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Lymph node characteristics of 6279 N1 differentiated thyroid cancer patients.

Endocr Connect 2020 Jan 1. Epub 2020 Jan 1.

H Sun, Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.

Purpose: This study examined the clinicopathological characteristics of 6279 N1 differentiated thyroid cancer (DTC) patients who underwent operations in our center.

Methods: This was a retrospective longitudinal analysis. We categorized the DTC on the basis of various lymph node (LN) characteristics. Read More

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January 2020

Priority of lymph node dissection for advanced esophagogastric junction adenocarcinoma with the tumor center located below the esophagogastric junction.

Medicine (Baltimore) 2019 Dec;98(51):e18451

Department of General Surgery, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, China.

To clarify the priority of lymph node dissection (LND) in advanced Siewert type II and III AEG, in which the center of the tumor is located below the esophagogastric junction (EGJ).Data in 395 patients with advanced Siewert type II or III AEG was analyzed retrospectively. The index of estimated benefit from LND (IEBLD) was used to evaluate the efficacy of LND for each nodal station. Read More

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December 2019

Endoscopic ultrasound and fine-needle aspiration for the detection of residual nodal disease after neoadjuvant chemoradiotherapy for esophageal cancer.

Endoscopy 2020 03 9;52(3):186-192. Epub 2019 Dec 9.

Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.

Background: Endoscopic ultrasound (EUS) and fine-needle aspiration (FNA) are potential tools for the detection of residual disease after neoadjuvant chemoradiotherapy (nCRT) for esophageal cancer. This study investigated yield of EUS and FNA for detection of malignant lymph nodes (LNs) after nCRT.

Methods: This was a post hoc analysis of the preSANO trial. Read More

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Exposure to solar UV radiation in outdoor construction workers using personal dosimetry.

Environ Res 2020 02 27;181:108967. Epub 2019 Nov 27.

'Carol Davila' University of Medicine and Pharmacy, Department of Dermatology 2, "Colentina" Clinical Hospital, Bucharest, Romania.

Occupational exposure to solar UV radiation (SUVR), a Group 1 carcinogen according to the IARC classification is at high exposure levels in outdoor construction workers, usually above the suggested occupational limits. Furthermore, there are no regulations related to this exposure in the EU, except for the artificial UVR. Also, the use of the ICNIRP exposure guideline in an outdoor setting poses problems of adequate dose assessment. Read More

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February 2020

Added value of para-aortic surgical staging compared to F-FDG PET/CT on the external beam radiation field for patients with locally advanced cervical cancer: An ONCO-GF study.

Eur J Surg Oncol 2020 05 11;46(5):883-887. Epub 2019 Nov 11.

Department of Obstetrics and Gynecology, University of Liège, Belgium.

Objective: Extended field chemoradiation is recommended for patients with locally advanced cervical cancer (LACC) and para-aortic lymph node (PALN) metastases. The radiation planning may be based on PET/CT while others recommend to rely on surgical staging. We report the rate of patients for whom the radiation field defined on PET/CT was modified by the histological PALN status. Read More

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Hypoxia-induced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKC-EZR (ezrin) pathway.

Autophagy 2020 08 27;16(8):1436-1452. Epub 2019 Nov 27.

Molecular Disease Mechanisms Group, Life Sciences Research Unit, University of Luxembourg , Esch-sur-Alzette, Luxembourg.

In solid tumors, cancer stem cells (CSCs) or tumor-initiating cells (TICs) are often found in hypoxic niches. Nevertheless, the influence of hypoxia on TICs is poorly understood. Using previously established, TIC-enrichedpatient-derived colorectal cancer (CRC) cultures, we show that hypoxia increases the self-renewal capacity of TICs while inducing proliferation arrest in their more differentiated counterpart cultures. Read More

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Microanatomy of inferior mesenteric artery sheath in colorectal cancer surgery.

J Anus Rectum Colon 2019 30;3(4):167-174. Epub 2019 Oct 30.

Department of Gastrointestinal Tract Surgery, School of Medicine, Fukushima Medical University, Fukushima, Japan.

Objectives: Left colic artery preserving lymph node dissection around the inferior mesenteric artery (IMA) is a standard procedure for rectal cancer surgery. Although the IMA sheath is a well-known structure, to our knowledge, there are no reports describing its microanatomy from an oncological point of view; therefore, there is no consensus on how to handle the sheath for accurate lymph node dissection around IMA. We aimed to investigate the components of the IMA sheath pathologically, focusing particularly on the presence of lymph nodes (LNs) and lymphatic ducts (LDs). Read More

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October 2019

Operative safety and oncologic outcomes in rectal cancer based on the level of inferior mesenteric artery ligation: a stratified analysis of a large Korean cohort.

Ann Surg Treat Res 2019 Nov 1;97(5):254-260. Epub 2019 Nov 1.

Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.

Purpose: To compare high and low inferior mesenteric artery (IMA) ligation in a large number of patients, and investigate the short-term and long-term outcomes.

Methods: This retrospective study compared outcomes between high IMA ligation and low IMA ligation with dissection of lymph nodes (LNs) around the IMA origin. A total of 1,213 patients underwent elective low anterior resection with double-stapling anastomosis for stage I-III rectal cancer located ≥6 cm from the anal verge (835 patients underwent IMA ligation at the IMA origin; 378 patients underwent IMA ligation directly distal to the root of the left colic artery along with dissection of LNs around the IMA origin). Read More

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November 2019

Delay in diagnosing patients with right-sided glioblastoma induced by hemispheric-specific clinical presentation.

J Neurooncol 2020 Jan 11;146(1):63-69. Epub 2019 Nov 11.

Department of Neurology, Goethe University, Schleusenweg 2-16, 60528, Frankfurt am Main, Germany.

Purpose: Cognitive functions are differentially represented in brain hemispheres. Aphasia is an "easy to recognize" symptom of diseases affecting the left side. In contrast, lesions in the right hemisphere cause subtle neuropsychological deficits such as neglect and anosognosia. Read More

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January 2020

B cell dissemination patterns during the germinal center reaction revealed by whole-organ imaging.

J Exp Med 2019 11 6;216(11):2515-2530. Epub 2019 Sep 6.

Department of Immunology, Weizmann Institute of Science, Rehovot, Israel

Germinal centers (GCs) are sites wherein B cells proliferate and mutate their immunoglobulins in the dark zone (DZ), followed by affinity-based selection in the light zone (LZ). Here, we mapped the location of single B cells in the context of intact lymph nodes (LNs) throughout the GC response, and examined the role of BCR affinity in dictating their position. Imaging of entire GC structures and proximal single cells by light-sheet fluorescence microscopy revealed that individual B cells that previously expressed AID are located within the LN cortex, in an area close to the GC LZ. Read More

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November 2019

Therapeutic index of lymphadenectomy among patients with pancreatic neuroendocrine tumors: A multi-institutional analysis.

J Surg Oncol 2019 Dec 29;120(7):1080-1086. Epub 2019 Aug 29.

Department of Surgery, Division of Surgical Oncology, The Ohio State University Wexner Medical Center, Columbus, Ohio.

Background: The benefit derived from lymph node dissection (LND) in patients with pancreatic neuroendocrine tumors (pNETs) based on clinicopathological characteristics remains unclear.

Methods: Patients undergoing surgery for pNET between 1997 and 2016 were identified using a multi-institutional dataset. The therapeutic index of LND relative to patient characteristics was calculated. Read More

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December 2019

Functional Reorganization of Cortical Language Function in Glioma Patients-A Preliminary Study.

Front Oncol 2019 29;9:446. Epub 2019 May 29.

Department of Neurosurgery, Klinikum rechts der Isar, School of Medicine, Technische Universität München, Munich, Germany.

Functional reorganization (FR) was shown in glioma patients by direct electrical stimulation (DES) during awake craniotomy. This option for repeated mapping is available in cases of tumor recurrence and after decision for a second surgery. Navigated repetitive transcranial magnetic stimulation (nrTMS) has shown a high correlation with results of DES during awake craniotomy for language-negative sites (LNS) and allows for a non-invasive evaluation of language function. Read More

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Peripheral lymph nodes contain migratory and resident innate lymphoid cell populations.

Sci Immunol 2019 05;4(35)

Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

Tissue residency is considered a defining feature of the innate lymphoid cell (ILC) populations located within mucosal and adipose tissues. ILCs are also present within all lymphoid tissues, but whether ILCs migrate between lymphoid and nonlymphoid sites and in what context is poorly understood. To determine whether migratory ILCs exist within peripheral lymph nodes (LNs), we labeled all cells within the brachial LN (bLN) of transgenic mice expressing a photoconvertible fluorescent protein by direct exposure to light. Read More

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Should a standard lymphadenectomy include the No. 9 lymph nodes for body and tail pancreatic ductal adenocarcinoma?

Pancreatology 2019 Apr 15;19(3):414-418. Epub 2019 Mar 15.

Department of General Surgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, 197 Ruijin Er Road, Shanghai, 200025, China. Electronic address:

Objectives: This study aimed to use a retrospective data base to investigate whether a standard lymphadenectomy during distal pancreatectomy should include the No. 9 lymph nodes (LNs) for resectable pancreatic ductal adenocarcinoma (PDAC) located in the body and tail of the pancreas.

Methods: Data from 169 patients undergoing curative distal pancreatectomy for PDAC between Jan 1, 2013 and Dec 31, 2016 were collected. Read More

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Pontine tumor in a neonate: case report and analysis of the current literature.

J Neurosurg Pediatr 2019 Feb 15:1-7. Epub 2019 Feb 15.

1Pediatric Hematology and Oncology, Goethe University; Departments of.

Tumors of the central nervous system represent the largest group of solid tumors found in pediatric patients. Pilocytic astrocytoma is the most common pediatric glioma, mostly located in the posterior fossa. The majority of brainstem tumors, however, are classified as highly aggressive diffuse intrinsic pontine gliomas (DIPGs) and their prognosis is dismal. Read More

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February 2019

Patterns of regional nodal relapse after D2 lymphadenectomy in gastric cancer: rethinking the target volume.

Onco Targets Ther 2018 12;11:8015-8024. Epub 2018 Nov 12.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China,

Purpose: This study mapped the localization of regional nodal recurrence to determine whether the clinical target volume (CTV) should be redefined in adjuvant radiotherapy.

Patients And Methods: Between January 2004 and October 2015, a total of 129 patients with gastric cancer following D2 resection who experienced regional recurrence were retrospectively examined. The lymph nodes (LNs) were hand-drawn proportionally on template computed tomography (CT) images of a standard patient by referencing surrounding anatomic landmarks. Read More

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November 2018

Nodal Oligorecurrent Prostate Cancer: Anatomic Pattern of Possible Treatment Failure in Relation to Elective Surgical and Radiotherapy Treatment Templates.

Eur Urol 2019 05 29;75(5):826-833. Epub 2018 Nov 29.

Department of Radiation Oncology and Experimental Cancer Research, Ghent University, Ghent, Belgium. Electronic address:

Background: Patients with biochemical recurrence following primary prostate cancer (PCa) treatment often experience relapse in the lymph nodes (LNs). Both salvage LN dissection (sLND) and elective nodal radiotherapy (ENRT) are potential treatment options.

Objective: To describe anatomic patterns of nodal oligorecurrent PCa in relation to different surgical and radiotherapy templates. Read More

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Multiple roles of lymphatic vessels in peripheral lymph node development.

J Exp Med 2018 11 24;215(11):2760-2777. Epub 2018 Oct 24.

Department of Oncology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Epalinges, Switzerland

The mammalian lymphatic system consists of strategically located lymph nodes (LNs) embedded into a lymphatic vascular network. Mechanisms underlying development of this highly organized system are not fully understood. Using high-resolution imaging, we show that lymphoid tissue inducer (LTi) cells initially transmigrate from veins at LN development sites using gaps in venous mural coverage. Read More

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November 2018

Therapeutic Value of Lymph Node Dissection Along the Superior Mesenteric Vein and the Posterior Surface of the Pancreatic Head in Gastric Cancer Located in the Lower Third of the Stomach.

Yonago Acta Med 2018 Sep 26;61(3):175-181. Epub 2018 Sep 26.

Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8504, Japan.

Background: Therapeutic value of lymph node dissection along the superior mesenteric vein (14v) and the posterior surface of the pancreatic head (13) remains unclear in gastric cancer patients.

Methods: We reviewed 355 patients with advanced gastric cancer in the lower third of the stomach who had undergone gastrectomy at our hospital.

Results: The frequency of lymph node (LN) metastasis was 10. Read More

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September 2018

Personal exposure to traffic-related air pollutants and relationships with respiratory symptoms and oxidative stress: A pilot cross-sectional study among urban green space workers.

Sci Total Environ 2019 Feb 27;649:620-628. Epub 2018 Aug 27.

Unit Health Impact Assessment, Sciensano, Rue Juliette Wytsman 14, 1050 Brussels, Belgium; Environment and Health, Department of Public Health and Primary Care, University of Leuven (KU Leuven), Kapucijnenvoer 35D-7001, 3000 Leuven, Belgium; Department of Health Protection, Laboratoire National de Santé (LNS), Rue Louis Rech 1, L-3555 Dudelange, Luxembourg. Electronic address:

Exposure to ambient air pollution has been associated with various adverse health effects including respiratory, cardiovascular and neurological diseases. Exposure data for some specific pollutants and settings are however still insufficient and mechanisms underlying negative health outcomes are not fully elucidated. This pilot study aimed to assess individual exposure to three traffic-related air pollutants, black carbon (BC), polycyclic aromatic hydrocarbons (PAHs) and benzene, and the relationship with respiratory and oxidative stress outcomes in a cross-sectional sample of 48 green space workers in Brussels, Belgium. Read More

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February 2019

Sentinel lymph node dissection in prostate cancer using superparamagnetic particles of iron oxide: early clinical experience.

Int Urol Nephrol 2018 Aug 15;50(8):1427-1433. Epub 2018 Jun 15.

Department of Urologic Oncology, Clinic of Surgical Oncology, Masaryk Memorial Cancer Institute, Žlutý Kopec 7, 65653, Brno, Czech Republic.

Purpose: Superparamagnetic nanoparticles of iron oxide (SPION) were shown to be non-inferior to standard radioisotope tracer in breast cancer and may be used as an alternative to identify sentinel lymph nodes (SLN). The aim of this study was to assess the feasibility of sentinel lymph node dissection (SLND) using SPION in prostate cancer and to evaluate its diagnostic accuracy.

Methods: Twenty patients with intermediate- and high-risk prostate cancer were prospectively enrolled in 2016. Read More

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Lymph node dissection during sublobar resection: why, when and how?

J Thorac Dis 2018 Apr;10(Suppl 10):S1145-S1150

Department of Thoracic Surgery, North Hospital, Aix-Marseille University & Assistance Publique-Hôpitaux de Marseille, Marseille, France.

Appropriate lymph node (LN) assessment is a hallmark of surgical quality of curative intent operations for non-small cell lung cancer (NSCLC). Even in the era of extensive pre-treatment work-up including routine PET-scanning and brain imaging, and selective invasive LN evaluation, unexpected LN metastases are found at surgery in more than 10% of patients with a cT1aN0 tumor. Systematic lymphadenectomy minimizes the risk of leaving tumor-LN behind and thus the risk of an incomplete resection, and provides the most truthful pTNM, which is decisive in directing adjuvant chemotherapy. Read More

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The anatomical configuration of the splenic artery influences suprapancreatic lymph node dissection in laparoscopic gastrectomy: analysis using a 3D volume rendering program.

Surg Endosc 2018 08 3;32(8):3697-3705. Epub 2018 May 3.

Department of Surgery, Seoul National University Hospital, Daehak-ro 101, Jongno-gu, Seousl, 03080, South Korea.

Background: The aim of this study is to categorize splenic artery and vein configurations, and examine their influence on suprapancreatic lymph node (LN) dissection in laparoscopic gastrectomy.

Methods: Digital Imaging and Communications in Medicine images from 169 advanced cancer patients who underwent laparoscopic gastrectomy with D2 dissection were used to reconstruct perigastric vessels in 3D using a volume rendering program (VP Planning). Splenic artery and vein configuration were classified depending on the relative position of their lowest part in regard to the pancreas. Read More

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Blind spot in lung cancer lymph node metastasis: Cross-lobe peripheral lymph node metastasis in early stage patients.

Thorac Cancer 2018 04 8;9(4):480-485. Epub 2018 Mar 8.

Department of Thoracic Surgery, National Cancer Center/Cancer Hospital, Chinese Academic of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: At present, it has not yet been determined whether metastasis can be transferred cross-lobe to peripheral lymph nodes (LNs) from other lobes in early stages of lung cancer, especially without any direct involvement to the pleura and parenchyma of the lobe. This study was conducted to investigate this issue.

Methods: A retrospective analysis was conducted at the Chinese Academy of Medical Sciences. Read More

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Comparison of Salmonella Prevalence Rates in Bovine Lymph Nodes across Feeding Stages.

J Food Prot 2018 04;81(4):549-553

Department of Animal Science, Texas A&M Agrilife Research, Texas A&M University, 2471 TAMU, College Station, Texas 77843-2471, USA.

Peripheral lymph nodes (LNs) located in the fatty tissues of beef carcasses have been shown to harbor Salmonella and, thus, potentially contaminate ground beef. Salmonella prevalence within LNs is known to differ among feedlots. Two South Texas feeding operations (identified as locations A and B) known to harbor salmonellae in the feedlot environment, while historically producing cattle with opposing rates (one "high" and one "low") of Salmonella prevalence in LNs, were used in this study. Read More

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Dendritic Cell Migration to Skin-Draining Lymph Nodes Is Controlled by Dermatan Sulfate and Determines Adaptive Immunity Magnitude.

Front Immunol 2018 8;9:206. Epub 2018 Feb 8.

Department of Molecular Cell Biology and Immunology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, Netherlands.

For full activation of naïve adaptive lymphocytes in skin-draining lymph nodes (LNs), presentation of peptide:MHC complexes by LN-resident and skin-derived dendritic cells (DCs) that encountered antigens (Ags) is an absolute prerequisite. To get to the nearest draining LN upon intradermal immunization, DCs need to migrate from the infection site to the afferent lymphatics, which can only be reached by traversing a collagen-dense network located in the dermis of the skin through the activity of proteolytic enzymes. Here, we show that mice with altered collagen fibrillogenesis resulting in thicker collagen fibers in the skin display a reduced DC migration to the draining LN upon immune challenge. Read More

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Intraoperative measurement of thyroglobulin in lymph node aspirates for the detection of metastatic papillary thyroid carcinoma.

Onco Targets Ther 2017 11;10:4435-4441. Epub 2017 Sep 11.

Department of General Surgery, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin, People's Republic of China.

Background: Among patients with papillary thyroid carcinoma (PTC), 30%-80% have cervical lymph node (LN) metastases, which are most commonly located in the central compartment. However, preoperative ultrasonography identifies malignant central compartment LNs in only 20%-30% of cases. We aimed to evaluate the diagnostic value of intraoperative thyroglobulin (Tg) measurement in fine-needle aspirates (FNA-Tg) of suspicious metastatic LNs. Read More

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September 2017

The value of F-FDG PET/CT in the distinction between retroperitoneal fibrosis and its malignant mimics.

Semin Arthritis Rheum 2018 02 3;47(4):593-600. Epub 2017 Aug 3.

Department of Rheumatology, Chinese PLA General Hospital, Beijing, China. Electronic address:

Objective: To discuss the utility of F-fluorodeoxyglucose (FDG) positron emission tomography/computerized tomography (PET/CT) in the diagnosis of idiopathic retroperitoneal fibrosis (iRPF).

Methods: IRPF patients diagnosed between September 2011 and June 2016 were included. Retroperitoneal malignancy patients were included as control. Read More

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February 2018

More extended lymph node dissection template at radical prostatectomy detects metastases in the common iliac region and in the fossa of Marcille.

BJU Int 2018 05 17;121(5):725-731. Epub 2017 Sep 17.

Department of Urology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Objectives: To assess the effect of adding lymph nodes (LNs) located along the common iliac vessels and in the fossa of Marcille to the extended pelvic LN dissection (PLND) template at radical prostatectomy (RP).

Patients And Methods: A total of 485 patients underwent RP and PLND at a referral centre between 2000 and 2008 (historical cohort: classic extended PLND template) and a total of 268 patients between 2010 and 2015 (contemporary cohort: extended PLND template including LNs located along the common iliac vessels and in the fossa of Marcille). Descriptive analyses were used to compare baseline, pathological, complication and functional data between the two cohorts. Read More

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T Cell Zone Resident Macrophages Silently Dispose of Apoptotic Cells in the Lymph Node.

Immunity 2017 08 8;47(2):349-362.e5. Epub 2017 Aug 8.

Aix Marseille Univ, CNRS, INSERM, CIML, Marseille, France. Electronic address:

In lymph nodes (LNs), dendritic cells (DCs) are thought to dispose of apoptotic cells, a function pertaining to macrophages in other tissues. We found that a population of CX3CR1 MERTK cells located in the T cell zone of LNs, previously identified as DCs, are efferocytic macrophages. Lineage-tracing experiments and shield chimeras indicated that these T zone macrophages (TZM) are long-lived macrophages seeded in utero and slowly replaced by blood monocytes after birth. Read More

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