697,792 results match your criteria liver diseases

Non-genetic influences on lipoprotein(a) concentrations.

Atherosclerosis 2022 May;349:53-62

Department of Internal Medicine, School of Medicine, University of California Davis, Davis, CA, USA.

An elevated level of lipoprotein(a) [Lp(a)] is a genetically regulated, independent, causal risk factor for cardiovascular disease. However, the extensive variability in Lp(a) levels between individuals and population groups cannot be fully explained by genetic factors, emphasizing a potential role for non-genetic factors. In this review, we provide an overview of current evidence on non-genetic factors influencing Lp(a) levels with a particular focus on diet, physical activity, hormones and certain pathological conditions. Read More

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Warm autoimmune haemolytic anaemia seen in association with primary sclerosing cholangitis in the setting of bacteraemia.

BMJ Case Rep 2022 May 23;15(5). Epub 2022 May 23.

Division of Hematology and Oncology, Department of Internal Medicine, University of Texas McGovern Medical School, Houston, Texas, USA.

Warm autoimmune haemolytic anaemia mediated by warm agglutinins is a rare and heterogeneous disease which can be idiopathic or secondary to an underlying disease. Primary sclerosing cholangitis is a chronic autoimmune cholangiopathy that is very rarely associated with haemolytic anaemia. Infections can also act as triggers for immune haemolytic anaemia. Read More

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Perceived Barriers And Benefits In The Participation In Faecal Occult Blood Test Colorectal Cancer Screening Programme.

Gastroenterol Hepatol 2022 May 20. Epub 2022 May 20.

South Galicia Health Research Institute, Vigo, España; Digestive Service, Hospital Universitario de Ourense, Ourense, España; Center for Biomedical Research Network for Liver and Digestive Diseases, Ourense, España. Electronic address:

Background: Colorectal cancer is the second cancer-related cause of death in the world. Tumor stage at diagnosis is the principal prognosis factor of survival. However, the participation in the program is around 50%. Read More

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PREX1 depletion ameliorates high-fat diet-induced non-alcoholic fatty liver disease in mice and mitigates palmitic acid-induced hepatocellular injury via suppressing the NF-κB signaling pathway.

Toxicol Appl Pharmacol 2022 May 20:116074. Epub 2022 May 20.

Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. Electronic address:

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver diseases worldwide. Oxidative stress has been considered a key factor in the pathogenesis of NAFLD. Phosphatidylinositol (3,4,5)-trisphosphate-dependent Rac exchanger 1 (PREX1), a guanine nucleotide exchange factor for Rac, has been associated with inflammation and oxidative stress. Read More

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Recent advances on FXR-targeting therapeutics.

Mol Cell Endocrinol 2022 May 20:111678. Epub 2022 May 20.

Research Unit for Translational Nuclear Receptor Research, Medical University Graz, Graz, Austria; Division of Gastroenterology and Hepatology, Medical University Graz, Graz, Austria. Electronic address:

The bile acid receptor FXR has emerged as a bona fide drug target for chronic cholestatic and metabolic liver diseases, ahead of all non-alcoholic fatty liver disease (NAFLD). FXR is highly expressed in the liver and intestine and activation at both sites differentially contributes to its desired metabolic effects. Unrestricted FXR activation, however, also comes along with undesired effects such as a pro-atherogenic lipid profile, pruritus and hepatocellular toxicity under certain conditions. Read More

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Apelin/APJ system in inflammation.

Int Immunopharmacol 2022 May 20;109:108822. Epub 2022 May 20.

Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China. Electronic address:

Apelin, an endogenous ligand for the G protein-coupled receptor (APJ), is widely distributed within the central nervous system and diverse organs in human and animals. Recent studies indicate that the apelin/APJ system plays an important role in physiological and pathophysiological situations. Apelin/APJ could inhibit inflammatory response by down-regulation of the nuclear factor-κB (NF-κB) pathway and by up-regulation of the extracellular signal-regulated kinase 1 and 2 (ERK1/2) pathway etc. Read More

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Dimethyl fumarate ameliorates autoimmune hepatitis in mice by blocking NLRP3 inflammasome activation.

Int Immunopharmacol 2022 May 20;108:108867. Epub 2022 May 20.

Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China. Electronic address:

Dimethyl fumarate (DMF) is a fumaric acid derivative clinically approved for the treatment of some inflammatory diseases, but the underlying mechanism for its therapeutic effects remains incompletely understood. NLR family pyrin domain containing 3 (NLRP3) inflammasome activation has critical roles in innate immune responses to various infections and sterile inflammations. In this study, we aimed to explore whether DMF affects auto-immune hepatitis (AIH) in mice induced by concanavalin A (Con A) by modulating NLRP3 inflammasome activation. Read More

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Safety, tolerability, and anti-fibrotic efficacy of the CBP/β-catenin inhibitor PRI-724 in patients with hepatitis C and B virus-induced liver cirrhosis: An investigator-initiated, open-label, non-randomised, multicentre, phase 1/2a study.

EBioMedicine 2022 May 20;80:104069. Epub 2022 May 20.

Department of Gastroenterology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.

Background: We conducted an exploratory study to assess the safety tolerability, and anti-fibrotic effects of PRI-724, a CBP/β-catenin inhibitor, in patients with hepatitis C virus (HCV)- and hepatitis B virus (HBV)-induced cirrhosis.

Methods: This multicentre, open-label, non-randomised, non-placebo-controlled phase 1/2a trial was conducted at three hospitals in Japan. Between July 27, 2018, and July 13, 2021, we enrolled patients with HCV- and HBV-induced cirrhosis classified as Child-Pugh (CP) class A or B. Read More

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Effects of small molecule inhibitor SW033291 on hepatic ischemia-reperfusion injury in mice.

Biochem Biophys Res Commun 2022 May 16;615:70-74. Epub 2022 May 16.

State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, China. Electronic address:

Hepatic ischemia-reperfusion injury (IRI) is an important factor in the recovery of liver function and prognosis after liver surgery. 15-hydroxyprostaglandin dehydrogenase (15-PGDH) small molecule inhibitor SW033291 is thought to play an important role in promoting tissue regeneration. The aim of this study was to investigate the effect of 15-PGDH on ischemia-reperfusion injury in mouse liver. Read More

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Chronic exposure to low concentration of MC-LR caused hepatic lipid metabolism disorder.

Ecotoxicol Environ Saf 2022 May 20;239:113649. Epub 2022 May 20.

Hunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Central South University, Changsha 410078, China; Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, University of South China, Hengyang 421001, China; Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China; The Key Laboratory of Ecological Environment and Critical Human Diseases Prevention of Hunan Province Department of Education, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang 421001, China. Electronic address:

Microcystin-LR (MC-LR), a potent hepatotoxin can cause liver damages. However, research on hepatic lipid metabolism caused by long-term exposure to environmental concentrations MC-LR is limited. In the current study, mice were exposed to various low concentrations of MC-LR (0, 1, 30, 60, 90, 120 μg/L in the drinking water) for 9 months. Read More

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Zinc carnosine: Frontiers advances of supplement for cancer therapy.

Biomed Pharmacother 2022 May 20;151:113157. Epub 2022 May 20.

Center for Healthy Ageing & Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia; Biocompatibility Laboratory, Centre for Research and Instrumentation, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor Darul Ehsan, Malaysia. Electronic address:

Zinc (Zn) has an existence within large quantities in the human brain, while accumulating within synaptic vesicle. There is growing evidence that Zn metabolic equilibrium breaking participates into different diseases (e.g. Read More

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Hepatocellular carcinoma in Stockholm, Sweden 2003-2018: a population-based cohort study.

Scand J Gastroenterol 2022 May 23:1-9. Epub 2022 May 23.

Division of Hepatology, Department of Upper GI Diseases, Karolinska University Hospital, Stockholm, Sweden.

Background And Aims: Available epidemiological data on hepatocellular carcinoma (HCC) originate mainly from centre-based or disease-specific cohorts and may not reflect the general population. This population-based register study presents the incidence, aetiologies, treatments, survival, and differences related to sex or socioeconomic status in patients with HCC from Stockholm, which constitutes more than a fifth of the Swedish population.

Methods: ICD-10 codes identified incident HCC cases in the regional administrative health care database 2003-2018. Read More

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Function and regulation of GPX4 in the development and progression of fibrotic disease.

J Cell Physiol 2022 May 23. Epub 2022 May 23.

School of Nursing, Hengyang Medical School, University of South China, Hengyang, Hunan, China.

Fibrosis is a common feature of fibrotic diseases that poses a serious threat to global health due to high morbidity and mortality in developing countries. There exist some chemical compounds and biomolecules associated with the development of fibrosis, including cytokines, hormones, and enzymes. Among them, glutathione peroxidase 4 (GPX4), as a selenoprotein antioxidant enzyme, is widely found in the embryo, testis, brain, liver, heart, and photoreceptor cells. Read More

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Targeting the lysosome: Mechanisms and treatments for nonalcoholic fatty liver disease.

Jing Pu

J Cell Biochem 2022 May 23. Epub 2022 May 23.

Department of Molecular Genetics and Microbiology, Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence, University of New Mexico, Albuquerque, New Mexico, USA.

The multiple functions of the lysosome, including degradation, nutrient sensing, signaling, and gene regulation, enable the lysosome to regulate lipid metabolism at different levels. In this review, I summarize the recent studies on lysosomal regulation of lipid metabolism and the alterations of the lysosome functions in the livers affected by nonalcoholic fatty liver disease (NAFLD). NAFLD is a highly prevalent lipid metabolic disorder. Read More

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Treatment of rheumatoid arthritis with conventional, targeted and biological disease-modifying antirheumatic drugs in the setting of liver injury and non-alcoholic fatty liver disease.

Rheumatol Int 2022 May 23. Epub 2022 May 23.

Department of Rheumatology, Clinical Immunology and Allergology, Faculty of Medicine Split, University of Split, Clinical Hospital Center Split, Split, Croatia.

Increased incidence of liver diseases emphasizes greater caution in prescribing antirheumatic drugs due to their hepatotoxicity. A transient elevation of transaminases to autoimmune hepatitis and acute liver failure has been described. For every 10 cases of alanine aminotransferase (ALT) elevation in a clinical trial, it is estimated that one case of more severe liver injury will develop once the investigated drug is widely available. Read More

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Autologous Skin Fibroblast-Based PLGA Nanoparticles for Treating Multiorgan Fibrosis.

Adv Sci (Weinh) 2022 May 23:e2200856. Epub 2022 May 23.

Department of Cardiovascular Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Fibrotic diseases remain a substantial health burden with few therapeutic approaches. A hallmark of fibrosis is the aberrant activation and accumulation of myofibroblasts, which is caused by excessive profibrotic cytokines. Conventional anticytokine therapies fail to undergo clinical trials, as simply blocking a single or several antifibrotic cytokines cannot abrogate the profibrotic microenvironment. Read More

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The amelioration of alcohol-induced liver and intestinal barrier injury by Gorbach-Goldin (LGG) is dependent on Interleukin 22 (IL-22) expression.

Bioengineered 2022 May;13(5):12650-12660

Department of Infectious Diseases, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang Provincial Key Laboratory for Accurate Diagnosis and Treatment of Chronic Liver Diseases, Wenzhou, China.

Alcoholic liver disease (ALD) is a common clinical liver injury disease. Gorbach-Goldin (LGG) has been revealed to alleviate alcohol-induced intestinal barrier and liver injury. However, the underlying mechanism of LGG treatment for ALD remains unclear. Read More

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[Advances in the mechanism of extracellular vesicles action in macrophage-related tissue fibrosis].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2022 May;38(5):466-471

The Affiliated Hospital of Nanjing University of Chinese Medicine, Department of Nephrology, Nanjing 210029, China. *Corresponding author, E-mail:

Fibrosis is a pathological healing process which occurs in the progression of various chronic diseases after tissue injury. Extracellular vesicles are involved in tissue fibrosis through communication between cells. Macrophages are important immune cells that maintain tissue integrity by eliminating or repairing damaged cells and matrix. Read More

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A chronic moderate methionine administration induced hyperhomocysteinemia associated with cardiovascular disease phenotype in the sand rat Psammomys obesus.

Folia Histochem Cytobiol 2022 May 23. Epub 2022 May 23.

Laboratory of Cellular and Molecular Biology, Biochemistry and Remodeling of the Extracellular Matrix, Faculty of Biological Sciences, Houari Boumediene University of Science and Technology (USTHB), Bab Ezzouar, El Alia, 16111, Algiers, Algeria.

Introduction: Cardiovascular diseases were defined as coronary artery, cerebrovascular, or peripheral arterial disease.Hyperhomocysteinemia (Hhcy) is an independent risk factor of cardiovascular diseases, including atherosclerosis. Our previous studies demonstrated the involvement of Hhcy in cardiovascular remodeling in the sand rat Psammomys obesus. Read More

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The Tyrosine Phosphatase PRL Regulates Attachment of Toxoplasma gondii to Host Cells and Is Essential for Virulence.

mSphere 2022 May 23:e0005222. Epub 2022 May 23.

Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

The pathogenesis of Toxoplasma gondii is mainly due to tissue damage caused by the repeating lytic cycles of the parasite. Many proteins localized to the pellicle of the parasite, particularly kinases, have been identified as critical regulators of the lytic cycle. However, little is known about the associated protein phosphatases. Read More

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Hepatic ultrastructural features distinguish pediatric Wilson disease from NAFLD and autoimmune hepatitis.

Liver Int 2022 May 23. Epub 2022 May 23.

Department of Pathology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

Background & Amis: Wilson disease (WD) has diverse presentations that frequently mimic other liver diseases. Distinguishing WD from non-alcoholic fatty liver disease (NAFLD) and autoimmune hepatitis (AIH), can be difficult and has critical implications for medical management. This study aimed to examine the utility of histological features of WD in children compared to those with NAFLD and AIH. Read More

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Potential mechanism of hepatic lipid accumulation during a long-term rest phase restricted feeding in mice.

Chronobiol Int 2022 May 23:1-12. Epub 2022 May 23.

Division of Pharmaceutics, Faculty of Pharmaceutical Sciences, Sanyo-Onoda City University, Yamaguchi, Japan.

Eating during a rest phase disrupts the biological clock system and leads to obesity and metabolic diseases. Although a rest phase restricted feeding (RF) is reported to enhance hepatic lipid accumulation, the mechanism(s) of the phenomenon is still unknown. This study evaluated the potential involvement of the CD36-related transport of lipids into the liver in mice with the RF procedure. Read More

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Genomic analysis of focal nodular hyperplasia with associated hepatocellular carcinoma unveils its malignant potential: a case report.

Commun Med (Lond) 2022 3;2:11. Epub 2022 Feb 3.

Visceral Surgery and Precision Medicine Research Laboratory, Department of Biomedicine, University of Basel, Basel, Switzerland.

Background: Focal nodular hyperplasia (FNH) is typically considered a benign tumor of the liver without malignant potential. The co-occurrence of FNH and hepatocellular carcinoma (HCC) has been reported in rare cases. In this study we sought to investigate the clonal relationship between these lesions in a patient with FNH-HCC co-occurrence. Read More

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February 2022

A cascade of care analysis on the elimination of hepatitis C from public hospitals in Madrid.

Commun Med (Lond) 2022 24;2:20. Epub 2022 Feb 24.

Hepatology Unit, Hospital Universitario La Paz, CIBERehd, IdiPAZ, Madrid, Spain.

Background: Direct-acting antivirals can cure ≥95% of hepatitis C virus (HCV) cases, but do not reach everyone in need. This cross-sectional study analyses the HCV cascade of care (CoC) in Madrid, Spain, in high-risk patients, to inform micro-elimination measures.

Methods: From September 2019 to May 2021, data from medical records were collected and analysed from six public hospitals in Madrid, including seven adult, high-risk patient groups: patients in haemodialysis or pre-dialysis programmes, co-infected with HIV, with advanced liver disease (ALD), with hereditary haematological diseases, with transplants and people who inject drugs (PWID). Read More

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February 2022

Mesenchymal Stem Cells and Their Small Extracellular Vesicles as Crucial Immunological Efficacy for Hepatic Diseases.

Front Immunol 2022 6;13:880523. Epub 2022 May 6.

Aoyang Institute of Cancer, Affiliated Aoyang Hospital of Jiangsu University, Suzhou, China.

Mesenchymal stem cell small extracellular vesicles (MSC-sEVs) are a priority for researchers because of their role in tissue regeneration. sEVs act as paracrine factors and carry various cargos, revealing the state of the parent cells and contributing to cell-cell communication during both physiological and pathological circumstances. Hepatic diseases are mainly characterized by inflammatory cell infiltration and hepatocyte necrosis and fibrosis, bringing the focus onto immune regulation and other regulatory mechanisms of MSCs/MSC-sEVs. Read More

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Hemodialysis-related Portal-systemic Encephalopathy: A Rare Cause of Recurrent Encephalopathy among Patients on Maintenance Hemodialysis.

Indian J Nephrol 2022 Mar-Apr;32(2):179-181. Epub 2022 Mar 9.

Department of Psychiatry, Iqraa International Hospital and Research Centre, Calicut, Kerala, India.

Portal-systemic venous shunts can rarely develop without any intrinsic liver diseases. However, the cause of shunt formation in these cases are not very clear. Literature suggests that hemodialysis can precipitate symptoms in patients with asymptomatic portal-systemic venous shunts (PSVS). Read More

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LPS-induced NLRP3 gene expression in chicken.

Open Vet J 2022 Mar-Apr;12(2):197-203. Epub 2022 Mar 27.

Department of Medical Laboratory Techniques, Kut-Technical Institute, Middle Technical University, Baghdad, Iraq.

Background: NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) is a cytosolic sensor that detects many microbial pathogen-associated molecular patterns and damage-associated molecular patterns. It works as a pro-inflammatory cytokine that is encoded in the NLRP3 gene. This protein is profoundly expressed in macrophage and other innate immune system cells, and participates in the assembly of NLRP3 inflammasome. Read More

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Nausea, Vomiting, and Dyspepsia Following Solid Organ Abdominal Transplant.

Cureus 2022 Apr 19;14(4):e24274. Epub 2022 Apr 19.

Division of Digestive Diseases, Emory University School of Medicine, Atlanta, USA.

Background and objective Multiple comorbidities may contribute to high readmission rates post-transplant procedures. In this study, we aimed to assess the rates and factors associated with hospital readmissions for dyspeptic symptoms among transplant patients. Methods This was a retrospective analysis of adult patients who underwent solid organ transplants at our institution. Read More

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Clinical effects of durability of immunosuppression in virologically suppressed ART-initiating persons with HIV in Latin America. A retrospective cohort study.

Lancet Reg Health Am 2022 Apr 13;8. Epub 2022 Jan 13.

Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INCMNSZ), Mexico City, Mexico.

Background: Clinical outcomes are rarely studied in virologically suppressed people living with HIV (PWH) and incomplete CD4 recovery. To explore whether time living with severe immunosuppression predict clinical outcomes better than baseline or time updated CD4, we estimated the association between cumulative percentage of time with CD4 <200 cells/μL during viral suppression (VS) (%t), and mortality and comorbidities during 2000-2019.

Methods: In a retrospective cohort analysis, we followed PWH initiating ART in Latin America from first VS (HIV-RNA<200 copies/μL) to death, virological failure or loss to follow-up. Read More

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A Molecular Insight into the Role of Antioxidants in Nonalcoholic Fatty Liver Diseases.

Oxid Med Cell Longev 2022 11;2022:9233650. Epub 2022 May 11.

Department of Pharmacology, Mandy Dental College, University of Dhaka, Bangladesh.

Nonalcoholic fatty liver disease (NAFLD) defines fat accumulation in the liver, and it is commonly associated with metabolic syndromes like diabetes and obesity. Progressive NAFLD leads to nonalcoholic steatohepatitis (NASH) and ultimately causes cirrhosis and hepatocellular carcinoma, and NASH is currently a frequent cause of liver transplantation. Oxidative stress is often contributed to the progression of NAFLD, and hence, antioxidants such as silymarin, silybin, or silibinin, pentoxifylline, resveratrol, and vitamins A, C, and E are used in clinical trials against NAFLD. Read More

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