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Robot-assisted enucleation of a giant submucosal tumor in the upper esophagus.

Asian J Endosc Surg 2021 Jul 29. Epub 2021 Jul 29.

Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.

Few reports have demonstrated robotic surgery for large tumors in the upper esophagus. We report a case of a 52-year-old woman with a giant submucosal tumor in the upper esophagus successfully enucleated using robotic surgery. She presented with odynophagia and dysphagia, with subsequent evaluation revealing a submucosal mass measuring approximately 10 cm in diameter in the upper esophagus. Read More

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Microrheology of colloidal suspensions via dynamic Monte Carlo simulations.

J Colloid Interface Sci 2021 Jul 21;605:182-192. Epub 2021 Jul 21.

Department of Chemical Engineering and Analytical Science, The University of Manchester, Manchester M13 9PL, UK. Electronic address:

Understanding the rheology of colloidal suspensions is crucial in the formulation of a wide selection of industry-relevant products, such as paints, foods and inks. To characterise the viscoelastic behaviour of these soft materials, one can analyse the microscopic dynamics of colloidal tracers diffusing through the host fluid and generating local deformations and stresses. This technique, referred to as microrheology, links the bulk rheology of fluids to the microscopic dynamics at the particle scale. Read More

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Total shutdowns, targeted restrictions, or individual responsibility: How to promote social distancing in the COVID-19 Era?

J Health Econ 2021 Jul 17;79:102497. Epub 2021 Jul 17.

University of Notre Dame, NBER and J-PAL, United States.

We examine the impact of early state and local COVID-19 policies to encourage social distancing. Outcomes are daily foot traffic at establishments spanning ten key industries, across which transmission risk varies substantially. Policies include state of emergency declarations, blunt general restrictions such as stay-at-home (SAH) orders, and targeted rules such as restrictions on bars, restaurants, entertainment venues, and schools. Read More

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MSDS-UNet: A multi-scale deeply supervised 3D U-Net for automatic segmentation of lung tumor in CT.

Comput Med Imaging Graph 2021 Jul 24;92:101957. Epub 2021 Jul 24.

Amii, University of Alberta, Edmonton, Alberta, Canada.

Lung cancer is one of the most common and deadly malignant cancers. Accurate lung tumor segmentation from CT is therefore very important for correct diagnosis and treatment planning. The automated lung tumor segmentation is challenging due to the high variance in appearance and shape of the targeting tumors. Read More

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Optimising existing speech-language therapy resources in an underserved community: A study of the Maldives.

J Commun Disord 2021 Jun 22;93:106136. Epub 2021 Jun 22.

The University of Queensland, School of Health and Rehabilitation Sciences, Queensland, Australia; Centre for Functioning and Health Research, Metro South Hospital and Health Service, Queensland, Australia. Electronic address:

Background: People living in Majority world countries face complex challenges regarding speech-language therapy services. As traditional individualised service delivery approaches may not suit the needs of the population, customised solutions are needed.

Aim: This study explored speech-language therapy and related resources available in the Maldives, a Majority world country, as seen by local government representatives and service providers. Read More

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Validity of the source term for the Fukushima Dai-ichi Nuclear Power Station accident estimated using local-scale atmospheric dispersion simulations to reproduce the large-scale atmospheric dispersion of Cs.

J Environ Radioact 2021 Jul 26;237:106704. Epub 2021 Jul 26.

Japan Atomic Energy Agency, 2-4 Shirakata, Tokai, Naka-gun, Ibaraki, 319-1195, Japan.

The source term of Cs from the Fukushima Dai-ichi Nuclear Power Station (FDNPS) accident was estimated from the results of local-scale atmospheric dispersion simulations and measurements. To confirm the source term's validity for reproducing the large-scale atmospheric dispersion of Cs, this study conducted hemispheric-scale atmospheric and oceanic dispersion simulations. In the dispersion simulations, the atmospheric-dispersion database system Worldwide version of System for Prediction of Environmental Emergency Dose Information (WSPEEDI)-DB and oceanic dispersion model SEA-GEARN-FDM that were developed by the Japan Atomic Energy Agency were used. Read More

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Evaluation of Psychometric Properties of the Persian Version of Brief Male Sexual Function Inventory: A Cross-Sectional Study.

Sex Med 2021 Jul 26;9(5):100409. Epub 2021 Jul 26.

Non-Communicable Diseases Research Center, Ilam University of Medical Sciences, Ilam, Iran.

Introduction: Male sexual dysfunction is a common problem, and there are many self-report questionnaires for measuring sexual function among men; however, the Brief Male Sexual Function Inventory (BSFI) is a tool that has 5 subscales, which is more complete than others. a validated self-report questionnaire, in the local language with modest expressions is required for men.

Aim: To determine the validity and reliability of the Persian version of the BSFI among men. Read More

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The methods of vibrational microspectroscopy reveals long-term biochemical anomalies within the region of mechanical injury within the rat brain.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jul 22;263:120214. Epub 2021 Jul 22.

AGH University of Science and Technology, Faculty of Physics and Applied Computer Science, Krakow, Poland. Electronic address:

Traumatic brain injury (TBI), meaning functional or structural brain damage which appear as a result of the application of the external physical force, constitutes the main cause of death and disability of individuals and a great socioeconomic problem. To search for the new therapeutic strategies for TBI, better knowledge about posttraumatic pathological changes occurring in the brain is necessary. Therefore in the present paper the Fourier transform infrared microspectroscopy and Raman microscopy were used to examine local and remote biochemical changes occurring in the rat brain as a result of focal cortex injury. Read More

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Trace metal content in sediment cores and seagrass biomass from a tropical southwest Pacific Island.

Mar Pollut Bull 2021 Jul 26;171:112745. Epub 2021 Jul 26.

Pacific Centre for Environment and Sustainable Development, The University of the South Pacific, Lower Laucala Campus, Laucala Bay Road, Suva, Fiji.

A unique feature of seagrass among other ecosystem services is to have high phytoremediation potential that is a cost-effective plant-based approach and environmentally friendly solution for metal contamination in coastal areas. The goal of this study was to assess the phytoremediation prospective of seagrass for Cu, Fe, Mn and Zn in Fiji Islands. Heavy metal content was measured in sediments and tissues of the seagrasses Halophila ovalis, Halodule pinifolia and Halodule uninervis to test for local-scale differences. Read More

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Agricultural practices drive biological loads, seasonal patterns and potential pathogens in the aerobiome of a mixed-land-use dryland.

Sci Total Environ 2021 Jul 22;798:149239. Epub 2021 Jul 22.

The Biodesign Center for Fundamental and Applied Microbiomics, Arizona State University, Tempe 85287-5001, AZ, USA; School of Life Sciences, Arizona State University, Tempe, AZ 85287-5001, USA. Electronic address:

Air carries a diverse load of particulate microscopic biological matter in suspension, either aerosolized or aggregated with dust particles, the aerobiome, which is dispersed by winds from sources to sinks. The aerobiome is known to contain microbes, including pathogens, as well as debris or small-sized propagules from plants and animals, but its variability and composition has not been studied comprehensibly. To gain a dynamic insight into the aerobiome existing over a mixed-use dryland setting, we conducted a biologically comprehensive, year-long survey of its composition and dynamics for particles less than 10 μm in diameter based on quantitative analyses of DNA content coupled to genomic sequencing. Read More

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Prolonged anesthesia and decreased toxicity of enantiomeric-excess Bupivacaine loaded in Ionic gradient liposomes.

Int J Pharm 2021 Jul 26:120944. Epub 2021 Jul 26.

Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (Unicamp), Campinas, Brazil. Electronic address:

Bupivacaine is the most employed local anesthetic in surgical procedures, worldwide. Its systemic toxicity has directed the synthesis of the less toxic, S(-) enantiomer. This work describes a formulation of ionic gradient liposomes (IGL) containing BVC, an enantiomeric excess mixture of 75% S(-) and 25% R(+) bupivacaine. Read More

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Identification of incorrectly oriented particles in Cryo-EM Single Particle Analysis.

J Struct Biol 2021 Jul 26:107771. Epub 2021 Jul 26.

Univ. San Pablo CEU, Campus Urb. Montepríncipe s/n, 28668, Boadilla del Monte, Madrid, Spain; National Center of Biotechnology, CSIC, Campus Univ. Autónoma de Madrid, 28049, Cantoblanco, Madrid, Spain. Electronic address:

The quality of a 3D map produced by the single-particle analysis method is highly dependent on an accurate assignment of orientations to the many experimental images. However, the problem's complexity implies the presence of several local minima in the optimized goal functions. Consequently, validation methods to confirm the angular assignment are very useful to yield higher-resolution 3D maps. Read More

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Analysis of flow field and turbulence predictions in a lung model applying RANS and implications for particle deposition.

Eur J Pharm Sci 2021 Jul 26:105959. Epub 2021 Jul 26.

Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus.

Airflow and aerosol deposition in the human airways are important aspects for applications such as pulmonary drug delivery and human exposure to aerosol pollutants. Numerical simulations are widely used nowadays to shed light in airflow features and particle deposition patterns inside the airways. For that purpose, the Euler/Lagrange approach is adopted for predicting flow field and particle deposition through point-particle tracking. Read More

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ROLE OF STEREOTACTIC RADIOSURGERY FOR THE TREATMENT OF BRAIN METASTASIS IN THE ERA OF IMMUNOTHERAPY: A SYSTEMATIC REVIEW ON CURRENT EVIDENCES AND PREDICTING FACTORS.

Crit Rev Oncol Hematol 2021 Jul 26:103431. Epub 2021 Jul 26.

Department of Neurosurgery and Gamma Knife Radiosurgery, San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy.

Stereotactic radiosurgery (SRS) in combination with immunotherapy (IT) is increasingly used in the setting of melanoma and non-small cell lung cancer (NSCLC) brain metastases (BM). The synergistic properties of this treatment combination are still not deeply understood. IT-SRS appropriate combination has been envisioned as a strategic point in patients' management. Read More

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Outcomes of cardiac diffuse large B-cell lymphoma (DLBCL) in the rituximab era.

Int J Cardiol 2021 Jul 26. Epub 2021 Jul 26.

Harrington Heart and Vascular Institute, University Hospitals, Cleveland, OH, United States of America; School of Medicine, Case Western Reserve University, Cleveland, OH, United States of America. Electronic address:

Background Cardiac diffuse large B-cell lymphoma (cDLBCL) are extremely rare. Introduction of rituximab has significantly improved survival in non-cardiac DLBCL, but there is limited data regarding outcomes of cDLBC. We sought to evaluate the outcomes of cDLBCL in both pre- and rituximab eras. Read More

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Evaluation of skin test indications for general anesthetics in real life: a prospective cohort study.

Braz J Anesthesiol 2021 Jul 26. Epub 2021 Jul 26.

Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Immunology and Allergic Diseases, Istanbul, Turkey. Electronic address:

Background: In daily practice, atopic patients and those who have other drug allergies are referred to allergy clinics for evaluation of possible general anesthetic allergy despite the fact that it is not recommended in recent guidelines.

Objective: The aim of this prospective study is to determine the negative predictive value of skin tests for common general anesthetic drugs prior to general anesthesia in atopic patients and in patients who had drug allergies by including the data of those who had previously tolerated or reacted to general anesthesia.

Methods: A database program was constituted to collect the preoperative skin test data of patients referred to our clinic between 2013 and 2018. Read More

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Multiscale pharmacokinetic modeling of systemic exposure of subcutaneously injected biotherapeutics.

J Control Release 2021 Jul 26. Epub 2021 Jul 26.

Industrial & Physical Pharmacy, Purdue University West Lafayette, Indiana, USA. Electronic address:

Subcutaneously injected formulations have been developed for many biological products including monoclonal antibodies (mAbs). A knowledge gap nonetheless remains regarding the absorption and catabolism mechanisms and kinetics of a large molecule at the administration site. A multiscale pharmacokinetic (PK) model was thus developed by coupling multiphysics simulations of subcutaneous (SC) absorption kinetics with whole-body pharmacokinetic (PK) modeling, bridged by consideration of the presystemic clearance by the initial lymph. Read More

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Biomaterial-based delivery of nucleic acids for tissue regeneration.

Adv Drug Deliv Rev 2021 Jul 26:113885. Epub 2021 Jul 26.

Department of Orthopaedics, Shanghai Key Laboratory for Prevention, Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, P.R.China. Electronic address:

Gene therapy is a promising novel method of tissue regeneration by stimulating or inhibiting key signaling pathways. However, their therapeutic applications in vivo are largely limited by several physiological obstacles, such as degradation of nucleases, impermeability of cell membranes, and transport to the desired intracellular compartments. Biomaterial-based gene delivery systems can overcome the problems of stability and local drug delivery, and can temporarily control the overexpression of therapeutic genes, leading to the local production of physiologically relevant levels of regulatory factors. Read More

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Covalent inhibition of hAChE by organophosphates causes homodimer dissociation through long-range allosteric effects.

J Biol Chem 2021 Jul 26:101007. Epub 2021 Jul 26.

Skaggs School of Pharmacy and Pharm. Sci., UC San Diego, La Jolla, CA 92093-0751. Electronic address:

Acetylcholinesterase (EC 3.1.1. Read More

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Clinical and Biological Indicators of Periodontal Disease in Obese and non-Obese adults with and without Bronchial Asthma.

J Asthma 2021 Jul 29:1-12. Epub 2021 Jul 29.

Medical Student, College of Medicine, Jordan University of Science & Technology, Irbid, Jordan.

The present study aims to assess clinical and inflammatory parameters as indicators for periodontal disease in obese and non-obese adults with and without bronchial asthma (BA). 168 patients visiting the outpatient pulmonary clinics were divided into four groups according to BA and obesity. Obesity was defined by body mass index (BMI) and BA was diagnosed by a pulmonary consultant and being on inhaled asthma medication for at least 12 months. Read More

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BALM: Watching the Formation of Tethered Bilayer Lipid Membranes with Submicron Lateral Resolution.

Langmuir 2021 Jul 29. Epub 2021 Jul 29.

Univ Lyon, Université Claude Bernard Lyon 1, CNRS, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, ICBMS, UMR 5246, GEMBAS Team, Lederer building, 1 rue Victor Grignard, F-69622 Villeurbanne, France.

Tethered bilayer lipid membranes (tBLMs) are artificial membranes largely used for the study of biological membranes and membrane-associated proteins. To date, the formation of these membranes was essentially monitored by surface averaging techniques like surface plasmon resonance (SPR) and quartz crystal microbalance with dissipation monitoring (QCM-D), which cannot provide both local and real-time information in a single approach. Here, we report an original application of backside absorbing layer microscopy (BALM), a novel white-light wide-field optical microscopy, to study tBLMs. Read More

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IGF-1 TMJ Injections Enhance Mandibular Growth and Bone Quality in Juvenile Rats.

Orthod Craniofac Res 2021 Jul 29. Epub 2021 Jul 29.

Division of Orthodontics, University of California San Francisco, California, USA.

Objectives: Dentofacial orthopedic treatment of mandibular hypoplasia has unpredictable skeletal outcomes. Although several biomodulators including insulin-like growth factor 1 (IGF-1) are known to contribute to chondrocyte proliferation, their efficacy in modulating mandibular growth has not been validated. The aim of this study was to determine the effect of locally delivered IGF-1 on mandibular growth and condylar bone quality/quantity in juvenile rats. Read More

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Cullin 2-RBX1 E3 ligase and USP2 regulate antithrombin ubiquitination and stability.

FASEB J 2021 Aug;35(8):e21800

Guangzhou Municipal and Guangdong Provincial Key Lab of Protein Modification and Degradation Lab, State Key Lab of Respiratory Disease, School of Basic Medical Sciences, Affiliated Cancer Hospital of Guangzhou Medical University, Guangzhou, China.

Hemophilia A and B are congenital bleeding disorders caused by a deficiency in pro-coagulant factor VIII or IX that is treated by downregulation of antithrombin. However, the molecular mechanisms that regulate antithrombin expression remain poorly understood. Here, we identified Cullin 2 and USP2 (ubiquitin-specific peptidase-2) as novel regulators of antithrombin expression that act by modulating antithrombin ubiquitination. Read More

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The safety and efficacy of cold vs. hot snare polypectomy including colorectal polyps ≥1 cm in size.

Dig Endosc 2021 Jul 29. Epub 2021 Jul 29.

Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan.

Cold snare polypectomy (CSP; polypectomy without electrocautery) has rapidly spread worldwide during the past decade in what has been called a Cold Revolution. We performed a PubMed literature search for studies investigating CSP outcomes for colorectal polyps. Five randomized controlled trials (RCTs) assessed the complete resection rates (CRRs). Read More

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Evidence for Systemic Reactive Oxygen Species in UVB-mediated Microvesicle Formation.

Photochem Photobiol 2021 Jul 29. Epub 2021 Jul 29.

Departments of Pharmacology and Toxicology, Boonshoft School of Medicine at Wright State University, Dayton, OH, 45435, USA.

Recent studies have implicated subcellular microvesicle particles (MVP) in the ability of Ultraviolet B radiation to exert both local and systemic effects. Indeed, UVB generates MVP (UVB-MVP) in human skin and systemically following phototherapy. The current studies were designed to test the hypothesis that the ability of UVB to generate MVP was dependent upon reactive oxygen species (ROS). Read More

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Structuro-functional surrogates of response to subcallosal cingulate deep brain stimulation for depression.

Brain 2021 Jul 29. Epub 2021 Jul 29.

Division of Neurosurgery, Department of Surgery, University Health Network and University of Toronto, Toronto, M5T 2S8, Canada.

Subcallosal cingulate deep brain stimulation (SCC-DBS) produces long-term clinical improvement in approximately half of patients with severe treatment-resistant depression (TRD). We hypothesized that both structural and functional brain attributes may be important in determining responsiveness to this therapy. In a TRD SCC-DBS cohort, we retrospectively examined baseline and longitudinal differences in MRI-derived brain volume (n = 65) and 18F-fluorodeoxyglucose-PET glucose metabolism (n = 21) between responders and non-responders. Read More

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Using a public database of Neisseria gonorrhoeae genomes to detect mutations associated with zoliflodacin resistance.

J Antimicrob Chemother 2021 Jul 29. Epub 2021 Jul 29.

Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA.

Background: Antimicrobial resistance (AMR) in Neisseria gonorrhoeae is an urgent global health threat. Zoliflodacin is a novel antibiotic undergoing clinical trials for the treatment of gonorrhoea. While there are limited data regarding zoliflodacin resistance in N. Read More

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The Quiescent Center and Root Regeneration.

J Exp Bot 2021 Jul 29. Epub 2021 Jul 29.

The Institute of Plant Sciences, Faculty of Agriculture, The Hebrew University, Israel.

Since its discovery by F.A.L Clowes, extensive research has been dedicated to identifying the functions of the quiescent center (QC). Read More

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Sri Lanka's early success in the containment of COVID-19 through its rapid response: Clinical & epidemiological evidence from the initial case series.

PLoS One 2021 29;16(7):e0255394. Epub 2021 Jul 29.

Department of Community Medicine, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka.

Background: Despite the rising global burden, Sri Lanka reported a relatively low caseload and mortality (13 deaths as of 20 October 2020) for COVID-19. This warrants exploration of the clinical and epidemiological characteristics of the case series during the initial passive case detection phase in Sri Lanka, in order to understand the success in containment of the disease for more than nine months in the country through its initial early and rapid pandemic response.

Methods: A retrospective study was conducted using secondary data (hospital records and investigation reports) extracted from all laboratory-confirmed patients admitted to the three main state-sector hospitals in Sri Lanka from 11 March to 7 April 2020. Read More

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Relationship between practices of eye protection against solar ultraviolet radiation and cataract in a rural area.

PLoS One 2021 29;16(7):e0255136. Epub 2021 Jul 29.

Institute of Health Policy and Management, College of Public Health, National Taiwan University, Taipei, Taiwan.

Background: Cataract is a public health concern worldwide that differentially affects rural residents of outlying islands where ultraviolet radiation (UVR) may have greater penetration because of less shading.

Objectives: To assess the relationships between attitudes and practices of eye protection and eye diseases for residents of an offshore island of Taiwan.

Methods: Questionnaire survey was administered to local residents (age > 50 years) regarding socio-demographic information, attitudes/practices of eye protection under sun exposure and eye diseases. Read More

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