283,058 results match your criteria liver cancer


Optimisation of high-speed lipidome analysis by nanoflow ultrahigh-performance liquid chromatography-tandem mass spectrometry: Application to identify candidate biomarkers for four different cancers.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 May 1;1175:122739. Epub 2021 May 1.

Department of Chemistry, Yonsei University, 50 Yonsei-ro, Seoul 03722, South Korea. Electronic address:

Lipid analysis is a powerful tool that can elucidate the pathogenic roles of lipids in metabolic diseases, and facilitate the development of potential biomarkers. Lipid analysis by large-scale lipidomics requires a high-speed and high-throughput analytical platform. In the present study, a high-speed analytical method for lipid analysis using nanoflow ultrahigh-performance liquid chromatography-electrospray ionisation-tandem mass spectrometry (nUHPLC-ESI-MS/MS) was optimised by investigating the effects of column flow rate, pump flow rate, dwell time, initial binary mobile phase composition, and gradient duration on the separation efficiency of standard lipid mixtures. Read More

View Article and Full-Text PDF

Associations between malignancy and cardiovascular complications following emergency laparotomy - A retrospective cohort study.

Surg Oncol 2021 May 5;38:101591. Epub 2021 May 5.

Center for Surgical Science, Department of Surgery, Zealand University Hospital, Denmark; Department of Clinical Medicine, University of Copenhagen, Denmark.

Background: Systemic inflammation in patients with malignant disease has been associated with increased risk of cardiovascular events. The pro-inflammatory perturbations following surgical trauma may further promote adverse perioperative cardiovascular events and increase the risk of patients with cancer undergoing major surgery. Our objective was to estimate the association between malignant disease and postoperative cardiovascular complications. Read More

View Article and Full-Text PDF

An intervention to increase hepatitis C virus diagnosis and treatment uptake among people in custody in Iran.

Int J Drug Policy 2021 May 12;95:103269. Epub 2021 May 12.

Digestive Oncology Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: Iran is among countries with high opioid agonist therapy (OAT) coverage in prisons, which provides an infrastructure to increase feasibility of HCV programs. We aimed to evaluate the impact of an intervention to improve HCV screening, diagnosis, and treatment, including alongside the provision of OAT, in an Iranian prison.

Methods: During July-December 2018, in the Gorgan prison, all incarcerated adults (>18 years) received HCV antibody rapid testing and, if positive, provided a venepuncture sample for HCV RNA testing. Read More

View Article and Full-Text PDF

The role of clips in preventing delayed bleeding after colorectal polyp resection: an individual patient data meta-analysis.

Clin Gastroenterol Hepatol 2021 May 12. Epub 2021 May 12.

Department of Gastroenterology and Hepatology, Radboudumc, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.

Background & Aims: Non-pedunculated colorectal polyps are normally endoscopically removed to prevent neoplastic progression. Delayed bleeding is the most common major adverse event. Clipping the resection defect has been suggested to reduce delayed bleedings. Read More

View Article and Full-Text PDF

Activated platelets contribute to the progression of hepatocellular carcinoma by altering the tumor environment.

Life Sci 2021 May 12:119612. Epub 2021 May 12.

Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden. Electronic address:

Aim Hepatocellular carcinoma (HCC) is a primary liver cancer that usually develops in a background of chronic liver disease and prolonged inflammation. A major contributor in the complex molecular pathogenesis of HCC is the highly intertwined cross-talk between the tumor and the surrounding stromal cells, such as hepatic stellate cells, endothelial cells, macrophages and other immune cells. These tumor-stroma interactions actively fuel tumor growth and modulate the hepatic microenvironment to benefit tumor invasion and disease progression. Read More

View Article and Full-Text PDF

Multi-biomarker panel prediction model for diagnosis of pancreatic cancer.

J Hepatobiliary Pancreat Sci 2021 May 15. Epub 2021 May 15.

Department of Surgery and Cancer Research Institute, College of Medicine, Seoul National University, Seoul, Korea.

Background/purpose: The current study aimed to develop a prediction model using a multi-marker panel as a diagnostic screening tool for pancreatic-ductal-adenocarcinoma.

Methods: Multi-center cohort of 1,991 blood samples were collected from January 2011 to September 2019, of which 609 are normal, 145 are other-cancer (colorectal, thyroid, and breast cancer), 314 are pancreatic-benign-disease, and 923 are pancreatic-ductal-adenocarcinoma. The automated multi-biomarker Enzyme-Linked Immunosorbent Assay kit was developed using three potential biomarkers, LRG1, TTR, and CA 19-9. Read More

View Article and Full-Text PDF

High prevalence of BRAF in patients with cholestasis, sclerosing cholangitis or liver fibrosis secondary to Langerhans cell histiocytosis.

Pediatr Blood Cancer 2021 May 15:e29115. Epub 2021 May 15.

Hematology/Oncology Department, Hospital de Pediatria SAMIC Prof Dr Juan P Garrahan, Buenos Aires, Argentina.

Targeted therapies with MAPK inhibitors have proven to modulate the clinical manifestations of patients with Langerhans cell histiocytosis (LCH). We explored the presence of BRAF mutation in our cohort of patients with LCH and cholestasis, sclerosing cholangitis, or liver fibrosis that presented resistance to chemotherapy. The BRAF mutation was detected either in the diagnosis (skin and bone) or liver biopsy in our cohort of 13 patients. Read More

View Article and Full-Text PDF

Letter to the Editor: Cancer after liver transplant: don't forget tobacco and tacrolimus.

Hepatology 2021 May 15. Epub 2021 May 15.

Department of Hepatogastroenterology, Hepatology and Liver Transplant Unit, Saint Eloi Hospital, University of Montpellier, Montpellier, France.

We read with interest the paper by Nasser-Ghodsi et al. (1) describing a high-risk population of liver transplant (LT) recipients who developed de novo colorectal and pancreatic cancer. This retrospective study of data from the United Network for Organ Sharing database described 405 colorectal and 216 pancreatic cancers in 866 de novo gastrointestinal malignancies. Read More

View Article and Full-Text PDF

A case of laparoscopic hepatectomy for a primary hepatic neuroendocrine tumor.

Clin J Gastroenterol 2021 May 15. Epub 2021 May 15.

Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-8638, Japan.

Neuroendocrine tumors (NETs) account for approximately 1-2% of all gastrointestinal tumors. In particular, primary hepatic NETs (PHNETs) are extremely rare. A 42-year-old female patient was given a diagnosis of liver tumor after a medical check-up with ultrasonography. Read More

View Article and Full-Text PDF

HIF1α-mediated RelB/APOBEC3B downregulation allows Hepatitis B Virus persistence.

Hepatology 2021 May 15. Epub 2021 May 15.

Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.

New therapeutic strategies against Hepatitis B virus (HBV) focus, among others, on the activation of the immune system to enable the infected host to eliminate HBV. Hypoxia inducible factor 1 alpha (HIF1α) stabilisation has been associated with impaired immune responses. HBV pathogenesis triggers chronic hepatitis-related scaring, leading inter alia to modulation of liver oxygenation and transient immune activation, both factors playing a role in HIF1α stabilisation. Read More

View Article and Full-Text PDF

Current situation of viral hepatitis in Egypt.

Microbiol Immunol 2021 May 15. Epub 2021 May 15.

Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.

An estimated 8-10 million people suffer from viral hepatitis in Egypt. Hepatitis A virus (HAV) and hepatitis E virus (HEV) are major causes of viral hepatitis in Egypt since ≥ 50% of the Egyptian population are already exposed to HAV infection by the age of 15 years. In addition, > 60% of the Egyptian population tested seropositive for anti-HEV in the first decade of life. Read More

View Article and Full-Text PDF

A preliminary single-center investigation of percutaneous biliary stenting in malignant hilar biliary obstruction: what impacts the clinical success and the long-term outcomes?

Support Care Cancer 2021 May 14. Epub 2021 May 14.

Department of Radiology, Shengjing Hospital of China Medical University, Huaxiang Road 39, Shenyang City, 110004, Liaoning Province, China.

Purpose: The purpose of this study is to investigate the influencing factors that may impact the clinical success, jaundice-free time, and overall survival in patients of malignant hilar biliary obstruction (MHBO) treated with a self-expanding metallic stent (SEMS).

Materials And Methods: Patients diagnosed with MHBO and treated with SEMS through percutaneous access from 1 Jul. 2013 to 1 Jul. Read More

View Article and Full-Text PDF

Tissue context determines the penetrance of regulatory DNA variation.

Nat Commun 2021 May 14;12(1):2850. Epub 2021 May 14.

Department of Genome Sciences, University of Washington, Seattle, WA, USA.

Functional assessment of disease-associated sequence variation at non-coding regulatory elements is complicated by their high degree of context sensitivity to both the local chromatin and nuclear environments. Allelic profiling of DNA accessibility across individuals has shown that only a select minority of sequence variation affects transcription factor (TF) occupancy, yet low sequence diversity in human populations means that no experimental assessment is available for the majority of disease-associated variants. Here we describe high-resolution in vivo maps of allelic DNA accessibility in liver, kidney, lung and B cells from 5 increasingly diverged strains of F1 hybrid mice. Read More

View Article and Full-Text PDF

Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption.

Nat Commun 2021 May 14;12(1):2830. Epub 2021 May 14.

Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, the Netherlands.

Coffee and tea are extensively consumed beverages worldwide which have received considerable attention regarding health. Intake of these beverages is consistently linked to, among others, reduced risk of diabetes and liver diseases; however, the mechanisms of action remain elusive. Epigenetics is suggested as a mechanism mediating the effects of dietary and lifestyle factors on disease onset. Read More

View Article and Full-Text PDF

Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint.

Nat Commun 2021 May 14;12(1):2814. Epub 2021 May 14.

Division of Infection & Immunity, Institute of Immunity & Transplantation, University College London, London, UK.

Determining divergent metabolic requirements of T cells, and the viruses and tumours they fail to combat, could provide new therapeutic checkpoints. Inhibition of acyl-CoA:cholesterol acyltransferase (ACAT) has direct anti-carcinogenic activity. Here, we show that ACAT inhibition has antiviral activity against hepatitis B (HBV), as well as boosting protective anti-HBV and anti-hepatocellular carcinoma (HCC) T cells. Read More

View Article and Full-Text PDF

H Long Terminal Repeat-Associating 2 (HHLA2) is a Biomarker of Advanced Stage Hepatocellular Carcinoma and Promotes Tumor Cell Development In Vitro.

Med Sci Monit 2021 May 15;27:e930215. Epub 2021 May 15.

Department of Endoscopy, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, China (mainland).

BACKGROUND Several risk factors contribute to the inflammation promoting hepatocellular carcinoma (HCC) development, but the underlying mechanisms are unknown. Human endogenous retrovirus H long terminal repeat-associating 2 (HHLA2), a B7 family member, is highly expressed in various malignant tumor tissues and is related to tumor progression and metastasis. MATERIAL AND METHODS Bioinformatics analysis was used to analyze the gene expression chip GSE33006 of HCC tissue in the GEO database, draw a heat map of differentially expressed genes, and analyze the GO pathway of gene function annotation. Read More

View Article and Full-Text PDF

.

Mol Pharmacol 2021 May 14. Epub 2021 May 14.

Centre de Recherche des Cordeliers, INSERM UMRS1138, France

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is one of the leading causes of cancer-related deaths worldwide. The multi-target inhibitor sorafenib is a first-line treatment for patients with advanced unresectable HCC. Recent clinical studies have evidenced that patients treated with sorafenib together with the anti-diabetic drug metformin have a survival disadvantage compared to patients receiving sorafenib only. Read More

View Article and Full-Text PDF

Liver enzyme elevation after Lu-PSMA radioligand therapy for metastasized castration-resistant prostate cancer.

J Nucl Med 2021 May 14. Epub 2021 May 14.

Department of Urology, University Medicine Goettingen, Germany.

Lu-PSMA radioligand therapy (Lu-PSMA-RLT) is a promising new therapeutic option for patients with metastasized castration-resistant prostate cancer (mCRPC). The spectrum of adverse events with this treatment has to be evaluated. Here, we describe the case of a mCRPC patient with M1c disease (mediastinum, lungs, bones and liver) who presented with elevated liver enzyme levels after Lu-PSMA-RLT administration. Read More

View Article and Full-Text PDF

Appendiceal adenocarcinoma with breast metastases.

BMJ Case Rep 2021 May 14;14(5). Epub 2021 May 14.

General Surgery, University Hospital Crosshouse, Kilmarnock, UK.

Malignant lesions of the vermiform appendix make up a rare subset of colorectal cancer. While colorectal cancer frequently metastasises to the liver, lung, regional lymph nodes and peritoneum, metastasis to the breast is extremely rare. Here, we describe the case of an 84-year-old woman who had the incidental finding of appendiceal adenocarcinoma following emergency laparoscopic appendectomy. Read More

View Article and Full-Text PDF

Surgical resection significantly promotes the overall survival of patients with hepatocellular carcinoma: a propensity score matching analysis.

BMC Gastroenterol 2021 May 14;21(1):220. Epub 2021 May 14.

Division of Gastroenterology and Hepatology, E-Da Dachang Hospital, I-Shou University, No. 1, Yida Road, Jiaosu Village, Yanchao District, Kaohsiung, 807, Taiwan, ROC.

Background: The benefits of surgical resection (SR) for various Barcelona Clinic Liver Cancer (BCLC) stages of hepatocellular carcinoma (HCC) remain unclear. We investigated the risk factors of overall survival (OS) and survival benefits of SR over nonsurgical treatments in patients with HCC of various BCLC stages.

Methods: Overall, 2316 HCC patients were included, and their clinicopathological data and OS were recorded. Read More

View Article and Full-Text PDF

Lysionotin Induces Apoptosis of Hepatocellular Carcinoma Cells via Caspase-3 Mediated Mitochondrial Pathway.

Chem Biol Interact 2021 May 11:109500. Epub 2021 May 11.

Department of Translational Medicine Research, First Hospital, Jilin University, Changchun, Jilin, 130061, China. Electronic address:

As the sixth most prevalent cancer, liver cancer has been reported as the second cause of cancer-induced deaths globally. Lysionotin, a flavonoid compound widely distributed in Lysionotus pauciflorus Maxim, has attracted considerable attention due to its multiple biological activities. The present study analyzes the anti-liver cancer effects of lysionotin in cell and mouse models. Read More

View Article and Full-Text PDF

Mechanisms and disease consequences of nonalcoholic fatty liver disease.

Cell 2021 May;184(10):2537-2564

Departments of Internal Medicine and Cellular & Molecular Physiology, Yale Diabetes Research Center, Yale School of Medicine, New Haven, CT 06520, USA. Electronic address:

Nonalcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. Its more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver injury that can lead to cirrhosis and hepatocellular carcinoma. Here we provide an in-depth discussion of the underlying pathogenetic mechanisms that lead to progressive liver injury, including the metabolic origins of NAFLD, the effect of NAFLD on hepatic glucose and lipid metabolism, bile acid toxicity, macrophage dysfunction, and hepatic stellate cell activation, and consider the role of genetic, epigenetic, and environmental factors that promote fibrosis progression and risk of hepatocellular carcinoma in NASH. Read More

View Article and Full-Text PDF

Isotope tracing in adult zebrafish reveals alanine cycling between melanoma and liver.

Cell Metab 2021 May 11. Epub 2021 May 11.

Department of Chemistry, Washington University in St. Louis, St. Louis, MO, USA; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA. Electronic address:

The cell-intrinsic nature of tumor metabolism has become increasingly well characterized. The impact that tumors have on systemic metabolism, however, has received less attention. Here, we used adult zebrafish harboring BRAF-driven melanoma to study the effect of cancer on distant tissues. Read More

View Article and Full-Text PDF

Downregulation of SUMO2 inhibits hepatocellular carcinoma cell proliferation, migration and invasion.

FEBS Open Bio 2021 May 14. Epub 2021 May 14.

Department of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.

This study aimed to evaluate the prognostic value and biological function of small ubiquitin-like modifier 2 (SUMO2) in hepatocellular carcinoma (HCC). SUMO2 expression in HCC tissues was markedly higher than that in normal liver tissues, and patients with high SUMO2 expression had significantly shorter median overall survival than those with low SUMO2 expression. Furthermore, SUMO2 expression was closely correlated with lymph node metastasis and vascular invasion and was a predictor of poor prognosis. Read More

View Article and Full-Text PDF

Is there a role for neuregulin 4 in human nonalcoholic fatty liver disease?

PLoS One 2021 14;16(5):e0251822. Epub 2021 May 14.

Laboratory of Hepatology, Department Chronic Diseases, Metabolism & Ageing (CHROMETA), KU Leuven, Leuven, Belgium.

Background: Neuregulin 4 (Nrg4), a novel adipokine enriched in brown adipose tissue has been observed to negatively regulate de novo hepatic lipogenesis and limit nonalcoholic fatty liver disease (NAFLD) progression to nonalcoholic steatohepatitis (NASH) in rodents. However, the role of Nrg4 in human NAFLD remains unclear to date. We analysed Nrg4 plasma levels and its association with liver disease severity together with the transcriptional profile of the Nrg4 pathway in liver and visceral adipose tissue (VAT) of NAFLD patients. Read More

View Article and Full-Text PDF

Letter to the editor : both simplified and revised IAIHG scores should be considered in diagnosing acute autoimmune hepatitis.

Liver Int 2021 May 14. Epub 2021 May 14.

Department of Gastroenterology & Hepatology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.

We read the article wrote by Paolo Muratori et al with great interest . In this article, authors said that the revised international autoimmune hepatitis group (IAIHG) score was more appropriate to acute-onset autoimmune hepatitis (AIH) when determining the diagnosis. But according to our experience, we have different opinion to the scoring system of acute AIH. Read More

View Article and Full-Text PDF

The effect of autocrine motility factor alone and in combination with methyl jasmonate on liver cancer cell growth.

Biosci Biotechnol Biochem 2021 May 14. Epub 2021 May 14.

Department of Biomedical Science, Catholic University of Daegu, Gyeongsan, 38430, Korea.

Neoplastic cells secrete autocrine motility factor (AMF) to stimulate the motility of cancer cells. In this study, AMF secreted from HT-29 colorectal cancer cells selectively suppressed liver cancer cells by downregulating pAKT and β-catenin. In addition, HT-29 AMF significantly augmented the activity of methyl jasmonate (MJ) against liver cancer cells and is a promising alternative for liver cancer therapy. Read More

View Article and Full-Text PDF

Immunosuppressive Nanoparticles for Management of Immune-Related Adverse Events in Liver.

ACS Nano 2021 May 14. Epub 2021 May 14.

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu 215123, China.

Immune checkpoint blockade (ICB) therapy has been considered as an effective way to boost immune cells to recognize and attack tumors. However, side effects known as immune-related adverse events (irAEs) should be carefully managed. Here, we engineer immunosuppressive nanoparticles by coating PD-L1 overexpressed mesenchymal stem cells (MSCs) plasma membrane on poly lactic--glycolic acid nanoparticles (MSC-PD-L1 NPs) for managing and reducing irAEs induced by immune checkpoint inhibitors. Read More

View Article and Full-Text PDF

LI-RADS Version 2018 Treatment Response Algorithm: Diagnostic Performance after Transarterial Radioembolization for Hepatocellular Carcinoma.

Korean J Radiol 2021 May 4. Epub 2021 May 4.

Department of Radiology and Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Objective: To assess the diagnostic performance of the Liver Imaging Reporting and Data System (LI-RADS) version 2018 treatment response algorithm (TRA) for the evaluation of hepatocellular carcinoma (HCC) treated with transarterial radioembolization.

Materials And Methods: This retrospective study included patients who underwent transarterial radioembolization for HCC followed by hepatic surgery between January 2011 and December 2019. The resected lesions were determined to have either complete (100%) or incomplete (< 100%) necrosis based on histopathology. Read More

View Article and Full-Text PDF

Fatal acute hepatic failure secondary to thrombotic portal venopathy after commencing abemaciclib and fulvestrant treatment for advanced breast carcinoma: a unique autopsy finding.

Breast J 2021 May 14. Epub 2021 May 14.

Medical Education, University of Bristol, Bristol, UK.

We present an autopsy case of hepatic thrombotic portal venopathy resulting in decompensated liver failure and death which occurred rapidly after commencing abemaciclib and fulvestrant chemotherapy for advanced invasive lobular carcinoma of the breast. The diagnosis was confirmed histologically. This is the first reported case of such a finding. Read More

View Article and Full-Text PDF