4,239 results match your criteria literature supplemented

A resource to explore the discovery of rare diseases and their causative genes.

Sci Data 2021 May 4;8(1):124. Epub 2021 May 4.

Department of Bioinformatics - BiGCaT, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.

Here, we describe a dataset with information about monogenic, rare diseases with a known genetic background, supplemented with manually extracted provenance for the disease itself and the discovery of the underlying genetic cause. We assembled a collection of 4166 rare monogenic diseases and linked them to 3163 causative genes, annotated with OMIM and Ensembl identifiers and HGNC symbols. The PubMed identifiers of the scientific publications, which for the first time described the rare diseases, and the publications, which found the genes causing the diseases were added using information from OMIM, PubMed, Wikipedia, whonamedit. Read More

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Assessment toolbox for Indian medical graduate competencies.

J Postgrad Med 2021 Apr-Jun;67(2):80-90

Department of Pharmacology, Adesh Institute of Medical Sciences and Research, Bathinda, Punjab, India.

The new competency-based medical education curriculum for Bachelor of Medicine and Bachelor of Surgery is being implemented in a phased manner in medical colleges across India since the year 2019. The Graduate Medical Education Regulations enlist a total of 35 global competencies for the five roles expected of an Indian medical graduate, the roles being clinician, communicator, leader, professional, and life-long learner. Along with an effective implementation of the new curriculum, both in spirit and in action, it is imperative to assess the listed competencies. Read More

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Implementation outcomes of HIV self-testing in low- and middle- income countries: A scoping review.

PLoS One 2021 3;16(5):e0250434. Epub 2021 May 3.

Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.

Introduction: HIV self-testing (HIV-ST) is an effective means of improving HIV testing rates. Low- and middle-income countries (LMIC) are taking steps to include HIV-ST into their national HIV/AIDS programs but very few reviews have focused on implementation in LMIC. We performed a scoping review to describe and synthesize existing literature on implementation outcomes of HIV-ST in LMIC. Read More

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Identifying the challenges in implementing open science [version 1; peer review: 2 approved].

MNI Open Res 2018 12;2. Epub 2018 Oct 12.

Faculty of Law, Centre for Intellectual Property Policy (CIPP), McGill University, Montreal, Quebec, H3A 1W9, Canada.

Areas of open science (OS) policy and practice are already relatively well-advanced in several countries and sectors through the initiatives of some governments, funders, philanthropy, researchers and the community. Nevertheless, the current research and innovation system, including in the focus of this report, the life sciences, remains weighted against OS. In October 2017, thought-leaders from across the world gathered at an Open Science Leadership Forum in the Washington DC office of the Bill and Melinda Gates Foundation to share their views on what successful OS looks like. Read More

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October 2018

Physiology of Cultured Human Microglia Maintained in a Defined Culture Medium.

Immunohorizons 2021 Apr 30;5(4):257-272. Epub 2021 Apr 30.

Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, MO;

Microglia are the primary immune cell of the CNS, comprising 5-20% of the ∼60 billion neuroglia in the human brain. In the developing and adult CNS, they preferentially target active neurons to guide synapse maturation and remodeling. At the same time, they are the first line of defense against bacterial, fungal, and viral CNS infections. Read More

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The role of integrated community case management projects in strengthening health systems: case study analysis in Ethiopia, Malawi and Mozambique.

Health Policy Plan 2021 Apr 30. Epub 2021 Apr 30.

Formerly Save the Children, Department of Global Health, 899 North Capitol St NE #900, Washington, DC 20002, USA.

Integrated community case management (iCCM) has now been implemented at scale globally. Literature to-date has focused primarily on the effectiveness of iCCM and the systems conditions required to sustain iCCM. In this study, we sought to explore opportunities taken and lost for strengthening health systems through successive iCCM programmes. Read More

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Response of Key Metabolites during a UV-A Exposure Time-Series in the Cyanobacterium PCC 6912.

Microorganisms 2021 Apr 24;9(5). Epub 2021 Apr 24.

Department of Biosciences, Swansea University, Singleton Park, Swansea SA2 8PP, UK.

Ultraviolet A (UV-A) is the major component of UV radiation reaching the Earth's surface, causing indirect damage to photosynthetic organisms via the production of reactive oxygen species (ROS). In comparison, UV-B causes both direct damage to biomolecules and indirect damage. UV-B is well studied in cyanobacterial research due to their long evolutionary history and adaptation to high levels of UV, with less work on the effects of UV-A. Read More

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A Cell-Based Approach to Dental Pulp Regeneration Using Mesenchymal Stem Cells: A Scoping Review.

Sahng G Kim

Int J Mol Sci 2021 Apr 22;22(9). Epub 2021 Apr 22.

Division of Endodontics, Columbia University College of Dental Medicine, New York, NY 10032, USA.

Despite the recent explosion of investigations on dental pulp regeneration using various tissue engineering strategies, the translation of the findings from such studies into therapeutic applications has not been properly achieved. The purpose of this scoping review was to systematically review the efficacy of mesenchymal stem cell transplantation for dental pulp regeneration. A literature search was conducted using five electronic databases from their inception to January 2021 and supplemented by hand searches. Read More

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Relation between Vitamin D and COVID-19 in Aged People: A Systematic Review.

Nutrients 2021 Apr 17;13(4). Epub 2021 Apr 17.

Department of Geriatrics, General Hospital of Valenciennes, 59300 Valenciennes, France.

Background: Vitamin D has diverse and extensive effects on the immune system, including activating innate immunity and reducing the overactive adaptive immune response. A systematic review was performed to identify and synthesize the best available evidence on the association between vitamin D level and risk of COVID-19, adverse outcomes and possible benefits of supplementation in aged 60 years or over.

Methods: A literature search was performed in PubMed© and Scopus© for all publications from inception published before 15 March 2021. Read More

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Treating Diabetic Foot Osteomyelitis: A Practical State-of-the-Art Update.

Medicina (Kaunas) 2021 Apr 1;57(4). Epub 2021 Apr 1.

Department of Orthopedic Surgery, Balgrist University Hospital, University of Zurich, 8008 Zurich, Switzerland.

Diabetic foot osteomyelitis (DFO) can be difficult to treat and securing optimal clinical outcomes requires a multidisciplinary approach involving a wide variety of medical, surgical and other health care professionals, as well as the patient. Results of studies conducted in the past few years have allowed experts to formulate guidelines that can improve clinical outcomes. We conducted a narrative review of the literature on treat- ment of DFO, with an emphasis on studies published in the last two years, especially regarding antimicrobial therapies and surgical approached to treatment of DFO, supplemented by our own extensive clinical and research experience in this field. Read More

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Annual Research Review: Achieving universal health coverage for young children with autism spectrum disorder in low- and middle-income countries: a review of reviews.

J Child Psychol Psychiatry 2021 May;62(5):514-535

Child and Adolescent Psychiatry, University of Manchester and Manchester Academic Health Sciences Centre, Manchester, UK.

Background: Autism presents with similar prevalence and core impairments in diverse populations. We conducted a scoping review of reviews to determine key barriers and innovative strategies which can contribute to attaining universal health coverage (UHC), from early detection to effective interventions for autism in low- and middle-income countries (LAMIC).

Methods: A systematic literature search of review articles was conducted. Read More

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Medicaid Waivers and Tenancy Supports for Individuals Experiencing Homelessness: Implementation Challenges in Four States.

Milbank Q 2021 Apr 27. Epub 2021 Apr 27.

Rutgers Center for State Health Policy.

Policy Points Medicaid policymakers have a growing interest in addressing homelessness as a social determinant of health and driver of the potentially avoidable use of expensive medical services. Drawing on extensive document reviews and in-depth interviews in four early-adopter states, we examined the implementation of Medicaid's Section 1115 demonstration waivers to test strategies to finance tenancy support services for persons experiencing or at risk of homelessness.

Context: The Affordable Care Act extended Medicaid eligibility to large numbers of individuals experiencing or at risk of homelessness. Read More

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Intrajejunal Infusion of Levodopa/Carbidopa for Advanced Parkinson's Disease: A Systematic Review.

Mov Disord 2021 Apr 25. Epub 2021 Apr 25.

Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.

Advanced Parkinson's disease is inconsistently defined, and evidence is lacking in relation to device-aided therapies. To update existing reviews of intrajejunal infusion of levodopa/carbidopa (LCIG), we performed a literature search for relevant articles (to November 3, 2020) using PubMed supplemented by hand searching. Retrieved articles were categorized by relevance to identified research questions, including motor complications and symptoms; nonmotor symptoms; functioning, quality of life, and caregiver burden; optimal timing of treatment initiation and administration duration; discontinuation; and complications. Read More

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An Integrative Review of Contemporary Perspectives on Videoconference-Based Therapy-Prioritising Indigenous and Ethnic Minority Populations in the Global South.

J Technol Behav Sci 2021 Apr 21:1-14. Epub 2021 Apr 21.

Auckland University of Technology, Auckland, New Zealand.

An integrative literature review was undertaken as a means of drawing together contemporary perspectives on the outcomes and affordances of videoconference-based therapy. This review was conducted in a way which placed emphasis on the need for mental healthcare strategies which are mindful of the cultural and social needs of indigenous and ethnic minority populations, particularly those situated in the Global South. The review was undertaken using an inverse funnelling approach which sought to prioritise literature on videoconference-based therapy literature which specifically focused on indigenous and ethnic minority populations. Read More

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Psychological autopsy: Overview of Indian evidence, best practice elements, and a semi-structured interview guide.

Indian J Psychiatry 2020 Nov-Dec;62(6):631-643. Epub 2020 Dec 12.

Department of Psychiatry, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India.

Background: No review has been attempted, so far, on Indian psychological autopsy (PA) literature. There is also a dearth of interview guides which is at the heart of a PA procedure.

Materials And Methods: Electronic searches of MEDLINE through PubMed, PsycINFO, and Google scholar databases were carried out from inception till February 2020 to identify relevant English language peer-reviewed articles from India, as well as global literature that provided information on best practice elements in PA. Read More

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December 2020

Development of a Resource Guide to Support the Engagement of Mental Health Providers and Patients With Digital Health Tools: Multimethod Study.

J Med Internet Res 2021 04 22;23(4):e25773. Epub 2021 Apr 22.

Memorial University, St. John's, NL, Canada.

Background: As mental illness continues to affect 1 in 5 individuals, and the need for support has increased during the COVID-19 pandemic, the promise of digital mental health tools remains largely unrealized due to a lack of uptake by patients and providers. Currently, most efforts on supporting the uptake of digital mental health tools remain fragmented across organizations and geography. There is a critical need to synthesize these efforts in order to provide a coordinated strategy of supporting the adoption of digital mental health tools. Read More

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Not Just Uterine Adenocarcinoma-Neoplastic and Non-Neoplastic Masses in Domestic Pet Rabbits (): A Review.

Berit Baum

Vet Pathol 2021 Apr 20:3009858211002190. Epub 2021 Apr 20.

Vet Med Labor GmbH, Kornwestheim, Germany.

With increasing numbers of pet rabbits living out their natural lifespan, rabbit oncology is stepping more and more into the limelight. On the other hand, rabbit tumors are less covered in recent editions of textbooks of veterinary pathology than before. We present 1238 cases with neoplastic and non-neoplastic masses in rabbit tissue, submitted from 2008 to 2019, supplemented by a review of the literature on neoplasms in rabbits. Read More

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Executive Summary Diagnosis and Evaluation of Hypersensitivity Pneumonitis: CHEST Guideline and Expert Panel Report.

Chest 2021 Apr 15. Epub 2021 Apr 15.

American College of Chest Physicians, Glenview, IL.

Background: The purpose of this analysis is to provide evidence-based and consensus-derived guidance for clinicians to improve individual diagnostic decision-making for hypersensitivity pneumonitis (HP) and decrease diagnostic practice variability.

Study Design And Methods: Approved panelists developed key questions regarding the diagnosis of HP using the PICO (Population, Intervention, Comparator, and Outcome) format. MEDLINE (via PubMed) and the Cochrane Library were systematically searched for relevant literature, which was supplemented by manual searches. Read More

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Exploring the challenges and features of implementing performance-based payment plan in hospitals: a protocol for a systematic review.

Syst Rev 2021 Apr 17;10(1):114. Epub 2021 Apr 17.

Student Research Committee (SRC), Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Implementing performance-based payment (PBP) plan has led to developing a number of significant potentialities such as performance improvement and effectiveness, quality improvement of provided services, and decline in health system expenditure in hospitals. Despite the fact that PBP plan has a variety of potential advantages, its implementation still may face some challenges. Hence, it seems crucial to identify these barriers and challenges in order to devise some strategies and interventions to pave the way for better implementation of PBP in hospitals. Read More

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Fast track sacrospinous ligament fixation: subjective and objective outcomes at 6 months.

BMC Womens Health 2021 Apr 16;21(1):154. Epub 2021 Apr 16.

Department of Obstetrics and Gynecology, Aarhus University Hospital, Aarhus, Denmark.

Background: Sacrospinous ligament fixation (SSLF) is a widely used vaginal procedure for correction of apical vaginal prolapse. The objective of this study was to evaluate subjective and objective outcomes of SSLF performed in a fast-track setting.

Methods: This was a prospective cohort study of sacrospinous ligament fixation performed using local anesthesia and light sedation in a fast-track setting at Aarhus University Hospital between April 2016 and December 2017. Read More

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Diagnosis and Evaluation of Hypersensitivity Pneumonitis: CHEST Guideline and Expert Panel Report.

Chest 2021 Apr 13. Epub 2021 Apr 13.

American College of Chest Physicians, Glenview, IL, USA.

Background: The purpose of this analysis is to provide evidence-based and consensus-derived guidance for clinicians to improve individual diagnostic decision-making for hypersensitivity pneumonitis (HP) and decrease diagnostic practice variability.

Methods: Approved panelists developed key questions regarding the diagnosis of HP using the PICO (population, intervention, comparator, and outcome) format. MEDLINE (via PubMed) and the Cochrane Library were systematically searched for relevant literature, which was supplemented by manual searches. Read More

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Evaluating the conduct and application of health utility studies: a review of critical appraisal tools and reporting checklists.

Eur J Health Econ 2021 Apr 11. Epub 2021 Apr 11.

Department of Health Research Methodology, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.

Background: Published health utility studies are increasingly cited in cost-utility analyses to inform reimbursement decision-making. However, there is limited guidance for investigators looking to systematically evaluate the methodological quality of health utility studies or their applicability to decision contexts.

Objective: To describe how health utility concepts are reflected in tools intended for use with the health economic literature, particularly with respect to the evaluation of methodological quality and context applicability. Read More

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Assessment of hearing screening programmes across 47 countries or regions III: provision of childhood hearing screening after the newborn period.

Int J Audiol 2021 Apr 9:1-8. Epub 2021 Apr 9.

Department of Otorhinolaryngology and Head, Neck Surgery and Department of Ophthalmology, Erasmus University Medical Center, Rotterdam, The Netherlands.

Objective: To inventory provision and features of childhood hearing screening after the newborn period (CHS), primarily in Europe.

Design: From each participating country or region, experts provided information through an extensive questionnaire: implementation year, age at screening, test method, pass criteria, screening location, screener profession, and quality indicators: coverage, referral, follow-up and detection rates, supplemented by literature sources.

Study Sample: Forty-two European countries or regions, plus Russia, Malawi, Rwanda, India, and China. Read More

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[Difficulties in diagnosing an osteoid osteoma of the big toe : A case report with review of the literature].

Orthopade 2021 Apr 8. Epub 2021 Apr 8.

Orthopädische Universitätsklinik, Klinikum Bad Bramstedt GmbH, Bad Bramstedt, Deutschland.

Background: Osteoid osteomas belong to the benign osseous neoplasia and can occur on the entire skeleton. The prolonged diagnosis of an osteoid osteoma of the great toe prompted us to prepare a case report with a literature review to identify possible sources of error and to contribute to a more expeditious diagnosis and therapy.

Literature: Currently, only two case reports on osteoid osteomas of the toes are known in the German literature. Read More

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Treatment of medication-related osteonecrosis of the jaw (MRONJ). A systematic review.

Eur Rev Med Pharmacol Sci 2021 Mar;25(6):2662-2673

Department of Biomedical, Surgical and Dental Sciences, University of Milano, Milan, Italy.

Objective: Medication-related osteonecrosis of the jaw (MRONJ) is a severe drug-related side effect mostly seen in the maxillofacial region of patients under current or previous treatment with antiresorptive and/or angiogenic agents. There is a wide range of treatment options explained in literature for the management of this condition, from conservative treatments to surgical procedures of various levels of invasiveness, which are sometimes supplemented with adjunctive therapies. The present systematic review aimed at evaluating the treatment options of MRONJ in terms of successful outcomes. Read More

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Twelve tips for surgeons to maximise medical student learning in the operating theatre.

Med Teach 2021 Apr 7:1-6. Epub 2021 Apr 7.

Hillingdon Hospital NHS Foundation Trust, Uxbridge, UK.

Theatre-based learning is an essential component of undergraduate surgical education and offers a wide range of learning opportunities. However, studies have demonstrated that medical students have not always benefited from this holistic learning environment due to many reasons, including intimidation, hierarchies within the surgical environment and fear of making mistakes. The lead surgical educator's approach is an important influence on the experience and learning of their medical students. Read More

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Oncofertility Information Available for Recently Approved Novel Non Cytotoxic and Immunotherapy Oncology Drugs.

Clin Pharmacol Ther 2021 Apr 7. Epub 2021 Apr 7.

Kids Cancer Centre, Sydney Children's Hospital, Sydney, New South Wales, Australia.

We reviewed the available animal and human reproductive function studies of recently approved noncytotoxic oncology drugs. We reviewed the oncofertility information in the prescribing information for the US Food and Drug Administration (FDA)-approved products and/or the product information and consumer medicine information for Therapeutic Goods Administration (TGA)-approved drugs of 32 novel oncology drugs approved between 2014 and 2018 in the United States and/or Australia supplemented by a literature review for additional reproductive effects. No human studies were available on the reproductive effects of all 32 drugs. Read More

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Methodology of measuring postoperative cognitive dysfunction: a systematic review.

Br J Anaesth 2021 Apr 2. Epub 2021 Apr 2.

Haga Teaching Hospital, Department of Intensive Care Medicine, The Hague, the Netherlands. Electronic address:

Background: Postoperative cognitive dysfunction (POCD) is an adverse outcome that impacts patients' quality of life. Its diagnosis relies on formal cognitive testing performed before and after surgery. The substantial heterogeneity in methodology limits comparability and meta-analysis of studies. Read More

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Non-local Muscle Fatigue Effects on Muscle Strength, Power, and Endurance in Healthy Individuals: A Systematic Review with Meta-analysis.

Sports Med 2021 Apr 5. Epub 2021 Apr 5.

School of Sport, Health and Social Science, Solent University, Southampton, UK.

Background: The fatigue of a muscle or muscle group can produce global responses to a variety of systems (i.e., cardiovascular, endocrine, and others). Read More

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Impact of the Diet on the Formation of Oxidative Stress and Inflammation Induced by Bacterial Biofilm in the Oral Cavity.

Materials (Basel) 2021 Mar 12;14(6). Epub 2021 Mar 12.

Department of Animal Nutrition, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jabłonna, Poland.

The diet is related to the diversity of bacteria in the oral cavity, and the less diverse microbiota of the oral cavity may favor the growth of pathogenic bacteria of all bacterial complexes. Literature data indicate that disturbances in the balance of the bacterial flora of the oral cavity seem to contribute to both oral diseases, including periodontitis, and systemic diseases. If left untreated, periodontitis can damage the gums and alveolar bones. Read More

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