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Epidemiology of Sepsis-Associated Acute Kidney Injury in Beijing, China: A Descriptive Analysis.

Int J Gen Med 2021 14;14:5631-5649. Epub 2021 Sep 14.

Department of Intensive Care Unit, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, People's Republic of China.

Background: Sepsis is the most common contributing factor towards development of acute kidney injury (AKI), which is strongly associated to poor prognostic outcomes. There are numerous epidemiological studies about sepsis-associated acute kidney injury (S-AKI), however current literature is limited with the majority of studies being conducted only in the intensive care unit (ICU) setting. The aim of this study was to assess the epidemiology of S-AKI in all hospitalized in-patients. Read More

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September 2021

Methodological quality of multivariate prognostic models for intracranial haemorrhages in intensive care units: a systematic review.

BMJ Open 2021 Sep 21;11(9):e047279. Epub 2021 Sep 21.

UMR 1246 Methods in Patients-Centered Outcomes and Health Research, INSERM, Nantes, France.

Objectives: Patients with severe spontaneous intracranial haemorrhages, managed in intensive care units, face ethical issues regarding the difficulty of anticipating their recovery. Prognostic tools help clinicians in counselling patients and relatives and guide therapeutic decisions. We aimed to methodologically assess prognostic tools for functional outcomes in severe spontaneous intracranial haemorrhages. Read More

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September 2021

Perineal Lacerations: A Retrospective Study in a Habitual-Risk Public Maternity.

Rev Bras Ginecol Obstet 2021 Aug 21;43(8):588-594. Epub 2021 Sep 21.

Medical School, Universidade Franciscana, Santa Maria, Rio Grande do Sul, RS, Brazil.

Objective:  In around 85% of vaginal births, the parturients undergo perineal lacerations and/or episiotomy. The present study aimed to determine the incidence of lacerations and episiotomies among parturients in 2018 in a habitual-risk public maternity hospital in southern Brazil, and to determine the risk and protective factors for such events.

Methodology:  A retrospective cross-sectional study. Read More

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The use of SBRT in the management of oligometastatic gynecological cancer: report of promising results in terms of tolerability and clinical outcomes.

J Cancer Res Clin Oncol 2021 Sep 20. Epub 2021 Sep 20.

Advanced Radiation Oncology Department, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, VR, Italy.

Background: The use of stereotactic radiotherapy (SBRT) for oligometastases is supported by several literature studies, but in the setting of gynecological malignancies, this scenario remains quite unexplored. This study reports a preliminary assessment of clinical outcomes in a cohort of 40 patients with oligometastatic gynecological neoplasms.

Methods: Radiotherapy was delivered in 3-10 fractions with VMAT-IGRT technique. Read More

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September 2021

Predictors of unfavorable responses to therapy in rifampicin-sensitive pulmonary tuberculosis using an integrated approach of radiological presentation and sputum mycobacterial burden.

PLoS One 2021 20;16(9):e0257647. Epub 2021 Sep 20.

Department of Clinical Research, National Institute for Research in Tuberculosis (formerly Tuberculosis Research Centre), Indian Council of Medical Research, Chennai, Tamil Nadu, India.

Introduction: Despite the exalted status of sputum mycobacterial load for gauging pulmonary tuberculosis treatment and progress, Chest X-rays supplement valuable information for taking instantaneous therapeutic decisions, especially during the COVID-19 pandemic. Even though literature on individual parameters is overwhelming, few studies have explored the interaction between radiographic parameters denoting severity with mycobacterial burden signifying infectivity. By using a sophisticated approach of integrating Chest X-ray parameters with sputum mycobacterial characteristics, evaluated at all the three crucial time points of TB treatment namely pre-treatment, end of intensive phase and completion of treatment, utilizing the interactive Cox Proportional Hazards model, we aimed to precisely deduce predictors of unfavorable response to TB treatment. Read More

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September 2021

Advanced brain ageing in Parkinson's disease is related to disease duration and individual impairment.

Brain Commun 2021 23;3(3):fcab191. Epub 2021 Aug 23.

Institute of Neuroscience and Medicine (INM-1, INM-7, INM-11), Jülich, Germany.

Machine learning can reliably predict individual age from MRI data, revealing that patients with neurodegenerative disorders show an elevated biological age. A surprising gap in the literature, however, pertains to Parkinson's disease. Here, we evaluate brain age in two cohorts of Parkinson's patients and investigated the relationship between individual brain age and clinical characteristics. Read More

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Analysing "tear-drop" prints of acute promyelocytic leukemia (APML): immunophenotypic prognostication of APML by FCM.

Am J Blood Res 2021 15;11(4):446-457. Epub 2021 Aug 15.

ICMR-National Institute of Pathology, Safdarjung Hospital Campus Ansari Nagar, New Delhi, India.

Introduction: Acute promyelocytic leukemia (APML), although genetically and morphologically distinct from other AML (acute myeloid leukemia) subtypes, is one of the most best responsive acute myeloid leukemia. -Conventional diagnostic methods and morphological hints often fail in the majority of the cases in the peripheral laboratories owing to resource constraints, unavailability of cytogenetic work-up, hypogranular variants, morphological mimicry by AML-monocytic and myelo-monocytic, etc. Flowcytometry (FCM), however, can be utilized as a feasible and reliable immunophenotypic diagnostic and prognostic tool for prompt identification of APML. Read More

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Risk factors for major complications after liver resection: A large liver resection study from Morocco and audit of a non-Eastern/non-Western experience.

Arab J Gastroenterol 2021 Sep 15. Epub 2021 Sep 15.

Faculty of Medicine, Mohammed V University, and Surgical Department A, Ibn Sina Hospital, Rabat, Morocco.

Background And Study Aims: In developing countries, endemic indications, blood shortages, and the scarcity of liver surgeons and intensive care providers can affect liver resection (LR) outcomes, but these have been rarely addressed in the literature. Therefore, in this study we determined risk factors for major complications after LR in a North African general surgery and teaching department.

Patients And Methods: From January 2010 to December 2015, 213 consecutive LRs were performed on 203 patients. Read More

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September 2021

Psychological distress, low-income, and socio-economic vulnerability in the COVID-19 pandemic.

Public Health 2021 Aug 27;199:42-45. Epub 2021 Aug 27.

Division of Translational Medicine, School of Medicine, Federal University of São Paulo, São Paulo, Brazil; Institute of Advanced Studies, University of São Paulo, São Paulo, Brazil. Electronic address:

Objectives: Although literature broadly reports the impact of COVID-19 on global mental health, little is known about the extent of its deleterious impact on the most vulnerable individuals. The present study aimed to evaluate the level of psychological distress of adult's residents of two urban shantytown communities located in São Paulo city, Brazil.

Study Design: This was a cross-sectional study. Read More

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Using the modified frailty index to predict negative outcomes in free-flap breast reconstruction: A National Surgical Quality Improvement Project-based study.

Microsurgery 2021 Sep 17. Epub 2021 Sep 17.

Division of Plastic and Reconstructive Surgery, University of California, Los Angeles, Los Angeles, California, USA.

Background: Post-mastectomy free-flap breast reconstruction is becoming increasingly common in the United States. However, predicting which patients may suffer complications remains challenging. We sought to apply the validated modified frailty index (mFI) to free-flap breast reconstruction in breast cancer patients and determine its utility in predicting negative outcomes. Read More

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September 2021

The prevalence of vertebral fractures among Indian perimenopausal women and its association with ovarian biomarkers.

J Bone Miner Metab 2021 Sep 17. Epub 2021 Sep 17.

Departments of Endocrinology, Christian Medical College and Hospital, Vellore, India.

Introduction: There is dearth of data on prevalent vertebral fractures in perimenopausal women in India and limited literature on the utility of FSH, AMH and estradiol in evaluating bone health them. The objective was to study the prevalence of vertebral fractures (VF) and to assess the utility of FSH, estradiol and AMH in predicting them in Indian perimenopausal women MATERIALS AND METHODS: It was a cross-sectional study. Perimenopausal women aged 40-49 years underwent assessment for prevalent vertebral fractures, bone mineral density (BMD) and trabecular bone score (TBS). Read More

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September 2021

Risk Factors for Inadequate Bowel Preparation During Colonoscopy in Nigerian Patients.

Cureus 2021 Aug 13;13(8):e17145. Epub 2021 Aug 13.

Colorectal and Minimal Access Surgery Unit, Department of Surgery, University of Port Harcourt Teaching Hospital, Port Harcourt, NGA.

Background The past few decades have witnessed the introduction of various innovative technologies into colon study by colonoscopy. A well-prepared bowel is crucial to their effective utilization. An inadequate bowel preparation during colonoscopy is associated with increased technical difficulties, enhanced risks of perforation, longer examination durations, reduced adenoma detection rates, and additional costs related to repeated colonoscopies. Read More

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Associations between sinus tachycardia and adverse cardiovascular outcomes and mortality in cancer patients.

J Thorac Dis 2021 Aug;13(8):4845-4852

Director of Cardio-Oncology Services, Department of Cardiology, Rush University Medical Center, Chicago, IL, USA.

Background: Sinus tachycardia in cancer reflects a significant multi-system organ stressor and disease, with sparse literature describing its clinical significance. We assessed cardiovascular (CV) and mortality prognostic implications of sinus tachycardia in cancer patients.

Methods: We conducted a case-control study of 622 cancer patients at a U. Read More

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Explainable artificial intelligence based analysis for interpreting infant fNIRS data in developmental cognitive neuroscience.

Commun Biol 2021 09 15;4(1):1077. Epub 2021 Sep 15.

Centre for Brain Science, Department of Psychology, University of Essex, Colchester, UK.

In the last decades, non-invasive and portable neuroimaging techniques, such as functional near infrared spectroscopy (fNIRS), have allowed researchers to study the mechanisms underlying the functional cognitive development of the human brain, thus furthering the potential of Developmental Cognitive Neuroscience (DCN). However, the traditional paradigms used for the analysis of infant fNIRS data are still quite limited. Here, we introduce a multivariate pattern analysis for fNIRS data, xMVPA, that is powered by eXplainable Artificial Intelligence (XAI). Read More

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September 2021

Activated osteoarthritis following immune checkpoint inhibitor treatment: an observational study.

J Immunother Cancer 2021 Sep;9(9)

Division of Rheumatology, Hospital for Special Surgery, New York, New York, USA.

Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy but can result in toxicities, known as immune-related adverse events (irAEs), due to a hyperactivated immune system. ICI-related inflammatory arthritis has been described in literature, but herewith we introduce and characterize post-ICI-activated osteoarthritis (ICI-aOA). We conducted a multicenter, retrospective, observational study of patients with cancer treated with ICIs and diagnosed with ICI-aOA by a rheumatologist. Read More

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September 2021

Development and validation of a nomogram for prediction of the risk of positive hidden blood loss in the perioperative period of single-level thoracolumbar burst fracture.

J Orthop Surg Res 2021 Sep 15;16(1):560. Epub 2021 Sep 15.

Department of Orthopedics, Baoji City Hospital of Traditional Chinese Medicine, 43 Baofu Road, Baoji, 721000, Shaanxi Province, People's Republic of China.

Background: This study aimed to develop and validate an individualized nomogram to predict the risk of positive hidden blood loss (HBL) in patients with single-level thoracolumbar burst fracture (TBF) during the perioperative period.

Methods: We conducted a retrospective investigation including 150 consecutive patients with TBL, and the corresponding patient data was extracted from March 2013 to March 2019. The independent risk factors for positive HBL were screened using univariate and multivariate logistic regression analyses. Read More

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September 2021

Arsenic-induced oxidative stress in Brassica oleracea: Multivariate and literature data analyses of physiological parameters, applied levels and plant organ type.

Environ Geochem Health 2021 Sep 15. Epub 2021 Sep 15.

Centre d'Etude et de Recherche Travail Organisation Pouvoir (CERTOP), UMR5044, Université J. Jaurès - Toulouse II, 5 allée Machado A, 31058cedex 9, Toulouse, France.

Plant redox homeostasis governs the uptake, toxicity and tolerance mechanism of toxic trace elements and thereby elucidates the remediation potential of a plant. Moreover, plant toxicity/tolerance mechanisms control the trace element compartmentation in edible and non-edible plant organs as well as the associated health hazards. Therefore, it is imperative to unravel the cellular mechanism involved in trace element toxicity and tolerance. Read More

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September 2021

Role of poorly differentiated cluster in gastric cancer: is it a new prognosis factor?

Scand J Gastroenterol 2021 Sep 15:1-6. Epub 2021 Sep 15.

Department of General Surgery - Unit of General, Emergency and Oncological Surgery, AOU of Modena University of Modena and Reggio Emilia, Modena, Italy.

Background: Poorly differentiated Clusters (PDCs) of tumor cells composed of more than five elements have been recently described in gastrointestinal cancers and correlate with a worse prognosis. Our study aims to investigate PDC occurrence in a series of patients with gastric cancer and correlate it with lymph node status and clinical outcome.

Material And Methods: 50 patients were included in the study; PDCs count was graduated as G1, G2, and G3 according to Ueno classification (PDCs count at 20× <5, 5-9 and ≥10 respectively). Read More

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September 2021

Temporal Transcriptomics of Gut Escherichia coli in Caenorhabditis elegans Models of Aging.

Microbiol Spectr 2021 Sep 15:e0049821. Epub 2021 Sep 15.

Juniata Collegegrid.258264.f, Huntingdon, Pennsylvania, USA.

Host-bacterial interactions over the course of aging are understudied due to complexities of the human microbiome and challenges of collecting samples that span a lifetime. To investigate the role of host-microbial interactions in aging, we performed transcriptomics using wild-type Caenorhabditis elegans () and three long-lived mutants (, , and ) fed Escherichia coli OP50 and sampled at days 5, 7.5, and 10 of adulthood. Read More

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September 2021

Sociodemographic and Clinical Characteristics of Vapers Using E-Cigarettes Exclusively: The French Vapoquid Study.

Subst Use Misuse 2021 Sep 15:1-9. Epub 2021 Sep 15.

Centre Ambulatoire d'Addictologie, Département Médico-Universitaire de Psychiatrie et Addictologie, AP-HP.Centre-Université de Paris, Paris, France.

Background: Electronic cigarettes are increasingly being used as smoking cessation aids. Most studies assess the dual use of e-cigarettes and traditional cigarettes, but there remains a paucity of literature concerning individuals who use e-cigarettes exclusively. : The aim of this study is to examine the sociodemographic and clinical characteristics of exclusive e-cigarette users, and consider their willingness to quit e-cigarette use. Read More

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September 2021

Corneal endothelial cell density and morphology in ophthalmologically healthy young individuals in Japan: An observational study of 16842 eyes.

Sci Rep 2021 Sep 14;11(1):18224. Epub 2021 Sep 14.

Department of Ophthalmology, Miyata Eye Hospital, 6-3, Kuraharacho, Miyakonojo, Miyazaki, 885-0051, Japan.

We aimed to investigate the cell density and morphology of the corneal endothelium in ophthalmologically healthy young Japanese, given the lack of normative data in literature. This observational study included eyes without ophthalmologic diseases, besides refractive errors, examined between 1996 and 2015 at Miyata Eye Hospital. Eyes with a history of ophthalmologic diseases or contact lens usage were excluded. Read More

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September 2021

Smoking Is Associated With Lower Satisfaction in Nondiabetic Patients Undergoing Minimally Invasive Single-level Transforaminal Lumbar Interbody Fusion.

Clin Spine Surg 2021 Sep 9. Epub 2021 Sep 9.

Department of Orthopedic Surgery, Singapore General Hospital The Orthopaedic Centre Orthopaedic and Spine Clinic, Mount Elizabeth Medical Centre, Singapore.

Study Design: This was a retrospective review of prospectively collected registry data.

Objective: The objective of this study was to investigate the effect of smoking on 2 years postoperative functional outcomes, satisfaction, and radiologic fusion in nondiabetic patients undergoing minimally invasive transforaminal lumbar interbody fusion (TLIF) for degenerative spine conditions.

Summary Of Background Data: There is conflicting data on the effect of smoking on long-term functional outcomes following lumbar fusion. Read More

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September 2021

Nativity moderates the relationship between nationality and healthcare access for some Latinx women in the United States.

Ethn Health 2021 Sep 12:1-17. Epub 2021 Sep 12.

The Steve Hicks School of Social Work at the University of Texas at Austin, Austin, USA.

Objectives: Gender has been identified as a social determinant of health, particularly as it relates to healthcare access for women of color. Yet, few analyses focus on the unique barriers that impact Latinx women's access to healthcare, which demonstrates a significant gap in the literature given the heterogeneity of the Latinx population. The purpose of this study is to (1) describe how sociodemographic characteristics impact access to healthcare for Latinx women and (2) examine whether intersecting factors, particularly nativity and nationality, influence barriers to healthcare for Latinx women in the United States (US). Read More

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September 2021

Post-COVID syndrome. A case series and comprehensive review.

Autoimmun Rev 2021 Sep 10:102947. Epub 2021 Sep 10.

Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.

The existence of a variety of symptoms with a duration beyond the acute phase of COVID-19, is referred to as post-COVID syndrome (PCS). We aimed to report a series of patients with PCS attending a Post-COVID Unit and offer a comprehensive review on the topic. Adult patients with previously confirmed SARS-CoV-2 infection and PCS were systematically assessed through a semi-structured and validated survey. Read More

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September 2021

Are proton pump inhibitors associated with implant failure and peri-implantitis?

Oral Surg Oral Med Oral Pathol Oral Radiol 2021 May 15:4626. Epub 2021 May 15.

Assistant Professor, Department of Oral and Maxillofacial Surgery and Pharmacology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Objective: Proton pump inhibitors (PPIs) may be linked to implant failure by affecting bone metabolism and osseointegration. This study evaluated how PPIs influence long-term implant failure and peri-implantitis in PPI users and nonusers.

Study Design: This was a retrospective cohort study of patients treated at the Philadelphia Veterans Affairs Medical Center between 2006 and 2013. Read More

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Systematic review of the link between maternal anxiety and overprotection.

J Affect Disord 2021 Aug 31;295:541-551. Epub 2021 Aug 31.

Miami University, 90 N. Patterson Ave., Oxford, OH, 45056, United States.

Background: Theoretical and empirical evidence suggests that maternal anxiety relates to overprotection, yet studies have found conflicting evidence. The literature would benefit from a systematic review.

Methods: In April 2020, a systematic review on the relation between maternal anxiety and overprotection was conducted. Read More

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Rhabdomyosarcoma in Adults: A Retrospective Analysis of Case Records Diagnosed between 1979 and 2018 in Western Denmark.

Sarcoma 2021 30;2021:9948885. Epub 2021 Aug 30.

Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.

Introduction: Adult rhabdomyosarcoma is a rare tumour that has an inferior survival compared to the paediatric patient population. The reason for this consistently worse outcome remains mostly unknown. It has been suggested that this disparity may be related to biological and/or treatment-related factors, which in the literature has been shown to be distributed differently among paediatric and adult patients. Read More

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Correlates of High School Boys' Intention to Garner Sexual Consent.

J Interpers Violence 2021 Sep 9:8862605211042623. Epub 2021 Sep 9.

Brown University, Providence, RI, USA.

The current study examines correlates of high school boys' intentions to garner consent in a future sexual encounter ( = 816). Bivariate correlation analyses demonstrated that increased intention to garner sexual consent was negatively correlated with rape myth acceptance and perceived peer acceptance of violence, and positively correlated with gender equitable attitudes. In multivariate linear regression analyses, perceived peer acceptance of violence and gender equitable attitudes remained significant in relation to intentions to garner sexual consent. Read More

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September 2021

The Use of Computational Methods for the Development of Molecularly Imprinted Polymers.

Polymers (Basel) 2021 Aug 24;13(17). Epub 2021 Aug 24.

Bioorganic & Biophysical Chemistry Laboratory, Linnaeus University Centre for Biomaterials Chemistry, Department of Chemistry & Biomedical Sciences, Linnaeus University, SE-391 82 Kalmar, Sweden.

Recent years have witnessed a dramatic increase in the use of theoretical and computational approaches in the study and development of molecular imprinting systems. These tools are being used to either improve understanding of the mechanisms underlying the function of molecular imprinting systems or for the design of new systems. Here, we present an overview of the literature describing the application of theoretical and computational techniques to the different stages of the molecular imprinting process (pre-polymerization mixture, polymerization process and ligand-molecularly imprinted polymer rebinding), along with an analysis of trends within and the current status of this aspect of the molecular imprinting field. Read More

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Effects of Exposure to Road, Railway, Airport and Recreational Noise on Blood Pressure and Hypertension.

Int J Environ Res Public Health 2021 Aug 30;18(17). Epub 2021 Aug 30.

IPool S.r.l., Via Cocchi 7, 56121 Pisa, Italy.

Noise is one of the most diffused environmental stressors affecting modern life. As such, the scientific community is committed to studying the main emission and transmission mechanisms aiming at reducing citizens' exposure, but is also actively studying the effects that noise has on health. However, scientific literature lacks data on multiple sources of noise and cardiovascular outcomes. Read More

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