12,129 results match your criteria literature detect

Wildlife poisoning: a novel scoring system and review of analytical methods for anticoagulant rodenticide determination.

Ecotoxicology 2021 Apr 17. Epub 2021 Apr 17.

Toxicology and Forensic Veterinary Service, Faculty of Veterinary, University of Murcia, Campus de Espinardo, Murcia, Spain.

Anticoagulant rodenticides (ARs) are commonly used to control rodent populations and frequently involved in wildlife and domestic animal poisoning. These poisoning cases (especially for ARs) are a challenge for forensic toxicologists, and adequate post-mortem examination and toxicological analyses become essential for a proper diagnosis. Publications describing different analytical methods for AR analysis in biological samples are growing, and a clear compilation of the overall picture is needed to standardize methodologies in future research. Read More

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Update in imaging of cancer therapy-related cardiac toxicity in adults.

Open Heart 2021 Apr;8(1)

Pediatric Cardiology, Wilhelmina Children's Hospital University Medical Centre, Utrecht, The Netherlands

Over the past decades, prognosis of patients with cancer has strongly improved and the number of cancer survivors is rapidly growing. Despite this success, cancer treatment is associated with development of serious cardiovascular diseases including left ventricular (LV) systolic dysfunction, heart failure, valvular disease, myocardial infarction, arrhythmias or pericardial diseases. Serial non-invasive cardiac imaging is an important tool to detect early signs of cardiotoxicity, to allow for timely intervention and provide optimal circumstances for long-term prognosis. Read More

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The role of digital health technologies in COVID-19 surveillance and recovery: a specific case of long haulers.

Int Rev Psychiatry 2021 Apr 16:1-12. Epub 2021 Apr 16.

Penn Medicine Center for Digital Health, University of Pennsylvania, Philadelphia, PA, USA.

Digital health and technologies are essential to curbing the novel coronavirus 2019 (COVID-19) pandemic especially with shelter-in-place and social distancing orders. Epidemiologists and public health officials are tapping into frequently used technologies like wearables, digital devices, digital and social media data to detect and validate COVID-19 symptoms throughout the pandemic, especially during early stages when symptoms were evolving. In this article, we review how digital technologies and social media platforms can identify and inform our understanding of COVID-19 pandemic surveillance and recovery efforts. Read More

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Magnetic Resonance Imaging Features in Different Types of Invasive Breast Cancer: A Systematic Review of the Literature.

Cureus 2021 Mar 12;13(3):e13854. Epub 2021 Mar 12.

Cardiology, Rush University Medical Center, Chicago, USA.

Breast cancer is the most common malignancy affecting women worldwide, and early diagnosis of breast cancer is the key to its successful and effective treatment. Traditional imaging techniques such as mammography and ultrasound are used to detect and configure breast abnormalities; unfortunately, these modalities have low sensitivity and specificity, particularly in young patients with dense breast tissue, breast implants, or post-surgical scar/architecture distortions. Therefore, breast magnetic resonance imaging (MRI) has been superior in the characterization and detection of breast cancer, especially that with invasive features. Read More

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Halo Nevi Are Not Trivial: About 2 Young Patients of Regressed Primary Melanoma That Simulates Halo Nevi.

Case Rep Dermatol Med 2021 22;2021:6672528. Epub 2021 Mar 22.

Dermatology Department, CHU UCL Namur, Site Sainte Elisabeth, Place Louise Godin 15, 5000 Namur, Belgium.

Background: Halo nevi are often considered benign, and the possibility of malignancy is not always clear to practitioners. We present two case reports suggesting that a halo nevus appearance can be seen in melanoma, even in young adults. A literature search for halo nevi revealing melanoma shows that this is a very rare condition. Read More

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What does the patient have to say? Valuing the patient experience to improve the patient journey.

BMC Health Serv Res 2021 Apr 15;21(1):347. Epub 2021 Apr 15.

Campus Bio-Medico di Roma University, Rome, Italy.

Background: Patient-reported data-satisfaction, preferences, outcomes and experience-are increasingly studied to provide excellent patient-centred care. In particular, healthcare professionals need to understand whether and how patient experience data can more pertinently inform the design of service delivery from a patient-centred perspective when compared with other indicators. This study aims to explore whether timely patient-reported data could capture relevant issues to improve the hospital patient journey. Read More

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Gastric tumorigenesis after radical resection combined with adjuvant chemotherapy for colorectal cancer: two case reports and a literature review.

J Int Med Res 2021 Apr;49(4):3000605211007050

Department of Colorectal and Anal Surgery, The Second Hospital of Jilin University, Changchun, Jilin, China.

Radical resection with or without adjuvant chemotherapy is a common option for stage II and III colorectal cancer. Few reports exist regarding gastric tumorigenesis, including gastric cancer, gastric intraepithelial neoplasia, and gastric stromal tumor, in patients who received this protocol as the standard treatment for colorectal cancer. We present two cases of gastric tumorigenesis in patients with colorectal cancer following radical resection combined with adjuvant chemotherapy. Read More

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Screening for the early detection of pulmonary arterial hypertension in patients with systemic sclerosis: A systematic review and meta-analysis of long-term outcomes.

Semin Arthritis Rheum 2021 Apr 4;51(3):495-512. Epub 2021 Apr 4.

The University of Melbourne, Victoria, Australia; The University of Melbourne, St. Vincent's Hospital, Level 3, 35 Victoria Pde, Fitzroy, Melbourne, Victoria 3065, Australia. Electronic address:

Background: Systemic sclerosis (scleroderma, SSc) is a chronic multisystem autoimmune disease characterised by fibrosis of the skin and internal organs and vasculopathy. One of the major contributors to mortality in patients with SSc is pulmonary arterial hypertension (PAH). International recommendations advise annual screening for the early detection of PAH in asymptomatic patients with SSc. Read More

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Undergraduate STEM Majors on and off the Pre-Med/Health Track: A STEM Identity Perspective.

CBE Life Sci Educ 2021 Jun;20(2):ar24

STEM Transformation Institute, Florida International University, Miami, FL 33155.

Despite the wealth of research exploring science, technology, engineering, and mathematics (STEM) identity and career goals in both formal and informal settings, existing literature does not consider STEM identity for undergraduate students pursuing health and medical careers through STEM pathways. We address this gap by examining the STEM identity of undergraduate STEM majors on pre-med/health tracks as it compares with that of other STEM majors, thus focusing on a population that is chronically understudied in STEM education research. We surveyed 440 undergraduate STEM students enrolled in entry-level STEM courses to assess their STEM identities and three identity precursors: interest, performance-competence, and recognition. Read More

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Breath analysis for the detection of digestive tract malignancies: systematic review.

BJS Open 2021 Mar;5(2)

Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centre, Maastricht, the Netherlands.

Background: In recent decades there has been growing interest in the use of volatile organic compounds (VOCs) in exhaled breath as biomarkers for the diagnosis of multiple variants of cancer. This review aimed to evaluate the diagnostic accuracy and current status of VOC analysis in exhaled breath for the detection of cancer in the digestive tract.

Methods: PubMed and the Cochrane Library database were searched for VOC analysis studies, in which exhaled air was used to detect gastro-oesophageal, liver, pancreatic, and intestinal cancer in humans, Quality assessment was performed using the QUADAS-2 criteria. Read More

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Accuracy of heart rate variability estimated with reflective wrist-PPG in elderly vascular patients.

Sci Rep 2021 Apr 14;11(1):8123. Epub 2021 Apr 14.

Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Optical heart rate monitoring (OHR) with reflective wrist photoplethysmography is a technique mainly used in the wellness application domain for monitoring heart rate levels during exercise. In the absence of motion, OHR technique is also able to estimate individual beat-to-beat intervals relatively well and can therefore also be used, for example, in monitoring of cardiac arrhythmias, stress, or sleep quality through heart rate variability (HRV) analysis. HRV analysis has also potential in monitoring the recovery of patients, e. Read More

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Rhinolithiasis, a rare entity: Analysis of 31 cases and literature review.

North Clin Istanb 2021 26;8(2):172-177. Epub 2020 Oct 26.

Department of Ear Nose Throat Head and Neck Surgery, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.

Objective: Rhinolithiasis is a rare condition which results from deposition of salt around a endogenous or exogenous nidus. In the literature, most of the reports are single case studies. In this study, we aimed to present the characteristics, symptoms, diagnosis, and treatment methods of 31 rhinolithiasis cases and to focus on the current literature. Read More

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October 2020

High-grade salivary gland carcinoma with the ETV6-NTRK3 gene fusion: A case report and literature review of secretory carcinoma with high-grade transformation.

Pathol Int 2021 Apr 13. Epub 2021 Apr 13.

Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan.

Secretory carcinoma or mammary analog secretory carcinoma is an entity of salivary gland carcinoma that is characterized by the ETV6-NTRK3 gene fusion. Although it is generally considered to be a low-grade malignancy, some cases of secretory carcinoma with high-grade transformation (SCHG) have been reported. We herein describe a case of SCHG composed almost exclusively of the high-grade component. Read More

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Neuroimaging Biomarkers of Chronic Traumatic Encephalopathy: Targets for the Academic Memory Disorders Clinic.

Neurotherapeutics 2021 Apr 13. Epub 2021 Apr 13.

Department of Neurology, Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Boston University School of Medicine, 72 E Concord St, Suite B7800, MA, 02118, Boston, USA.

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with exposure to repetitive head impacts, such as those from contact sports. The pathognomonic lesion for CTE is the perivascular accumulation of hyper-phosphorylated tau in neurons and other cell process at the depths of sulci. CTE cannot be diagnosed during life at this time, limiting research on risk factors, mechanisms, epidemiology, and treatment. Read More

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The meta-analysis of the effect of 68Ga-PSMA-PET/CT diagnosis of prostatic cancer compared with bone scan.

Medicine (Baltimore) 2021 Apr;100(15):e25417

Department of Urology, General Hospital of Ningxia Medical University.

Background: 68Ga-PSMA-PET/CT (positron emission tomography/computed tomography) is a promising method for prostate cancer (PC) detection. However, the ability of 68Ga-PSMA-PET/CT to detect malignant bone lesions, and whether this method is superior to the existing bone imaging methods are still lack of systematic analysis.

Purpose: To evaluate the value of 68Ga-PSMA-PET/CT and bone scan in clinical diagnosis of prostatic cancer from the perspective of evidence-based medicine. Read More

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Current concepts on diffuse choroidal hemangioma in Sturge Weber syndrome.

Ophthalmic Genet 2021 Apr 12:1-8. Epub 2021 Apr 12.

Ophthalmology Unit, Neurosciences, Mental Health, and Sense Organs (NESMOS) Department, Sapienza University of Rome, Faculty of Medicine and Psychology, St. Andrea Hospital, Rome, Italy.

: Diffuse choroidal hemangioma (DCH) is a benign vascular tumor that is characteristically found in the Sturge-Weber syndrome (SWS). Recent genetic discoveries demonstrate that DCH occurs sporadically from an activating mutation in at codon . Mutations in or result in dysregulation of the mitogen-activated protein kinase, which influences gene transcription and results in cellular proliferation. Read More

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How does "A Bit of Everything American" state feel about COVID-19? A quantitative Twitter analysis of the pandemic in Ohio.

Cantay Caliskan

J Comput Soc Sci 2021 Apr 5:1-27. Epub 2021 Apr 5.

Department of Data Analytics, Denison University, 100 W. College Street, Granville, OH 43023 USA.

COVID-19 has proven itself to be one of the most important events of the last two centuries. This defining moment in our lives has created wide-ranging discussions in many segments of our societies, both politically and socially. Over time, the pandemic has been associated with many social and political topics, as well as sentiments and emotions. Read More

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Evaluating Simulations as Preparation for Health Crises like CoVID-19: Insights on Incorporating Simulation Exercises for Effective Response.

Int J Disaster Risk Reduct 2021 Apr 5:102245. Epub 2021 Apr 5.

Bournemouth University Disaster Management Centre, Bournemouth University Business School, DG14, Dorset House, Talbot Campus, Fern Barrow, Poole, BH12 5BB, UK.

Today's health emergencies are increasingly complex due to factors such as globalization, urbanization and increased connectivity where people, goods and potential vectors of disease are constantly on the move. These factors amplify the threats to our health from infectious hazards, natural disasters, armed conflicts and other emergencies wherever they may occur. The current CoVID-19 pandemic has provided a clear demonstration of the fact that our ability to detect and predict the initial emergence of a novel human pathogen (for example, the spill-over of a virus from its animal reservoir to a human host), and our capacity to forecast the spread and transmission the pathogen in human society remains limited. Read More

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Non-prostate uptake on F-PSMA-1007 PET/CT: a case of myeloma.

BJR Case Rep 2021 Apr 3;7(2):20200102. Epub 2020 Nov 3.

Department of Radiology, Royal United Hospital, Combe Park, Bath, Avon, United Kingdom.

Prostate-specific membrane antigen (PSMA), a glycoprotein that is highly expressed in prostate cancer, has been used as a target for molecular radiotherapy as well as imaging. Over the last couple of years, F-PSMA gained popularity due to its longer half-life (110 min) compared to gallium Ga-PSMA (68 min). This has helped the dissemination beyond large metropolitan centres. Read More

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Ion Channels Orchestrate Pancreatic Ductal Adenocarcinoma Progression and Therapy.

Front Pharmacol 2020 19;11:586599. Epub 2021 Jan 19.

Institute of Physiology II, University of Münster, Münster, Germany.

Pancreatic ductal adenocarcinoma is a devastating disease with a dismal prognosis. Therapeutic interventions are largely ineffective. A better understanding of the pathophysiology is required. Read More

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January 2021

Should serial monitoring of procalcitonin be done routinely in critically ill patients of ICU: A systematic review and meta-analysis.

J Anaesthesiol Clin Pharmacol 2020 Oct-Dec;36(4):458-464. Epub 2021 Jan 18.

Biostatistics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Sepsis is a life-threatening condition with dysregulated host response to infection. It is a major determinant of mortality in the intensive care unit (ICU). Procalcitonin (PCT) is widely investigated for prognosis in patients with sepsis. Read More

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January 2021

Identifying predictors of ventral hernia recurrence: systematic review and meta-analysis.

BJS Open 2021 Mar;5(2)

Centre of Medical Imaging, University College Hospital, London, UK.

Background: Ventra hernias are increasing in prevalence and many recur despite attempted repair. To date, much of the literature is underpowered and divergent. As a result there is limited high quality evidence to inform surgeons succinctly which perioperative variables influence postoperative recurrence. Read More

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Model-based pathway enrichment analysis applied to the TGF-beta regulation of autophagy in autism.

Judith Somekh

J Biomed Inform 2021 Apr 8:103781. Epub 2021 Apr 8.

Department of Information Systems, University of Haifa, Haifa, Israel, 3498838. Electronic address:

To differentiate between conditions of health and disease, current pathway enrichment analysis methods detect the differential expression of distinct biological pathways. System-level model-driven approaches, however, are lacking. Here we present a new methodology that uses a dynamic model to suggest a unified subsystem to better differentiate between diseased and healthy conditions. Read More

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The Role of Endothelial Dysfunction in the Pathophysiology and Cerebrovascular Effects of Migraine: A Narrative Review.

J Clin Neurol 2021 Apr;17(2):164-175

Headache and Neurosonology Unit, Neurology, Campus Bio-Medico University of Rome, Rome, Italy.

Background And Purpose: Migraine is a complex neurovascular disorder whose triggers are not entirely understood. Endothelial dysfunction might play a role in migraine, and there have been numerous reports on endothelium dysfunction and migraine pathophysiology, but their reciprocal cause-effect relationship remains unclear. This review reports the current evidence on endothelium dysfunction, its link with migraine, and its possible consequences for cerebral hemodynamics. Read More

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Lung ultrasound-guided management to reduce hospitalization in chronic heart failure: a systematic review and meta-analysis.

Heart Fail Rev 2021 Apr 9. Epub 2021 Apr 9.

Department of Cardiovascular Medicine, University of Toledo, Toledo, OH, USA.

Pulmonary edema is a leading cause of hospital admissions, morbidity, and mortality in heart failure (HF) patients. A point-of-care lung ultrasound (LUS) is a useful tool to detect subclinical pulmonary edema. We performed a comprehensive literature search of multiple databases for studies that evaluated the clinical utility of LUS-guided management versus standard care for HF patients in the outpatient setting. Read More

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Imaging, Identification and Inhibition of Microorganisms Using AIEgens.

Top Curr Chem (Cham) 2021 Apr 9;379(3):21. Epub 2021 Apr 9.

Department of Chemistry, University of Massachusetts Lowell, Lowell, MA, 01854, USA.

Microorganisms, including bacteria, viruses and fungi, are ubiquitous in nature. Some are extremely beneficial to life on Earth, whereas some cause diseases and disrupt normal human physiology. Pathogenic microorganisms can also undergo mutations and develop resistance to antimicrobial agents, which complicates diagnostic and therapeutic regimens. Read More

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Dermoscopic Features of Giant Molluscum Contagiosum in a Patient with Acquired Immunodeficiency Syndrome.

Acta Dermatovenerol Croat 2020 Dec;28(7):233-235

Martyna Sławińska MD, PhD, Department of Dermatology, Venereology and Allergology Medical University of Gdańsk, Smoluchowskiego 17 Street, 80-214 Gdańsk;

Giant molluscum contagiosum (MC) is a peculiar variant of the disease with the presence of multiple or single lesions larger than 5 mm. In contrast to typical molluscum contagiosum, dermoscopic features of giant lesions have been poorly described, and none of the reports included multiple giant lesions in an immunocompromised patient. We present a patient with acquired immunodeficiency syndrome diagnosed with multiple giant molluscum contagiosum along with the dermoscopic features of this entity. Read More

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December 2020

Asymptomatic Joint Bleeding and Joint Health in Hemophilia: A Review of Variables, Methods, and Biomarkers.

J Blood Med 2021 1;12:209-220. Epub 2021 Apr 1.

Katharine Dormandy Haemophilia Centre, Royal Free Hospital, London, UK.

Joint health is a key contributor to quality of life in patients with hemophilia. However, variables that impact long-term joint outcomes have not been comprehensively defined. A systematic literature search identified publications relating to joint health in patients with hemophilia. Read More

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Whole-exome sequencing reveals the etiology of the rare primary hepatic mucoepidermoid carcinoma.

Diagn Pathol 2021 Apr 8;16(1):29. Epub 2021 Apr 8.

Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital of Nanchang University, No.1, Minde Road, Nanchang, China.

Background: Primary hepatic mucoepidermoid carcinoma (HMEC) is extremely rare and the molecular etiology is still unknown. The CRTC1-MAML2 fusion gene was previously detected in a primary HMEC, which is often associated with MEC of salivary gland in the literature.

Methods: A 64-year-old male was diagnosed with HMEC based on malignant squamous cells and mucus-secreting cells in immunohistochemical examination. Read More

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Aortic Intimo-intimal Intussusception: A Pooled Analysis of Published Reports.

Ann Vasc Surg 2021 Apr 5. Epub 2021 Apr 5.

Department of Vascular Surgery, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, P.R.China. Electronic address:

Aim: Aortic intimo-intimal intussusception (AoII) is a rare manifestation of aortic dissection with high mortality. This study aimed to obtain a comprehensive understanding of AoII.

Methods: Three databases (Pubmed, Scopus, Embase) were searched with predefined search terms ["intimal intussusception", "aortic intussusception", "(circumferential) AND (intimal dissection)" and "(circumferential) AND (aortic dissection)"]. Read More

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