16,934 results match your criteria living liver


Factors associated with phosphatidylethanol (PEth) sensitivity for detecting unhealthy alcohol use: An individual patient data meta-analysis.

Alcohol Clin Exp Res 2021 Apr 10. Epub 2021 Apr 10.

Department of Community Health Sciences, Boston University, School of Public Health, Section of General Internal Medicine, Boston University, School of Medicine and Boston Medical Center, Grayken Center on Addiction, Boston Medical Center, Boston, MA, USA.

Background: Objective measurement of alcohol consumption is important for clinical care and research. Adjusting for self-reported alcohol use, we conducted an individual participant data (IPD) meta-analysis to examine factors associated with the sensitivity of phosphatidylethanol (PEth), an alcohol metabolite, among persons self-reporting unhealthy alcohol consumption.

Methods: We identified 21 eligible studies and obtained 4073 observations from 3085 participants with Alcohol Use Disorders Identification Test - Consumption (AUDIT-C) positive scores (≥3 for women and ≥4 for men) and PEth measurements. Read More

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Minimally Invasive Living Donor Liver Transplantation: Pure Laparoscopic Explant Hepatectomy and Graft Implantation Using Upper Midline Incision.

Liver Transpl 2021 Apr 10. Epub 2021 Apr 10.

Department of Surgery, Seoul National University College of Medicine, Seoul, South Korea.

Minimally invasive approaches, including laparoscopic procedures, have increasingly been applied in surgery due to their advantages such as reduced surgical trauma, a better quality of life, shorter hospital stay, and less postoperative morbidity compared with open surgeries. Minimally invasive approaches in liver transplantation (LT) may have similar advantages for the recipients, including less pain and a shorter hospital stay, which could facilitate rehabilitation. Read More

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Virtual noncontrast images derived from dual-energy CT for assessment of hepatic steatosis in living liver donors.

Eur J Radiol 2021 Mar 27;139:109687. Epub 2021 Mar 27.

Department of Radiology, Seoul National University Hospital, Seoul, South Korea; Department of Radiology, Seoul National University College of Medicine, Seoul, South Korea; Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, South Korea.

Purpose: This study aimed to investigate the correlation of attenuation between virtual noncontrast (VNC) and true noncontrast (TNC) CT images and compare the diagnostic performance for hepatic steatosis using MR spectroscopy (MRS) as the reference standard.

Methods: A total of 131 consecutive hepatic donor candidates who underwent dual-source dual-energy CT and MRS within one month from January 2018 to April 2019 were included. An MRS value > 5. Read More

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Hungry Bone Syndrome After Living Donor Liver Transplant for Biliary Atresia.

Exp Clin Transplant 2021 Apr;19(4):386-389

From the Department of Pediatric Surgery and Transplantation, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.

Hungry bone syndrome is a rare but potentially lethal complication that is characterized by rapid, severe, long-lasting hypocalcemia and hypophosphatemia secondary to increased bone metabolism. We present a case of hungry bone syndrome after living donor liver transplant for biliary atresia. Following a failed Kasai procedure for biliary atresia, a 5-month-old boy underwent living donor liver transplant with reduced left lateral lobe from his father. Read More

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Letter to the Editor: Left Lobe Living Donor Graft Could Be a Good Choice for Liver Transplantation.

Liver Transpl 2021 Apr 9. Epub 2021 Apr 9.

Division of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.

We enjoyed the article by Kitajima et al.(1) describing living donor liver transplantation (LDLT) for patients with a combination of a mid-Model for End-Stage Liver Disease (MELD) score and ascites. These patients had significantly increased hazards for mortality than patients undergoing deceased donor liver transplantation (DDLT). Read More

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Reduction of Visceral Adiposity as a Predictor for Resolution of Nonalcoholic Fatty Liver in Potential Living Liver Donors.

Liver Transpl 2021 Apr 9. Epub 2021 Apr 9.

Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

This study aimed to determine the factors associated with resolution of nonalcoholic fatty liver (NAFL) after lifestyle intervention in potential living liver donors, as assessed by gold standards in a longitudinal setting. This retrospective study included 115 potential living liver donors (mean age, 30.5 ± 7. Read More

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Fontan-associated liver disease and total cavopulmonary anatomical flow effectors.

J Card Surg 2021 Apr 8. Epub 2021 Apr 8.

Children's Heart Center Nevada, Las Vegas, Nevada, USA.

Objective: We investigated a relationship between a composite index comprised of Fontan-circuit anatomical features and hepatic fibrosis scores from biopsy.

Methods: We identified living extracardiac Fontan patients, ≥7 years old and ≥5 but <20 years postoperative, that underwent cardiac catheterization and transvenous liver biopsy between March 2012 and September 2020. We divided patients into anatomical groups and applied a risk score to each patient. Read More

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Live cell ATR-FTIR spectroscopy as a novel bioanalytical tool for cell glucose metabolism research.

Biochim Biophys Acta Mol Cell Res 2021 Apr 5:119024. Epub 2021 Apr 5.

Institute of Pharmaceutical Science, School of Cancer and Pharmaceutical Sciences, King's College London, SE1 9NH, United Kingdom. Electronic address:

Current novel drug developments for the treatment of diabetes require multiple bioanalytical assays to interrogate the cellular metabolism, which are costly, laborious and time-consuming. Fourier-transform infrared (FTIR) spectroscopy is a nondestructive, label-free, sensitive and low-cost technique that is recently found to be suitable for studying living cells. The aim of this study is to demonstrate that live-cell FTIR can be applied to study the differences in glucose metabolism in cells in normal culturing medium and cells treated in high glucose (a diabetes model) in order to highlight the potential of the technique in diabetes research. Read More

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Tacrolimus, Sirolimus and Everolimus Doses in HIV-Infected Solid-Organ Recipients, Requiring a Cobicistat-Based Antiretroviral Regimen: Report of Three Cases and Review.

Infect Dis Ther 2021 Apr 8. Epub 2021 Apr 8.

HIV Unit and Infectious Diseases Service, Hospital Clinic - IDIBAPS, University of Barcelona, Barcelona, Spain.

People living with HIV should be considered candidates for solid-organ transplantation (SOT). However, managing HIV-infected patients undergoing SOT represents a major challenge due to the potential drug-drug interactions between antiretroviral drugs and immunosuppressive agents, particularly when resorting to antiretroviral drugs that require pharmacokinetic enhancers. We report three cases of cobicistat-tacrolimus co-administration, two of which also include the co-administration of mTOR inhibitors, in HIV-positive patients undergoing SOT (2 kidney and 1 liver recipient). Read More

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Perioperative blood transfusion decreases long-term survival in pediatric living donor liver transplantation.

World J Gastroenterol 2021 Mar;27(12):1161-1181

Department of Gastroenterology, Division of Liver and Gastrointestinal Transplant, Hospital das Clinicas, University of São Paulo School of Medicine, São Paulo 05402-000, Brazil.

Background: The impact of perioperative blood transfusion on short- and long-term outcomes in pediatric living donor liver transplantation (PLDLT) must still be ascertained, mainly among young children. Clinical and surgical postoperative complications related to perioperative blood transfusion are well described up to three months after adult liver transplantation.

Aim: To determine whether transfusion is associated with early and late postoperative complications and mortality in small patients undergoing PLDLT. Read More

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Comparing purely laparoscopic versus open living donor right hepatectomy: propensity score-matched analysis.

Br J Surg 2021 Apr 2. Epub 2021 Apr 2.

Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Ulsan University and Asan Medical Centre, Seoul, Korea.

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Bioaccumulation of heavy metals in fish species of Iran: a review.

Environ Geochem Health 2021 Apr 5. Epub 2021 Apr 5.

Department of Environmental Science and Engineering, Faculty of Natural Resources, University of Tehran, P.O. Box: 4314, 31587-77878, Karaj, Iran.

Accumulation of heavy metals (HMs) in fish tissues is an important factor in monitoring the health and safety of aquatic ecosystems. Furthermore, fish are important parts of aquatic food chains and play a significant role in human health. Considering the significant role of fish in the diet of humans and their ability to transfer and biomagnify HMs, it is necessary to determine and study these contaminants in fish tissues, especially in the edible parts of the fish. Read More

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Histopathological evaluation of long-term tenofovir disoproxil fumarate treatment in patients with hepatitis be antigen-negative chronic hepatitis B.

World J Gastrointest Pharmacol Ther 2021 Mar;12(2):32-39

Department of Gastroenterology, Hepatology and Liver Transplantation, Koc University, School of Medicine, İstanbul 34300, Turkey.

Background: Hepatitis B virus is a universal health problem. There are approximately 250 million people living with hepatitis B worldwide, and approximately 600000 of these people die every year due to the virus.

Aim: To compare the pretreatment and post-treatment histopathological results of patients with hepatitis be antigen (HBeAg)-negative chronic hepatitis B (CHB) who had been receiving tenofovir disoproxil fumarate (TDF) treatment at our clinic for at least 5 years. Read More

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Organ integration in kidney transplant patients - Results of a KTx360° substudy.

J Psychosom Res 2021 Mar 25:110464. Epub 2021 Mar 25.

Department of Psychosomatic Medicine and Psychotherapy, Hannover Medical School, Hannover, Germany; Project Kidney Transplantation 360° (NTx360°), Hannover Medical School, Hannover, Germany. Electronic address:

Objective: Organ transplantation is the treatment of choice for patients with end-stage organ disease. From early on, the psychological perspective on integrating the organ has been of interest. As quantitative studies on organ integration are scarce, we aimed at evaluating this aspect in a large sample of kidney transplant (KTx) recipients. Read More

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Clinical Impact of Mild to Moderate Pulmonary Hypertension in Living-Donor Liver Transplantation.

Transpl Int 2021 Apr 2. Epub 2021 Apr 2.

Departments of Cardiology Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Severe pulmonary hypertension (PHT) is a contraindication to liver transplantation (LT); however, the prognostic implication of mild to moderate PHT in living-donor LT (LDLT) is unknown. The study cohort retrospectively included 1,307 patients with liver cirrhosis who underwent LDLT. PHT was defined as a mean pulmonary artery pressure (PAP) of ≥25 mmHg, measured intraoperatively just before surgery. Read More

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Alleviation of non-alcoholic fatty liver disease by Huazhi Fugan Granules is associated with suppression of TLR4/NF-κB signaling pathway.

Clin Investig Arterioscler 2021 Mar 30. Epub 2021 Mar 30.

Department of Liver Disease, Shaanxi Provincial Hospital of traditional Chinese Medicine, Xi'an, China. Electronic address:

Introduction: In parallel with the improvement of living standard, Non-alcoholic fatty liver disease (NAFLD) becomes the most common liver disease around the world. Huazhi Fugan Granules (HZFGG) is a formula which is used to treating of fatty liver, Based on the data we studied, HZFGG may have potential as a therapeutic formula for the alleviation of NAFLD.

Objectives: The aim of our study was to identifying the improvement of HZFGG on NAFLD and exploring the potential mechanisms. Read More

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Monitoring Campaign over an Edible Dormouse Population (; Rodentia: Gliridae) in Sicily: First Report of Mesocestodiasis.

Animals (Basel) 2021 Mar 25;11(4). Epub 2021 Mar 25.

Istituto Zooprofilattico Sperimentale della Sicilia, Via Gino Marinuzzi 3, 90129 Palermo, Italy.

This study reports on the health status of the edible dormouse () living in Nebrodi Park (Sicily, Italy), responsible for nut crop damage in the area. In the frame of a monitoring campaign for potential zoonotic risk involving 30 dormice, rectal and conjunctival swabs and fur and nest content were collected for bacteriological and parasitological examinations, respectively. A large presence of fleas belonging to was found. Read More

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Study of the l-Phenylalanine Ammonia-Lyase Penetration Kinetics and the Efficacy of Phenylalanine Catabolism Correction Using In Vitro Model Systems.

Pharmaceutics 2021 Mar 13;13(3). Epub 2021 Mar 13.

Institute of Living Systems, Immanuel Kant Baltic Federal University, A. Nevskogo Street 14, 236016 Kaliningrad, Russia.

The kinetics of l-phenylalanine ammonia-lyase (PAL) penetration into the monolayer of liver cells after its release from capsules was studied. The studies showed the absence of the effect of the capsule shell based on plant hydrocolloids on the absorption of l-phenylalanine ammonia-lyase in systems simulating the liver surface. After 120 min of incubation, in all variants of the experiment, from 87. Read More

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Dimethyl Fumarate, an Approved Multiple Sclerosis Treatment, Reduces Brain Oxidative Stress in SIV-Infected Rhesus Macaques: Potential Therapeutic Repurposing for HIV Neuroprotection.

Antioxidants (Basel) 2021 Mar 9;10(3). Epub 2021 Mar 9.

Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Dimethyl fumarate (DMF), an antioxidant/anti-inflammatory drug approved for the treatment of multiple sclerosis, induces antioxidant enzymes, in part through transcriptional upregulation. We hypothesized that DMF administration to simian immunodeficiency virus (SIV)-infected rhesus macaques would induce antioxidant enzyme expression and reduce oxidative injury and inflammation throughout the brain. Nine SIV-infected, CD8-T-lymphocyte-depleted rhesus macaques were studied. Read More

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Environmental Exposure of Wild Carnivores to Zoonotic Pathogens: Infection in the First Free Living Wolf ( Linnaeus, 1758) Found Dead in the Friuli Venezia Giulia Region.

Int J Environ Res Public Health 2021 Mar 3;18(5). Epub 2021 Mar 3.

Istituto Zooprofilattico Sperimentale delle Venezie, Viale dell'Università, 35020 Legnaro, Italy.

Leptospirosis is a worldwide-spread zoonosis causing disease and death in dogs and in humans. A Leptospiral infection has been recorded in several wild carnivore species in Europe, but tissue pathological changes were not commonly described. The Grey wolf () has been expanding its distribution range in north-eastern Italy during the last decade. Read More

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PNPLA3 Single Nucleotide Polymorphism Prevalence and Association with Liver Disease in a Diverse Cohort of Persons Living with HIV.

Biology (Basel) 2021 Mar 21;10(3). Epub 2021 Mar 21.

Robert Stempel School of Public Health, Florida International University, Miami, FL 33199, USA.

In persons living with HIV (PLWH), there are multiple sources of liver injury. Gene polymorphisms of PNPLA3 (patatin-like phospholipase domain-containing protein 3) have been identified as an important cofactor for increased disease severity in both alcoholic and non-alcoholic steatohepatitis (NASH). We utilized a well-characterized cohort of ethnically and racially diverse patients with HIV to define the prevalence of PNPLA3 SNPs (single nucleotide polymorphism) (rs738409), and to determine the relationship to hepatic steatosis and liver fibrosis. Read More

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Ameliorative effect of N-acetylcysteine against glyphosate-induced hepatotoxicity in adult male albino rats: histopathological, biochemical, and molecular studies.

Environ Sci Pollut Res Int 2021 Apr 2. Epub 2021 Apr 2.

Cytology and Histology Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

Glyphosate (GLP) is the most commonly used herbicide that presents many hazards to the environment and living organisms. The present study aimed to explore hepatotoxic properties of GLP on adult albino rats, and the ability of N-acetylcysteine (NAC) to ameliorate these toxic effects. Thirty mature male albino rats were distributed into 3 groups (10 rats/group): Group I (C) a negative control, Group II (GLP) orally administered Roundup 0. Read More

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A no-ligation technique to prevent intraoperative hepatic artery dissection in living-donor liver transplantation.

Surg Today 2021 Apr 1. Epub 2021 Apr 1.

Departments of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Intrahepatic recipient hepatic artery dissection caused by hepatic artery thrombosis is a lethal complication of living-liver donor liver transplantation (LDLT). We herein report a new surgical technique that avoids the ligation of the recipient hepatic arteries in LDLT. Patients undergoing LDLT between 2009 and 2019 were evaluated. Read More

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Optimal drainage of anastomosis stricture after living donor liver transplantation.

Surg Endosc 2021 Apr 1. Epub 2021 Apr 1.

Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

Background: Endoscopic biliary stenting (EBS) with a fully covered, self-expandable metallic stent (FC-SEMS) and plastic stent (PS) is safe and efficient for biliary anastomotic strictures (ASs) after a deceased donor liver transplantation. Limited studies have investigated the use of FC-SEMSs for biliary strictures post-living donor liver transplantation (LDLT). We compared the resolution rate of biliary ASs post-LDLT and the 12-month recurrence rates post-stent removal between EBS with an FC-SEMS, PS, and percutaneous transhepatic biliary drainage (PTBD). Read More

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Chronic Hepatitis B and HIV Coinfection: A Continuing Challenge in the Era of Antiretroviral Therapy.

Authors:
H Nina Kim

Curr Hepatol Rep 2020 Dec 16;19(4):345-353. Epub 2020 Sep 16.

Department of Medicine, Division of Allergy & Infectious Diseases, University of Washington, Seattle, WA.

Purpose Of Review: The burden of chronic hepatitis B (HBV) remains disproportionately high among people living with HIV (PLWH) despite the advent of HBV vaccination and HBV-active antiretroviral therapy (ART). This review summarizes new insights and evolving issues in HIV-HBV coinfection.

Recent Findings: HBV-HIV coinfection is still a leading cause of cirrhosis, hepatocellular carcinoma (HCC) and liver-related mortality more than a decade after the approval of tenofovir. Read More

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December 2020

Cancer Screening in Solid Organ Transplant Recipients: A Focus on Screening Liver, Lung, and Kidney Recipients for Cancers Related to the Transplanted Organ.

Transplantation 2021 Mar 29. Epub 2021 Mar 29.

Department of Medicine, Division of Nephrology, University Health Network, Toronto, ON, Canada. Department of Medicine, Division of Cardiology, Montreal Heart Institute, Montreal, QC, Canada.

Over the last few decades, the life expectancy of solid organ transplant recipients (SOTR) has improved significantly. With SOTR living longer, more recipients are dying from cancer. There is a reported 2- to 3-fold increased risk of cancer-specific mortality in SOTR compared to the general population. Read More

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Synthesis, optical properties, determination and imaging in living cells and bamboo of cinnamaldehyde derivatives.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Mar 22;255:119730. Epub 2021 Mar 22.

China National Bamboo Research Center, Hangzhou 310012, Zhejiang, China; Key Laboratory of High Efficient Processing of Bamboo of Zhejiang Province, Hangzhou 310012, Zhejiang, China; Key Laboratory of Resources and Utilization of Bamboo of State Forestry and Grass Administration, Hangzhou 310012, Zhejiang, China. Electronic address:

Two Schiff-base fluorescent probes (1 and 2) were directly synthesized from natural cinnamaldehyde, and they were characterized by FT-IR, H and C NMR, HRMS. Compound 1 had no fluorescence, while compound 2 could emit significant yellow fluorescence in solid and provide green light in solution. Probe 1 could selectively sense ClO with a fluorescence enhancement, providing a good linear relationship between the fluoresence intensity and ClO concentrations (0-5. Read More

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Successful living donor liver transplantation for liver failure due to maternal T cell engraftment following cord blood transplantation in X-linked severe combined immunodeficiency disease: case report.

Am J Transplant 2021 Apr 1. Epub 2021 Apr 1.

Department of Gastroenterological, General and Transplant Surgery, Jichi Medical University, Tochigi-ken, Japan.

Maternal T-cells from perinatal transplacental passage have been identified in up to 40% of patients with severe combined immunodeficiency (SCID). Although engrafted maternal T cells sometimes injure newborn tissue, liver failure due to maternal T cells has not been reported. We rescued a boy with X-linked SCID who developed liver failure due to engrafted maternal T-cell invasion following living donor liver transplantation (LDLT) following unrelated umbilical cord blood transplantation (UCBT). Read More

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An Italian survey on the use of T-tube in liver transplantation: old habits die hard!

Updates Surg 2021 Apr 1. Epub 2021 Apr 1.

Liver-Kidney Transplantation Unit, Department of Medicine, University of Udine, Udine, Italy.

There is enough clinical evidence that a T-tube use in biliary reconstruction at adult liver transplantation (LT) does not significantly modify the risk of biliary stricture/leak, and it may even sustain infective and metabolic complications. Thus, the policy on T-tube use has been globally changing, with progressive application of more restrictive selection criteria. However, there are no currently standardized indications in such change, and many LT Centers rely only on own experience and routine. Read More

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