142 results match your criteria locally practically

Familial Hypercholesterolemia in Asia Pacific: A Review of Epidemiology, Diagnosis, and Management in the Region.

J Atheroscler Thromb 2021 Mar 19. Epub 2021 Mar 19.

Departments of Internal Medicine and Medical Research, Mackay Memorial Hospital, Mackay Medical College.

Familial hypercholesterolemia (FH) is a common genetic disease that is estimated to affect at least 15 million people in the Asia Pacific region. Affected individuals are at significantly increased risk of premature atherosclerotic cardiovascular disease. A literature review was undertaken to provide an overview of the epidemiology, diagnosis, and management of FH across the region. Read More

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Robust Pointing Control of Marching Tank Gun With Matched and Mismatched Uncertainty.

IEEE Trans Cybern 2021 Jan 27;PP. Epub 2021 Jan 27.

This article focuses on a robust control scheme for pointing control of the marching tank gun. Both matched and mismatched uncertainties, which may be nonlinear (possibly fast) time varying but bounded, are considered. First, the pointing control system is constructed as a coupled, nonlinear, and uncertain dynamical system with two interconnected (horizontal and vertical) subsystems. Read More

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January 2021

Compatibility of household appliances with DC microgrid for PV systems.

Heliyon 2020 Dec 17;6(12):e05699. Epub 2020 Dec 17.

Institute of Sustainable Energy and Institute of Power Engineering, University Tenaga National (UNITEN), Selangor, 43000, Malaysia.

DC distribution of PV systems has spread back especially in the residential sector as a variety of electronic appliances became locally available in the market. The compatibility of household appliances with the best voltage-level in a DC environment is the field that still in the research phase and has not yet made a practically extensive appearance. This paper mainly discusses this issue by providing a review of the concerning research efforts, identifying the gaps in the existing knowledge. Read More

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December 2020

Livelihood intervention and mental well-being among women living with HIV in Delhi.

AIDS Care 2020 Oct 26:1-7. Epub 2020 Oct 26.

Emmanuel Hospital Association, New Delhi, India.

Poverty-alleviation programmes aimed to improved mental well-being among persons living with HIV (PLWH) in low and middle income countries have underscored the importance of understanding how and why such programmes work. We present findings from a six-month ethnographic process evaluation of , an economic livelihood programme locally designed to improve mental well-being among women affected by HIV in Delhi, India. In addition to benefits of improved economic standing, we found that supportive relationships cultivated among participants ( = 9) and with providers ( = 3) provided respite from worry about their illness and reframed what was relationally and practically possible in the context of living with HIV. Read More

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October 2020

Global COVID-19 pandemic demands joint interventions for the suppression of future waves.

Proc Natl Acad Sci U S A 2020 10 28;117(42):26151-26157. Epub 2020 Sep 28.

Ministry of Education Key Laboratory for Earth System Modeling, Department of Earth System Science, Tsinghua University, 100084 Beijing, China;

Emerging evidence suggests a resurgence of COVID-19 in the coming years. It is thus critical to optimize emergency response planning from a broad, integrated perspective. We developed a mathematical model incorporating climate-driven variation in community transmissions and movement-modulated spatial diffusions of COVID-19 into various intervention scenarios. Read More

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October 2020

Solid-State NMR and NQR Spectroscopy of Lead-Halide Perovskite Materials.

J Am Chem Soc 2020 Nov 3;142(46):19413-19437. Epub 2020 Nov 3.

Department of Chemistry and Applied Biosciences, ETH Zürich, Vladimir Prelog Weg 1-5, Zurich CH-8093, Switzerland.

Two- and three-dimensional lead-halide perovskite (LHP) materials are novel semiconductors that have generated broad interest owing to their outstanding optical and electronic properties. Characterization and understanding of their atomic structure and structure-property relationships are often nontrivial as a result of the vast structural and compositional tunability of LHPs as well as the enhanced structure dynamics as compared with oxide perovskites or more conventional semiconductors. Nuclear magnetic resonance (NMR) spectroscopy contributes to this thrust through its unique capability of sampling chemical bonding element-specifically (H, C, N, Cl, K, Br, Rb, I, Cs, and Pb nuclei) and locally and shedding light onto the connectivity, geometry, topology, and dynamics of bonding. Read More

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November 2020

Efficient search for informational cores in complex systems: Application to brain networks.

Neural Netw 2020 Dec 28;132:232-244. Epub 2020 Aug 28.

Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan. Electronic address:

An important step in understanding the nature of the brain is to identify "cores" in the brain network, where brain areas strongly interact with each other. Cores can be considered as essential sub-networks for brain functions. In the last few decades, an information-theoretic approach to identifying cores has been developed. Read More

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December 2020

Nanoprobing of MoS by Synchrotron Radiation When van der Waals Epitaxy Is Locally Invalid.

ACS Appl Mater Interfaces 2020 Jul 30;12(28):32041-32053. Epub 2020 Jun 30.

Department of Materials Science and Engineering, National Tsing-Hua University, Hsinchu 30013, Taiwan.

In this work, we demonstrated nano-scaled Laue diffractions by a focused polychromatic synchrotron radiation beam to discover what happens in MoS when van der Waals epitaxy is locally invalid. A stronger exciton recombination with a local charge depletion in the density of 1 × 10 cm, extrapolated by Raman scattering and photoluminescence, occurs in grains, which exhibits a preferred orientation of 30° rotation with respect to the -plane of a sapphire substrate. Else, the charge doping and trion recombination dominate instead. Read More

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The Effects of Loading Conditions on the Behaviour of Fixed-Ended Plain Channel Columns.

Materials (Basel) 2020 Mar 21;13(6). Epub 2020 Mar 21.

Department of Aerospace Engineering, Universiti Putra Malaysia, Selangor 43400, Malaysia.

The compressive behaviour of column members can be considerably affected by local buckling, material yielding and local end conditions. In this paper, the effects of the loading conditions at the ends of plain channel section columns subjected to uniformly compressed loading, and fixed conditions at the column ends with respect to global rotations, was examined. Finite element simulation was employed to look at the post-buckled response of thin-walled, plain channel section columns that covered the complete loading history of the compression columns from the onset of elastic local buckling through the nonlinear elastic and elastoplastic post-buckling phases of behaviour to final collapse and unloading. Read More

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The MOMENTUM study: Putting the 'Three Delays' to work to evaluate access to emergency obstetric and neonatal care in a remote island community in Western Kenya.

Glob Public Health 2020 07 17;15(7):1016-1029. Epub 2020 Mar 17.

Organic Health Response, Mfangano Island, Kenya.

Despite worldwide improvements in maternal and infant mortality, mothers and babies in remote, low-resource communities remain disproportionately vulnerable to adverse health outcomes. In these settings, delays in accessing emergency care are a major driver of poor outcomes. The 'Three Delays' model is now widely utilised to conceptualise these delays. Read More

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[Alternative treatment options for periorbital basal cell carcinoma].

Ophthalmologe 2020 Feb;117(2):113-123

Zentrum für Augenheilkunde, Medizinische Fakultät und Uniklinik Köln, Universität zu Köln, Köln, Deutschland.

Background: Latest developments as well as established procedures offer alternative treatment approaches to basal cell carcinoma (BCC) when micrographically controlled surgical removal is not a valid option.

Objective: Alternative treatment options for periorbital BCC are presented.

Methods: A literature search was carried out and a structured display and analysis of the results are given. Read More

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February 2020

Fluoride removal by Ca-Al-CO layered double hydroxides at environmentally-relevant concentrations.

Chemosphere 2020 Mar 6;243:125307. Epub 2019 Nov 6.

Faculty of Civil Engineering and Geosciences, Department of Sanitary Engineering, Delft University of Technology, P.O. Box 5048, 2600 GA, Delft, the Netherlands.

In this study, F removal by Ca-Al-CO layered double hydroxides (LDHs) was investigated at environmentally-relevant concentration ranges (2-12 mg/L) to below the WHO guideline, with an emphasis on the effect of LDHs' modification, as well as the effects of initial F concentration, adsorbent dose, pH, temperature and co-existing ions. Ca-Al-CO LDHs, either untreated, calcined or microwave treated, showed affinity for the removal of F from synthetic groundwater with capacities of 6.7-8. Read More

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Addition of a surfactant to water increases the acaricidal activity of extracts of some plant species used to control ticks by Zimbabwean smallholder farmers.

BMC Vet Res 2019 Nov 9;15(1):404. Epub 2019 Nov 9.

Phytomedicine Programme, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort, Pretoria, 0110, South Africa.

Background: Many studies have revealed that bioactive compounds for different indications are not extracted from plants with water, the only extractant practically available to rural communities. We compared the acaricidal activity of acetone extracts of 13 species used traditionally to protect cattle against ticks. We also investigated if the extraction of biologically active compounds against Rhipicephalus (Boophilus) decoloratus ticks could be enhanced by adding a liquid soap that is locally available to smallholder farmers. Read More

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November 2019

Modeling photoplethysmographic signals in camera-based perfusion measurements: optoelectronic skin phantom.

Biomed Opt Express 2019 Sep 2;10(9):4353-4368. Epub 2019 Aug 2.

Medical Information Technology (MedIT), Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany.

The remote acquisition of photoplethysmographic (PPG) signals via a video camera, also known as photoplethysmography imaging (PPGI), is not yet standardized. In general, PPGI is investigated with test persons in a laboratory setting. While these tests have the advantage of generating real-life data, they suffer from the lack of repeatability and are comparatively effort-intensive because human subjects are required. Read More

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September 2019

Visualizing Alzheimer's disease progression in low dimensional manifolds.

Heliyon 2019 Aug 2;5(8):e02216. Epub 2019 Aug 2.

Banner Alzheimer's Institute, USA.

While tomographic neuroimaging data is information rich, objective, and with high sensitivity in the study of brain diseases such as Alzheimer's disease (AD), its direct use in clinical practice and in regulated clinical trial (CT) still has many challenges. Taking CT as an example, unless the relevant policy and the perception of the primary outcome measures change, the need to construct univariate indices (out of the 3-D imaging data) to serve as CT's primary outcome measures will remain the focus of active research. More relevant to this current study, an overall global index that summarizes multiple complicated features from neuroimages should be developed in order to provide high diagnostic accuracy and sensitivity in tracking AD progression over time in clinical setting. Read More

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Optimal designs in three-level cluster randomized trials with a binary outcome.

Stat Med 2019 09 4;38(20):3733-3746. Epub 2019 Jun 4.

Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.

Cluster randomized trials (CRTs) were originally proposed for use when randomization at the subject level is practically infeasible or may lead to a severe estimation bias of the treatment effect. However, recruiting an additional cluster costs more than enrolling an additional subject in an individually randomized trial. Under budget constraints, researchers have proposed the optimal sample sizes in two-level CRTs. Read More

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September 2019

Learning Visual Instance Retrieval from Failure: Efficient Online Local Metric Adaptation from Negative Samples.

IEEE Trans Pattern Anal Mach Intell 2020 Nov 23;42(11):2858-2873. Epub 2019 May 23.

Existing visual instance retrieval (VIR) approaches attempt to learn a faithful global matching metric or discriminative feature embedding offline to cover enormous visual appearance variations, so as to directly use it online on various unseen probes for retrieval. However, their requirement for a huge set of positive training pairs is very demanding in practice and the performance is largely constrained for the unseen testing samples due to the severe data shifting issue. In contrast, this paper advocates a different paradigm: part of the learning can be performed online but with nominal costs, so as to achieve online metric adaptation for different query probes. Read More

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November 2020

Linking social and emotional learning standards to the WCSD Social-Emotional Competency Assessment: A Rasch approach.

Sch Psychol 2019 May;34(3):281-295

The Collaborative for Academic, Social, and Emotional Learning.

Growing interest in understanding the role of students' social-emotional competence for school success necessitates valid measures for large-scale use. We provide validity evidence for the 40-item Washoe County School District Social-Emotional Competency Assessment (WCSD-SECA), a student self-report measure that came from a researcher-practitioner partnership. The WCSD's social and emotional learning standards, which detail when and at what grade students are expected to express different competencies, contributed to hypotheses about the social-emotional competency levels targeted by the WCSD-SECA items. Read More

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A facile strategy for the synthesis of three-dimensional heterostructure self-assembled MoSe nanosheets and their application as an anode for high-energy lithium-ion hybrid capacitors.

Nanoscale 2019 Apr;11(15):7263-7276

State Key Laboratory of Advanced Processing and Recycling of Non-Ferrous Metals, Lanzhou University of Technology, Lanzhou 730050, P. R. China.

As energy storage devices, lithium-ion hybrid capacitors (LIHCs) are currently favored by researchers, because they combine the high energy density of lithium-ion batteries and the high power density as well as the long cycle life of electric double-layer capacitors. However, the reason that LIHCs are problematic for researchers and cannot be applied practically is the slow dynamic behavior of the battery type anode that leads to low magnification and cycle performance of the anode, furthermore, causing a dynamic imbalance between the Faraday embedded electrode and the capacitive electrode. Hence, it is imperative to find an anode material that can quickly intercalate/de-intercalate lithium. Read More

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Dominant tree species drive beta diversity patterns in western Amazonia.

Ecology 2019 04 28;100(4):e02636. Epub 2019 Feb 28.

International Center for Tropical Botany, Florida International University, 4013 South Douglas Road, Miami, Florida, 33133, USA.

The forests of western Amazonia are among the most diverse tree communities on Earth, yet this exceptional diversity is distributed highly unevenly within and among communities. In particular, a small number of dominant species account for the majority of individuals, whereas the large majority of species are locally and regionally extremely scarce. By definition, dominant species contribute little to local species richness (alpha diversity), yet the importance of dominant species in structuring patterns of spatial floristic turnover (beta diversity) has not been investigated. Read More

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Intracrinology and menopause: the science describing the cell-specific intracellular formation of estrogens and androgens from DHEA and their strictly local action and inactivation in peripheral tissues.

Fernand Labrie

Menopause 2019 02;26(2):220-224

Laval University, Quebec City, Quebec, Canada.

The secretion of estrogens by the ovaries stops at menopause. Afterward, dehydroepiandrosterone (DHEA) becomes the only source of both estrogens and androgens during all the postmenopausal years. To maintain very low and biologically inactive concentrations of estrogens and androgens in the circulation, DHEA is transformed intracellularly into cell-specific small amounts of estrogens and androgens (except in the endometrium) which then act and are inactivated locally in the same cells, thus avoiding biologically significant systemic exposure to active sex steroids. Read More

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February 2019

Kernel Clustering: Density Biases and Solutions.

IEEE Trans Pattern Anal Mach Intell 2019 01 6;41(1):136-147. Epub 2017 Dec 6.

Kernel methods are popular in clustering due to their generality and discriminating power. However, we show that many kernel clustering criteria have density biases theoretically explaining some practically significant artifacts empirically observed in the past. For example, we provide conditions and formally prove the density mode isolation bias in kernel K-means for a common class of kernels. Read More

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January 2019

Electronic properties of FeCl and CrO interacting with GaN nanotubes from density functional calculations.

J Mol Model 2018 Jul 4;24(8):192. Epub 2018 Jul 4.

Departamento de Física, Universidade Federal do Maranhão, 65080-805, São Luís, MA, Brazil.

The structural and electronic properties of FeCl and CrO interacting with (10,0) GaNNT were obtained using first principles calculations based on the density functional theory. The results show that for the CrO interacting with the GaNNT, the structure was locally deformed. However, in case of FeCl adsorbed with the GaNNT, the structure remained practically the same with the negligible deformation observed on tube surface. Read More

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Practical quantification of image registration accuracy following the AAPM TG-132 report framework.

J Appl Clin Med Phys 2018 Jul 7;19(4):125-133. Epub 2018 Jun 7.

Department of Radiation Oncology, Moffitt Cancer Center, Tampa, FL, USA.

The AAPM TG 132 Report enumerates important steps for validation of the medical image registration process. While the Report outlines the general goals and criteria for the tests, specific implementation may be obscure to the wider clinical audience. We endeavored to provide a detailed step-by-step description of the quantitative tests' execution, applied as an example to a commercial software package (Mirada Medical, Oxford, UK), while striving for simplicity and utilization of readily available software. Read More

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Aligning an undergraduate psychological medicine subject with the mental health needs of the local region.

BMC Med Educ 2018 May 31;18(1):118. Epub 2018 May 31.

College of Medicine and Dentistry, James Cook University, QLD, Townsville, 4811, Australia.

Background: The James Cook University (JCU) medical school recently revised its Year 2 human development and behaviour module to be more relevant and practical for students, and more aligned with the mental health priorities of the local region (north Queensland). This study reports medical students' level of preparedness conferred by the re-designed 'Psychological Medicine and Human Development' (PMHD) subject for their later 4-week, rural clinical placement in Year 2.

Methods: Non-randomized, controlled 'naturalistic' study with pre- and post-intervention surveys. Read More

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A Treatment Planning Method for Better Management of Radiation-Induced Oral Mucositis in Locally Advanced Head and Neck Cancer.

J Med Phys 2018 Jan-Mar;43(1):9-15

Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, USA.

Purpose/aim: To describe a two-phase intensity-modulated radiation therapy (IMRT) treatment planning approach, that is, promising for reduction of oral mucositis risk in locally advanced head-and-neck cancer.

Materials And Methods: Ten locally advanced head-and-neck cancer patients who underwent RT were retrospectively collected. Conventional IMRT and volumetric-modulated arc therapy (VMAT) plans were generated for these patients following clinical protocol. Read More

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[Significance of Endothelin-1 in Glaucoma - a Short Overview].

Klin Monbl Augenheilkd 2018 Feb 15;235(2):140-145. Epub 2018 Feb 15.

Augenklinik, Universitätsspital Basel, Schweiz.

This review article is focused on the various facets of possible endothelin's role in glaucoma; involvement of endothelin in other ocular, in particular vascular, diseases is not specifically discussed. Endothelin is an ubiquitous molecule that occurs in practically all ocular tissues. Its primary physiological function is regulation of the blood vessel diameter and hence regulation of the blood supply in tissues. Read More

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February 2018

Quantization improves stabilization of dynamical systems with delayed feedback.

Chaos 2017 Nov;27(11):114306

Department of Applied Mechanics, Budapest University of Technology and Economics and MTA-BME Lendület Human Balancing Research Group, 1111 Budapest, Hungary.

We show that an unstable scalar dynamical system with time-delayed feedback can be stabilized by quantizing the feedback. The discrete time model corresponds to a previously unrecognized case of the microchaotic map in which the fixed point is both locally and globally repelling. In the continuous-time model, stabilization by quantization is possible when the fixed point in the absence of feedback is an unstable node, and in the presence of feedback, it is an unstable focus (spiral). Read More

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November 2017

Potential landscape of high dimensional nonlinear stochastic dynamics with large noise.

Sci Rep 2017 Nov 17;7(1):15762. Epub 2017 Nov 17.

Key Laboratory of Systems Biomedicine Ministry of Education, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China.

Quantifying stochastic processes is essential to understand many natural phenomena, particularly in biology, including the cell-fate decision in developmental processes as well as the genesis and progression of cancers. While various attempts have been made to construct potential landscape in high dimensional systems and to estimate transition rates, they are practically limited to the cases where either noise is small or detailed balance condition holds. A general and practical approach to investigate real-world nonequilibrium systems, which are typically high-dimensional and subject to large multiplicative noise and the breakdown of detailed balance, remains elusive. Read More

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November 2017