7,015 results match your criteria local deposition

The bacterial effector HopZ1a acetylates MKK7 to suppress plant immunity.

New Phytol 2021 May 7. Epub 2021 May 7.

Instituto de Hortofruticultura Subtropical y Mediterránea, Universidad de Málaga-Consejo Superior de Investigaciones Científicas (IHSM-UMA-CSIC), Depto. Biología Celular, Genética y Fisiología, Campus de Teatinos, Málaga, E-29071, Spain.

The Pseudomonas syringae type III secretion system translocates effector proteins into the host cell cytosol to suppress plant basal immunity. Effector HopZ1a suppresses local and systemic immunity triggered by pathogen-associated molecular patterns (PAMPs) and effectors, through target acetylation. HopZ1a has been shown to target several plant proteins, but none fully substantiates HopZ1a-associated immune suppression. Read More

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Modulating surface charge of dexamethasone non-spherical microcrystals for improved inner ear delivery.

Colloids Surf B Biointerfaces 2021 Apr 29;204:111806. Epub 2021 Apr 29.

Biomedical Barriers Research Center, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin Key Laboratory of Biomedical Materials, Tianjin, 300192, China. Electronic address:

It is important to achieve precise surface charge manipulation of non-spherical drug microcrystals using facile and time-efficient methods for local drug delivery. In this study, silk-coated dexamethasone (DEX) non-spherical microcrystals were synthesized by precipitation technique followed by alternate deposition of poly(allylamine hydrochloride) (PAH) (or PAH-coated FeO) and silk fibroin (SF) via layer-by-layer assembly. EDC and glutaraldehyde were employed to manipulate positive or negative charge of particles by simple chemical cross-linking reactions, respectively. Read More

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Structural evolution in thermoelectric zinc antimonide thin films studied by X-ray scattering techniques.

IUCrJ 2021 May 13;8(Pt 3):444-454. Epub 2021 Apr 13.

Center for Materials Crystallography, Department of Chemistry and iNANO, Aarhus University, Aarhus C, DK-8000, Denmark.

Zinc antimonides have been widely studied owing to their outstanding thermoelectric properties. Unlike in the bulk state, where various structurally unknown phases have been identified through their specific physical properties, a number of intermediate phases in the thin-film state remain largely unexplored. Here, X-ray diffraction and X-ray total scattering are combined with measurement of electrical resistivity to monitor the crystallization process of as-deposited amorphous Zn-Sb films during post-deposition annealing. Read More

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Regional and organ-level responses to local lung irradiation in sheep.

Sci Rep 2021 May 5;11(1):9553. Epub 2021 May 5.

The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, Edinburgh, EH25 9RG, UK.

Lung is a dose-limiting organ in radiotherapy. This may limit tumour control when effort is made in planning to limit the likelihood of radiation-induced lung injury (RILI). Understanding the factors that dictate susceptibility to radiation-induced pulmonary fibrosis will aid in the prevention and management of RILI, and may lead to more effective personalized radiotherapy treatment. Read More

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Triple sulfur-oxygen-strontium isotopes probabilistic geographic assignment of archaeological remains using a novel sulfur isoscape of western Europe.

PLoS One 2021 5;16(5):e0250383. Epub 2021 May 5.

CNRS, CAGT, UMR 5288, Université Paul Sabatier, Toulouse, France.

Sulfur isotope composition of organic tissues is a commonly used tool for gathering information about provenance and diet in archaeology and paleoecology. However, the lack of maps predicting sulfur isotope variations on the landscape limits the possibility to use this isotopic system in quantitative geographic assignments. We compiled a database of 2,680 sulfur isotope analyses in the collagen of archaeological human and animal teeth from 221 individual locations across Western Europe. Read More

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Trends of nutrients and metals in precipitation in northern Germany: the role of emissions and meteorology.

Environ Monit Assess 2021 May 5;193(6):325. Epub 2021 May 5.

Landesamt für Landwirtschaft, Umwelt und ländliche Räume des Landes Schleswig-Holstein, Abteilung Gewässer, Dezernat Fließgewässerökologie, Hamburger Chaussee 25, Flintbek, 24220, Germany.

We analyzed the precipitation chemistry for a maritime region in northern Germany (Schleswig-Holstein) from 1997 to 2017 in order to reveal temporal and spatial patterns and to evaluate the role of meteorological factors relative to emission reductions in Germany and Europe. Therefore, we applied several statistical methods such as time series decomposition, principal component, and redundancy analysis. We extracted two main groups: (i) a marine group (Cl, Na, Mg) that was related to natural processes like sea spray input and (ii) an anthropogenic group (Pb, Cd, As, Zn, and nitrogen species) with a terrestrial subgroup (Fe, Al, Mn), which were both related to emissions. Read More

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Low-dose IL-34 has no effect on osteoclastogenesis but promotes osteogenesis of hBMSCs partly via activation of the PI3K/AKT and ERK signaling pathways.

Stem Cell Res Ther 2021 May 4;12(1):268. Epub 2021 May 4.

Department of Orthopedics Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88, Jiefang Road, Hangzhou, 310009, China.

Background: Inflammatory microenvironment is significant to the differentiation and function of mesenchymal stem cells (MSCs). It evidentially influences the osteoblastogenesis of MSCs. IL-34, a newly discovered cytokine, playing a key role in metabolism. Read More

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Spatial distribution of microplastics in the fluvial sediments of a transboundary river - A case study of the Tisza River in Central Europe.

Sci Total Environ 2021 Apr 26;785:147306. Epub 2021 Apr 26.

Department of Physical Geography and Geoinformatics, University of Szeged, Egyetem u. 2-6, Szeged 6722, Hungary.

The geographical environment fundamentally influences the transport and deposition of sediments, including microplastics. In addition, the socioeconomic differences inherent in transboundary catchments result in various waste management strategies among the different countries influencing the input of microplastics into rivers. The catchment of the Tisza River in Central Europe is shared by five countries with different economic statuses and wastewater treatment practices. Read More

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The stable isotope composition of hoarfrost.

Isotopes Environ Health Stud 2021 May 3:1-14. Epub 2021 May 3.

Emil Racoviță Institute of Speleology, Cluj-Napoca, Romania.

Atmospherically deposited hoarfrost is probably the least important quantitative component of the hydrosphere, yet in places acts as an important source of water. Although countless studies have investigated the stable isotope composition of virtually all other components of the global hydrosphere, little is known on its stable isotope composition. We addressed this gap in knowledge by investigating the stable isotope composition of hoarfrost and precipitation in the Southern Carpathian Mountains (East-Central Europe) in relation with the local and regional meteorological parameters and hoarfrost characteristics. Read More

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Amyloid-β Protein Precursor Deficiency Changes Neuronal Electrical Activity and Levels of Mitochondrial Proteins in the Medial Prefrontal Cortex.

J Alzheimers Dis 2021 Apr 28. Epub 2021 Apr 28.

Precise Genome Engineering Center, School of Life Sciences, Guangzhou University, Guangzhou, China.

Background: Neuropathological features of Alzheimer's disease are characterized by the deposition of amyloid-β (Aβ) plaques and impairments in synaptic activity and memory. However, we know little about the physiological role of amyloid-β protein precursor (AβPP) from which Aβ derives.

Objective: Evaluate APP deficiency induced alterations in neuronal electrical activity and mitochondrial protein expression. Read More

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The contradictory role of androgens in cutaneous and major burn wound healing.

Burns Trauma 2021 Jan 20;9:tkaa046. Epub 2021 Apr 20.

Burns Research Group, ANZAC Research Institute, University of Sydney, Concord Hospital, Gate, 3 Hospital road, Concord, NSW 2139, Australia.

Wound healing is a complex process involving four overlapping phases: haemostasis, inflammation, cell recruitment and matrix remodeling. In mouse models, surgical, pharmacological and genetic approaches targeting androgen actions in skin have shown that androgens increase interleukin-6 and tumor necrosis factor-α production and reduce wound re-epithelization and matrix deposition, retarding cutaneous wound healing. Similarly, clinical studies have shown that cutaneous wound healing is slower in men compared to women. Read More

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January 2021

Influence of Reactive Chain Extension on the Properties of 3D Printed Poly(Lactic Acid) Constructs.

Polymers (Basel) 2021 Apr 23;13(9). Epub 2021 Apr 23.

Digital Manufacturing and Materials Characterization Laboratory, School of Science and Technology, International Hellenic University, 14 km Thessaloniki, 57001 N. Moudania, Greece.

Fused deposition modeling (FDM) is currently the most popular 3D printing method, where thermoplastic polymers are predominantly used. Among them, the biobased poly(lactic acid) (PLA) governs the FDM filament market, with demand higher than supply, since not all grades of PLA are suitable for FDM filament production. In this work, the effect of a food grade chain extender (Joncryl ADR 4400) on the physicochemical properties and printability of PLA marketed for injection molding was examined. Read More

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Polarized SERS Controlled by Anisotropic Growth on Ordered Curvature Substrate.

Molecules 2021 Apr 17;26(8). Epub 2021 Apr 17.

Center for Advanced Optoelectronic Materials, School of Material and Environmental Engineering, Hangzhou Dianzi University, Hangzhou 310018, China.

Colloidal lithography is an efficient and low-cost method to prepare an ordered nanostructure array with new shapes and properties. In this study, square-shaped and cone-shaped Au nanostructures were obtained by 70° angle deposition onto polystyrene bead array with the diameter of 500 nm when a space of 120 nm is created between the neighbor beads by plasma etching. The gaps between the units decrease when the Au deposition time increases, which leads to the polarized enhanced local field, in agreement with the surface-enhanced Raman scattering spectra (SERS) observations and finite-difference time-domain (FDTD) simulations. Read More

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Contribution of Gut Microbiota-Derived Uremic Toxins to the Cardiovascular System Mineralization.

Toxins (Basel) 2021 04 10;13(4). Epub 2021 Apr 10.

Department of Nephrology, Hypertension and Internal Medicine, University of Warmia and Mazury in Olsztyn, 10-561 Olsztyn, Poland.

Chronic kidney disease (CKD) affects more than 10% of the world population and leads to excess morbidity and mortality (with cardiovascular disease as a leading cause of death). Vascular calcification (VC) is a phenomenon of disseminated deposition of mineral content within the media layer of arteries preceded by phenotypic changes in vascular smooth muscle cells (VSMC) and/or accumulation of mineral content within the atherosclerotic lesions. Medial VC results in vascular stiffness and significantly contributes to increased cardio-vascular (CV) morbidity, whereas VC of plaques may rather increase their stability. Read More

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Confocal Blood Flow Videomicroscopy of Thrombus Formation over Human Arteries and Local Targeting of P2X7.

Int J Mol Sci 2021 Apr 14;22(8). Epub 2021 Apr 14.

Myocardial Diseases and Atherosclerosis Unit, Cardiovascular Research Center, San Raffaele Scientific Institute IRCCS, Via Olgettina, 58, 20132 Milano, Italy.

Atherothrombosis exposes vascular components to blood. Currently, new antithrombotic therapies are emerging. Herein we investigated thrombogenesis of human arteries with/without atherosclerosis, and the interaction of coagulation and vascular components, we and explored the anti-thrombogenic efficacy of blockade of the P2X purinoceptor 7 (P2X7). Read More

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Quantification of the radiosensitization effect of high-Z nanoparticles on photon irradiated cells: combining Monte Carlo simulations and an analytical approach to the local effect model.

Phys Med Biol 2021 Apr 29. Epub 2021 Apr 29.

Departamento de Investigación en Física, Universidad de Sonora, Blvd. Luis Encinas y Rosales S/N, Col. Centro, C.P. 83000, Hermosillo, Sonora, México, Hermosillo, Sonora, 83000, MEXICO.

In vitro experiments show significant reduction in the survival fraction of cells under irradiation treatments assisted with high-Z nanoparticles (NPs). In order to predict the radiosensitization effect of NPs, a modification of the local effect model, in which the energy deposition from NPs is assessed by Monte Carlo (MC) radiation transport codes, has been employed in the past. In this work, a combined framework that splits the consideration of the radiosensitization effect into two steps is proposed. Read More

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Surface and interface analysis of a low-dimensional Au-Si surface alloy on Au(110) by means of XPS and XPD.

J Phys Condens Matter 2021 Apr 27. Epub 2021 Apr 27.

Experimentelle Physik 1, TU Dortmund, Poststelle: August-Schmidt-Straße 1 Rektorat:, August-Schmidt-Straße 4, 44227 Dortmund, Germany, Dortmund, Nordrhein-Westfalen, 44227, GERMANY.

The chemical and structural characteristics of a low-dimensional Au-Si surface alloy are presented in this work. Alloy formation was obtained by deposition of a sub-monolayer Si on Au(110). This preliminary phase to Si nano-ribbons is being investigated, as the transition from clean Au(110) to a silicon nano-ribbon coated surface is not yet understood. Read More

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Does mercury emission from small-scale gold mining cause widespread soil pollution in Ghana?

Environ Pollut 2021 Mar 22;284:116945. Epub 2021 Mar 22.

Aarhus University, Department of Bioscience, Velsoevej 25, 8600, Silkeborg, Denmark. Electronic address:

The use of mercury in small-scale gold mining is globally the largest anthropogenic source of mercury in the environment. In countries like Ghana, where small-scale gold mining is a highly important economic sector, the activity is also expected to cause local pollution. This study is based on a hypothesis that the mining activity in Ghana is causing more widespread soil pollution also outside active mining sites, and that the main part of regional differences in soil concentrations of mercury might come from pollution. Read More

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Mitochondrial complex I abnormalities is associated with tau and clinical symptoms in mild Alzheimer's disease.

Mol Neurodegener 2021 04 26;16(1):28. Epub 2021 Apr 26.

Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Douglas Research Institute, Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal; Department of Neurology and Neurosurgery, Psychiatry and Pharmacology and Therapeutics, McGill University, 6875 Boulevard LaSalle, Montreal, H4H 1R3, Canada.

Background: Mitochondrial electron transport chain abnormalities have been reported in postmortem pathological specimens of Alzheimer's disease (AD). However, it remains unclear how amyloid and tau are associated with mitochondrial dysfunction in vivo. The purpose of this study is to assess the local relationships between mitochondrial dysfunction and AD pathophysiology in mild AD using the novel mitochondrial complex I PET imaging agent [F]BCPP-EF. Read More

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Hepatocyte Growth Factor-Induced Tendon Stem Cell Conditioned Medium Promotes Healing of Injured Achilles Tendon.

Front Cell Dev Biol 2021 7;9:654084. Epub 2021 Apr 7.

Department of Pediatric Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

Tendon repair is a medical challenge. Our present study investigated the effectiveness of acellular therapy consisting of conditioned medium (CM) of tendon stem cells (TSCs) induced with hepatocyte growth factor (HGF) in promoting the healing of injured Achilles tendon in a rat model. Proteomic analysis of soluble substances in the CM was performed using an array chip, and bioinformatic analysis was carried out to evaluate interactions among the factors. Read More

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IGF-1-Expressing Placenta-Derived Mesenchymal Stem Cells Promote Scalding Wound Healing.

J Surg Res 2021 Apr 22;265:100-113. Epub 2021 Apr 22.

Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang, China. Electronic address:

Background: Stem cell-based regenerative therapy is a novel approach to severe damaged skin. Perinatal tissues such as placenta are considered as promising alternatives. The present study aimed to investigate the effect of insulin-like growth factor-1 (IGF-1)-expressing placenta-derived mesenchymal stem cells (hPMSCs) on healing of burn wounds. Read More

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Multimodal Nanoscopic Study of Atomic Diffusion and Related Localized Optoelectronic Response of WS/MoS Lateral Heterojunctions.

ACS Appl Mater Interfaces 2021 May 23;13(17):20361-20370. Epub 2021 Apr 23.

School of Sciences, Hangzhou Dianzi University, 310018 Hangzhou, P. R. China.

The atomic diffusion in transition metal dichalcogenides (TMDs) van der Waals heterojunctions (HJs) strongly modifies their optoelectronic properties in the nanoscale. However, probing such localized properties challenges the spatial resolution and the sensitivity of a variety of analytic tools. Herein, a multimodal nanoscopy (based on tip enhanced Raman spectroscopy (TERS) and photoluminescence (TEPL)) combined with the Kelvin probe force microscopy (KPFM) method was used to probe such nanoscale localized optoelectronic properties induced by atomic diffusion. Read More

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Dietary obesity in mice is associated with lipid deposition and metabolic shifts in the lungs sharing features with the liver.

Sci Rep 2021 Apr 22;11(1):8712. Epub 2021 Apr 22.

Univ Lyon, CarMeN Laboratory, INSERM, INRA, INSA Lyon, Université Claude Bernard Lyon 1, 69921, Oullins Cedex, France.

Obesity is associated with both chronic and acute respiratory illnesses, such as asthma, chronic obstructive pulmonary disease (COPD) or increased susceptibility to infectious diseases. Anatomical but also systemic and local metabolic alterations are proposed contributors to the pathophysiology of lung diseases in the context of obesity. To bring perspective to this discussion, we used NMR to compare the obesity-associated metabolomic profiles of the lung with those of the liver, heart, skeletal muscles, kidneys, brain and serum from male C57Bl/6J mice fed with a high-fat and high-sucrose (HFHSD) diet vs. Read More

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PMMA-Based Continuous Hemofiltration Modulated Complement Activation and Renal Dysfunction in LPS-Induced Acute Kidney Injury.

Front Immunol 2021 1;12:605212. Epub 2021 Apr 1.

Nephrology, Dialysis and Transplantation Unit, Department of Medical and Surgical Science, University of Foggia, Foggia, Italy.

Sepsis-induced acute kidney injury (AKI) is a frequent complication in critically ill patients, refractory to conventional treatments. Aberrant activation of innate immune system may affect organ damage with poor prognosis for septic patients. Here, we investigated the efficacy of polymethyl methacrylate membrane (PMMA)-based continuous hemofiltration (CVVH) in modulating systemic and tissue immune activation in a swine model of LPS-induced AKI. Read More

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Occurrence, spatiotemporal distribution, seasonal and annual variation, and source apportionment of poly- and perfluoroalkyl substances (PFASs) in the northwest of Tai Lake Basin, China.

J Hazard Mater 2021 Apr 2;416:125784. Epub 2021 Apr 2.

School of Environment, Beijing Key Laboratory for Emerging Organic Contaminants Control, State Key Joint Laboratory of Environment Simulation and Pollution Control (SKLESPC), Tsinghua University, Beijing 100084, PR China; Research Institute for Environmental Innovation (Suzhou), Tsinghu, Building 16, 101 Business Park, No, 158 Jinfeng Road, New District, Suzhou 215163, PR China.

Poly- and perfluoroalkyl substances (PFASs) have attracted mounting attention due to their potential harmful effects and degradation-resistant property. This study continuously monitored the concentration of PFASs for four seasons in two years in the northwest of Tai Lake Basin. The occurrence, spatiotemporal distribution, seasonal and annual variation, and source apportionment of 13 PFASs were investigated in 60 surface water sampling sites and 33 emission sources. Read More

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Apelin-13 Protects Corpus Cavernosum Against Fibrosis Induced by High-Fat Diet in an MMP-Dependent Mechanism.

J Sex Med 2021 Apr 13. Epub 2021 Apr 13.

Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

Background: An increased fibrosis of the corpora cavernosa is a prevalent process that underlies most cases of erectile dysfunction. Apelin, an endogenous circulating peptide, has been documented as an important effector on cardiovascular homeostasis, controlling vascular function and reducing fibrosis in multiple pathological conditions. Recently, initial studies have shown that Apelin, acting through the APJ receptor, also modulates penile erection, however, the role of this system on penile structure and intracorporal collagen remodeling has not been investigated yet. Read More

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Gold Nanostar Spatial Distribution Impacts the Surface-Enhanced Raman Scattering Detection of Uranyl on Amidoximated Polymers.

Langmuir 2021 Apr 16;37(16):4891-4899. Epub 2021 Apr 16.

Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, United States.

The plasmonic properties of carboxylated gold nanostars distributed on amidoximated polyacrylonitrile (AO PAN) electrospun polymer films scale with surface-enhanced Raman scattering (SERS) intensities for coordinated uranium(VI) oxide (uranyl) species. This two-step plasmonic sensor first isolates uranyl from solution using functionalized polymers; then carboxylated gold nanostars are subsequently deposited for SERS. Spatially resolved localized surface plasmon resonance (LSPR) and SERS facilitate correlated nanostar optical density and uranyl quantification. Read More

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Fish tissues for biomonitoring toxic and essential trace elements in the Lower Amazon.

Environ Pollut 2021 Mar 26;283:117024. Epub 2021 Mar 26.

Department of Animal Pathology, Veterinary Faculty, University of Santiago de Compostela, 27002, Lugo, Spain.

Brazilian soils can have high concentrations of toxic elements, mainly mercury (Hg) and arsenic (As), metals also associated with anthropogenic activities (e.g. intensive agriculture, mining, deforestation and hydroelectric plants). Read More

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Efficiency of atorvastatin on in-hospital mortality of patients with acute aortic dissection (AAD): study protocol for a randomized, open-label, superiority clinical trial.

Trials 2021 Apr 14;22(1):281. Epub 2021 Apr 14.

The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, Guangdong, China.

Background: Dyslipidemia and local inflammation at sites of lipid deposition on blood vessel walls have been demonstrated to be risk factors for patients with acute aortic dissection (AAD). Statins have anti-inflammatory and lipid-lowering effects, which suggest that statins may play an important role in the prevention and treatment of AAD. Some retrospective studies show that statins can protect patients with aortic dissection. Read More

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Capillary-Induced Wrinkle-to-Fold Transitions Under Biaxial Compression.

Langmuir 2021 May 14;37(17):5282-5289. Epub 2021 Apr 14.

Division of Mechanical Engineering, Osaka University, Suita 565-0871, Japan.

Wrinkles in bilayer systems comprising a thin stiff film attached to a soft substrate can globally transition into folds under sufficiently large compression. This phenomenon has been extensively studied primarily using uniaxially compressed systems. However, inducing the wrinkle-to-fold transition at designated locations on a wrinkled surface under small biaxial compression remains a challenge. Read More

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