159,549 results match your criteria local recurrence


Deep (aggressive) angiomyxoma of the vagina misdiagnosed as Gartner cyst: A case report.

Int J Surg Case Rep 2021 Apr 30;83:105948. Epub 2021 Apr 30.

Anatomic Pathology Department, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Introduction And Importance: Aggressive angiomyxoma is a rare soft tissue tumor. Aggressive angiomyxoma is a slow-growing vulvovaginal mesenchymal neoplasm with a marked tendency for local recurrence, but with a low tendency to metastasize. As it has a predilection for the pelvic and perineal regions, Aggressive angiomyxoma is often misdiagnosed. Read More

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Treatment methods for vulvovaginal candidiasis in pregnancy.

J Mycol Med 2021 May 7;31(3):101138. Epub 2021 May 7.

Department of Obstetrics and Gynecology, Okan University School of Medicine, Istanbul, Turkey.

Introduction: Vulvovaginal candidiasis (VVC) is one of the three most common vaginal infections of women. Our goal is to check which treatment method (vaginal or vaginal combined with oral) is more effective for each trimester to treat VVC.

Materials And Method: A retrospective analysis was performed and vaginal culture results after treatment of 61 pregnant women who were treated with vaginal or vaginal plus oral antifungals, were collected. Read More

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Cost-Effectiveness Analysis of No Adjuvant Therapy Versus Partial Breast Irradiation Alone Versus Combined Treatment for Treatment of Low-Risk DCIS: A Microsimulation.

JCO Oncol Pract 2021 May 10:OP2000992. Epub 2021 May 10.

Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH.

Purpose: Adjuvant therapy in patients with ductal carcinoma in situ who undergo partial mastectomy remains controversial, particularly for low-risk patients (60 years or older, estrogen-positive, tumor extent < 2.5 cm, grade 1 or 2, and margins ≥ 3 mm). We performed a cost-effectiveness analysis comparing three strategies: no adjuvant treatment after surgery, a five-fraction course of accelerated partial breast irradiation using intensity-modulated radiation therapy (accelerated partial breast irradiation [APBI]-alone), or APBI plus an aromatase inhibitor for 5 years. Read More

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Learning curve of TaTME for rectal cancer is associated with local recurrence; results from a multicentre external audit.

Colorectal Dis 2021 May 9. Epub 2021 May 9.

Department of Surgery, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Centre Amsterdam, The Netherlands.

Background: Transanal total mesorectal excision has been suggested as a potential solution for the resection of challenging mid and low rectal cancer. This relatively complex procedure has been implemented in many centres over the last years, despite absence of long-term safety data. Recently, concern has risen because of an increase in local recurrence in the implementation phase. Read More

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Clinicopathological features of superficial CD34-positive fibroblastic tumor.

World J Clin Cases 2021 Apr;9(12):2739-2750

Department of Pathology, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, Anhui Province, China.

Background: Superficial CD34-positive fibroblastoma (SCPFT) is a newly discovered mesenchymal tumor characterized by high polymorphism, low mitotic rate, and diffuse CD34-positive reactions.

Aim: To further determine the clinicopathological features of SCPFT.

Methods: We retrospectively analyzed the clinicopathological data, immunohistochemistry results, and differential diagnoses of four patients with SCPFT and performed a literature review. Read More

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Case Report: Primary Extraskeletal Osteosarcoma in the Lung and Pulmonary Artery.

Front Oncol 2021 22;11:673494. Epub 2021 Apr 22.

Department of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Extraskeletal osteosarcoma is an uncommon and high-grade soft tissue malignancy. The incidence is even lower when the lung and pulmonary artery are the primary site. The purpose of this report is to present the radiological features of this neoplasm in a 52-year-old man. Read More

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Multiple nerve root metastasis of breast carcinoma: a report of two cases.

Gland Surg 2021 Apr;10(4):1542-1546

Department of Neurosurgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Nerve root metastases are extremely rare with only a handful of cases ever reported. Metastasis to sites other than the primary site is common in malignant tumors whereas spinal ganglion metastasis is extremely rare and has been only reported in individual cases. The lumbar spine tends to be more common areas of presentation whereas breast cancer metastasis has been rarely reported. Read More

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A huge malignant phyllodes tumor of the breast with osteoclast-like giant cells: a case report.

Gland Surg 2021 Apr;10(4):1508-1514

Department of Breast Surgery, Second Affiliated Hospital of Dalian Medical University, Dalian, China.

The malignant phyllodes tumor (PT) of the breasts is a rare type of fibroepithelial neoplasm. Osteoclast-like giant cells (OLGCs) exist in many types of tumors. But malignant PTs with OLGCs were rarely reported. Read More

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Quantitative Analysis of Tumor-Associated Mast Cells in Recurrent and Non-recurrent Urothelial Bladder Cancer in Stage pTa and pT1.

Cureus 2021 Apr 5;13(4):e14311. Epub 2021 Apr 5.

General and Clinical Pathology, Forensic Medicine and Deontology, Medical University of Varna, Varna, BGR.

Background Urothelial carcinoma of the urinary bladder (UCUB) is a common malignancy in both genders with a very high recurrence rate. There has been increasing evidence for a correlation between tumor-associated mast cells (TAMC) and tumor growth and recurrence rates. In the present study, we set out to establish a link between TAMC and the clinical morphological characteristics of UCUB in stages pTa and pT1. Read More

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Intraperitoneal gemcitabine chemotherapy is safe for patients with resected pancreatic cancer: final clinical and pharmacologic data from a phase II protocol and recommended future directions.

J Gastrointest Oncol 2021 Apr;12(Suppl 1):S99-S109

Center for Gastrointestinal Malignancies, MedStar Washington Hospital Center, Washington, DC, USA.

Worldwide, the surgical management of pancreas cancer using the Whipple procedure results in long-term survival in approximately 20% of patients when there is a R0 resection. Local recurrence within the resection site and peritoneal metastases are a prominent part of this treatment failure. Gemcitabine was used for a regional chemotherapy treatment strategy. Read More

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Hyperthermic intra-operative intraperitoneal chemotherapy as an adjuvant to pancreatic cancer resection.

J Gastrointest Oncol 2021 Apr;12(Suppl 1):S91-S98

Surgical Oncology, Peritoneal Surface Malignancy Program, Euromedica Kyanous Stavros, Thessaloniki, Greece.

Background: Even after potentially curative resection the long-term survival of pancreatic cancer is poor. The local-regional failures are frequent. Previous studies have shown that adjuvant treatment with hyperthermic intra-operative intraperitoneal chemotherapy (HIPEC) may effectively control local disease. Read More

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Expression of p53 at invasive front of oral squamous cell carcinoma and negative histopathological surgical margins to establish correlation at 3-year survival.

J Oral Maxillofac Pathol 2020 Sep-Dec;24(3):582. Epub 2021 Jan 9.

Department of Oral Pathology, Sharad Pawar Dental College, Wardha, Maharashtra, India.

Background: Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity. The histologic features of OSCC differ from area to area within same tumor, and most prognostic information can be revealed from the invasive front of tumor. The most accepted line of treatment is radical neck dissection. Read More

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January 2021

Squamous cell carcinoma of the external ear: 170 cases treated with Mohs surgery.

J Plast Reconstr Aesthet Surg 2021 Apr 8. Epub 2021 Apr 8.

Angel H. Roffo Oncology Institute, Mohs Surgery Unit, Head and Neck Department, Alexander Fleming Institute, Skin Cancer Oncology, 1180 Cramer St., CABA (ZIP 1426), Buenos Aires, Argentina.

Introduction: Squamous cell carcinoma of the ear (SCC-E) shows high rates of local recurrence (LR) and lymph node metastases (NM). SCC-E is the leading cause of death from nonmelanoma skin cancer.

Objective: To determine the LR and NM rates and survival after Mohs micrographic surgery (MMS). Read More

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Gastrointestinal leiomyosarcoma demonstrate a predilection for distant recurrence and poor response to systemic treatments.

Eur J Surg Oncol 2021 May 4. Epub 2021 May 4.

The Royal Marsden Hospital NHS Foundation Trust, London, UK; The Institute of Cancer Research, London, UK. Electronic address:

Background: Primary leiomyosarcoma (LMS) of the gastrointestinal (GI) tract is rare. Limited literature exists regarding the clinical characteristics and outcome for patients with localised and metastatic disease.

Methods: A retrospective chart review was performed for patients greater than 18 years of age diagnosed with GI LMS at The Royal Marsden Hospital between 1 January 2000-1 May 2020. Read More

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A novel biodegradable injectable chitosan hydrogel for overcoming postoperative trauma and combating multiple tumors.

Carbohydr Polym 2021 Aug 16;265:118065. Epub 2021 Apr 16.

Department of Health Technology, Technical University of Denmark, Kongens Lyngby, DK-2800, Denmark. Electronic address:

Wound bacterial infections and tumor recurrence are the main reasons for the poor prognosis after primary tumor resection. Here, we fabricated a novel therapeutic nanocomposite using chitosan (CS) hydrogel combined with black phosphate nanosheets (BPNSs) and in situ grown copper nanoparticles (CuNPs). The obtained hydrogel (CS@BPNSs@CuNPs), possessing a remarkable temperature-sensitive spongy-like state, offered 24. Read More

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Partial open tumorectomy for a renal tumor in a horseshoe kidney with a close contact with the vena cava: A case report.

Int J Surg Case Rep 2021 Apr 27;82:105923. Epub 2021 Apr 27.

Urology Department, Charles Nicolle Hospital, Tunis, Tunisia.

Introduction And Importance: Horseshoe kidney has unique anatomical features, such as a complex blood supply. We report a patient with renal tumor in a horseshoe kidney in close contact with the vena cava, who underwent open tumorectomy.

Case Presentation: A 72-year-old woman was referred to our hospital with a 4-cm enhancing mid-pole mass in the right moiety of a horseshoe kidney. Read More

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Completion Pneumonectomy for Second Primary/Primary Lung Cancer and Local Recurrence Lung Cancer.

Ann Thorac Surg 2021 May 5. Epub 2021 May 5.

Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria. Electronic address:

Background: Completion pneumonectomy (CP) for second primary/primary lung cancer (SPLC) and local recurrence lung cancer (LRLC) is still controversial. Although several case series on such a practice exist, the oncological benefit is under debate. The purpose of this study was to review available literatures on CP for SPLC and LRLC and evaluate postoperative and long-term outcomes. Read More

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ENB-guided microwave ablation combined with uniportal VATS for multiple ground glass opacities.

Ann Thorac Surg 2021 May 5. Epub 2021 May 5.

Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China. Electronic address:

Background: An increasing number of patients are being diagnosed with multiple ground glass opacities (GGOs), but a consensus on the treatment of these patients is still lacking. The aim of this study was to investigate the safety and feasibility of a novel technique, electromagnetic navigation bronchoscopy (ENB)-guided microwave ablation combined with uniportal video-assisted thoracoscopic surgery (Uni-VATS), in patients with multiple GGOs.

Methods: The clinical, radiographic, surgical, and pathological data of patients with multiple GGOs who underwent ENB-guided microwave ablation combined with Uni-VATS from October 2018 to December 2019 were reviewed. Read More

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Laparoscopic repair of perineal hernia without suture fixation.

Colorectal Dis 2021 May 8. Epub 2021 May 8.

Chief of Department, General and Digestive Surgery, Hospital Universitari Arnau de Vilanova, Lleida, Spain.

We present the case of a 76 years old lady with a perineal hernia after an abdominoperineal resection for a locally advanced rectal cancer with prior neoadjuvant chemo-radiotherapy. She had a hysterectomy because of myomas. 6 months after the operation, she complained of perineal discomfort, physical examination and a CT-scan demonstrated a perineal hernia. Read More

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Medulloblastoma recurrence and metastatic spread are independent of colony-stimulating factor 1 receptor signaling and macrophage survival.

J Neurooncol 2021 May 8. Epub 2021 May 8.

Division of Hematology/Oncology, Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.

Purpose: Tumor infiltration by immunosuppressive myeloid cells or tumor-associated macrophages (TAMs) contributes to tumor progression and metastasis. In contrast to their adult counterparts, higher TAM signatures do not correlate with aggressive tumor behavior in pediatric brain tumors. While prominent TAM infiltrates exist before and after radiation, the degree to which irradiated macrophages and microglia support progression or leptomeningeal metastasis remains unclear. Read More

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Use of a Tumor Bed Boost in the Radiotherapy after Oncoplastic Breast Conserving Surgery.

Chirurgia (Bucur) 2021 Mar-Apr;116(2 Suppl):110-119

Aim Of The Study: Use of a radiotherapy (RT) tumor bed boost in addition to whole breast irradiation (WBI) after oncoplastic breast conserving surgery (OBCS) can be very challenging due to the massive tissue displacements. The aim of our study is to present relevant RT data regarding the use of a boost RT in patients who underwent OBCS and received adjuvant RT at Neolife Medical Center Bucharest. 12 patients treated with intensity modulated radiotherapy (IMRT), after OBCS, using conventional or hypofractionated schedules, between 10/2018 and 12/2020 were included in the study. Read More

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Advanced Oncoplastic Breast Conserving Surgery: Single Institution Experience with 823 Patients.

Chirurgia (Bucur) 2021 Mar-Apr;116(2 Suppl):59-72

Oncoplastic breast conserving surgery (BCS) becomes the standard of care in multidisciplinary breast cancer treatment. From our perspective, the aim of oncoplastic BCS is the best oncological, aesthetic and functional surgical treatment results. The study's objective is to present our approaches to the selection of surgical techniques and determine operative and oncological outcomes of oncoplastic surgery. Read More

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SBRT for HCC: Overview of technique and treatment response assessment.

Abdom Radiol (NY) 2021 May 7. Epub 2021 May 7.

Department of Radiology, University of Michigan, Ann Arbor, MI, USA.

Stereotactic body radiation therapy (SBRT) is an emerging locoregional treatment (LRT) modality used in the management of patients with hepatocellular carcinoma (HCC). The decision to treat HCC with LRT is evaluated in a multidisciplinary setting, and the specific LRT chosen depends on the treatment intent, such as bridge-to-transplant, down-staging to transplant, definitive/curative treatment, and/or palliation, as well as underlying patient clinical factors. Accurate assessment of treatment response is necessary in order to guide clinical management in these patients. Read More

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Systematic review of classification systems for locally recurrent rectal cancer.

BJS Open 2021 May;5(3)

Department of Radiology, Royal Marsden Hospital, London, UK.

Background: Classification of pelvic local recurrence (LR) after surgery for primary rectal cancer is not currently standardized and optimal imaging is required to categorize anatomical site and plan treatment in patients with LR. The aim of this review was to evaluate the systems used to classify locally recurrent rectal cancer (LRRC) and the relevant published outcomes.

Methods: A systematic review of the literature prior to April 2020 was performed through electronic searches of the Science Citation Index Expanded, EMBASE, MEDLINE and CENTRAL databases. Read More

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Germinal GLT8D1, GATAD2A and SLC25A39 mutations in a patient with a glomangiopericytal tumor and five different sarcomas over a 10-year period.

Sci Rep 2021 May 7;11(1):9765. Epub 2021 May 7.

INSERM U1037, Cancer Research Center in Toulouse (CRCT), Toulouse, France.

Soft tissue sarcoma represents about 1% of all adult cancers. Occurrence of multiple sarcomas in a same individual cannot be fortuitous. A 72-year-old patient had between 2007 and 2016 a glomangiopericytal tumor of the right forearm and a succession of sarcomas of the extremities: a leiomyosarcoma of the left buttock, a myxofibrosarcoma (MFS) of the right forearm, a MFS of the left scapula, a left latero-thoracic MFS and two undifferentiated sarcomas on the left forearm. Read More

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A Systematic Review of the Impact of Surgeon and Hospital Caseload Volume on Oncological and Nononcological Outcomes After Radical Prostatectomy for Nonmetastatic Prostate Cancer.

Eur Urol 2021 May 4. Epub 2021 May 4.

Department of Urology, University Hospital, St. Etienne, France.

Context: The impact of surgeon and hospital volume on outcomes after radical prostatectomy (RP) for localised prostate cancer (PCa) remains unknown.

Objective: To perform a systematic review on the association between surgeon or hospital volume and oncological and nononcological outcomes following RP for PCa.

Evidence Acquisition: Medline, Medline In-Process, Embase, and the Cochrane Central Register of Controlled Trials were searched. Read More

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Systematic Review and Meta-Analysis of Local Recurrence Rates of Head and Neck Cutaneous Melanomas after Wide Local Excision, Mohs Micrographic Surgery, or Staged Excision.

J Am Acad Dermatol 2021 May 4. Epub 2021 May 4.

Department of Dermatology, Hospital of the University of Pennsylvania; Philadelphia, PA. Electronic address:

Background: Prospective trials have not compared local recurrence rates for different excision techniques for cutaneous melanomas on the head and neck.

Objective: To determine local recurrence rates of cutaneous head and neck melanoma after wide local excision (WLE), Mohs micrographic surgery (MMS), or staged excision.

Methods: A systematic review of PubMed, EMBASE, and Web of Science identified all English case series, cohort studies and randomized controlled trials that reported local recurrence rates after surgery of cutaneous head and neck melanoma. Read More

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[Predictors for locoregional recurrence after radical prostatectomy].

Urologiia 2021 May(2):100-105

Institute of Urology and Reproductive Health, FGAOU VO I.M. Sechenov First Moscow State Medical University, Moscow, Russia.

An analysis of domestic and foreign literature on the predictors of prostate cancer recurrence are presented in the article. A deep analysis of both pathological and histological risk factors for progression was provided, as well as of laboratory and clinical predictors. Read More

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A phase I open label dose-escalation study to evaluate the tolerability, safety and immunological efficacy of sub-urothelial durvalumab injection in adults with muscle-invasive or high-risk non-muscle-invasive bladder cancer (SUBDUE-1, SUB-urothelial DUrvalumab injection-1 study): clinical trial protocol.

BJU Int 2021 May 6. Epub 2021 May 6.

University of Western Australia (UWA) Medical School, University of Western Australia, Perth, WA, Australia.

Objectives: This article presents the clinical trial protocol for a phase I open label dose-escalation study to evaluate the tolerability, safety and immunological efficacy of sub-urothelial durvalumab injection in adults with muscle-invasive or high-risk non-muscle-invasive bladder cancer (NMIBC), the SUB-urothelial DUrvalumab injection-1 study (SUBDUE-1). The primary objectives of this study are to assess the safety of sub-urothelial injection of durvalumab using patient reported outcome measures and observed local or systemic adverse events. The secondary objectives are to examine the local immunological efficacy of sub-urothelial administration of durvalumab. Read More

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Research Progress of Urine Biomarkers in the Diagnosis, Treatment, and Prognosis of Bladder Cancer.

Adv Exp Med Biol 2021 ;1306:61-80

Departments of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Bladder cancer (BC) is one of the most common tumor with high incidence. Relative to other cancers, BC has a high rate of recurrence, which results in increased mortality. As a result, early diagnosis and life-long monitoring are clinically significant for improving the long-term survival rate of BC patients. Read More

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