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Outcomes of surgical and/or medical treatment in patients with prolactinomas during long-term follow-up: a retrospective single-centre study.

Horm Mol Biol Clin Investig 2020 Dec 17;42(2):153-157. Epub 2020 Dec 17.

Division of Endocrinology, Faculty of Medicine, Cukurova University, Adana, Turkey.

Objectives: Prolactinoma is the most common cause of pituitary tumours. Current medical guidelines recommend dopamine agonists (cabergoline or bromocriptine) as the initial therapy for prolactinoma. However, surgical removal can also be considered in selected cases, such as patients with macroadenomas with local complications (bleeding or optic chiasm pressure) or those not responding to medical treatment. Read More

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December 2020

Transanal approach after preoperative imatinib treatment of a rectal gastrointestinal stromal tumors with external anal sphincter invasion: A case report.

Int J Surg Case Rep 2021 Jul 19;85:106217. Epub 2021 Jul 19.

Department of Surgery, Japan Community Health Care Organization Isahaya General Hospital, Nagasaki, Japan.

Introduction And Importance: Rectal gastrointestinal stromal tumors (GISTs) are rare, and preserving anorectal function can be challenging. We report the case of a patient with rectal GIST with external anal sphincter invasion, treated via the laparoscopic and transanal approaches.

Case Presentation: A 61-year-old man with locally advanced GIST in the right anterolateral wall of the lower rectum was examined. Read More

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Rare cutaneous toxicity of immune checkpoint inhibitors: A case of durvalumab-induced dermatomyositis.

Eur J Cancer 2021 Jul 28;155:25-27. Epub 2021 Jul 28.

Department of Internal Medicine, Multi-Organic Diseases, Local Referral Center for Rare Auto-immune Diseases, Montpellier University Hospital, Montpellier, France; Institute of Regenerative Medicine and Biotherapy, Institut national de la santé et de la recherche médicale U1183, Montpellier, France. Electronic address:

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Population structure and the influence of microenvironment and genetic similarity on individual growth at Alaskan white spruce treelines.

Sci Total Environ 2021 Jul 26;798:149267. Epub 2021 Jul 26.

Institute of Botany und Landscape Ecology, University of Greifswald, Soldmannstr. 15, 17487 Greifswald, Germany. Electronic address:

Knowledge on the adaptation of trees to rapid environmental changes is essential to preserve forests and their ecosystem services under climate change. Treeline populations are particularly suitable for studying adaptation processes in trees, as environmental stress together with reduced gene flow can enhance local adaptation. We investigated white spruce (Picea glauca) populations in Alaska on one moisture-limited and two cold-limited treeline sites with a paired plot design of one forest and one treeline population each, resulting in six plots. Read More

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Environmental sustainability of a pork and bean stew.

Sci Total Environ 2021 Jul 26;798:149203. Epub 2021 Jul 26.

School of Industrial Engineering (ETSII), C/José Gutiérrez Abascal, 2, Grupo de Agroenergética, Universidad Politécnica de Madrid, Madrid 28006, Spain.

The aim of this investigation is to quantify the environmental footprint of an industrially produced bean and pork stew produced using a combination of local/imported and fresh/ processed ingredients. The study describes 16 midpoint categories and an aggregated score, calculated following the EC Product Environmental Footprint (PEF) methodology. The carbon footprint of 1 kg of stew amounts to 2. Read More

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Risk of hospitalised falls and hip fractures in working age adults receiving mental health care.

Gen Hosp Psychiatry 2021 Jul 20;72:81-87. Epub 2021 Jul 20.

Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, United Kingdom; South London and Maudsley NHS Foundation Trust, Denmark Hill, London, United Kingdom.

Objective: This retrospective cohort study investigates risks of hospitalised fall or hip fractures in working age adults receiving mental health care in South London.

Methods: Patients aged 18 to 64, who received a first mental illness diagnosis between 2008 and 2016 were included. Primary outcome was hospitalised falls, secondary outcome was hip fractures. Read More

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Genetic insights into the paternal admixture history of Chinese Mongolians via high-resolution customized Y-SNP SNaPshot panels.

Forensic Sci Int Genet 2021 Jul 20;54:102565. Epub 2021 Jul 20.

Institute of Forensic Medicine, West China School of Basic Science and Forensic Medicine, Sichuan University, Chengdu 610041, China. Electronic address:

The Mongolian people, one of the Mongolic-speaking populations, are native to the Mongolian Plateau in North China and southern Siberia. Many ancient DNA studies recently reported extensive population transformations during the Paleolithic to historic periods in this region, while little is known about the paternal genetic legacy of modern geographically different Mongolians. Here, we genotyped 215 Y-chromosomal single nucleotide polymorphisms (Y-SNPs) and 37 Y-chromosomal short tandem repeats (Y-STRs) among 679 Mongolian individuals from Hohhot, Hulunbuir, and Ordos in North China using the AGCU Y37 kit and our developed eight Y-SNP SNaPshot panels (including two panels first reported herein). Read More

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Local and systemic gene expression levels of IL-10, IL-17 and TGF-β in active ocular toxoplasmosis in humans.

Cytokine 2021 Jul 28;146:155643. Epub 2021 Jul 28.

Department of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Background: To compare mRNA expression of interleukin 10 (IL-10), interleukin 17 (IL-17) and Transforming Growth Factor-β (TGF-β) in aqueous humor (AH) and peripheral blood mononuclear cells (PBMCs) in human ocular toxoplasmosis (OT) and controls.

Method: RNA isolation, cDNA synthesis and real-time polymerase chain reaction were performed on AH sediments and PBMCs of 16 patients with active OT and 21 controls at the Khatam-al-Anbia Eye Hospital, Iran. For comparison, Mann Whitney U test was used at a discrimination level of p < 0. Read More

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Concentrations and health risks of heavy metals in five major marketed marine bivalves from three coastal cities in Guangxi, China.

Ecotoxicol Environ Saf 2021 Jul 28;223:112562. Epub 2021 Jul 28.

Department of Cell Biology, School of Life Sciences, and School of Medicine, Guangxi University, Nanning 530004, China. Electronic address:

Seafood consumption provides essential elements to humans while also posing risks to human health. A total of 2610 individuals of five edible marine bivalve species (Ruditapes philippinarum, Paphia undulata, Meretrix meretrix, Sinonovacula constricta and Meretrix lyrata) were randomly sampled from six farmer markets in three cities (Beihai, Qinzhou and Fangchenggang) in the southernmost coastal region of China. The concentrations of heavy metals (Cu, Pb, Zn, Cd, Cr, Hg and As) were determined by inductively coupled plasma mass spectrometry (ICP-MS). Read More

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A temperature-dependent Raman scattering and X-ray diffraction study of KMoO·HO and ab initio calculations of KMoO.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jul 16;263:120184. Epub 2021 Jul 16.

Instituto de Ciências Exatas e Naturais, Universidade Federal do Pará, CEP 66075-110, Belém, PA, Brazil.

This study reports a temperature-dependent Raman scattering and X-ray diffraction study of KMoO·HO. The high-temperature Raman scattering analysis shows that the material remains structurally stable, with triclinic symmetry, in a temperature range from 300 to 413 K and undergoes a structural phase transition between 413 and 418 K. This phase transition is most likely connected with the dehydration process of KMoO·HO. Read More

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Source impact and contribution analysis of ambient ozone using multi-modeling approaches over the Pearl River Delta region, China.

Environ Pollut 2021 Jul 27;289:117860. Epub 2021 Jul 27.

Guangdong Provincial Key Laboratory of Atmospheric Environment and Pollution Control, College of Environment and Energy, South China University of Technology, Guangzhou Higher Education Mega Center, Guangzhou, 510006, China.

Quantification of source impacts and contributions is a key element for the design of effective air pollution control policies. In this study, O source impacts and contributions were comprehensively assessed over the Pearl River Delta (PRD) region of China using brute-force method (BFM), response surface modeling with BFM (RSM-BFM) and differential method (RSM-DM) respectively, high-order decoupled direct method (HDDM), and ozone source apportionment technology (OSAT). The multi-modeling comparison results indicated that under typical nonlinear atmospheric conditions during the O formation, BFM, RSM-BFM, and HDDM seemed to be appropriate for assessing the impact of single source emissions; however, the results of HDDM could deviate from those of BFM when the emission reduction ratio was higher than 50 %. Read More

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Adaptive current-flow models of ECT: Explaining individual static impedance, dynamic impedance, and brain current density.

Brain Stimul 2021 Jul 28. Epub 2021 Jul 28.

Department of Biomedical Engineering, The City College of New York, CUNY, New York, NY, USA. Electronic address:

Background: Improvements in electroconvulsive therapy (ECT) outcomes have followed refinement in device electrical output and electrode montage. The physical properties of the ECT stimulus, together with those of the patient's head, determine the impedances measured by the device and govern current delivery to the brain and ECT outcomes.

Objective: However, the precise relations among physical properties of the stimulus, patient head anatomy, and patient-specific impedance to the passage of current are long-standing questions in ECT research and practice. Read More

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Accelerated theta burst stimulation for the treatment of depression: A randomised controlled trial.

Brain Stimul 2021 Jul 28. Epub 2021 Jul 28.

Epworth Centre for Innovation in Mental Health, Epworth Healthcare and Department of Psychiatry, Monash University, Camberwell, Victoria, Australia.

Introduction: Theta burst pattern repetitive transcranial magnetic stimulation (TBS) is increasingly applied to treat depression. TBS's brevity is well-suited to application in accelerated schedules. Sizeable trials of accelerated TBS are lacking; and optimal TBS parameters such as stimulation intensity are not established. Read More

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Local ablation of gastric cancer by reconstituted apolipoprotein B lipoparticles carrying epigenetic drugs.

Nanomedicine 2021 Jul 28:102450. Epub 2021 Jul 28.

Department of Surgery, National Cheng Kung University, Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:

Epigenetic inhibitors have shown anticancer effects. Combination chemotherapy with epigenetic inhibitors has shown high effectiveness in gastric cancer clinical trials, but severe side effect and local progression are the causes of treatment failure. Therefore, we sought to develop an acidity-sensitive drug delivery system to release drugs locally to diminish unfavorable outcome of gastric cancer. Read More

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A comparative study on chemical compositions and biological activities of four essential oils: Cymbopogon citratus (DC.) Stapf, Cinnamomum cassia (L.) Presl, Salvia japonica Thunb. and Rosa rugosa Thumb.

J Ethnopharmacol 2021 Jul 28:114472. Epub 2021 Jul 28.

School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, China. Electronic address:

Ethnopharmacological Relevance: Essential oils (EOs) are important active ingredients in Chinese herbal medicine. Cymbopogon citratus (DC.) Stapf, Cinnamomum cassia (L. Read More

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Thermo-Responsive Hydrogels for Cancer Local Therapy: Challenges and State-of-Art.

Int J Pharm 2021 Jul 28:120954. Epub 2021 Jul 28.

Drug Delivery and Targeting Group, Molecular Biology and Biochemistry Research Centre for Nanomedicine (CIBBIM-Nanomedicine), Vall d'Hebron Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, Spain; Networking Research Centre for Bioengineering, Biomaterials, and Nanomedicine (CIBER-BBN), Instituto de Salud Carlos III, Madrid, Spain; Functional Validation and Preclinical Research (FVPR), CIBBIM-Nanomedicine, Vall d'Hebron Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, Spain.

Despite the enormous efforts done by the scientific community in the last decades, advanced cancer is still considered an incurable disease. New formulations are continuously under investigation to improve drugs therapeutic index, i.e. Read More

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Degree of Improving TMS Focality through a Geometrically Stable Solution of an Inverse TMS Problem.

Neuroimage 2021 Jul 28:118437. Epub 2021 Jul 28.

Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115 USA.

The Transcranial Magnetic Stimulation (TMS) inverse problem (TMS-IP) investigated in this study aims to focus the TMS induced electric field close to a specified target point defined on the gray matter interface in the M1 area while otherwise minimizing it. The goal of the study is to numerically evaluate the degree of improvement of the TMS-IP solutions relative to the well-known sulcus-aligned mapping (a projection approach with the 90 local sulcal angle). In total, 1536 individual TMS-IP solutions have been analyzed for multiple target points and multiple subjects using the boundary element fast multipole method (BEM-FMM) as the forward solver. Read More

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Peripheral Levels of C-reactive protein, tumor necrosis factor-α, interleukin-6, and interleukin-1β across the mood spectrum in bipolar disorder: a meta-analysis of mean differences and variability.

Brain Behav Immun 2021 Jul 28. Epub 2021 Jul 28.

Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, 75 Pigdon's Road, Waurn Ponds, Geelong, VIC, 3216, Australia. Electronic address:

Importance: It is unclear whether differences exist in the magnitude and variability of pro-inflammatory mediators in the different phases of bipolar disorder (BD) and among subjects with BD, as compared to healthy controls.

Objective: To run a comparative meta-analysis of C-Reactive Protein (CRP), IL-1, IL-6, TNF-α in BD vs healthy controls, measuring mean and variability effects on all subjects. Sensitivity analyses include disease activity. Read More

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Super-rational aspiration induced strategy updating helps resolve the tragedy of the commons in a cooperation system with exit rights.

Biosystems 2021 Jul 28:104496. Epub 2021 Jul 28.

School of Ecology and Environment, Northwestern Polytechnical University, Xi'an, 710129, China. Electronic address:

Avoiding the tragedy of the commons requires altruists to incur some losses to benefit the group. Although specific rules and self-enforcing agreements could help maintain the cooperation system stable, the costly recognition and free-rider problem are still questioned these two cooperation maintenance mechanisms. We here considered the situation of both exit costs and exit benefits in the asymmetric prisoner's dilemma game and introduced a super-rational aspiration induced strategy updating, where players adjust strategies in line with their payoffs and aspirations. Read More

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The crosstalk between brain and periphery: Implications for brain health and disease.

Neuropharmacology 2021 Jul 28:108728. Epub 2021 Jul 28.

Centre for Neuroscience Studies, Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, Canada; Department of Psychiatry, Queen's University, Kingston, ON K7L 3N6, Canada; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, 22281-100, Brazil; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, 21941-902, Brazil. Electronic address:

Mounting evidence indicates that signaling molecules identified primarily in the peripheral circulation can affect cognitive function in physiological and pathological conditions, including in the development of several neurological diseases. However, considering the properties of the vascular blood-brain barrier (BBB), circulating lipophobic molecules would not be expected to cross this vascular structure. Thus, if and how peripheral lipophobic molecules, such as hormones and cytokines, reach the brain to exert their reported effects remains to be better established. Read More

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Proximity of schools to roads and students' academic performance: A cross-sectional study in the Federal District, Brazil.

Environ Res 2021 Jul 28:111770. Epub 2021 Jul 28.

Department of Public Health, University of Copenhagen, Copenhagen, Denmark.

Investigations of the educational implications of children's exposure to air pollutants at school are crucial to enhance our understanding of the hazards for children. Most of the existing literature is based on studies performed in North America and Europe. Further investigation is required in low- and middle-income countries, where there are important challenges related to public health, transportation, environment, and education sector. Read More

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Down-staging Outcomes for Hepatocellular Carcinoma: Results from the Multicenter Evaluation of Reduction in Tumor Size before Liver Transplantation (MERITS-LT) Consortium.

Gastroenterology 2021 Jul 28. Epub 2021 Jul 28.

Division of Gastroenterology, Department of Medicine, University of California, San Francisco; Division of Transplant Surgery, Department of Surgery, University of California, San Francisco.

Background/aims: United Network of Organ Sharing (UNOS) has adopted uniform criteria for down-staging (UNOS-DS) of hepatocellular carcinoma (HCC) prior to liver transplantation (LT), but down-staging success rate and intention-to-treat outcomes across broad geographic regions are unknown.

Methods: In this first multi-regional study (7 centers, 4 UNOS regions), consecutive patients with HCC undergoing down-staging based on UNOS-DS criteria were prospectively evaluated from 2016-2019 (n=209).

Results: Probability of successful down-staging to Milan criteria and dropout at 2 years from initial down-staging procedure was 87. Read More

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Embedded adaptive deep brain stimulation for cervical dystonia controlled by motor cortex theta oscillations.

Exp Neurol 2021 Jul 28:113825. Epub 2021 Jul 28.

Movement Disorders and Neuromodulation Centre, University of California San Francisco, San Francisco, CA, USA. Electronic address:

Dystonia is a disabling movement disorder characterized by excessive muscle contraction for which the underlying pathophysiology is incompletely understood and treatment interventions limited in efficacy. Here we utilize a novel, sensing-enabled, deep brain stimulator device, implanted in a patient with cervical dystonia, to record local field potentials from chronically implanted electrodes in the sensorimotor cortex and subthalamic nuclei bilaterally. This rechargeable device was able to record large volumes of neural data at home, in the naturalistic environment, during unconstrained activity. Read More

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Oral vaccination with attenuated Salmonella encoding the Trichinella spiralis 43-kDa protein elicits protective immunity in BALB/c mice.

Acta Trop 2021 Jul 28:106071. Epub 2021 Jul 28.

College of Veterinary Medicine, Jilin Agricultural University, Changchun, China; Jilin Provincial Engineering Research Center of Animal Probiotics, Jilin Agricultural University, Changchun, China; Key Laboratory of animal production and product quality safety of Ministry of Education, Jilin Agricultural University, Changchun, China. Electronic address:

A vaccine against Trichinella spiralis infection is urgently needed to interrupt its transmission from domestic animals to humans. However, no vaccine against T. spiralis is currently available. Read More

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Phylogenetic analysis of lice infested chicken (Gallus gallus domisticus) with new records in Kurdistan of Iraq.

Ann Parasitol 2021 ;67(2):161-168

Department of Biology, College of Sciences, University of Duhok, Kurdistan Region-Iraq.

The domestic chickens are the most important protein sources of human populations in every part of the world; many parasites' species may affect birds. Ectoparasites can be found practically in all birds. They feed on their body components like blood, feathers. Read More

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January 2021

High prevalence of syphilis in women, minors, and precarious patients: a cross-sectional study in a Reunion Island sexually transmitted infection clinic, 2017-2020.

J Eur Acad Dermatol Venereol 2021 Jul 31. Epub 2021 Jul 31.

CHU Réunion, Service des Maladies Infectieuses - Dermatologie, Saint Pierre, La Réunion, France.

Background: Syphilis is a sexually transmitted infection (STI) with a global prevalence estimated at 0.5% in 2012. Syphilis has been on the rise among men who have sex with men (MSM) in high-income countries and remains at endemic levels in low- and middle-income countries. Read More

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Implementation of the Australian Computer-Assisted Theragnostics (AusCAT) network for radiation oncology data extraction, reporting and distributed learning.

J Med Imaging Radiat Oncol 2021 Jul 31. Epub 2021 Jul 31.

Institute of Medical Physics, School of Physics, University of Sydney, Sydney, New South Wales, Australia.

Introduction: There is significant potential to analyse and model routinely collected data for radiotherapy patients to provide evidence to support clinical decisions, particularly where clinical trials evidence is limited or non-existent. However, in practice there are administrative, ethical, technical, logistical and legislative barriers to having coordinated data analysis platforms across radiation oncology centres.

Methods: A distributed learning network of computer systems is presented, with software tools to extract and report on oncology data and to enable statistical model development. Read More

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Brucellosis reemergence after a decade of quiescence in palestine, 2015-2017: a seroprevalence and molecular characterization study.

Transbound Emerg Dis 2021 Jul 31. Epub 2021 Jul 31.

Palestine Korea Biotechnology Center, Palestine Polytechnic University, Hebron, Palestine.

Brucellosis is an endemic disease in many developing countries and ranked by the World Health Organization among the top seven "neglected zoonoses". Although a Palestinian brucellosis control program was launched in 1998, the disease reemerged after 2012. Interestingly, a similar reemerging pattern was reported in the neighboring Israeli regions. Read More

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A new Fe-C porous filter material from dredged sediment: preparation, characterization, and its application.

Environ Sci Pollut Res Int 2021 Jul 31. Epub 2021 Jul 31.

National and Local Joint Engineering Research Center of Ecological Treatment Technology for Urban Water Pollution, Wenzhou University, Wenzhou, 325035, China.

A new Fe-C porous filter material was prepared with dredged sediment of river as raw material. The orthogonal test L(3) and component ratio experiment of raw material were conducted to investigate the optimum technological condition. Further, the filter obtained was characterized by Brunauer-Emmett-Teller (BET), scanning electron microscopy (SEM), energy dispersive X-ray spectroscope (EDS), and X-ray diffraction (XRD). Read More

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The impact of air pollution on COVID-19 pandemic varied within different cities in South America using different models.

Environ Sci Pollut Res Int 2021 Jul 31. Epub 2021 Jul 31.

Center for Excellence in Regional Atmospheric Environment, Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, China.

There is a rising concern that air pollution plays an important role in the COVID-19 pandemic. However, the results were not consistent on the association between air pollution and the spread of COVID-19. In the study, air pollution data and the confirmed cases of COVID-19 were both gathered from five severe cities across three countries in South America. Read More

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