24,068 results match your criteria lobe epilepsy

Palinacousis: an eloquent symptom of temporal lobe lesion.

BMJ Case Rep 2021 Apr 13;14(4). Epub 2021 Apr 13.

Division of Neurosurgery, University of Montreal, Montreal, Quebec, Canada

A 24-year-old woman was referred to us for an intracranial haemorrhage in the left temporal lobe caused by a ruptured cavernous malformation; the bleeding extended over the left Heschl's gyrus and Wernicke area. On admission, the patient had global aphasia. A few days later, she spontaneously improved but remained with mild residual comprehensive dysphasia. Read More

View Article and Full-Text PDF

Long term evolution of Fast Ripples during epileptogenesis.

J Neural Eng 2021 Apr 13. Epub 2021 Apr 13.

Universite de Rennes 1, Campus Beaulieu, Rennes, Bretagne, 35065, FRANCE.

Objective: Fast Ripples (FRs) have received considerable attention in the last decade since they represent an electrophysiological biomarker of the Epileptogenic Zone (EZ). However, the real dynamics underlying the occurrence, amplitude, and time-frequency content of FRs generation during epileptogenesis are still not well understood. This work aims at characterizing and explaining the evolution of these features. Read More

View Article and Full-Text PDF

The effect of injection time on rates of epileptogenic zone localization using SISCOM and STATISCOM.

Epilepsy Behav 2021 Apr 9;118:107945. Epub 2021 Apr 9.

Department of Neurology, Royal Melbourne Hospital, Parkville, VIC, Australia; Department of Medicine and Radiology, University of Melbourne, Parkville, VIC, Australia; Department of Neurosciences, Monash University, Melbourne, VIC, Australia; Department of Neurology, Alfred Hospital, Melbourne, VIC, Australia. Electronic address:

Background: The identification of hyperperfusion on ictal single-photon emission computed tomography (SPECT) scan is a technique for the localization of the epileptogenic zone (EZ) in patients with focal epilepsy undergoing presurgical evaluation. The accuracy of this technique has been improved by subtraction from an interictal image and coregistration with magnetic resonance imaging (MRI) (subtraction ictal SPECT coregistered to MRI (SISCOM)), and subsequently by the development of Statistical Ictal SPECT Co-registered to MRI (STATISCOM) which is reported to further improve localization accuracy by statistically accounting for random variation between images. However, the use of ictal SPECT is limited by the necessity for rapid injection of the radiotracer. Read More

View Article and Full-Text PDF

Distinctive clinical presentation and pathogenic specificities of anti-AK5 encephalitis.

Brain 2021 Apr 12. Epub 2021 Apr 12.

French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hospices Civils de Lyon, Hôpital Neurologique, Bron, France.

Limbic encephalitis (LE) with antibodies against adenylate kinase 5 (AK5) has been difficult to characterize because of its rarity. In this study, we identified 10 new cases and reviewed 16 previously reported patients, investigating clinical features, IgG subclasses, human leukocyte antigen (HLA), and CSF proteomic profiles. Patients with anti-AK5 LE were mostly men (20/26, 76. Read More

View Article and Full-Text PDF

Are HFOs in the Intra-operative ECoG Related to Hippocampal Sclerosis, Volume and IQ?

Front Neurol 2021 24;12:645925. Epub 2021 Mar 24.

Department of Neurology and Neurosurgery, University Medical Center Utrecht Brain Center, University Utrecht, Utrecht, Netherlands.

Temporal lobe epilepsy (TLE) is the most common form of refractory focal epilepsy and is often associated with hippocampal sclerosis (HS) and cognitive disturbances. Over the last decade, high frequency oscillations (HFOs) in the intraoperative electrocorticography (ioECoG) have been proposed to be biomarkers for the delineation of epileptic tissue but hippocampal ripples have also been associated with memory consolidation. Healthy hippocampi can show prolonged ripple activity in stereo- EEG. Read More

View Article and Full-Text PDF

Anxiety and depressive symptoms long after mesial temporal epilepsy surgery: A prospective study.

Epilepsy Behav 2021 Apr 8;118:107936. Epub 2021 Apr 8.

Graduate Program in Translational Neuroscience, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil; Center for Applied Neuroscience, University Hospital (HU), Universidade Federal de Santa Catarina (UFSC), Florianópolis, Brazil; Graduate Program in Neuroscience, UFSC, Florianópolis, Brazil; Neurology Division, Internal Medicine Department, HU, UFSC, Florianópolis, Brazil; Graduate Program in Medical Sciences, UFSC, Florianópolis, SC, Brazil.

Background: Anxiety and depressive symptoms are prevalent in patients with refractory mesial temporal lobe epilepsy related to hippocampal sclerosis (MTLE-HS) before and after anterior temporal lobectomy (ATL).

Aims: (1) To follow the levels of anxiety and depressive symptoms long-term after ATL among patients with refractory MTLE-HS; (2) To identify pre- and postsurgical variables associated with the levels of anxiety and depressive symptoms after surgery.

Methods: We compared the levels of anxiety and depressive symptoms determined by the Hospital Anxiety and Depression Scale (HADS) before and long after ATL (mean 104 months, range 70-130) in 41 consecutive patients refractory MTLE-HS. Read More

View Article and Full-Text PDF

Resective epilepsy surgery in patients aged 50years and older - a retrospective study regarding seizure outcome, memory performance, and psychopathology.

Epilepsy Behav 2021 Apr 8;118:107933. Epub 2021 Apr 8.

Protestant Hospital Alsterdorf, Epilepsy Center Hamburg, Elisabeth-Flügge-Str. 1, 22337 Hamburg, Germany. Electronic address:

Purpose: To assess clinical and demographic characteristics in two cohorts of elderly patients with drug-resistant focal epilepsy, undergoing resective epilepsy surgery (RES). Further, to determine seizure, neuropsychological, and mental health outcomes after RES and evaluate possible influencing factors.

Methods: Consecutive patients aged ≥50 years with temporal lobe epilepsy (TLE) who underwent curative RES in the Hamburg epilepsy surgery program (2004-2017) were identified. Read More

View Article and Full-Text PDF

Anxiety symptoms are the strongest predictor of quality of life in temporal lobe epilepsy.

Seizure 2021 Mar 23;88:78-82. Epub 2021 Mar 23.

Department of Psychiatry, Hospital das Clínicas, University of São Paulo Medical School (IPq/HCFMUSP), Brazil.

Purpose: It is established that the severity of depressive and anxiety symptoms is associated with poorer quality of life (QOL) in persons with drug-resistant epilepsy. We aimed to verify the presence of subsyndromic depressive episodes (SDEs) and subsyndromic anxiety episodes (SAEs) in persons with temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) compared to healthy controls and to determine the impact of depressive and anxiety symptoms on patients' QOL.

Methods: We prospectively evaluated 35 persons with TLE-HS and 90 healthy controls. Read More

View Article and Full-Text PDF

Feasibility, Contrast Sensitivity and Network Specificity of Language fMRI in Presurgical Evaluation for Epilepsy and Brain Tumor Surgery.

Brain Topogr 2021 Apr 10. Epub 2021 Apr 10.

Department of Medicine, School of Health Sciences, Democritus University of Thrace, Xanthi, Greece.

Language fMRI has become an integral part of the planning process in brain surgery. However, fMRI may suffer from confounding factors both on the patient side, as well as on the provider side. In this study, we investigate how patient-related confounds affect the ability of the patient to perform language fMRI tasks (feasibility), the task sensitivity from an image contrast point of view, and the anatomical specificity of expressive and receptive language fMRI protocols. Read More

View Article and Full-Text PDF

A pioneering FreeSurfer volumetric study of a series of patients with mesial temporal lobe epilepsy and hippocampal sclerosis with comorbid depression.

Psychiatry Res Neuroimaging 2021 Mar 19;311:111281. Epub 2021 Mar 19.

Department of Neurology and Neurosurgery, Universidade Federal de São Paulo (UNIFESP), Pedro de Toledo Street, 650, 1st floor. Postal number: 04039-002 Vila Clementino, São Paulo, Brazil.

Depression is the most frequent psychiatric comorbidity in patients with mesial temporal lobe epilepsy (MTLE) and hippocampal sclerosis (HS). This study aimed to confirm whether patients with comorbid depression have different volumetric patterns on magnetic resonance imaging, analysing the influence of HS sides. Psychiatrists conducted semi-structured interviews with 75 patients, who were divided into non-depression group (NDG, n = 52) and depression group (DG, n = 23), and compared with 98 controls. Read More

View Article and Full-Text PDF

Hippocampal and Septal 5-HT Receptor Expression in Two Rat Models of Temporal Lobe Epilepsy.

Neuroscience 2021 Apr 6. Epub 2021 Apr 6.

Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig-Maximilians-University Munich, Germany. Electronic address:

Experimental and clinical data suggest an impact of serotonergic signaling on seizure susceptibility and epilepsy-associated psychiatric comorbidities. Previous µPET studies revealed increased binding of 5-HT receptor ligand [F]MPPF in two rat models with spontaneous recurrent seizures. These findings raised the question whether these alterations are due to altered 5-HT receptor expression or a modification of extracellular serotonin concentrations. Read More

View Article and Full-Text PDF

Systematic Literature Review of Psychiatric Comorbidities in Adults with Epilepsy.

J Clin Neurol 2021 Apr;17(2):176-186

Departments of Neurology and Psychiatry, Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Background And Purpose: Mental illness is disproportionately common in people with epilepsy (PWE). This systematic literature review identified original research articles that reported the prevalence of psychiatric comorbidities based upon clinical assessments in a sample of PWE and assessed the clinical features of the populations found in studies included in our review of mental health comorbidity.

Methods: The included articles were written in English and published from 2008 to 2018, and focused on adults aged ≥18 years who had psychiatric diagnoses determined in clinical assessments, such as those found in medical records, clinician psychiatric evaluations, structured diagnostic interviews, and mental health screening questionnaires specific for a psychiatric disorder. Read More

View Article and Full-Text PDF

Treatment of pharmacoresistant sleep-related hypermotor epilepsy (SHE) with the selective AMPA receptor antagonist perampanel.

Sleep Med 2021 Apr 5;81:382-386. Epub 2021 Apr 5.

Section of Epilepsy, Department of Neurology, Chang Gung Memorial Hospital Linkou Medical Center and Chang Gung University College of Medicine, Taoyuan, Taiwan; Department of Neurology, Xiamen Chang Gung Hospital, Xiamen, Fujian, China. Electronic address:

This study aimed to evaluate the efficacy and tolerability of perampanel (PER) as adjunctive therapy in patients with pharmacoresistant sleep-related hypermotor epilepsy (SHE). Patients diagnosed with SHE who received PER treatment between 2016 and 2019 were included, and their data were reviewed retrospectively. Diagnosis was based on reports of patients or family members witnessing the events and clinical characteristics of seizures captured by video or during video-electroencephalography monitoring. Read More

View Article and Full-Text PDF

Psychiatric disorders in patients with resistant temporal lobe epilepsy two years after undergoing elective surgery. A longitudinal study.

Epilepsy Behav 2021 Apr 5;118:107921. Epub 2021 Apr 5.

Department of Psychiatry, Hospital Clinic of Barcelona, Barcelona 08036, Spain; Clinical Institute of Neurosciences, Hospital Clinic of Barcelona, Barcelona 08036, Spain; Epilepsy Unit, Neurology Department, Hospital Clinic of Barcelona, Barcelona 08036, Spain; Biomedical Research Institute August Pi i Sunyer (IDIBAPS), Hospital Clinic of Barcelona, Barcelona, 08036, Spain. Electronic address:

Purpose: Psychiatric morbidity in temporal lobe epilepsy (TLE) is frequent and negatively affects patients' life quality. Surgery is the procedure of choice when treating seizures, although the effects on psychiatric disorders remain unclear. We evaluate the effect of surgery on psychiatric disorders in patients with TLE two years after the intervention, to then shed light on how these are related to anxiety and depression symptoms, and Interictal Dysphoric Disorder (IDD). Read More

View Article and Full-Text PDF

Decreased excitatory drive onto hilar neuronal nitric oxide synthase expressing interneurons in chronic models of epilepsy.

Brain Res 2021 Apr 5:147467. Epub 2021 Apr 5.

Department of Physiology, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, China.

Excitation-inhibition imbalance of GABAergic interneurons is predisposed to develop chronic temporal lobe epilepsy (TLE). We have previously shown that virtually every neuronal nitric oxide synthase (nNOS)-positive cell is a GABAergic inhibitory interneuron in the denate gyrus. The present study was designed to quantify the number of nNOS-containing hilar interneurons using stereology in pilocapine- and kainic acid (KA)-exposed transgenic adult mice that expressed GFP under the nNOS promoter. Read More

View Article and Full-Text PDF

LncRNA UCA1 alleviates aberrant hippocampal neurogenesis through regulating miR-375/SFRP1-mediated WNT/β-catenin pathway in kainic acid-induced epilepsy.

Acta Biochim Pol 2021 Apr 8. Epub 2021 Apr 8.

Department of Graduate School, Guangxi University of Chinese Medicine, Nanning, Guangxi, 530023, China.

Temporal lobe epilepsy (TLE) is a chronic disease of the nervous system, associated with increased proliferation in the hippocampus. Urothcarcinoma associated 1 (UCA1) is a long long non-coding RNA that was shown to regulate proliferation and differentiation of neural progenitors in vitro. We hypothesised that TLE-associated abnormal proliferation is a consequence of the downregulation of UCA1. Read More

View Article and Full-Text PDF

Investigation of long interspersed element-1 retrotransposons as potential risk factors for idiopathic temporal lobe epilepsy.

Epilepsia 2021 Apr 7. Epub 2021 Apr 7.

Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Objective: To determine if long interspersed element-1 (L1) retrotransposons convey risk for idiopathic temporal lobe epilepsy (TLE).

Methods: Surgically resected temporal cortex from individuals with TLE (N = 33) and postmortem temporal cortex from individuals with no known neurological disease (N = 33) were analyzed for L1 content by Restriction Enzyme Based Enriched L1Hs sequencing (REBELseq). Expression of three KCNIP4 splice variants was assessed by droplet digital PCR (ddPCR). Read More

View Article and Full-Text PDF

Laser interstitial thermal therapy for gyrus rectus cortical dysplasia in a child: a technical note.

Childs Nerv Syst 2021 Apr 7. Epub 2021 Apr 7.

Department of Neurosurgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY, USA.

Laser interstitial thermal therapy (LITT) has become a popular tool in the treatment of tumors and epilepsy. While most commonly used for the treatment of mesial temporal lobe epilepsy, it can be used as a minimally invasive option for the treatment of any seizure focus but has very rarely been discussed in the setting of cortical dysplasia. Here, we discuss the case of a 5-year-old girl with medically refractory epilepsy secondary to a right medial orbital gyrus and gyrus rectus cortical dysplasia successfully treated with LITT. Read More

View Article and Full-Text PDF

Effects of scorpion venom heat-resistant peptide on the hippocampal neurons of kainic acid-induced epileptic rats.

Braz J Med Biol Res 2021 2;54(5):e10717. Epub 2021 Apr 2.

Department of Neurosurgery, The 900th Hospital of Joint Logistic Support Force, PLA, Fuzhou, China.

Scorpion venom is a Chinese medicine for epilepsy treatment, but the underlying mechanism is not clear. Scorpion venom heat-resistant peptide (SVHRP), a peptide isolated from the venom of Buthus martensii Karsch, has an anti-epileptic effect by reducing seizure behavior according to a modified Racine scale. The present study aimed to investigate the molecular mechanism of SVHRP on temporal lobe epilepsy. Read More

View Article and Full-Text PDF

Voxel-wise functional connectivity of the default mode network in epilepsies: a systematic review and meta-analysis.

Curr Neuropharmacol 2021 Mar 25. Epub 2021 Mar 25.

The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731. China.

Background: Default mode network (DMN) is recognized to be involved in generation and propagation of epileptic activities in various epilepsies. Converging evidence has suggested disturbed functional connectivity (FC) in epilepsies, which was inferred to be related to underlying pathological mechanisms. However, abnormal changes of FC in DMN revealed by different studies are controversial, which obscures the role of DMN in distinct epilepsies. Read More

View Article and Full-Text PDF

Neurovascular multiparametric MRI defines epileptogenic and seizure propagation regions in experimental mesiotemporal lobe epilepsy.

Epilepsia 2021 Apr 5. Epub 2021 Apr 5.

Univ. Grenoble Alpes, Grenoble Institut Neurosciences, Inserm, U1216, Grenoble 38000, France.

Objective: Improving the identification of the epileptogenic zone and associated seizure-spreading regions represents a significant challenge. Innovative brain-imaging modalities tracking neurovascular dynamics during seizures may provide new disease biomarkers.

Methods: With use of a multi-parametric magnetic resonance imaging (MRI) analysis at 9. Read More

View Article and Full-Text PDF

A case report of delayed manifestation of new-onset focal seizures presenting after COVID infection.

Epilepsy Behav Rep 2021 Mar 31:100447. Epub 2021 Mar 31.

Department of Neurology, University of Toledo, Toledo, Ohio, USA.

View Article and Full-Text PDF

Association between autophagy-related protein 5 gene polymorphisms and epilepsy in Chinese patients.

Neurosci Lett 2021 Apr 1;753:135870. Epub 2021 Apr 1.

Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. Electronic address:

Autophagy is a highly conserved degradative process that has been associated with a number of neurological diseases. Autophagy-related protein 5 (ATG5) is one of the key genes for the regulation of the autophagy pathway. In this study, we investigated the potential relationship between ATG5 gene polymorphisms and epilepsy in Han Chinese population. Read More

View Article and Full-Text PDF

Aura: epilepsy vs. functional (psychogenic) seizures.

Seizure 2021 Mar 27;88:53-55. Epub 2021 Mar 27.

Epilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: To compare auras between three groups of people with seizures [i.e., Idiopathic generalized epilepsies (IGE) vs. Read More

View Article and Full-Text PDF

Predictors and Long-term Outcome of Resective Epilepsy Surgery in Patients with Tuberous Sclerosis Complex: A Single-centre Retrospective Cohort Study.

Seizure 2021 Mar 25;88:45-52. Epub 2021 Mar 25.

Department of Neurosurgery, Center of Epilepsy, Sanbo Brain Hospital, Capital Medical University, XiangshanYikesong 50, Haidian District, Beijing 100093, China. Electronic address:

Objective: To identify prognostic factors and long-term seizure outcomes for patients with tuberous sclerosis complex (TSC) who underwent resective treatment for epilepsy.

Methods: We enrolled 81 patients with TSC who had undergone resective epilepsy surgery at Sanbo Brain Hospital, Capital Medical University, between April 2004 and June 2019. We estimated cumulative probability of remaining seizure-free and plotted survival curves. Read More

View Article and Full-Text PDF

The TAAR1 inhibitor EPPTB suppresses neuronal excitability and seizure activity in mice.

Brain Res Bull 2021 Mar 31;171:142-149. Epub 2021 Mar 31.

Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong, PR China; Central Laboratory, Affiliated Hospital of Jining Medical University, Jining, Shandong, PR China. Electronic address:

Epilepsy is a common neurological disease. G protein-coupled receptors (GPCRs) are extensively distributed and play an important role in human health by serving as therapeutic targets for various diseases. As one of the GPCRs, trace amine-associated receptor 1 (TAAR1) has recently aroused increasing interest as a potential therapeutic target for psychiatric disorders. Read More

View Article and Full-Text PDF

Dissecting the Molecular Determinants of GABA Receptors Current Rundown, a Hallmark of Refractory Human Epilepsy.

Brain Sci 2021 Mar 30;11(4). Epub 2021 Mar 30.

Department of Physiology and Pharmacology, Istituto Pasteur-Fondazione Cenci Bolognetti, University of Rome Sapienza, 00185 Rome, Italy.

GABA receptors-(Rs) are fundamental for the maintenance of an efficient inhibitory function in the central nervous system (CNS). Their dysfunction is associated with a wide range of CNS disorders, many of which characterized by seizures and epilepsy. Recently, an increased use-dependent desensitization due to a repetitive GABA stimulation (GABA current rundown) of GABARs has been associated with drug-resistant temporal lobe epilepsy (TLE). Read More

View Article and Full-Text PDF

Short-Term Amygdala Low-Frequency Stimulation Does not Influence Hippocampal Interneuron Changes Observed in the Pilocarpine Model of Epilepsy.

Cells 2021 Mar 1;10(3). Epub 2021 Mar 1.

Department of Physiology, Faculty of Medicine, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, 540142 Târgu Mureș, Romania.

Temporal lobe epilepsy (TLE) is characterized by changes in interneuron numbers in the hippocampus. Deep brain stimulation (DBS) is an emerging tool to treat TLE seizures, although its mechanisms are not fully deciphered. We aimed to depict the effect of amygdala DBS on the density of the most common interneuron types in the CA1 hippocampal subfield in the lithium-pilocarpine model of epilepsy. Read More

View Article and Full-Text PDF

Morphological Description of Frontal EEG Interictal and Ictal Discharges in an Adult Cohort of 175 Patients.

J Clin Med 2021 Mar 15;10(6). Epub 2021 Mar 15.

Sjællands Universitets Hospital, 4000 Roskilde, Denmark.

Clinical and electroencephalogram (EEG) features in frontal lobe epilepsy (FLE) vary considerably among patients, making the diagnosis a challenge. The objective of this study was to describe interictal and ictal EEG activity, identifying variables that could help to differentiate and diagnose frontal lobe epilepsy cases. A prospective cross-sectional study from patients with frontal interictal epileptiform discharges (IED) referred to the Vall d'Hebron University Hospital (Barcelona, Spain) after a clinical event compatible with epileptic seizures was designed. Read More

View Article and Full-Text PDF

Automatic Sleep-Stage Scoring in Healthy and Sleep Disorder Patients Using Optimal Wavelet Filter Bank Technique with EEG Signals.

Int J Environ Res Public Health 2021 Mar 17;18(6). Epub 2021 Mar 17.

School of Engineering, Ngee Ann Polytechnic, Singapore 599489, Singapore.

Sleep stage classification plays a pivotal role in effective diagnosis and treatment of sleep related disorders. Traditionally, sleep scoring is done manually by trained sleep scorers. The analysis of electroencephalogram (EEG) signals recorded during sleep by clinicians is tedious, time-consuming and prone to human errors. Read More

View Article and Full-Text PDF