43,692 results match your criteria liver transaminase

Prevalence of liver injury in 445 patients with Corona Virus Disease-19-Single-centre experience from southern India.

Indian J Gastroenterol 2021 May 15. Epub 2021 May 15.

Department of Gastroenterology and Hepatology, MIOT International, 4/112, Mount Poonamalle High Road, Sathya Nagar, Manapakkam, Chennai, 600 089, India.

Background: Abnormal liver function tests (LFT) are common in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and vary from 15% to 53%. There are scanty data  from India on the prevalence of liver injury in corona virus disease 2019 (COVID-19) patients.

Methods: We did this retrospective study in a tertiary care hospital, Chennai, India. Read More

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CHI3L1 alleviate acute liver injury by inhibiting Th1 cells differentiation through STAT3 signaling pathway.

Ann Transl Med 2021 Apr;9(7):529

Liver Transplantation Center, First Affiliated Hospital, Nanjing Medical University, Nanjing, China.

Background: Acute liver injury (ALI) is a severe liver disease. Chitinase 3-like-1 (CHI3L1), a protein belonging to the glycosyl hydrolase family 18, is involved in many diseases, such as inflammatory diseases, bacterial infections, and various malignant tumors; however, the function of CHI3L1 in ALI remains unclear. The objective of this study was to evaluate the protective functions of CHI3L1 against thioacetamide (TAA)-induced ALI in mice and explore its potential mechanisms. Read More

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Elevated transaminases and hypoalbuminemia in Covid-19 are prognostic factors for disease severity.

Sci Rep 2021 May 13;11(1):10308. Epub 2021 May 13.

Department of Internal Medicine, Division of Gastroenterology, Hepatology and Nutrition, St. Joseph Medical Center, Steward Health, 1315 St Joseph Parkway, Houston, TX, 77002, USA.

Prognostic markers are needed to understand the disease course and severity in patients with Covid-19. There is evidence that Covid-19 causes gastrointestinal symptoms and abnormalities in liver enzymes. We aimed to determine if hepatobiliary laboratory data could predict disease severity in patients with Covid-19. Read More

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A model based on routine liver tests can reliably exclude intrahepatic cholestasis of pregnancy.

Eur J Intern Med 2021 May 10. Epub 2021 May 10.

Faculty of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Center, POB 12000, Jerusalem 91120, Israel. Electronic address:

Objectives: Serum bile acid (BA) levels testing is used for the diagnosis of intrahepatic cholestasis of pregnancy (ICP). We aimed to determine the performance of routine liver tests in the evaluation of ICP.

Methods: A retrospective cohort study conducted at a university hospital, including all pregnant women who underwent serum BA levels testing due to suspected ICP during 2007-2019. Read More

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Impact of Donor and Recipient Clinical Characteristics and Hepatic Histology on Steatosis/Fibrosis Following Liver Transplantation.

Transplantation 2021 Feb 8. Epub 2021 Feb 8.

1Department of Surgery, University of California San Francisco, San Francisco, CA, USA 2Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA 3Division of Hepatology and Comprehensive Transplant Center, Northwestern Memorial Hospital, Chicago, IL, USA 4Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA 5Department of Surgery, University of Michigan, Ann Arbor, MI, USA 6Department of Surgery, University of Washington, Seattle, WA, USA 7Baylor Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX, USA 8Division of Gastroenterology and Hepatology, University of Colorado Denver, Aurora, CO, USA 9Immune Tolerance Network, San Francisco, CA, USA 10Division of Gastroenterology and Hepatology, University of Pennsylvania, Philadelphia, PA, USA.

Background: Deceased donor and recipient predictors of post transplant steatosis/steatohepatitis and fibrosis are not well known.

Aim: Evaluate the prevalence and assess donor and recipient predictors of steatosis, steatohepatitis, and fibrosis in LT recipients.

Methods: Using the ITN A-WISH multicenter study (NCT00135694), donor and recipient demographic and clinical features were collected. Read More

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February 2021

Sex difference in the tolerance of hepatic ischemia-reperfusion injury and hepatic estrogen receptor expression according to age and macrosteatosis in healthy living liver donors.

Transplantation 2021 Feb 22. Epub 2021 Feb 22.

1From the Department of Anesthesiology and Pain Medicine 2 Department of Surgery Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 3From the Department of Obstetrics and Gynecology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea 4Statistics and Data Center, Samsung Medical Center, Seoul, Korea 5 Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: Hepatic estrogen signaling, which is important in liver injury/recovery, is determined by the level of systemic estrogen and hepatic estrogen receptor. We aimed to evaluate whether female's advantage in the tolerance of hepatic ischemia-reperfusion injury decreases according to the age of 40 y (systemic estrogen decrease) and macrosteatosis (hepatic estrogen receptor decrease).

Methods: We included 358 living liver donors (128 females and 230 males). Read More

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February 2021

Successful treatment of amiodarone-induced hepatic injury with n-acetylcysteine: A case report.

Indian J Pharmacol 2021 Jan-Feb;53(1):60-62

Department of Cardiology, Faculty of Medicine, Lokman Hekim University, Ankara, Turkey.

Intravenous amiodarone treatment may cause hepatic toxicity. N-acetylcysteine (NAC) is a powerful antioxidant, reduces the level of free radicals by increasing glutathione levels, and is used in acetaminophen intoxication. An 83-year-old female Caucasian patient who had congestive heart failure and implantable cardioverter-defibrillator was admitted to the hospital with palpitations and confusion. Read More

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CRP is a superior and prognostically significant inflammation biomarker for hepatocellular cancer patients treated by liver transplantation.

Clin Pract (Lond) 2021 ;18(2):1626-1632

Department of Surgery, Liver Transplantation Institute, Inonu University, Turkey.

Background: Inflammation and its markers are considered prognostically important for many cancers, including Hepatocellular Carcinoma (HCC). However, it is not really clear which markers are the best.

Aims: To assess in a cohort of prospectively-evaluated HCC patients who were treated with liver transplant and whose survival was known, multiple commonly used inflammatory markers in relation to survival and to both clinical and tumor aggressiveness parameters. Read More

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January 2021

Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes.

Nat Commun 2021 May 10;12(1):2579. Epub 2021 May 10.

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Serum concentration of hepatic enzymes are linked to liver dysfunction, metabolic and cardiovascular diseases. We perform genetic analysis on serum levels of alanine transaminase (ALT), alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) using data on 437,438 UK Biobank participants. Replication in 315,572 individuals from European descent from the Million Veteran Program, Rotterdam Study and Lifeline study confirms 517 liver enzyme SNPs. Read More

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Metformin Modulates T Cell Function and Alleviates Liver Injury Through Bioenergetic Regulation in Viral Hepatitis.

Front Immunol 2021 21;12:638575. Epub 2021 Apr 21.

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, United States.

Metformin is not only the first-line medication for the treatment of type 2 diabetes, but it is also effective as an anti-inflammatory, anti-oxidative and anti-tumor agent. However, the effect of metformin during viral hepatitis remains elusive. Using an adenovirus (Ad)-induced viral hepatitis mouse model, we found that metformin treatment significantly attenuated liver injury, with reduced serum aspartate transaminase (AST) and alanine transaminase (ALT) levels and liver histological changes, presumably decreased effector T cell responses. Read More

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Severe Liver Injury Associated With High-Dose Atorvastatin Therapy.

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211014050

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Statins are recommended for first-line management of elevated cholesterol in the primary and secondary prevention of atherosclerotic cardiovascular disease. Statins may occasionally be associated with mild transaminase elevations but can also result in life-threatening liver injury. Atorvastatin is the most common cause of clinically significant liver injury in this drug class. Read More

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Analysis on the value of soluble intercellular adhesion molecule-1 (sICAM-1), alpha fetoprotein (AFP), and aspartate aminotransferase/platelet ratio index (APRI) in predicting the prognostic survival of patients with primary liver cancer after radiofrequency ablation.

Ann Palliat Med 2021 Apr;10(4):4760-4767

Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Background: To analyze the value of soluble intercellular adhesion molecule-1 (sICAM-1), alpha fetoprotein (AFP), and aspartate aminotransferase (AST)/platelet (PLT) ratio index (APRI) in predicting the prognostic survival of patients with primary liver cancer after radiofrequency ablation (RFA).

Methods: The data of 115 patients with primary liver cancer admitted to our hospital from June 2016 to June 2018 were retrospectively analyzed as the research group, and 120 healthy people who were examined during the same period were selected as the control group. Multivariate logistic regression analysis was used to analyze the risk factors that affect the prognostic survival of patients with primary liver cancer treated with RFA. Read More

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The combination of conventional ultrasound and shear-wave elastography in evaluating the segmental heterogeneity of liver fibrosis in biliary atresia patients after Kasai portoenterostomy.

Pediatr Surg Int 2021 May 9. Epub 2021 May 9.

Department of Medical Ultrasonics, Institute for Diagnostic and Interventional Ultrasound, The First Affiliated Hospital, Sun Yat-Sen University, No. 58, Zhongshan Er Road, Guangzhou, 510080, People's Republic of China.

Objective: To retrospectively assess the value of the combination of conventional ultrasound and shear-wave elastography (SWE) in evaluating the segmental heterogeneity of liver fibrosis in biliary atresia (BA) patients after Kasai portoenterostomy.

Methods: A total of 35 BA patients with liver segmental deformation were enrolled. The segmental deformation was assessed by conventional ultrasound followed with SWE examinations for evaluating the liver stiffness. Read More

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Effects of co-administration of pharmacopoeia formulations and with CAT-I antitubercular drugs in rats.

J Complement Integr Med 2021 May 10. Epub 2021 May 10.

ICMR-National Institute for Research in Tuberculosis (NIRT), Chennai, Tamil Nadu, India.

Objectives: Tuberculosis continues to be a major public health problem globally, despite incredible advancements in healthcare system. In system of medicine, (QTS) and (AHB) have been traditionally used for tuberculosis like conditions. The study was aimed to investigate the effects of co-administration of QTS and AHB with category I first line antitubercular drugs (CAT-I) on the indices of liver and kidney function in rats. Read More

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Health-related quality of life in Chinese population with non-alcoholic fatty liver disease: a national multicenter survey.

Health Qual Life Outcomes 2021 May 7;19(1):140. Epub 2021 May 7.

Hepatopancreatobiliary Center, Beijing Tsinghua Changgung Hospital, Tsinghua University, No.168, Litang Road, Changping District, Beijing, 102218, China.

Background: Health Related Quality of Life (HRQL) is a multi-dimensional construct that can comprehensively evaluate the patient's health status, including physical, emotional, mental and social well-being. In this study, we aimed to evaluate the impact of non-alcoholic fatty liver disease (NAFLD) on HRQL in a Chinese population.

Methods: In this national multicenter cross-sectional survey, patients with NAFLD were enrolled. Read More

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[Clinical meaning of elevated aminotransferases].

MMW Fortschr Med 2021 05;163(9):51

Transplantationszentrum der LMU, Campus Großhadern, Marchioninistr. 15, 81377, München, Deutschland.

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Bilobalide Enhances AMPK Activity to Improve Liver Injury and Metabolic Disorders in STZ-Induced Diabetes in Immature Rats via Regulating HMGB1/TLR4/NF-B Signaling Pathway.

Biomed Res Int 2021 17;2021:8835408. Epub 2021 Apr 17.

Department of Pediatrics, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, 441021 Hubei Province, China.

This study was aimed at examining the effect and underlying mechanisms of bilobalide (BB) on hepatic injury in streptozotocin- (STZ-) induced diabetes mellitus (DM) in immature rats. Immature rats (one day old) were randomly divided into five groups: group I, control nondiabetic rats; group II, STZ-induced, untreated diabetic rats; groups III/IV/V, STZ-induced and BB-treated diabetic rats, which were intraperitoneally injected with BB (2.5 mg/kg, 5 mg/kg, or 10 mg/kg) after 3 days followed by STZ treatment. Read More

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Comparative analysis of liver involvement caused by two DENV-2 lineages using an immunocompetent murine model.

Sci Rep 2021 May 6;11(1):9723. Epub 2021 May 6.

Laboratory of Viral Morphology and Morphogenesis, Instituto Oswaldo Cruz, Fiocruz, Avenida Brasil 4365, Rio de Janeiro, RJ, 21040-900, Brazil.

Dengue (DEN) is the most prevalent arbovirus among humans, and four billion people live at risk of infection. The clinical manifestations of DEN are variable, and the disease may present subclinically or asymptomatically. A quarter of patients develop classical dengue (CD) or severe dengue (SD), which is potentially lethal and involves vascular permeability changes, severe hemorrhage and organ damage. Read More

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Parthenolide plays a protective role in the liver of mice with metabolic dysfunction‑associated fatty liver disease through the activation of the HIPPO pathway.

Mol Med Rep 2021 Jul 6;24(1). Epub 2021 May 6.

Department of Hepatology, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China.

Metabolic dysfunction‑associated fatty liver disease (MAFLD) is a serious threat to human health. Parthenolide (PAR) displays several important pharmacological activities, including the promotion of liver function recovery during hepatitis. The aim of the present study was to assess the effect of PAR on MAFLD in a mouse model. Read More

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Epidemiology of Drug- and Herb-Induced Liver Injury Assessed for Causality Using the Updated RUCAM in Two Hospitals from China.

Biomed Res Int 2021 24;2021:8894498. Epub 2021 Feb 24.

Department of Pharmacy, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China.

Drug- and herb-induced liver injury (DILI and HILI) is an increasingly common and serious condition. Here, data for DILI and HILI patients from two large tertiary hospitals were retrospectively analyzed. Patient characteristics, causes and severity of DILI and HILI, the correlation between expression of p62 and the severity of DILI and HILI, treatment of DILI and HILI, and the prognostic factors of DILI and HILI were studied. Read More

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February 2021

Total flavonoids of Ameliorated Bile Acid Metabolism Dysfunction in Diabetes Mellitus.

Evid Based Complement Alternat Med 2021 12;2021:6675567. Epub 2021 Apr 12.

Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, China.

is one of the common traditional Chinese medicines used to treat diabetes. However, the underlying mechanism is not fully understood. Flavones are a class of active components that have been reported to exert various activities. Read More

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A systematic study of Tupaia as a model for human acute hepatitis B infection.

J Vet Med Sci 2021 Apr 29. Epub 2021 Apr 29.

Institute of Immunology, Third Military Medical University.

The molecular features of hepatitis B virus (HBV) infection, eradication, and pathogenesis are poorly understood, partly due to the lack of an adequate animal model that faithfully reproduces the course of infection. Although Tupaia belangeri were previously recognized as HBV-susceptible animals, the course of infection in adult tupaias remains obscure. Herein, we performed a longitudinal study and demonstrated that adult tupaias were efficiently infected (90% infection rate) with 10 copies of the HBV genome. Read More

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A Phase 1 Open-Label, Fixed-Sequence Pharmacokinetic Drug Interaction Trial to Investigate the Effect of Cannabidiol on the CYP1A2 Probe Caffeine in Healthy Subjects.

Clin Pharmacol Drug Dev 2021 May 5. Epub 2021 May 5.

GW Research Ltd, Cambridge, UK.

This pharmacokinetic (PK) drug-interaction trial investigated the effects of repeated dosing of a plant-derived pharmaceutical formulation of highly purified cannabidiol (CBD; Epidiolex in the United States and Epidyolex in Europe; 100 mg/mL oral solution) on caffeine clearance via modulation of cytochrome P450 (CYP) 1A2 activity in healthy adults. In this phase 1 open-label, fixed-sequence trial, all subjects received a single 200 mg caffeine dose and placebo on day 1. Subjects then titrated CBD from 250 mg once daily to 750 mg twice daily between days 3 and 11 and took 750 mg CBD twice daily between days 12 and 27. Read More

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Total cholesterol, alanine aminotransferase and the risk of primary liver cancer: A population-based prospective study.

Medicine (Baltimore) 2021 May;100(18):e25746

Department of Hepatobiliary Surgery, Kailuan General Hospital Affiliated to North China University of Science and Technology.

Abstract: Previous studies have shown that serum total cholesterol (TC) and serum alanine aminotransferase (ALT) are associated with liver cancer risk. However, the common contribution of TC and normal-high ALT to primary liver cancer (PLC) has not been reported. We aim to assess the separate and joint effect of low TC level and normal-high ALT level on the risk of PLC, a large prospective cohort was conducted in our study. Read More

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A case report of atypical Kawasaki disease presented with severe elevated transaminases and literature review.

BMC Infect Dis 2021 May 4;21(1):415. Epub 2021 May 4.

Department of Paediatrics, ShaoXing KeQiao Women And Children's Hospital, ShaoXing, 312030, Zhejiang Province, PR China.

Background: Kawasaki disease (KD) is the most common cause of acquired heart disease among children in developed countries, in which the resulting coronary artery (CA) abnormalities cause myocardial ischemia, infarction, and death. Prompt diagnosis was essential, and supplemental information should be used to assist the diagnosis when classical clinical criteria are incomplete. The elevated levels of serum transaminases in most KD patients are mild. Read More

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Comparative assessments of the biodistribution and toxicity of oxidized single-walled carbon nanotubes dispersed with two different reagents after intravenous injection.

Nanotoxicology 2021 May 4:1-14. Epub 2021 May 4.

National Institute of Advanced Science and Technology (AIST), Tsukuba, Japan.

The present study compared the effects of two commonly-used dispersants, bovine serum albumin (BSA) and polyethylene glycol (PEG), on the biodistribution and toxicity of oxidized super-growth single-wall carbon nanotubes (oxSG) injected intravenously into mice over 3 months. About 1-2% of the injected dose (ID) of oxSG dispersed in BSA (oxSG-BSA) was present in the lungs at all time points. By contrast, about 15% of the ID of oxSG dispersed in PEG (oxSG-PEG) was present in the lungs at 1 day (D1), with accumulation decreasing to about 5% of the ID at 90 days (D90). Read More

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Untargeted lipidomics analysis of Mori Fructus polysaccharide on acute alcoholic liver injury in mice using ultra performance liquid chromatography-quadrupole-orbitrap-high resolution mass spectrometry.

Int Immunopharmacol 2021 May 1;97:107521. Epub 2021 May 1.

Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment, Guizhou Engineering Laboratory for Quality Control and Evaluation Technology of Medicine, Research Center for Quality Control of Natural Medicine, Guizhou Normal University, Guiyang 550001, China. Electronic address:

Ethnopharmacological Relevance: Mori Fructus (MF) is a traditional Chinese medicine with long application history, which has protective effects on liver diseases. Mori Fructus polysaccharide (MFP) is one of the active ingredients of MF and possesses therapeutic effects against acute alcoholic liver injury. Recent researches have reported that the therapeutic effects of MFP might be related to the regulation of several lipid metabolic pathways. Read More

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Savolitinib ± Osimertinib in Japanese Patients with Advanced Solid Malignancies or EGFRm NSCLC: Ph1b TATTON Part C.

Target Oncol 2021 May 3;16(3):339-355. Epub 2021 May 3.

Dana-Farber Cancer Institute, Boston, MA, USA.

Background: Preliminary data suggest that combining savolitinib, a potent and highly selective MET-tyrosine kinase inhibitor (TKI), with osimertinib, a third-generation, irreversible, oral epidermal growth factor receptor-TKI (EGFR-TKI), may overcome MET-based resistance to EGFR-TKIs.

Objective: To investigate the safety and tolerability of savolitinib in Japanese patients with advanced solid malignancies.

Patients And Methods: In Part C of the phase Ib, multi-arm, open-label, multicenter TATTON study, two cohorts of Japanese adult patients were evaluated across six study centers in Japan. Read More

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Effect of formaldehyde and urea contaminated feed exposure into the liver of young and adult pigeons ().

Vet World 2021 Mar 26;14(3):769-776. Epub 2021 Mar 26.

Department of Anatomy and Histology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh.

Background And Aim: Nowadays, toxic chemical contaminants in food are a major food safety problem in Bangladesh. Among toxic food contaminants, formalin is used to preserve fruit, vegetables, and fish, where urea is used for the whitening of rice and puffed rice. The purpose of this study was to determine the biochemical and histopathological effects on the liver of young and adult pigeons after exposure to formalin and urea contaminated feed. Read More

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