20,596 results match your criteria load failure

Antiviral kinetics of tenofovir alafenamide and tenofovir disoproxil fumarate over 24 weeks in women of childbearing potential with chronic HBV.

PLoS One 2021 13;16(5):e0251552. Epub 2021 May 13.

New Zealand Liver Transplant Unit, Auckland Clinical Studies, Auckland, New Zealand.

Background/purpose: Use of tenofovir disoproxil fumarate (TDF) improves patient outcomes in preventing mother-to-child transmission (pMTCT) of the hepatitis B virus (HBV) in mothers with chronic HBV and high viral loads. Given the lack of data for tenofovir alafenamide (TAF) in pMTCT, rates of early viral suppression with TAF and TDF were evaluated in women of childbearing potential (WOCBP) participating in 2 randomized, double-blind, Phase 3 studies in chronic HBV.

Methods: In a patient subset meeting WOCBP criteria and with baseline HBV DNA >200,000 IU/mL, rates of viral suppression with TAF or TDF in achieving the target of HBV DNA <200,000 IU/mL at weeks 12 and 24 were assessed. Read More

View Article and Full-Text PDF

Correlation between the immuno-virological response and the nutritional profile of treatment-experienced HIV-infected patients in the East region of Cameroon.

PLoS One 2021 13;16(5):e0229550. Epub 2021 May 13.

Chantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé, Cameroon.

Background: HIV management remains concerning and even more challenging in the frame of comorbidities like malnutrition that favors disease progression and mortality in resource-limited settings (RLS).

Objective: To describe the nutritional parameters of antiretroviral therapy (ART) recipients (without nutritional support) with respect to CD4 count and virological failure.

Methods: A cross-sectional study was conducted from October to December 2018 among 146 consenting participants enrolled in two health facilities of the East-Region of Cameroon. Read More

View Article and Full-Text PDF

From Systemic Inflammation to Myocardial Fibrosis: The Heart Failure With Preserved Ejection Fraction Paradigm Revisited.

Circ Res 2021 May 13;128(10):1451-1467. Epub 2021 May 13.

RHJ Department of Veterans Affairs Medical Center, Medical University of South Carolina, Charleston (M.R.Z.).

In accordance with the comorbidity-inflammation paradigm, comorbidities and especially metabolic comorbidities are presumed to drive development and severity of heart failure with preserved ejection fraction through a cascade of events ranging from systemic inflammation to myocardial fibrosis. Recently, novel experimental and clinical evidence emerged, which strengthens the validity of the inflammatory/profibrotic paradigm. This evidence consists among others of (1) myocardial infiltration by immunocompetent cells not only because of an obesity-induced metabolic load but also because of an arterial hypertension-induced hemodynamic load. Read More

View Article and Full-Text PDF

An ex vivo biomechanical comparison of two suture materials and two pattern combinations for equine superficial digital flexor tendon tenorrhaphy.

Vet Surg 2021 May 13. Epub 2021 May 13.

Weipers Centre Equine Hospital, School of Veterinary Medicine, University of Glasgow, Glasgow, UK.

Objective: To compare biomechanical characteristics of three-loop pulley (3LP) pattern versus Bunnell technique (BT) using polydioxanone (PDS) suture; to determine the influence of polyester tape (PT) versus PDS on the BT for equine superficial digital flexor tendon (SDFT) tenorrhaphy; to compare BT with PT versus 3LP with PDS.

Study Design: Ex vivo biomechanical study.

Sample Population: Forty equine forelimb SDFT. Read More

View Article and Full-Text PDF

Gut microbiota and its diet-related activity in children with intestinal failure on long-term parenteral nutrition.

JPEN J Parenter Enteral Nutr 2021 May 13. Epub 2021 May 13.

Department of Pediatric Gastroenterology, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam, The Netherlands.

Background: This study characterized the gut microbiota and its diet-related metabolic activity in children with intestinal failure (IF) on parenteral nutrition (PN) compared with healthy controls and in relation to disease characteristics.

Methods: Serial fecal samples were collected from 15 IF patients (n = 68) and from 25 healthy children (n = 25). The fecal microbiota, and short chain fatty acids (SCFA) were measured. Read More

View Article and Full-Text PDF

Resistin-Like Molecule α Dysregulates Cardiac Bioenergetics in Neonatal Rat Cardiomyocytes.

Front Cardiovasc Med 2021 26;8:574708. Epub 2021 Apr 26.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, United States.

Heart (right) failure is the most frequent cause of death in patients with pulmonary arterial hypertension. Although historically, increased right ventricular afterload has been considered the main contributor to right heart failure in such patients, recent evidence has suggested a potential role of load-independent factors. Here, we tested the hypothesis that resistin-like molecule α (RELMα), which has been implicated in the pathogenesis of vascular remodeling in pulmonary artery hypertension, also contributes to cardiac metabolic remodeling, leading to heart failure. Read More

View Article and Full-Text PDF

Association between depression and HIV treatment outcomes in a US military population with HIV infection.

AIDS Res Ther 2021 May 12;18(1):29. Epub 2021 May 12.

Brooke Army Medical Center, 3551 Roger Brooke Drive, Fort Sam Houston, TX, 78234-6200, USA.

Background: Depression is common among HIV-infected individuals and may contribute to suboptimal adherence to antiretroviral therapy (ART) and subsequent inability to attain viral load (VL) suppression. We evaluated associations between depression, self-reported adherence, and longitudinal HIV treatment outcomes in US Military HIV Natural History Study (NHS) participants with and without depression.

Methods: Male NHS participants with available ICD-9 data for mental health diagnoses, Center for Epidemiological Studies Depression (CES-D) measures, and self-reported adherence (SRA) were included. Read More

View Article and Full-Text PDF

Biomechanical Comparison of Three Stabilization Methods for Tibial Tuberosity Fractures in Dogs: A Cadaveric Study.

Vet Comp Orthop Traumatol 2021 May 12. Epub 2021 May 12.

Georgia Department of Agriculture, Animal Industry Division, Atlanta, Georgia, United States.

Objective:  The aim of this study was to compare the biomechanical properties of a hybrid external skeletal fixator (HESF) construct to the placement of paired interfragmentary Kirschner wires alone, and pin and tension band wire (PTBW) fixation for the stabilization of simulated tibial tuberosity fractures in dogs.

Study Design:  Tibias were harvested from 12 skeletally mature dog cadavers weighing 20 to 30 kg. An osteotomy was made through the base of the tibial tuberosity, which was subsequently repaired with either paired Kirschner wires, PTBW fixation or a HESF. Read More

View Article and Full-Text PDF

A Modified Flexor Tendon Suture Technique Combining Kessler and Loop Lock Flexor Tendon Sutures.

Clinics (Sao Paulo) 2021 5;76:e2358. Epub 2021 May 5.

Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Shahekou district, Dalian, Liaoning, China.

Objectives: In the present study, a novel single knot tenorrhaphy was developed by combining the modified Kessler flexor tendon suture (MK) with the loop lock technique.

Methods: A total of 48 porcine flexor digitorum profundus tendons were collected and randomly divided into six groups. The tendons were transversely cut and then repaired using six different techniques, the MK method, double knot Kessler-loop lock flexor tendon suture (DK), and single knot Kessler-loop lock flexor tendon suture (SK), each in combination with the epitendinous suture (P), and the same three techniques without P. Read More

View Article and Full-Text PDF

Use of intramedullary locking nail for displaced intraarticular fractures of the calcaneus: what is the evidence?

Arch Orthop Trauma Surg 2021 May 11. Epub 2021 May 11.

Foot and Ankle Unit, Royal National Orthopaedic Hospital, Stanmore, UK.

Introduction: Intramedullary locking devices (ILDs) have recently been advocated as a minimally invasive approach to manage displaced intraarticular calcaneal fractures (DIACFs), to minimise complications and improve outcomes. We reviewed clinical and biomechanical studies dealing with commercially available devices to identify their characteristics, efficacy and safety.

Methods: Following a PRISMA checklist, Medline, Scopus and EMBASE databases were searched to identify studies reporting the use of ILDs for treating DIACFs. Read More

View Article and Full-Text PDF

Higher Hand Grip Strength Is Associated With Greater Radius Bone Size and Strength in Older Men and Women: The Framingham Osteoporosis Study.

JBMR Plus 2021 May 30;5(5):e10485. Epub 2021 Mar 30.

Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife Boston Massachusetts USA.

Mechanical loading by muscles elicits anabolic responses from bone, thus age-related declines in muscle strength may contribute to bone fragility in older adults. We used high-resolution peripheral quantitative computed tomography (HR-pQCT) to determine the association between grip strength and distal radius bone density, size, morphology, and microarchitecture, as well as bone strength estimated by micro-finite element analysis (μFEA), among older men and women. Participants included 508 men and 651 women participating in the Framingham Offspring Study with grip strength measured in 2011-2014 and HR-pQCT scanning in 2012-2015. Read More

View Article and Full-Text PDF

Effects of different resistance training frequencies on body composition and muscular performance adaptations in men.

PeerJ 2021 21;9:e10537. Epub 2021 Apr 21.

M2S (Laboratoire Mouvement, Sport, Santé) - EA 1274, Univ Rennes, Rennes, France.

Background: The aim of this study was to compare the effects of 8 weeks resistance training (RT) with two sessions versus four sessions per week under volume load-equated conditions on body composition, maximal strength, and explosive actions performance in recreationally trained men.

Methods: Thirty-five healthy young men participated in the study and were randomly divided into a two sessions per-week RT (RT2, = 12), four sessions per-week RT (RT4, = 13) or a control group (CG, = 10). All subjects were evaluated for thigh, chest and arm circumference, countermovement jump (CMJ), medicine ball throw (MBT), 1-repetition maximum (1RM) leg press, bench press, arm curl, muscular endurance (i. Read More

View Article and Full-Text PDF

Lapidus arthrodesis in combination with arthrodesis of the first metatarsophalangeal joint-biomechanical cadaver study comparing two methods of fixation.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2021 May 11. Epub 2021 May 11.

Educational Center for Practical Anatomy, Brno, Czech Republic.

Aims: To assess the results of a biomechanical test of cadaveric specimens, comparing 2 methods of fixation of modified Lapidus arthrodesis in combination with arthrodesis of the first metatarsophalangeal joint.

Methods: A total of 12 cadaveric specimens were used in the test. Arthrodesis of the first MTP joint was in all patients fixed with a Variable Angle LCP 1st MTP Fusion Plate 2. Read More

View Article and Full-Text PDF

Expansion of GARP-Expressing CD4CD25FoxP3 T Cells and SATB1 Association with Activation and Coagulation in Immune Compromised HIV-1-Infected Individuals in South Africa.

Virol Sin 2021 May 11. Epub 2021 May 11.

Centre for Cardio-Metabolic Research in Africa (CARMA), Department of Physiological Sciences, Stellenbosch University, Stellenbosch, 7600, South Africa.

Although antiretroviral treatment lowers the burden of human immunodeficiency virus (HIV)-related disease, it does not always result in immunological recovery. This manifests as persistent chronic inflammation, immune activation or exhaustion that can promote the onset of co-morbidities. As the exact function of regulatory T (Treg) cells in HIV remains unclear, this cross-sectional study investigated three expression markers (Forkhead box protein P3 [FOXP3], glycoprotein A repetitions predominant [GARP], special AT-rich sequence binding protein 1 [SATB1]) and compared their expansion between CD4CD25 and CD4CD25 T cells. Read More

View Article and Full-Text PDF

SARS-CoV-2 infectivity by viral load, S gene variants and demographic factors and the utility of lateral flow devices to prevent transmission.

Clin Infect Dis 2021 May 11. Epub 2021 May 11.

NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.

Background: How SARS-CoV-2 infectivity varies with viral load is incompletely understood. Whether rapid point-of-care antigen lateral flow devices (LFDs) detect most potential transmission sources despite imperfect clinical sensitivity is unknown.

Methods: We combined SARS-CoV-2 testing and contact tracing data from England between 01-September-2020 and 28-February-2021. Read More

View Article and Full-Text PDF

Single-cell RNA sequencing of blood antigen-presenting cells in severe COVID-19 reveals multi-process defects in antiviral immunity.

Nat Cell Biol 2021 May 10;23(5):538-551. Epub 2021 May 10.

Université de Paris, INSERM U976, Paris, France.

COVID-19 can lead to life-threatening respiratory failure, with increased inflammatory mediators and viral load. Here, we perform single-cell RNA-sequencing to establish a high-resolution map of blood antigen-presenting cells (APCs) in 15 patients with moderate or severe COVID-19 pneumonia, at day 1 and day 4 post admission to intensive care unit or pulmonology department, as well as in 4 healthy donors. We generated a unique dataset of 81,643 APCs, including monocytes and rare dendritic cell (DC) subsets. Read More

View Article and Full-Text PDF

Improving the continuum of care monitoring in Brazilian HIV healthcare services: An implementation science approach.

PLoS One 2021 10;16(5):e0250060. Epub 2021 May 10.

Departamento de Medicina Preventiva, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, estado de São Paulo, Brazil.

Objective: To evaluate the impact of an intervention improving the continuum of care monitoring (CCM) within HIV public healthcare services in São Paulo, Brazil, and implementing a clinical monitoring system. This system identified three patient groups prioritized for additional care engagement: (1) individuals diagnosed with HIV, but not receiving treatment (the treatment gap group); (2) individuals receiving treatment for >6 months with a detectable viral load (the virologic failure group); and (3) patients lost to follow-up (LTFU).

Methods: The implementation strategies included three training sessions, covering system logistics, case discussions, and development of maintenance goals. Read More

View Article and Full-Text PDF

Rifampicin and Letermovir as potential repurposed drug candidate for COVID-19 treatment: insights from an in-silico study.

Pharmacol Rep 2021 May 10. Epub 2021 May 10.

School of Biotechnology, Gautam Buddha University, Greater Noida, Uttar Pradesh, 201310, India.

Introduction: Drug repurposing is the need of the hour considering the medical emergency caused by the COVID-19 pandemic. Recently, cytokine storm by the host immune system has been linked with high viral load, loss of lung function, acute respiratory distress syndrome (ARDS), multiple organ failure, and subsequent fatal outcome.

Objective: This study aimed to identify potential FDA approved drugs that can be repurposed for COVID-19 treatment using an in-silico analysis. Read More

View Article and Full-Text PDF

Effect of 10 sets versus 5 sets of resistance training on muscular endurance.

J Sports Med Phys Fitness 2021 May 10. Epub 2021 May 10.

NICM Health Research Institute, Western Sydney University, Westmead, Australia.

Background: A paucity of research exists examining whether resistance training with a greater number of sets per exercise enhances the development of muscular endurance. The aim of this study was to investigate the effects of ten sets versus five sets of resistance training on muscle endurance.

Methods: Fifteen healthy males (age 23. Read More

View Article and Full-Text PDF

Immuno-Isolating Dual Poly(ethylene glycol) Capsule Prevents Cancer Cells from Spreading Following Mouse Ovarian Tissue Auto-Transplantation.

Regen Med Front 2019 16;2019(1). Epub 2019 Sep 16.

Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

For female cancer survivors, premature ovarian insufficiency (POI) is a common complication of anticancer treatments. Ovarian tissue cryopreservation before treatment, followed by auto-transplantation after remission is a promising option to restore fertility and ovarian endocrine function. However, auto-transplantation is associated with the risk of re-introducing malignant cells harbored in the stroma of the ovarian autograft. Read More

View Article and Full-Text PDF
September 2019

Apelin improves cardiac function mainly through peripheral vasodilation in a mouse model of dilated cardiomyopathy.

Peptides 2021 May 6:170568. Epub 2021 May 6.

Cardiovascular&Metabolism Therapeutic Area, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France. Electronic address:

There is growing evidence that apelin plays a role in the regulation of the cardiovascular system by increasing myocardial contractility and acting as a vasodilator. However, it remains unclear whether apelin improves cardiac contractility in a load-dependent or independent manner in pathological conditions. For this purpose we investigated the cardiovascular effects of apelin in α-actin transgenic mice (mActin-Tg mice), a model of cardiomyopathy. Read More

View Article and Full-Text PDF

Suture Tape Augmentation Improves the Biomechanical Performance of Bone-Patellar Tendon-Bone Grafts Used for Anterior Cruciate Ligament Reconstruction.

Arthroscopy 2021 May 5. Epub 2021 May 5.

Washington University Department of Orthopedic Surgery, St. Louis, MO.

Purpose: The purpose of this study was to investigate the time-zero biomechanical properties (stiffness, displacement and load at failure) of bone-patellar tendon-bone (BTB) grafts used for anterior cruciate ligament (ACL) reconstruction with and without suture tape augmentation as a means to determine the potential clinical benefit of this technique.

Methods: Eight juvenile porcine knees underwent ACL reconstruction with a human cadaveric BTB graft (control). These were compared to eight juvenile porcine knees that underwent ACL reconstruction with a BTB graft augmented with suture tape. Read More

View Article and Full-Text PDF

Tissue-Based SARS-Cov-2 Detection in Fatal COVID-19 Infections: Sustained Direct Viral-Induced Damage is Not Necessary to Drive Disease Progression.

Hum Pathol 2021 May 4. Epub 2021 May 4.

Departments of Pathology, Molecular and Cell-Based Medicine, The Icahn School of Medicine at Mount Sinai Hospital, New York, NY. Electronic address:

Background: Coronavirus disease 2019 (COVID-19) is an ongoing pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although viral infection is known to trigger inflammatory processes contributing to tissue injury and organ failure, it is unclear whether direct viral damage is needed to sustain cellular injury. An understanding of pathogenic mechanisms has been handicapped by the absence of optimized methods to visualize the presence and distribution of SARS-CoV-2 in damaged tissues. Read More

View Article and Full-Text PDF

Rapid progression is associated with lymphoid follicle dysfunction in SIV-infected infant rhesus macaques.

PLoS Pathog 2021 May 7;17(5):e1009575. Epub 2021 May 7.

Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, United States of America.

HIV-infected infants are at an increased risk of progressing rapidly to AIDS in the first weeks of life. Here, we evaluated immunological and virological parameters in 25 SIV-infected infant rhesus macaques to understand the factors influencing a rapid disease outcome. Infant macaques were infected with SIVmac251 and monitored for 10 to 17 weeks post-infection. Read More

View Article and Full-Text PDF

Interlocked Pins Increase Strength by a Lateral Spread of Load in Femoral Neck Fixation: a Cadaver Study.

Acta Chir Orthop Traumatol Cech 2021 ;88(2):144-152

Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Norway.

PURPOSE OF THE STUDY To improve the important torsional, bending and compressive stability in femoral neck fixation, locking plates have been the latest contribution. However, increased strength by restricted fracture motion may come at expense of an altered load distribution and failure patterns. Within locking plate technology, the important intermediate fracture compression may principally be achieved by multiple sliding screws passing through a sideplate fixed to the femur or connected to an interlocking plate not fixed to the femur laterally, sliding "en bloc" with the plate. Read More

View Article and Full-Text PDF

Anatomic and Biomechanical Properties of Flat Medial Patellofemoral Ligament Reconstruction Using an Adductor Magnus Tendon Graft: A Human Cadaveric Study.

Am J Sports Med 2021 May 7:3635465211009540. Epub 2021 May 7.

Research Unit for Orthopaedic Sports Medicine and Injury Prevention, Institute for Sports Medicine, Alpine Medicine and Health Tourism, Private University for Health Sciences, Medical Informatics and Technology, Hall in Tirol, Austria.

Background: In contrast to the majority of existing techniques for reconstruction of the medial patellofemoral ligament (MPFL), the technique described in this article uses the adductor magnus muscle tendon to gain a flat, broad graft, leaving its distal femoral insertion intact, and does not require drilling within or near the femoral physis. It also allows for soft tissue patellar fixation and could facilitate anatomic MPFL reconstruction in skeletally immature patients.

Purpose: To evaluate the anatomic and structural properties of the native MPFL and the adductor tendon (AT), followed by biomechanical evaluation of the proposed reconstruction. Read More

View Article and Full-Text PDF

How Does Contact Length Impact Titanium Tapered Splined Stem Stability: A Biomechanical Matched Pair Cadaveric Study.

J Arthroplasty 2021 Apr 22. Epub 2021 Apr 22.

Stavros Niarchos Foundation Complex Joint Reconstruction Center, Hospital for Special Surgery, New York, NY.

Background: Titanium tapered stems (TTS) achieve fixation in the femoral diaphysis and are commonly used in revision total hip arthroplasty. The initial stability of a TTS is critical, but the minimum contact length needed and impact of implant-specific taper angles on axial stability are unknown. This biomechanical study was performed to better guide operative decision-making by addressing these clinical questions. Read More

View Article and Full-Text PDF

Relationship between biochemical markers and measles viral load in patients with immunologically naive cases and secondary vaccine failure -LDH is one of the potential auxiliary indicators for secondary vaccine failure.

Microbiol Immunol 2021 May 5. Epub 2021 May 5.

Osaka Institute of Public Health, 3-69, Nakamichi, 1-chome, Higashinari-ku, Osaka, 537-0025, Japan.

This study investigated the correlation between biochemical markers and viral load among 38 measles cases, including 15 immunologically naive patients and 23 patients with secondary vaccine failure (SVF). We examined four biochemical markers, namely, aspartate aminotransferase, alanine aminotransferase, C-reactive protein, and lactate dehydrogenase (LDH) and their relationship between virus genome copy numbers in peripheral blood mononuclear cells (PBMCs) and throat swabs as well as the concentration of measles-specific IgG. Although viral genome copies in both clinical specimens showed a significant correlation with specific IgG concentration, they had a higher correlation in PBMCs (Pearson's product-moment correlation coefficient, -0. Read More

View Article and Full-Text PDF

Impaired bone microarchitecture and strength in patients with tumor-induced osteomalacia.

J Bone Miner Res 2021 May 5. Epub 2021 May 5.

IDIM, Universidad del Salvador, Buenos Aires, Argentina.

Some studies based on bone biopsy have demonstrated that in patients with tumor-induced osteomalacia (TIO) the mineralization process of the bone matrix is profoundly disturbed. However, the interrelationship between clinical and biochemical features and bone microarchitecture in this disease needs further analysis. With this purpose in mind, we set out three objectives: i) to determine bone microarchitecture and estimated bone strength in a group of patients with tumor-induced osteomalacia using high-resolution peripheral quantitative computed tomography (HR-pQCT) and finite element analysis (FEA), ii) to investigate correlations between duration of disease, biochemical features, bone density, HR-pQCT and FEA parameters, and iii) to compare HR-pQCT and FEA parameters with a healthy control group. Read More

View Article and Full-Text PDF

Effect of Nitrogen Ion Implantation on the Cavitation Erosion Resistance and Cobalt-Based Solid Solution Phase Transformations of HIPed Stellite 6.

Materials (Basel) 2021 Apr 29;14(9). Epub 2021 Apr 29.

Institute of Physics, Maria Curie-Sklodowska University in Lublin, pl. M. Curie-Sklodowskiej 1, 20-031 Lublin, Poland.

From the wide range of engineering materials traditional Stellite 6 (cobalt alloy) exhibits excellent resistance to cavitation erosion (CE). Nonetheless, the influence of ion implantation of cobalt alloys on the CE behaviour has not been completely clarified by the literature. Thus, this work investigates the effect of nitrogen ion implantation (NII) of HIPed Stellite 6 on the improvement of resistance to CE. Read More

View Article and Full-Text PDF