutional database. Read More

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January 2020

Neural and vascular architecture of the septum pellucidum: an anatomical study and considerations for safe endoscopic septum pellucidotomy.

J Neurosurg 2019 Aug 2:1-10. Epub 2019 Aug 2.

2Department of Neurosurgery, Katharinenhospital, Klinikum Stuttgart, Germany; and.

Objective: The septum pellucidum is a bilateral thin membranous structure representing the border between the frontal horns of the lateral ventricles. Its most examined components are the septal veins due to their surgical importance during endoscopic septum pellucidotomy (ESP), which is a well-accepted method for surgical treatment of unilateral hydrocephalus. It is widely accepted that the septum pellucidum contains nerve fibers as well, but interestingly, no anatomical study has been addressed to its neural components before. Read More

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White matter neuron biology and neuropathology in schizophrenia.

NPJ Schizophr 2019 Jul 8;5(1):10. Epub 2019 Jul 8.

School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW, 2308, Australia.

Schizophrenia is considered a neurodevelopmental disorder as it often manifests before full brain maturation and is also a cerebral cortical disorder where deficits in GABAergic interneurons are prominent. Whilst most neurons are located in cortical and subcortical grey matter regions, a smaller population of neurons reside in white matter tracts of the primate and to a lesser extent, the rodent brain, subjacent to the cortex. These interstitial white matter neurons (IWMNs) have been identified with general markers for neurons [e. Read More

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Comparative Anatomy of Trunk Musculature in Salamandridae with Different Habitats.

Ayano Omura

Zoolog Sci 2019 06;36(3):208-214

Nihon University College of Art, 2-42-1, Asahigaoka Nerima-ku, Tokyo 176-8525, Japan,

The diversity of trunk muscle morphology of Salamandridae occupying different habitats (aquatic: ; terrestrial: and ) was examined. Trunk muscles were dissected, and muscle weight ratios were quantified. The terrestrial species have larger abdominal trunk muscles than the aquatic species do. Read More

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The crocodylian skull and osteoderms: A functional exaptation to ectothermy?

F Clarac A Quilhac

Zoology (Jena) 2019 02 12;132:31-40. Epub 2018 Dec 12.

CR2P (UMR 7207), CNRS/MNHN Sorbonne Université, "Centre de Recherches sur la Paléobiodiversité et les Paléoenvironnements", Muséum National d´Histoire Naturelle, Paris, France.

The crocodylians are ectothermic semi-aquatic vertebrates which are assessed to have evolved from endothermic terrestrial forms during the Mesozoic. Such a physiological transition should have involved modifications in their cardio-vascular system allowing to increase the heat transfers with the surrounding environment by growing a peripheral vascularization which would be mainly located in the dermal skeleton: the dermatocranium and the osteoderms. In order to assess the implication of these anatomical regions in thermal exchanges, we have recorded the temperature above a set of representative skin areas in order to draw comparisons between the skull, the osteoderms, and the rest of the body parts which present either none or residual dermal ossification. Read More

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February 2019

Network Profiling of Brain-Expressed X-Chromosomal MicroRNA Genes Implicates Shared Key MicroRNAs in Intellectual Disability.

J Mol Neurosci 2019 Feb 3;67(2):295-304. Epub 2019 Jan 3.

Servgen, Department of Genetics, Institute of Biology Roberto Alcantara Gomes, State University of Rio de Janeiro, Rio de Janeiro, Brazil.

MicroRNAs are endogenous non-protein-coding RNA molecules that regulate post-transcriptional gene expression. The majority of human miRNAs are brain-expressed and chromosome X is enriched in miRNA genes. We analyzed the genomic regions of 12 brain-expressed pre-miRNAs located on chromosome X coding for 18 mature miRNAs, aiming to investigate the involvement of miRNA sequence variants on X-linked intellectual disability (XLID). Read More

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February 2019

Small Mountainous Rivers Generate High-Frequency Internal Waves in Coastal Ocean.

A A Osadchiev

Sci Rep 2018 Nov 9;8(1):16609. Epub 2018 Nov 9.

Shirshov Institute of Oceanology, Russian Academy of Sciences, Moscow, Russia.

High-frequency internal waves propagating offshore in small river plumes are regularly observed at satellite imagery in many world regions. In this work we describe a mechanism of generation of these internal waves by discharges of small and rapid rivers inflowing to coastal sea. Friction between river runoff at high velocity and the subjacent sea of one order of magnitude lower velocity causes abrupt deceleration of a freshened flow and increase of its depth, i. Read More

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November 2018

A Single Nucleotide Polymorphism in the Vitamin D Receptor Gene Is Associated With Decreased Levels of the Protein and a Penetrating Pattern in Crohn's Disease.

Inflamm Bowel Dis 2018 06;24(7):1462-1470

Departamento de Farmacología and CIBERehd, Valencia, Spain.

Background: Vitamin D signaling modulates inflammation through the vitamin D receptor (VDR). The synonymous single nucleotide polymorphism (SNP) rs731236, located in the VDR gene, has been associated with a higher risk of Crohn's disease (CD). We analyzed differences in VDR expression levels among CD patients who were homozygous for allelic variants in this SNP and their relevance for disease course. Read More

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Resonant Raman scattering based approaches for the quantitative assessment of nanometric ZnMgO layers in high efficiency chalcogenide solar cells.

Sci Rep 2017 04 25;7(1):1144. Epub 2017 Apr 25.

Catalonia Institute for Energy Research (IREC), Jardins de les Dones de Negre 1, 08930, Sant Adria de Besos, Barcelona, Spain.

This work reports a detailed resonant Raman scattering analysis of ZnMgO solid solution nanometric layers that are being developed for high efficiency chalcogenide solar cells. This includes layers with thicknesses below 100 nm and compositions corresponding to Zn/(Zn + Mg) content rations in the range between 0% and 30%. The vibrational characterization of the layers grown with different compositions and thicknesses has allowed deepening in the knowledge of the sensitivity of the different Raman spectral features on the characteristics of the layers, corroborating the viability of resonant Raman scattering based techniques for their non-destructive quantitative assessment. Read More

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Phytoscreening as an efficient tool to delineate chlorinated solvent sources at a chlor-alkali facility.

Chemosphere 2017 May 25;174:82-89. Epub 2017 Jan 25.

Laboratoire Chrono-Environnement (UMR 6249), Université de Bourgogne Franche-Comté, Pôle Universitaire du Pays de Montbéliard, 4 place Tharradin, BP 71427, 25211 Montbéliard, France; Université de Lorraine, Faculté des Sciences et Technologies, BP 70239, 54506 Vandoeuvre-les-Nancy, France. Electronic address:

Chlorinated ethenes (CE) are among the most common volatile organic compounds (VOC) that contaminate groundwater, currently representing a major source of pollution worldwide. Phytoscreening has been developed and employed through different applications at numerous sites, where it was generally useful for detection of subsurface chlorinated solvents. We aimed at delineating subsurface CE contamination at a chlor-alkali facility using tree core data that we compared with soil data. Read More

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Intraepithelial ischemia is a principal factor promoting cancerization of the covering epithelial tissues.

A I Karseladze

Med Hypotheses 2016 Sep 28;94:154-60. Epub 2016 Jul 28.

Department of Pathology of the Cancer Research Center of the Russian Federation, Academy of Sciences of the Russian Federation, 115478 Kashirskoe sh.24, Moscow, Russian Federation. Electronic address:

Prominent angiogenesis, which is a hallmark of invasive cancer is preceded at the precancerous stage by marked ischemia. Our hypothesis proposes a structural mechanism responsible for altering blood flow in the covering epithelium and leading to marked reduction of vascularization in the foci of dysplasia. This mechanism varies from one type of epithelium to another. Read More

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September 2016

Clinicopathologic features, microvessel density, and immunohistochemical expression of ICAM-1 and VEGF in 15 cases of secondary syphilis with oral manifestations.

Oral Surg Oral Med Oral Pathol Oral Radiol 2016 Mar 13;121(3):274-81. Epub 2015 Oct 13.

Titular Professor and Head, Oral Pathology, Piracicaba Dental School, State University of Campinas, Piracicaba, SP, Brazil.

Background: Several studies have reported the clinical aspects of oral syphilis, but few papers have considered the involved immunoinflammatory mechanisms.

Objective: To analyze the clinicopathologic features and expression of immunoinflammatory and vascular proteins in oral secondary syphilis.

Study Design: Fifteen patients with oral secondary syphilis were included; histologic features were analyzed using hematoxylin-eosin-stained histologic slides and immunohistochemical reactions were performed against intercellular adhesion molecule 1 (ICAM-1), vascular endothelial growth factor (VEGF), and CD34. Read More

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New Insights in Histogenetic Pathways of Gastric Cancer.

Medicine (Baltimore) 2015 Oct;94(42):e1810

From the Department of Pathology, University of Medicine and Pharmacy of Tirgu-Mures, Romania (SG, IJ); Department of Tumor Pathology, Hamamatsu University School of Medicine, Hamamatsu, Japan (HS); Department of Pathology, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Warsaw, Poland (JO); and Department of Molecular Pathology, National Institute of Oncology, Budapest, Hungary (ZS).

The aim of this paper was to describe 3 possible histogenetic pathways for poorly cohesive (diffuse) carcinomas and 2 for intestinal-type gastric carcinomas (GCs), which might influence the behavior of GC. In the present observational study, 102 patients with early (n = 50) and advanced GCs (n = 52) were evaluated, and the histogenetic background was analyzed. All of the cases were sporadic GCs. Read More

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October 2015

The cracked tooth: histopathologic and histobacteriologic aspects.

J Endod 2015 Mar 30;41(3):343-52. Epub 2014 Oct 30.

University of Maryland School of Dentistry, Baltimore, Maryland.

Introduction: The diagnosis and treatment planning of cracked teeth depend on the understanding of how cracks affect the surrounding tissues. This study evaluated the dentin and pulp conditions in teeth affected by cracks and attrition.

Methods: Specimens under investigation included 12 cracked posterior teeth and 8 teeth with severe attrition. Read More

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Osteochondrosis Can Lead to Formation of Pseudocysts and True Cysts in the Subchondral Bone of Horses.

Vet Pathol 2015 Sep 26;52(5):862-72. Epub 2014 Nov 26.

Swedish University of Agricultural Sciences, Uppsala, Sweden.

Osteochondrosis arises as a result of focal failure of the blood supply to growth cartilage. The current aim was to examine the pathogenesis of pseudocysts and true cysts in subchondral bone following failure of the blood supply to the articular-epiphyseal cartilage complex in horses. Cases were recruited based on identification of lesions (n = 17) that were considered likely to progress to or to represent pseudocysts or true cysts in epiphyseal bone in histological sections and included 10 horses ranging in age from 48 days to 5 years old. Read More

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September 2015

Do Anterior Cervical Osteophytes Prevent Dynamization of Cervical Dynamic Plates?

Clin Spine Surg 2016 07;29(6):E314-8

*Department of Orthopaedic Surgery, Hallym University Sacred Heart Hospital, Medical College of Hallym University, Gyeonggi-do†Department of Orthopaedic Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea‡Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO.

Study Design: A retrospective study.

Objective: To evaluate radiographic changes of patients with osteophytes at the anterior border of the caudal vertebral body who were treated with anterior cervical discectomy and fusion using dynamic rotational plates.

Summary Of Background Data: Dynamic cervical plates are widely used in surgeries of the anterior cervical spine. Read More

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Role of nucleus accumbens glutamatergic plasticity in drug addiction.

Neuropsychiatr Dis Treat 2013 30;9:1499-512. Epub 2013 Sep 30.

Florida State University - Panama, Clayton, Panama ; Medical University of South Carolina, Charleston, South Carolina, USA ; Smithsonian Tropical Research Institute, Ancon, Republic of Panama.

Substance dependence is characterized by a group of symptoms, according to the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR). These symptoms include tolerance, withdrawal, drug consumption for alleviating withdrawal, exaggerated consumption beyond original intention, failure to reduce drug consumption, expending a considerable amount of time obtaining or recovering from the substance's effects, disregard of basic aspects of life (for example, family), and maintenance of drug consumption, despite facing adverse consequences. The nucleus accumbens (NAc) is a brain structure located in the basal forebrain of vertebrates, and it has been the target of addictive drugs. Read More

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Band-like arrangement of taste-like sensory cells at the gastric groove: evidence for paracrine communication.

Front Physiol 2013 2;4:58. Epub 2013 Apr 2.

Institute of Physiology, University of Hohenheim Stuttgart, Germany.

The discovery of taste-related elements within the gastrointestinal tract has led to a growing interest in the mechanisms and physiological significance of chemosensory monitoring of chymus composition. Previous work suggests that brush cells located in the "gastric groove," which parallels the "limiting ridge," a structure in rodents that divides the fundus from the corpus, are candidate sensory cells. A novel sectioning technique revealed that these cells are arranged in a palisade-like manner forming a band which borders the whole length of the corpus epithelium. Read More

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Tumor-infiltrating immune cells: triggers for tumor capsule disruption and tumor progression?

Int J Med Sci 2013 5;10(5):475-97. Epub 2013 Mar 5.

National Medical Centre of Colorectal Disease, The Third Affiliated Hospital, Nanjing University of Traditional Chinese Medicine TCM, Nanjing, China.

Background: Our previous studies of human breast and prostate cancer have shown that aberrant immune cell infiltration is associated with focal tumor capsule disruption and tumor cell budding that facilitate invasion and metastasis. Our current study attempted to determine whether aberrant immune cell infiltration would have similar impact on colorectal cancer (CRC).

Materials And Methods: Tissue sections from 100 patients with primary CRC were assessed for the frequencies of focal basement membrane (BM) disruption, muscularis mucosa (MM) fragmentation, and tumor cell dissemination in epithelial structures adjacent and distal to infiltrating lymphoid aggregates using a panel of biomarkers and quantitative digital imaging. Read More

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September 2013

Spectrophotometric measurements of human tissues for the detection of subjacent blood vessels in an endonasal endoscopic surgical approach.

J Biophotonics 2013 Apr 10;6(4):310-3. Epub 2012 Jul 10.

Applied Physics and Computer Science, Westsaechsische Hochschule Zwickau, University of Applied Sciences, 08056 Zwickau, Germany.

Thin slices of human tissues are characterized concerning reflection and transmission in a wavelength range from 400 to 1700 nm. The results are primarily useful to find a wavelength for the detection of subjacent blood vessels during surgical procedures, especially neurological surgery. The measurements have been conducted using a customized measuring station, utilizing two halogen bulb lamps and two spectrometers. Read More

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Healing process and laser therapy in the superficial periodontium: a histological study.

Rom J Morphol Embryol 2012 ;53(1):111-6

Department of Periodontology, Faculty of Dental Medicine, Grigore T. Popa University of Medicine and Pharmacy, Iassy, Romania.

Aim: To evaluate the efficiency of laser therapy in healing, regeneration and repair processes located in the superficial periodontium after gingivectomy procedures.

Materials And Methods: The study group consisted of 38 patients without any systemic diseases presenting with gingival hypertrophy developed exclusively within the clinical context of gingivitis and/or periodontitis. All patients were included in the study based on their informed consent. Read More

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Limbal epithelial stem/progenitor cells attract stromal niche cells by SDF-1/CXCR4 signaling to prevent differentiation.

Stem Cells 2011 Nov;29(11):1874-85

R&D Department, Tissue Tech, Inc, Ocular Surface Center, Ocular Surface Research & Education Foundation, Miami, Florida 33173, USA.

Corneal epithelial stem cells (SCs) are an ideal model for investigating how adult lineage-committed epithelial SCs are regulated by an anatomically defined and accessible niche, that is, limbal palisades of Vogt, located between the cornea and the conjunctiva. We have used collagenase digestion to isolate the entire limbal epithelial SCs and subjacent mesenchymal cells, and we have demonstrated that their close association is crucial for promoting epithelial clonal growth, implying that the latter serves as niche cells (NCs). After their close association was disrupted by trypsin/EDTA, single SCs and NCs could reunite to generate sphere growth in three-dimensional Matrigel in the embryonic SC medium, and that such sphere growth initiated by SC-NC reunion was mediated by SDF-1 uniquely expressed by limbal epithelial progenitor cells and its receptor CXCR4, but not CXCR7, strongly expressed by limbal stromal NCs. Read More

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November 2011

Pleiotropic patterning response to activation of Shh signaling in the limb apical ectodermal ridge.

Dev Dyn 2011 May 4;240(5):1289-302. Epub 2011 Apr 4.

Department of Reconstructive Sciences, University of Connecticut Health Center, Farmington, Connecticut, USA.

Sonic hedgehog (Shh) signaling in the limb plays a central role in coordination of limb patterning and outgrowth. Shh expression in the limb is limited to the cells of the zone of polarizing activity (ZPA), located in posterior limb bud mesoderm. Shh is not expressed by limb ectoderm or apical ectodermal ridge (AER), but recent studies suggest a role for AER-Shh signaling in limb patterning. Read More

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Endolymphatic sac tumor (aggressive papillary tumor of middle ear and temporal bone): sine qua non radiology-pathology and the University of Texas MD Anderson Cancer Center experience.

Ann Diagn Pathol 2011 Apr 16;15(2):117-23. Epub 2010 Dec 16.

Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, USA.

Endolymphatic sac tumor (ELST) is a rare lesion of the skull base for which the origin has recently been ascertained. The endolymphatic sac is derived from neuroectoderm and is located subjacent to the posteromedial surface of the temporal bone. Patients characteristically present with hearing loss, tinnitus, and vertigo; facial nerve paralysis occurs less commonly. Read More

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