22,324 results match your criteria lithium treatment


Acid leaching of LiCoO enhanced by reducing agent. Model formulation and validation.

Chemosphere 2021 Aug 25;287(Pt 1):132020. Epub 2021 Aug 25.

Department of Chemical Engineering, University of Malaga, Malaga, Spain.

In this work, a model has been formulated to describe the complex process of LiCoO leaching through the participation of competing reactions in acid media including the effect of HO as reducing agent. The model presented here describes the extraction of Li and Co in the presence and absence of HO, and it takes into account the different phenomena affecting the controlling mechanisms. In this context, the model predicts the swift from kinetic control to diffusion control. Read More

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Lamotrigine in the maintenance treatment of bipolar disorder.

Cochrane Database Syst Rev 2021 Sep 15;9:CD013575. Epub 2021 Sep 15.

Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Background: Bipolar disorder is a chronic mental disorder with repetitive mania/hypomania as well as depressive episodes, which eventually results in marked impairment in overall functioning and health-related quality of life.  A worldwide prevalence rate of 2.4% has been reported. Read More

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September 2021

A Randomized, Double-Blind, Controlled Trial of Lithium Versus Quetiapine for the Treatment of Acute Mania in Youth with Early Course Bipolar Disorder.

J Child Adolesc Psychopharmacol 2021 Sep 14. Epub 2021 Sep 14.

Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

To compare the efficacy and tolerability of lithium versus quetiapine for the treatment of manic or mixed episodes in youths with early course bipolar I disorder. Six-week, randomized, double-blind clinical trial of lithium versus quetiapine for the treatment of adolescents with acute manic/mixed episode. Target dose of quetiapine dose was adjusted to a target dose of 400-600 mg and target serum level for lithium was 1. Read More

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September 2021

Stereoselective Synthesis of Hydrindane and Hydroazulene Derivatives by Transannular Cyclization of Nine- and Ten-Membered Carbocycles.

J Org Chem 2021 Sep 14. Epub 2021 Sep 14.

Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.

Treatment of -fused bicyclic diene dicarboxylates with Li/naphthalene triggers a tandem ring-opening and transannular cyclization process that stereoselectively yields hydroazulenes and hydrindanes derivatives. Cyclononadienyl diesters, which can be isolated after the ring-opening step by judicious choice of the reaction conditions, undergo a tandem conjugate addition/intramolecular Michael addition upon treatment with chiral lithium amides to give bicyclic β-amino esters in a process where 4 contiguous stereocenters are formed with high diastereocontrol. A concise route toward the highly enantioenriched AEF ring core of the aconitine-type alkaloids has been developed as an application of this methodology. Read More

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September 2021

Evaluation of the Bond Strength of Densely Sintered Ceramics Subjected to Extended Firing.

Clin Cosmet Investig Dent 2021 1;13:371-377. Epub 2021 Sep 1.

Post-Graduation Program in Dentistry, University of Tuiuti of Paraná, Curitiba, 82010-330, Brazil.

Introduction: Critical failures in ceramic materials can be caused by the processing mode, which includes all steps taken in the manufacture of a ceramic part, from molding to firing.

Purpose: To evaluate the effect of extended firing on bond strength in densely sintered ceramics of the zirconium reinforced lithium silicate, lithium disilicate, and feldspathic ceramic.

Materials And Methods: Three types of ceramics were evaluated: zirconium reinforced lithium silicate, lithium disilicate, feldspathic ceramic. Read More

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September 2021

Effect of gap junction blockers on hippocampal ripple energy expression in rats with status epilepticus.

Zhongguo Dang Dai Er Ke Za Zhi 2021 Aug;23(8):848-853

Department of Neurology, Children's Hospital of Chongqing Medical University, Chongqing 400136.

Objectives: To study the effect of gap junction blockers, quinine (QUIN) and carbenoxolone (CBX), on hippocampal ripple energy expression in rats with status epilepticus (SE).

Methods: A total of 24 rats were randomly divided into four groups: model, QUIN, valproic acid (VPA), and CBX (=6 each). A rat model of SE induced by lithium-pilocarpine (PILO) was prepared. Read More

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Economic impact of treatment-resistant depression: A retrospective observational study.

J Affect Disord 2021 Aug 27;295:578-586. Epub 2021 Aug 27.

Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain. Electronic address:

Background: To determine the incidence of Treatment-Resistant Depression (TRD) in Spain and to estimate its economic burden, using real world data.

Methods: A retrospective, observational-study was carried out using data from the BIG-PAC database®. Patients aged ≥18 years with a diagnosis of major depressive-disorder (MDD) who initiated a new antidepressant treatment in 2015-2017 were included. Read More

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Determination of lithium in human serum by isotope dilution atomic absorption spectrometry.

Anal Bioanal Chem 2021 Sep 10. Epub 2021 Sep 10.

Bundesanstalt für Materialforschung und -prüfung (BAM), Richard-Willstätter-Str. 11, 12489, Berlin, Germany.

The therapeutic dose of lithium (Li) compounds, which are widely used for the treatment of psychiatric and hematologic disorders, is close to its toxic level; therefore, drug monitoring protocols are mandatory. Herein, we propose a fast, simple, and low-cost analytical procedure for the traceable determination of Li concentration in human serum, based on the monitoring of the Li isotope dilution through the partially resolved isotope shift in its electronic transition around 670.80 nm using a commercially available high-resolution continuum source graphite furnace atomic absorption spectrometer. Read More

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September 2021

Influence of Low-pH Beverages on the Two-Body Wear of CAD/CAM Monolithic Materials.

Polymers (Basel) 2021 Aug 30;13(17). Epub 2021 Aug 30.

Department of Mechanical and Aerospace Engineering, Politecnico di Torino, 10129 Turin, Italy.

The aim of this in vitro study is to evaluate the effect of different acidic media on volumetric wear and surface roughness of CAD/CAM monolithic materials. Forty-eight rectangular specimens were prepared using different CAD/CAM monolithic materials: nanohybrid composite (Grandio Blocks, Voco), resin-based composite (Cerasmart, GC), lithium disilicate (E-Max, Ivoclar), and high-translucency zirconia (Katana STML, Kuraray Noritake). After storage in distilled water at 37 °C for two days, the specimens were tested using a chewing machine with a stainless-steel ball as an antagonist (49N loads, 250,000 cycles). Read More

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Mood Stabilizers in Psychiatric Disorders and Mechanisms Learnt from In Vitro Model Systems.

Int J Mol Sci 2021 Aug 27;22(17). Epub 2021 Aug 27.

Sagol Department of Neurobiology, University of Haifa, Haifa 3498838, Israel.

Bipolar disorder (BD) and schizophrenia are psychiatric disorders that manifest unusual mental, behavioral, and emotional patterns leading to suffering and disability. These disorders span heterogeneous conditions with variable heredity and elusive pathophysiology. Mood stabilizers such as lithium and valproic acid (VPA) have been shown to be effective in BD and, to some extent in schizophrenia. Read More

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Phase structure engineering of MnCoO within electrospun carbon nanofibers towards high-performance lithium-ion batteries.

J Colloid Interface Sci 2021 Aug 31;607(Pt 1):171-180. Epub 2021 Aug 31.

State Key Lab of Electrical Insulation and Power Equipment, Center of Nanomaterials for Renewable Energy (CNRE), School of Electrical Engineering, Xi'an Jiaotong University, Xi'an 710049, PR China. Electronic address:

Metal oxides are prospective alternative anode materials to the commercial graphite for lithium ion batteries (LIBs), while their practical application is seriously hampered by their poor conductivities and large volume changes. Herein, we report the controllable synthesis of amorphous/crystalline MnCoO nanoparticles within porous carbon nanofibers (marked as [email protected]) through a facile electrospinning strategy and subsequent annealing reactions. The phase structures from Co/MnO to amorphous MnCoO and crystalline MnCoO can be readily tuned by thermal reduction/oxidation under controlled atmosphere and temperature. Read More

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Response and remission rates during 24 weeks of mood-stabilizing treatment for bipolar depression depending on early non-response.

Psychiatry Res 2021 Aug 29;305:114194. Epub 2021 Aug 29.

Department of Psychiatry, Massachusetts General Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States.

Background: We aimed to study the probability of bipolar depression response at 24 weeks given initial non-response.

Methods: We combined two multi-site, 24-week trials including similar populations following the same evidence-based guidelines randomizing patients to lithium or quetiapine. Additional mood-stabilizing treatment was possible if clinically indicated. Read More

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Global Competition in the Lithium-Ion Battery Supply Chain: A Novel Perspective for Criticality Analysis.

Environ Sci Technol 2021 Sep 9. Epub 2021 Sep 9.

State Key Laboratory of Automotive Safety and Energy, Tsinghua University, Beijing 100084, China.

With the accelerated pace of energy transition, competition in the lithium-ion battery (LIB) supply chain is intensifying across a wide scope of countries. In order to understand the potential risk derived from the competitors, this study quantifies the global competition intensities of 15 categories of LIB-related commodities, which has not been well characterized by previous criticality analysis studies. On the basis of the collected data and designed treatment techniques, the "competition index" is developed for this purpose. Read More

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September 2021

HLA-DRB1 and HLA-DQB1 genetic diversity modulates response to lithium in bipolar affective disorders.

Sci Rep 2021 Sep 8;11(1):17823. Epub 2021 Sep 8.

Department of Psychiatry & Center of Sleep Disorders, National Taiwan University Hospital, Taipei, Taiwan.

Bipolar affective disorder (BD) is a severe psychiatric illness, for which lithium (Li) is the gold standard for acute and maintenance therapies. The therapeutic response to Li in BD is heterogeneous and reliable biomarkers allowing patients stratification are still needed. A GWAS performed by the International Consortium on Lithium Genetics (ConLiGen) has recently identified genetic markers associated with treatment responses to Li in the human leukocyte antigens (HLA) region. Read More

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September 2021

Preventing new episodes of bipolar disorder in adults: Systematic review and meta-analysis of randomized controlled trials.

Eur Neuropsychopharmacol 2021 Sep 3. Epub 2021 Sep 3.

Department of Psychiatry & Behavioral Sciences, University of New Mexico Health Sciences Center, Albuquerque, NM, United States.

Uncertainty remains regarding the relative efficacy of maintenance pharmacotherapy for bipolar disorder (BD), and available data require updating. The present systematic review and meta-analysis aims to consolidate the evidence from the highest quality randomized controlled trials (RCTs) published up to July 2021, overcoming the limitations of earlier reviews. The PubMed and the Cochrane Central Register of Controlled Trials were searched for double-blind RCTs involving lithium, mood stabilizing anticonvulsants (MSAs), antipsychotics, antidepressants, and other treatments. Read More

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September 2021

Influence of surface treatment of resin composite substrate on the load-bearing capacity under fatigue of lithium disilicate monolithic simplified restorations.

J Mech Behav Biomed Mater 2021 Aug 24;124:104792. Epub 2021 Aug 24.

Post-Graduate Program in Oral Science, Prosthodontic Unit, Faculty of Odontology, Federal University of Santa Maria, Brazil. Electronic address:

This study evaluated the influence of surface treatments of resin composite substrate on the fatigue behavior of adhesively cemented lithium disilicate glass-ceramic simplified restorations. CAD/CAM lithium disilicate ceramic blocks were shaped into discs (N = 60, Ø = 10 mm; thickness = 1.0 mm). Read More

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Hollow urchin-like MnO microspheres as an advanced sulfur host for enabling Li-S batteries with high gravimetric energy density.

J Colloid Interface Sci 2021 Aug 18;606(Pt 2):1111-1119. Epub 2021 Aug 18.

Department of Environmental Science and Engineering, State Key Laboratory of Multiphase Flow in Power Engineering, Xi'an Jiaotong University, 28 Xianning West Road, Xi'an 710049, China. Electronic address:

Lithium-sulfur (Li-S) batteries are considered to be promising candidates for next-generation storage systems. However, the practical applications are still hindered by the severe capacity decay, mainly caused by the large volume change, polysulfide shuttle and sluggish sulfur conversion kinetics. Herein, hollow urchin-like MnO (HU-MnO) microspheres as sulfur hosts have been synthesized by the hydrothermal method and calcination treatment, aiming to prevent the polysulfide dissolution (benefiting from the strong polysulfide anchoring effect of MnO) and alleviate the volume expansion of sulfur (benefiting from the special hollow structure). Read More

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Dataset for: Modeling chemotherapy induced neurotoxicity with human induced pluripotent stem cell (iPSC)-derived sensory neurons.

Data Brief 2021 Oct 23;38:107320. Epub 2021 Aug 23.

Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Klinik und Hochschulambulanz für Neurologie, Charitéplatz 1, Berlin 10117, Germany.

Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent and potentially irreversible adverse event of cytotoxic chemotherapy. We evaluate whether sensory neurons derived from induced pluripotent stem cells (iPSC-DSN) can serve as human disease model system for chemotherapy induced neurotoxicity. Sensory neurons differentiated from two established induced pluripotent stem cell lines were used (s. Read More

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October 2021

Morphology-driven preparation technique for posterior indirect bonded restorations.

J Conserv Dent 2021 Jan-Feb;24(1):100-104. Epub 2021 Jul 5.

Department of Conservative Dentistry and Endodontics, YMT Dental College and Hospital, Navi Mumbai, India.

Restorative treatment in recent times has seen a paradigm shift due to minimally invasive adhesive dentistry. With advent of material science, bonding mechanisms, and superior isolation techniques, treatments based entirely on adhesion are effectively attainable. The choice between direct and indirect restorative technique, mainly in posterior areas, is still a challenge and involves biomechanical, anatomical, functional, esthetic, and economic considerations. Read More

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Dual-Element-Modified Single-Crystal LiNiCoMnO as a Highly Stable Cathode for Lithium-Ion Batteries.

ACS Appl Mater Interfaces 2021 Sep 2;13(36):43039-43050. Epub 2021 Sep 2.

Hunan Provincial Key Laboratory of Chemical Power Sources, Hunan Provincial Key Laboratory of Efficient and Clean Utilization of Manganese Resources, College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, P. R. China.

Single-crystalline LiNiCoMnO cathodes have received great attention due to their high discharge capacity and better electrochemical performance. However, the single-crystal materials are suffering from severe lattice distortion and electrode/electrolyte interface side reactions when cycling at high voltage. Herein, a unique single-crystal LiNiCoMnO with Al and Zr doping in the bulk and a self-formed coating layer of LiZrO in the surface has been constructed by a facile strategy. Read More

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September 2021

A single low-energy shockwave pulse opens blood-cerebrospinal fluid barriers and facilitates gastrodin delivery to alleviate epilepsy.

Ultrason Sonochem 2021 Aug 25;78:105730. Epub 2021 Aug 25.

Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital & National Taiwan University College of Medicine, Taipei City, Taiwan; Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli, Taiwan. Electronic address:

The blood-cerebrospinal fluid barrier (BCSFB) is another gatekeeper between systemic circulation and the central nervous system (CNS), mainly present at the boundary between choroid plexuses and the ventricular system. This study demonstrates BCSFB opening in rats by single pulse of low-energy focused shockwave (FSW, energy flux density 0.03 mJ/mm, 2 × 10 microbubbles/kg) treatment at lateral ventricle, resulting in significantly elevated cerebrospinal fluid (CSF) concentrations of systemically-administered gastrodin (GTD) (4 times vs. Read More

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Lithium causes differential effects on postsynaptic stability in normal and denervated neuromuscular synapses.

Sci Rep 2021 Aug 26;11(1):17285. Epub 2021 Aug 26.

Neuromuscular Studies Laboratory (NeSt Lab), Department of Cell Biology, CMA Bio-Bio, Facultad de Ciencias Biológicas, Universidad de Concepción, Casilla 160-C, Concepción, Chile.

Lithium chloride has been widely used as a therapeutic mood stabilizer. Although cumulative evidence suggests that lithium plays modulatory effects on postsynaptic receptors, the underlying mechanism by which lithium regulates synaptic transmission has not been fully elucidated. In this work, by using the advantageous neuromuscular synapse, we evaluated the effect of lithium on the stability of postsynaptic nicotinic acetylcholine receptors (nAChRs) in vivo. Read More

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Micro-CT and Microscopy Study of Internal and Marginal Gap to Tooth Surface of Crenelated versus Conventional Dental Indirect Veneers.

Medicina (Kaunas) 2021 Jul 29;57(8). Epub 2021 Jul 29.

Research Center in Dental Medicine Using Conventional and Alternative Technologies, School of Dental Medicine, "Victor Babes" University of Medicine and Pharmacy of Timisoara, 9 Revolutiei 1989 Ave., 300070 Timisoara, Romania.

: Ceramic veneers represent the most appropriate treatment option for minimally invasive aesthetic rehabilitation. For long-term clinical success, the accurate marginal and internal adaptation of dental restorations are of paramount importance. The aim of this in vitro study is to assess the effect of a novel (patented) design of veneers compared to conventional ones on their marginal and internal gap to the prepared tooth surface. Read More

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Genetic Findings as the Potential Basis of Personalized Pharmacotherapy in Phelan-McDermid Syndrome.

Genes (Basel) 2021 Jul 30;12(8). Epub 2021 Jul 30.

Healthcare Genetics Program, School of Nursing, Clemson University, Clemson, SC 29634, USA.

Phelan-McDermid syndrome (PMS) is a genetic disorder often characterized by autism or autistic-like behavior. Most cases are associated with haploinsufficiency of the gene resulting from deletion of the gene at 22q13.3 or from a pathogenic variant in the gene. Read More

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Lithium preserves peritoneal membrane integrity by suppressing mesothelial cell αB-crystallin.

Sci Transl Med 2021 Aug;13(608)

Christian Doppler Laboratory for Molecular Stress Research in Peritoneal Dialysis, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, 1090 Vienna, Austria.

Life-saving renal replacement therapy by peritoneal dialysis (PD) is limited in use and duration by progressive impairment of peritoneal membrane integrity and homeostasis. Preservation of peritoneal membrane integrity during chronic PD remains an urgent but long unmet medical need. PD therapy failure results from peritoneal fibrosis and angiogenesis caused by hypertonic PD fluid (PDF)-induced mesothelial cytotoxicity. Read More

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Effects of the decrease of β-catenin expression on human vaginal fibroblasts of women with pelvic organ prolapse.

J Obstet Gynaecol Res 2021 Aug 25. Epub 2021 Aug 25.

Department of Obstetrics and Gynecology, Liaoning Provincial Hospital for Women and Children, Shenyang, Liaoning, China.

Background: Pelvic organ prolapse (POP) lowers the quality of life in elderly women, and there have been no studies on its role in the pathogenesis of POP. The purpose of this study is to investigate the effect of β-catenin on proliferation and collagen anabolism in human vaginal fibroblasts (HVFs).

Materials And Methods: The adherence and differential adherence methods were used to culture and purify HVFs. Read More

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Constructing a High-Energy and Durable Single-Crystal NCM811 Cathode for All-Solid-State Batteries by a Surface Engineering Strategy.

ACS Appl Mater Interfaces 2021 Sep 25;13(35):41669-41679. Epub 2021 Aug 25.

State Key Laboratory for Physical Chemistry of Solid Surfaces, and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, People's Republic of China.

Single-crystal LiNiCoMnO (S-NCM811) with an electrochemomechanically compliant microstructure has attracted great attention in all-solid-state batteries (ASSBs) for its superior electrochemical performance compared to the polycrystalline counterpart. However, the undesired side reactions on the cathode/solid-state electrolyte (SSE) interface causes inferior capacity and rate capability than lithium-ion batteries, limiting the practical application of S-NCM811 in the ASSB technology. Herein, it shows that S-NCM811 delivers a high capacity (205 mAh g, 0. Read More

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September 2021

Lockdown of mitochondrial Ca extrusion and subsequent resveratrol treatment kill HeLa cells by Ca overload.

Int J Biochem Cell Biol 2021 Aug 21;139:106071. Epub 2021 Aug 21.

Bioengineering and Drug Design Laboratory, Department of Biotechnology, Indian Institute of Technology, Chennai, 600036, India. Electronic address:

Anticancer effect of resveratrol and the role of sodium/lithium/calcium exchanger in context with calcium ions are studied in human cervical cancer cell line. This therapeutic approach using siNCLX mediated gene silencing and drug therapy with resveratrol indicates the disruption of calcium homeostasis, increase in caspase (-3, 8, 9) mRNA expressions and DNA damage leading to apoptotic cell death. Monitoring the intracellular Ca changes using fluo-4AM indicates highest rise in [Ca] level in sodium/lithium/calcium exchanger silenced group with five different stages, that is distinguishable based on the fluorescence intensity. Read More

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Experimental investigation at CATANA facility of n-B and p-B reactions for the enhancement of proton therapy.

Phys Med 2021 Aug 20;89:226-231. Epub 2021 Aug 20.

Politecnico di Milano, Dipartimento di Energia, via La Masa 34, Milano, Italy; INFN-sezione di Milano, via Celoria 16, Milano, Italy.

The aim of the NEPTUNE (Nuclear process-driven Enhancement of Proton Therapy UNravEled) project is to investigate in detail both the physical and radiobiological phenomena that could justify an increase of the proton-induced cytogenetic effects in cells irradiated in presence of an agent containing natural boron. In this work, a double-stage silicon telescope coupled to different boron converters was irradiated at the CATANA proton therapy facility (INFN-LNS) for studying the proton boron fusion and the neutron boron capture reactions by discriminating secondary particles from primary protons. Different boron targets were developed by depositing boric acid, enriched with a higher than 99% content of B or B, on a 50 µm thick PolyMethilMetacrylate (PMMA) substrate. Read More

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