240,765 results match your criteria literature based


Repair Sequence and Management of the Premaxilla in Patients With Bilateral Cleft Lip and Palate: A Systematic Review of the Literature.

J Craniofac Surg 2021 Sep 23. Epub 2021 Sep 23.

Case Western Reserve University School of Medicine Department of Plastic Surgery, Cleveland Clinic, Cleveland, OH.

Background: Bilateral cleft lip and palate (BCLP) remains a difficult surgical problem due to the severely protruding premaxillary segment, with no consensus of optimal treatment sequence in older patients. A systematic review of the literature was performed to assess the current status of BCLP repair based on age.

Methods: A PRISMA systematic review of the PubMed, Web of Science, and Embase databases was performed using a series of search terms related to BCLP. Read More

View Article and Full-Text PDF
September 2021

Management of postoperative nausea and vomiting in adults: current controversies.

Curr Opin Anaesthesiol 2021 Sep 24. Epub 2021 Sep 24.

Department of Anesthesiology and Perioperative Medicine, Penn State Health, Hershey, Pennsylvania Department of Anesthesiology and Pain Management, University of Texas Southwestern, Dallas, Texas, USA.

Purpose Of Review: Postoperative nausea and vomiting (PONV) continue to plague the surgical patient population with an adverse impact on postoperative outcomes. The aim of this review is to critically assess current evidence for PONV management, including studies evaluating baseline risk reduction and antiemetic prophylaxis, to provide a pragmatic approach to prevention and treatment of PONV in routine clinical practice.

Recent Findings: Multiple recent reviews and guidelines have been published on this topic with some limitations. Read More

View Article and Full-Text PDF
September 2021

A standardized analytics pipeline for reliable and rapid development and validation of prediction models using observational health data.

Comput Methods Programs Biomed 2021 Sep 6;211:106394. Epub 2021 Sep 6.

Observational Health Data Analytics, Janssen Research and Development, Titusville, NJ, USA. Electronic address:

Background And Objective: As a response to the ongoing COVID-19 pandemic, several prediction models in the existing literature were rapidly developed, with the aim of providing evidence-based guidance. However, none of these COVID-19 prediction models have been found to be reliable. Models are commonly assessed to have a risk of bias, often due to insufficient reporting, use of non-representative data, and lack of large-scale external validation. Read More

View Article and Full-Text PDF
September 2021

Sex-based differences in body core temperature response across repeat work bouts in the heat.

Appl Ergon 2021 Sep 21;98:103586. Epub 2021 Sep 21.

School of Exercise and Nutrition Science, Queensland University of Technology, Brisbane, Queensland, Australia; Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia; Defence Science and Technology Group, Department of Defence, Melbourne, Victoria, Australia. Electronic address:

Objective: To investigate the effects of repeated work bouts in the heat on peak body core temperature and to explore sex-based differences in body core temperature responses.

Methods: Fourteen males and fifteen females performed four work bouts (two heavy and two moderate, alternating) in 32.5 °C Wet Bulb Globe Temperature (WBGT), each separated by 30-min seated rest in 28. Read More

View Article and Full-Text PDF
September 2021

Dietary intakes of monounsaturated fatty acids and risk of mortality from all causes, cardiovascular disease and cancer: A systematic review and dose-response meta-analysis of prospective cohort studies.

Ageing Res Rev 2021 Sep 21:101467. Epub 2021 Sep 21.

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran; Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

Background: Findings on the link between dietary intakes of monounsaturated fatty acids (MUFA) and risk of mortality are conflicting. This study aimed to summarize existing literature regarding the association between MUFA intake and risk of mortality from all causes, cardiovascular diseases (CVDs), and cancer.

Methods: PubMed, Scopus, and ISI Web of Science was systematically searched up to December 2020. Read More

View Article and Full-Text PDF
September 2021

Hippuric acid: Could became a barometer for frailty and geriatric syndromes?

Ageing Res Rev 2021 Sep 21:101466. Epub 2021 Sep 21.

Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy. Electronic address:

Aging is a natural biological event that has some downsides such as increased frailty, decline in cognitive and physical functions leading to chronical diseases, and lower quality of life. There is therefore a pressing need of reliable biomarkers to identify populations at risk of developing age-associated syndromes in order to improve their quality of life, promote healthy ageing and a more appropriate clinical management, when needed. Here we discuss the importance of hippuric acid, an endogenous co-metabolite, as a possible hallmark of human aging and age-related diseases, summarizing the scientific literature over the last years. Read More

View Article and Full-Text PDF
September 2021

Efficacy of hydrophilic resin-based sealant: A systematic review and meta-analysis.

J Dent 2021 Sep 21:103816. Epub 2021 Sep 21.

Restorative Dentistry, Department of Oral Rehabilitation, The Medical University of South Carolina, James B. Edwards College of Dental Medicine, 173 Ashley Avenue, Charleston, SC, 29425, USA. Electronic address:

Objectives: This meta-analysis review aims to answer two questions: 1) What is the effectiveness of hydrophilic resin-based sealant (RBS) in preventing/arresting pits and fissures caries in permanent teeth, and 2) What is the retention rate of a hydrophilic RBS as compared to alternative treatments.

Data: Randomized control trials investigating the efficacy of hydrophilic RBS compared to any other (placebo) treatment for permanent teeth. Outcomes were retention rate and caries prevention/arresting. Read More

View Article and Full-Text PDF
September 2021

Correlations between bone marrow radiation dose and hematologic toxicity in locally advanced cervical cancer patients receiving chemoradiation with cisplatin: a systematic review.

Radiother Oncol 2021 Sep 21. Epub 2021 Sep 21.

Department of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands. Electronic address:

Patients with locally advanced cervical cancer (LACC) treated with chemoradiation often experience hematologic toxicity (HT), as chemoradiation can induce bone marrow (BM) suppression. Studies on the relationship between BM dosimetric parameters and clinically significant HT might provide relevant indices for developing BM-sparing (BMS) radiotherapy techniques. This systematic review studied the relationship between bone marrow dose and HT in LACC-patients treated with primary cisplatin-based chemoradiation. Read More

View Article and Full-Text PDF
September 2021

Laryngeal myasthenia gravis following influenza vaccination: a case report and literature review.

Hum Vaccin Immunother 2021 Sep 24:1-3. Epub 2021 Sep 24.

Department of Neurology, Chengdu Second People's Hospital, Chengdu, Sichuan, China.

Background: Myasthenia gravis (MG) is an autoimmune disease of acquired neuromuscular junction transmission disorder mediated by auto-antibodies. Extranophthalmic muscles are the most susceptible to MG, while the larynx muscle may also be affected. MG can be aggravated by various types of drugs. Read More

View Article and Full-Text PDF
September 2021

Risk prediction models for intensive care unit-acquired weakness in intensive care unit patients: A systematic review.

PLoS One 2021 24;16(9):e0257768. Epub 2021 Sep 24.

Department of Neurosurgery Intensive Care Unit, The First Affiliated Hospital of Wannan Medical College, Wuhu, China.

Background And Objectives: Intensive care unit-acquired weakness (ICU-AW) commonly occurs among intensive care unit (ICU) patients and seriously affects the survival rate and long-term quality of life for patients. In this systematic review, we synthesized the findings of previous studies in order to analyze predictors of ICU-AW and evaluate the discrimination and validity of ICU-AW risk prediction models for ICU patients.

Methods: We searched seven databases published in English and Chinese language to identify studies regarding ICU-AW risk prediction models. Read More

View Article and Full-Text PDF
September 2021

An examination of gender imbalance in Scottish adolescents' vocational interests.

PLoS One 2021 24;16(9):e0257723. Epub 2021 Sep 24.

Department of Experimental Psychology, Ghent University, Ghent, Belgium.

This paper documents Scottish adolescents' vocational interest types. Our research is based on the responses of 1,306 pupils from 18 secondary schools to an empirically verified online interest inventory test. Our results are threefold. Read More

View Article and Full-Text PDF
September 2021

Time Trends in Physical Activity Using Wearable Devices: A Systematic Review and Meta-analysis of Studies from 1995 to 2017.

Med Sci Sports Exerc 2021 Sep 20. Epub 2021 Sep 20.

Department of Kinesiology, Boise State University, Boise, ID Department of Clinical & Applied Movement Sciences, University of North Florida, Jacksonville, FL Department of Kinesiology, Recreation, and Sport Studies, University of Tennessee, Knoxville, TN Department of Food, Nutrition, and Sport Science, University of Gothenburg, Sweden Faculty of Physical Culture, Palacký University, Olomouc, Czech Republic Department of Preventive Medicine and Public Health, Tokyo Medical University, Tokyo, Japan.

Introduction: Conflicting evidence exists on whether physical activity (PA) levels of humans have changed over the last quarter-century. The main objective of this study was to determine if there is evidence of time trends in PA, from cross-sectional studies that assessed PA at different time points using wearable devices (e.g. Read More

View Article and Full-Text PDF
September 2021

Perceptions, experiences, and attitudes of health care professionals regarding the role of librarians in fostering evidence-based health practice: a systematic review protocol.

JBI Evid Synth 2021 Sep 24. Epub 2021 Sep 24.

Kenneth Dike Library, University of Ibadan, Oyo State, Nigeria Sir Albert Cook Library, College of Health Sciences, Makerere University, Kampala, Uganda University of Witwatersrand Health Science Library, Johannesburg, South Africa University of Malawi College of Medicine Library, Blantyre, Malawi Queen's University Library, Queens University, Kingston, ON, Canada School of Nursing, Faculty of Health Sciences, Queens University, Kingston, Ontario, Canada Queen's Collaboration for Health Care Quality: A JBI Centre of Excellence, Kingston, ON, Canada.

Objective: The objective of this systematic review is to explore perceptions, experiences, and attitudes of health care professionals in teaching hospitals, academic health science centers, and health care professional colleges regarding the role of librarians in fostering the production of evidence-based research.

Introduction: Evidence-based health practice entails the use of the best research evidence, combined with knowledge and information gained through professional expertise as a practicing clinician, and consideration of patients' concerns and preferences to make the best possible decision for the care provided to those patients. With their extensive skills in literature searching, librarians and other information professionals contribute to the process of evidence-based health practice by locating and retrieving the most relevant information for clinical practice. Read More

View Article and Full-Text PDF
September 2021

Multipolar Force Fields for Amide-I Spectroscopy from Conformational Dynamics of the Alanine Trimer.

J Phys Chem B 2021 Sep 24. Epub 2021 Sep 24.

Department of Chemistry, University of Basel, Klingelbergstrasse 80, Basel 4056, Switzerland.

The dynamics and spectroscopy of -methyl-acetamide (NMA) and trialanine in solution are characterized from molecular dynamics simulations using different energy functions, including a conventional point charge (PC)-based force field, one based on a multipolar (MTP) representation of the electrostatics, and a semiempirical DFT method. For the 1D infrared spectra, the frequency splitting between the two amide-I groups is 10 cm from the PC, 13 cm from the MTP, and 47 cm from self-consistent charge density functional tight-binding (SCC-DFTB) simulations, compared with 25 cm from experiment. The frequency trajectory required for the frequency fluctuation correlation function (FFCF) is determined from individual normal mode (INM) and full normal mode (FNM) analyses of the amide-I vibrations. Read More

View Article and Full-Text PDF
September 2021

Clinical aspects of SARS-CoV-2 infection and vitamin D : COVID-19 and the endocrine system: special issue for reviews in endocrine and metabolic disorders (Felipe Casaneuva, Editor in Chief) A. Giustina and JP Bilezikian, Guest Editors.

Rev Endocr Metab Disord 2021 Sep 24. Epub 2021 Sep 24.

School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.

In December 2019, the first cases of severe acute respiratory syndrome due to a new coronavirus (SARS-Cov-2), later designated as Covid-19, were described in China. With rapid advance of the infection to several continents, in March 2020, WHO declared this to be a pandemic. In April 2020, the first papers suggesting a possible role of Vitamin D deficiency in the severity of this infection began to appear and dozens of articles evaluating a potential relationship of vitamin D with COVID have emerged subsequntly. Read More

View Article and Full-Text PDF
September 2021

Thirty years of teaching evidence-based medicine: have we been getting it all wrong?

Adv Health Sci Educ Theory Pract 2021 Sep 24. Epub 2021 Sep 24.

Department of Medicine, McMaster University, Hamilton, Canada.

Evidence based medicine (EBM) has been synonymous to delivery of quality care for almost thirty years. Since the movement's inception, the assumption has been that decisions based on high quality evidence would translate to better care for patients. Despite EBM's many attractive features and the substantive attention it has received in the contemporary clinical and medical education literature, how it is defined and operationalized as a component of training is often unclear and problematic. Read More

View Article and Full-Text PDF
September 2021

Does drainage or resection predict subsequent interventions and long-term quality of life in patients with Grade IV pancreatic injuries: A population-based analysis.

J Trauma Acute Care Surg 2021 Oct;91(4):708-715

From the Department of Surgery (C.G.B., A.W.K.), University of Calgary, Calgary, Alberta, Canada; Department of Surgery (W.L.B.), Scripps Clinic Medical Group, La Jolla, California; Department of Surgery (S.M.H.), University of British Columbia, Vancouver, BC, Canada; Department of Surgery (K.V., N.G.P.), Western University, London, Ontario, Canada; and Department of Surgery (M.K.), Cook County Hospital, Chicago, Illinois.

Background: Clinical equipoise remains significant for the treatment of Grade IV pancreatic injuries in stable patients (i.e., drainage vs. Read More

View Article and Full-Text PDF
October 2021

Effectiveness of empowerment-based intervention on HbA1c and self-efficacy among cases with type 2 diabetes mellitus: A meta-analysis of randomized controlled trials.

Medicine (Baltimore) 2021 Sep;100(38):e27353

Department of Endocrinology, Tianjin Medical University Hospital for Metabolic Diseases, Tianjin, China.

Objective: The aim of this study was to determine the effect of empowerment-based interventions on glucose metabolism control and psychosocial self-efficacy in people with type 2 diabetes mellitus (T2DM).

Methods: The Cochrane Library, Embase, PubMed, and Web of Science electronic databases were searched up to 22 February 2021 for randomized controlled trials (RCTs) that evaluated the effectiveness of empowerment-based intervention versus conventional treatment in type 2 diabetes cases. At least two investigators independently screened the literature, extracted data and evaluated the methodological quality. Read More

View Article and Full-Text PDF
September 2021

Acupuncture treatment of glaucoma based on radar plots: A protocol for an overview of systematic reviews.

Medicine (Baltimore) 2021 Sep;100(38):e27261

College of Acupuncture, Massage and Rehabilitation, Yunnan University of Chinese Medicine, Kunming, Yunnan Province, China.

Background: Glaucoma is the second most blinding eye disease in the world. Currently, lowering the intraocular pressure through various methods is the main treatment of glaucoma. Acupuncture has been effectively and safely used in the treatment of glaucoma. Read More

View Article and Full-Text PDF
September 2021

Longitudinal Neurocognitive and Pulmonological Profile of Long Covid: the COVIMMUNE-Clin Study Protocol.

JMIR Res Protoc 2021 Sep 8. Epub 2021 Sep 8.

Department of Neurodegenerative Diseases and Gerontopsychiatry, University of Bonn Medical Center, Bonn, DE.

Background: There is a dearth of information about "brain fog", concentration, word-finding or memory problems associated with the new World Health Organization provisional classification "U09.9 Post-COVID-19 Condition." Beyond this, the extent to which these symptoms may be associated with neurological, pulmonary or psychiatric difficulties is unclear. Read More

View Article and Full-Text PDF
September 2021

Quarantine: use with care.

Authors:
Steve Kisely

BJPsych Open 2021 Sep 24;7(5):e178. Epub 2021 Sep 24.

This editorial discusses the psychological effects of isolation and quarantine in terms of both the SARS-CoV-2 (COVID-19) pandemic and previous epidemics in the past 20 years. Although much of the literature is based on healthcare settings, there is emerging evidence from home or hotel quarantine, particularly concerning international travellers. Regardless of setting, depression, anxiety, anger and stress-related disorders are especially common but can vary according to demographic features and the characteristics of quarantine. Read More

View Article and Full-Text PDF
September 2021

Epidemiology and antibiotic susceptibility in anaerobic bacteraemia: a 15-year retrospective study in South-Eastern Hungary.

Infect Dis (Lond) 2021 Sep 24:1-10. Epub 2021 Sep 24.

Institute of Clinical Microbiology, University of Szeged, Szeged, Hungary.

Introduction: Bloodstream infections are considered as important factors of morbidity and represent a remarkable number of death, especially in developed countries.

Methods: In a 15-year retrospective study in the South-Eastern region of Hungary, the microbiological results of anaerobic blood culture (BC) bottles were analysed. The incubation of BCs was performed in the automated incubation system, and the isolates were cultured in an anaerobic chamber. Read More

View Article and Full-Text PDF
September 2021

Stakeholder perceptions about Group B Streptococcus disease and potential for maternal vaccination in low and middle-income countries.

Clin Infect Dis 2021 Sep 24. Epub 2021 Sep 24.

Department of Immunization, Vaccines and Biologicals, World Health Organization, Geneva, Switzerland.

Background: To inform WHO's full value of vaccines assessment for Group B Streptococcus (GBS) vaccines, a rapid literature appraisal was conducted to inform the operationalisation of maternal GBS vaccination. We found limited published information on stakeholder perceptions on the public health importance of GBS disease and vaccination and therefore undertook a multi-country survey.

Methods: A survey was conducted in late 2019 to collect information on stakeholders' awareness of GBS disease, and the priority accorded to vaccination. Read More

View Article and Full-Text PDF
September 2021

Time-to-enrollment in clinical trials investigating neurological recovery in chronic spinal cord injury: observations from a systematic review and ClinicalTrials.gov database.

Neural Regen Res 2022 May;17(5):953-958

Mayo Clinic Neuro-Informatics Laboratory; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA.

Currently, large numbers of clinical trials are performed to investigate different forms of experimental therapy for patients suffering from chronic spinal cord injury (SCI). However, for the enrollment process, there are different views on how the time period between injury and interventions should be determined. Herein, we sought to evaluate the impact of time-to-enrollment in chronic SCI clinical trials. Read More

View Article and Full-Text PDF

Nursing Presence in Pediatric Oncology: A Scoping Review.

J Pediatr Oncol Nurs 2021 Sep 24:10434542211041939. Epub 2021 Sep 24.

7235College of Nursing, University of Saskatchewan, Saskatoon, Canada.

Nursing presence creates meaningful and trusting relationships that facilitate healing for the patient and enhances the nurse's clinical experience. Although nursing presence has been linked to better health outcomes especially in chronic illnesses and end-of-life, little is known about its contribution in pediatric oncology. The purpose of this scoping review was to explore how nursing presence is understood and expressed in pediatric oncology. Read More

View Article and Full-Text PDF
September 2021

Proton therapy for prostate cancer: current state and future perspectives.

Br J Radiol 2021 Sep 24:20210670. Epub 2021 Sep 24.

Department of Radiation Oncology, New Taipei Municipal TuCheng Hospital, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.

Objective: Localized prostate cancer can be treated with several radiotherapeutic approaches. Proton therapy (PT) can precisely target tumors, thus sparing normal tissues and reducing side-effects without sacrificing cancer control. However, PT is a costly treatment compared with conventional photon radiotherapy, which may undermine its overall efficacy. Read More

View Article and Full-Text PDF
September 2021

A Consensus Statement on the use of Botulinum Toxin in Pediatric Patients.

PM R 2021 Sep 23. Epub 2021 Sep 23.

Children's Mercy, Kansas City, Missouri.

Botulinum Toxin has been used in medicine for the past 30 years. However, there continues to be controversy about appropriate uses and dosing, especially in the pediatric population. A panel of nine pediatric physiatrists from different regions and previous training programs in the United States were nominated based on institutional reputation and Botulinum Toxin (BoNT) experience. Read More

View Article and Full-Text PDF
September 2021

Is organic chemistry really growing exponentially?

Angew Chem Int Ed Engl 2021 Sep 23. Epub 2021 Sep 23.

Ulsan National Institute of Science and Technology, Chemistry, IBS Center for Soft and Living Matter, Advanced Materials Research Bldg. (#103), Rm.313, 50, UNIST-gil, 44919, Ulsan, KOREA, REPUBLIC OF.

In terms of molecules and specific reaction examples reported in the literature, organic chemistry features an impressive, exponential growth. However, new reaction classes/types that fuel this growth are being discovered at a much slower and only linear (or even sublinear) rate. In effect, the proportion of newly discovered reaction types to all reactions being performed keeps decreasing, suggesting that synthetic chemistry becomes more reliant on reusing the well-known methods. Read More

View Article and Full-Text PDF
September 2021

Facilitators, barriers and considerations for the implementation of healthcare innovation: A qualitative rapid systematic review.

Health Soc Care Community 2021 Sep 23. Epub 2021 Sep 23.

Department of Family Medicine, University of Alberta, Edmonton, Alberta, Canada.

Family caregiving scholars recommend that health providers receive competency-based education to partner with and support family caregivers to care and to maintain their own health. While it may be relatively easy to develop competency-based education for healthcare providers, ensuring widespread uptake and spread and scale of healthcare education is critical to ensuring consistent person-centered support for all family caregivers (FCGs) throughout the care trajectory. The development of novel healthcare innovations requires implementation strategies for uptake and spread, with implementation involving the use of strategies to integrate a novel innovation into healthcare. Read More

View Article and Full-Text PDF
September 2021

Toward more specific inhibitor for Solanum tuberosum polyphenol oxidase through a structural insight into its activities and inhibition.

J Food Biochem 2021 Sep 24:e13949. Epub 2021 Sep 24.

National Institute for Genetic Engineering and Biotechnology, Tehran, Iran.

To prevent enzymatic browning, applying a polyphenol oxidase (PPO) inhibitor is more desirable, especially when the freshness of the product matters. Most of the inhibition studies were done on mushroom tyrosinase (MT) while the literature indicates that MT and PPO of Solanum tuberosum (PPO ) respond differently to the same modulator despite their similar active sites. This research was conducted to deepen our knowledge about PPO and introduce a more specific inhibitor for this enzyme to be used in controlling the enzymatic browning of potatoes. Read More

View Article and Full-Text PDF
September 2021