50 results match your criteria litcovid data


COVID-19-Associated Acute Disseminated Encephalomyelitis: A Systematic Review.

Asian J Neurosurg 2021 Jul-Sep;16(3):457-469. Epub 2021 Sep 14.

Department of Neurology, King Edward Memorial Hospital, Pune, Maharashtra, India.

Objective: The objective of this study was to provide an overview of acute disseminating encephalomyelitis, a potential and serious complication of COVID-19.

Methods: Three primary databases were used, PubMed, LitCovid, and WHO. The final review articles reported acute disseminated encephalomyelitis (ADEM) in COVID-19-positive patients and were full-text, peer-reviewed articles. Read More

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September 2021

LitCovid-AGAC: cellular and molecular level annotation data set based on COVID-19.

Genomics Inform 2021 Sep 30;19(3):e23. Epub 2021 Sep 30.

Hubei Key Lab of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, 430070 Wuhan, China.

Currently, coronavirus disease 2019 (COVID-19) literature has been increasing dramatically, and the increased text amount make it possible to perform large scale text mining and knowledge discovery. Therefore, curation of these texts becomes a crucial issue for Bio-medical Natural Language Processing (BioNLP) community, so as to retrieve the important information about the mechanism of COVID-19. PubAnnotation is an aligned annotation system which provides an efficient platform for biological curators to upload their annotations or merge other external annotations. Read More

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September 2021

The impact of COVID-19 first wave national lockdowns on perinatal outcomes: a rapid review and meta-analysis.

BMC Pregnancy Childbirth 2021 Oct 6;21(1):676. Epub 2021 Oct 6.

College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.

Background: Since the emergence of COVID-19, preventative public health measures, including lockdown strategies, were declared in most countries to control viral transmission. Recent studies and anecdotes have reported changes in the prevalence of perinatal outcomes during national COVID-19lockdowns.The objective of this rapid review was to evaluate the impact of COVID-19 lockdowns on the incidence of low birth weight (LBW), preterm birth (PTB), and stillbirth. Read More

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October 2021

A scoping review of patient engagement activities during COVID-19: More consultation, less partnership.

PLoS One 2021 29;16(9):e0257880. Epub 2021 Sep 29.

Institute for Better Health, Trillium Health Partners, Mississauga, Ontario, Canada.

Background: The COVID-19 pandemic has had a devastating impact on healthcare systems and care delivery, changing the context for patient and family engagement activities. Given the critical contribution of such activities in achieving health system quality goals, we undertook to address the question: What is known about work that has been done on patient engagement activities during the pandemic?

Objective: To examine peer-reviewed and grey literature to identify the range of patient engagement activities, broadly defined (inclusive of engagement to support clinical care to partnerships in decision-making), occurring within health systems internationally during the first six months of the COVID-19 pandemic, as well as key barriers and facilitators for sustaining patient engagement activities during the pandemic.

Methods: The following databases were searched: Medline, Embase and LitCOVID; a search for grey literature focused on the websites of professional organizations. Read More

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October 2021

Acute Myocardial Infarction and Myocarditis following COVID-19 Vaccination.

QJM 2021 Sep 29. Epub 2021 Sep 29.

Department of Cardiology, National University Heart Centre, Singapore.

Background: Emerging reports raise concerns on the potential association between the COVID-19 vaccines and cardiac manifestations. We sought to evaluate cardiac complications associated with COVID-19 vaccination in a pooled analysis from our institution's cohort study and systematic review.

Methods: Consecutive patients admitted in a tertiary hospital in Singapore between 1 January 2021 and 31 March 2021, with onset of cardiac manifestations within 14 days following COVID-19 vaccination were studied. Read More

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September 2021

More than 50 long-term effects of COVID-19: a systematic review and meta-analysis.

Sci Rep 2021 08 9;11(1):16144. Epub 2021 Aug 9.

Department of Neurosurgery, Center for Neuroregeneration, Houston Methodist Research Institute, 6670 Bertnet Avenue, Houston, TX, 77030, USA.

COVID-19 can involve persistence, sequelae, and other medical complications that last weeks to months after initial recovery. This systematic review and meta-analysis aims to identify studies assessing the long-term effects of COVID-19. LitCOVID and Embase were searched to identify articles with original data published before the 1st of January 2021, with a minimum of 100 patients. Read More

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Association Between Mood Disorders and Risk of COVID-19 Infection, Hospitalization, and Death: A Systematic Review and Meta-analysis.

JAMA Psychiatry 2021 10;78(10):1079-1091

Mood Disorders Psychopharmacology Unit, Poul Hansen Family Centre for Depression, University Health Network, Toronto, Ontario, Canada.

Importance: Preexisting noncommunicable diseases (eg, diabetes) increase the risk of COVID-19 infection, hospitalization, and death. Mood disorders are associated with impaired immune function and social determinants that increase the risk of COVID-19. Determining whether preexisting mood disorders represent a risk of COVID-19 would inform public health priorities. Read More

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October 2021

RENET2: high-performance full-text gene-disease relation extraction with iterative training data expansion.

NAR Genom Bioinform 2021 Sep 5;3(3):lqab062. Epub 2021 Jul 5.

Department of Computer Science, The University of Hong Kong, Hong Kong, 999077, China.

Relation extraction (RE) is a fundamental task for extracting gene-disease associations from biomedical text. Many state-of-the-art tools have limited capacity, as they can extract gene-disease associations only from single sentences or abstract texts. A few studies have explored extracting gene-disease associations from full-text articles, but there exists a large room for improvements. Read More

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September 2021

COVID-19 in pregnancy: the foetal perspective-a systematic review.

BMJ Paediatr Open 2020 25;4(1):e000859. Epub 2020 Nov 25.

Paediatrics, Ras Al Khaimah Medical and Health Sciences University, Ras Al Khaimah, UAE.

Objective: We aimed to conduct a systematic review of the available literature to determine the effects of confirmed cases of COVID-19 in pregnant women from the foetal perspective by estimation of mother to child transmission, perinatal outcome and possible teratogenicity.

Methods: Data sources: eligible studies between 1 November 2019 and 10 August 2020 were retrieved from PubMed, Embase, LitCovid, Google Scholar, EBSCO MEDLINE, CENTRAL, CINAHL, MedRXiv, BioRXiv and Scopus collection databases. English language case reports, case series and cohort studies of SARS-CoV-2 confirmed pregnant women with data on perinatal outcome, congenital anomalies and mother to child transmission were analysed. Read More

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November 2020

SARS-CoV-2 and the role of fomite transmission: a systematic review.

F1000Res 2021 24;10:233. Epub 2021 Mar 24.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, OX2 6GG, UK.

SARS-CoV-2 RNA has been detected in fomites which suggests the virus could be transmitted via inanimate objects. However, there is uncertainty about the mechanistic pathway for such transmissions. Our objective was to identify, appraise and summarise the evidence from primary studies and systematic reviews assessing the role of fomites in transmission. Read More

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The application of artificial intelligence and data integration in COVID-19 studies: a scoping review.

J Am Med Inform Assoc 2021 08;28(9):2050-2067

Department of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, Florida, USA.

Objective: To summarize how artificial intelligence (AI) is being applied in COVID-19 research and determine whether these AI applications integrated heterogenous data from different sources for modeling.

Materials And Methods: We searched 2 major COVID-19 literature databases, the National Institutes of Health's LitCovid and the World Health Organization's COVID-19 database on March 9, 2021. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline, 2 reviewers independently reviewed all the articles in 2 rounds of screening. Read More

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Clinical Management of COVID-19: A Review of Pharmacological Treatment Options.

Pharmaceuticals (Basel) 2021 May 28;14(6). Epub 2021 May 28.

Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Campbell University, Buies Creek, NC 27501, USA.

Since the outbreak and subsequent declaration of COVID-19 as a global pandemic in March 2020, concerted efforts have been applied by the scientific community to curtail the spread of the disease and find a cure. While vaccines constitute a vital part of the public health strategy to reduce the burden of COVID-19, the management of this disease will continue to rely heavily on pharmacotherapy. This study aims to provide an updated review of pharmacological agents that have been developed and/or repurposed for the treatment of COVID-19. Read More

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[Implications on the scientific production of COVID-19.]

Rev Esp Salud Publica 2021 May 27;95. Epub 2021 May 27.

Biblioteca Nacional de Ciencias de la Salud. Instituto de Salud Carlos III. Madrid. España.

The impact and the universality of the pandemic by SARS-CoV-2 has caused the need to have information quickly and accessible for the benefit of decision-making among healthcare professionals. In 10 months the scientific production on this new coronavirus has exceeded the number of 66 thousand articles, according to the LitCovid database, created by the National Library of Medicine, doubling and tripling every few weeks. This same urgency has characterized some of the main features of this voluminous production, in addition to its continuous and exponential growth, such as greater dissemination in open access and preprint repositories, a certain acceleration in the manuscript review process by editorials and an abundance of opinion articles, recommendations or comments compared to a smaller number of original articles with clinical data from large groups of patients. Read More

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Evidence of integrated health service delivery during COVID-19 in low and lower-middle-income countries: protocol for a scoping review.

BMJ Open 2021 05 3;11(5):e042872. Epub 2021 May 3.

International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.

Introduction: The importance of integrated, people-centred health systems has been recognised as a central component of Universal Health Coverage. Integration has also been highlighted as a critical element for building resilient health systems that can withstand the shock of health emergencies. However, there is a dearth of research and systematic synthesis of evidence on the synergistic relationship between integrated health services and pandemic preparedness, response, and recovery in low-income and lower-middle-income countries (LMICs). Read More

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Modelling the Anatomic Distribution of Neurologic Events in Patients with COVID-19: A Systematic Review of MRI Findings.

AJNR Am J Neuroradiol 2021 07 22;42(7):1190-1195. Epub 2021 Apr 22.

Department of Health Sciences (G.R.P.), Mary Mackillop Institute for Health Research, Australian Catholic University, Melbourne, Australia.

Background: Neurologic events have been reported in patients with coronavirus disease 2019 (COVID-19). However, a model-based evaluation of the spatial distribution of these events is lacking.

Purpose: Our aim was to quantitatively evaluate whether a network diffusion model can explain the spread of small neurologic events. Read More

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COVID-19 and emerging spinal cord complications: A systematic review.

Mult Scler Relat Disord 2021 Jun 21;51:102917. Epub 2021 Mar 21.

Department of Neurology, University Hospital "12 de Octubre",Madrid, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain; Department of Medicine, Complutense University, Madrid, Spain. Electronic address:

Background: Spinal cord complications associated with coronavirus infectious disease of 2019 (COVID-19) are being widely reported. The purpose of this systematic review was to summarize so far available pieces of evidence documenting de novo novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) mediated spinal cord demyelinating diseases. Indeed, the spinal demyelinating disorders that have been reported in those patients who have suffered from COVID-19 rather than on the people already living with diagnosed or undiagnosed primary demyelinating disorders. Read More

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Families With Children With Neurodevelopmental Disorders During COVID-19: A Scoping Review.

J Pediatr Psychol 2021 06;46(5):514-525

Department of Paediatrics, Khoo Teck Puat-National University Children's Medical Institute (KTP-NUCMI), National University Hospital.

Objective: Prolonged home isolation may lead to long-term negative consequences for both children and caregivers' psychological wellbeing, especially in families with children with neurodevelopmental disorders. Therefore, a scoping review was conducted to identify challenges faced by caregivers of children with neurodevelopmental disorders during the coronavirus disease 2019 (COVID-19) pandemic and to consolidate parenting interventions and guidelines.

Methods: A systematic search was conducted on Embase, PsycInfo, PubMed, Scopus, and LitCovid. Read More

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Direct and indirect evidence of efficacy and safety of rapid exercise tests for exertional desaturation in Covid-19: a rapid systematic review.

Syst Rev 2021 03 16;10(1):77. Epub 2021 Mar 16.

Department of Primary Health Care Sciences, University of Oxford, Oxford, UK.

Background: Even when resting pulse oximetry is normal in the patient with acute Covid-19, hypoxia can manifest on exertion. We summarise the literature on the performance of different rapid tests for exertional desaturation and draw on this evidence base to provide guidance in the context of acute Covid-19.

Main Research Questions: 1. Read More

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Coronavirus disease-19: The multi-level, multi-faceted vasculopathy.

Atherosclerosis 2021 04 15;322:39-50. Epub 2021 Feb 15.

Discipline of Cardiology, Faculty of Medical Science - State University of Campinas - UNICAMP, Campinas, São Paulo, Brazil. Electronic address:

Background And Aims: The new coronavirus disease (COVID-19) is a systemic disease. Mounting evidence depict signs and symptoms involving multiple organs, most of which supported by pathological data. A plausible link to these manifestations is vascular and endothelial dysfunction/damage. Read More

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More Than 50 Long-Term Effects of COVID-19: A Systematic Review and Meta-Analysis.

Res Sq 2021 Mar 1. Epub 2021 Mar 1.

Houston Methodist Research Institute.

COVID-19, caused by SARS-CoV-2, can involve sequelae and other medical complications that last weeks to months after initial recovery, which has come to be called Long-COVID or COVID long-haulers. This systematic review and meta-analysis aims to identify studies assessing long-term effects of COVID-19 and estimates the prevalence of each symptom, sign, or laboratory parameter of patients at a post-COVID-19 stage. . Read More

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Effects of the COVID-19 pandemic on chronic pain in Spain: a scoping review.

Pain Rep 2021 Jan-Feb;6(1):e899. Epub 2021 Feb 16.

Brain and Pain (BaP) Lab, Faculty of Psychology, Department of Clinical Psychology and Psychobiology, University of Santiago de Compostela, Santiago de Compostela, Spain.

The COVID-19 outbreak has been a great challenge in the management of chronic pain patients. We have conducted a rapid scoping review to assess the impact of the pandemic (and the associated public health measures) on the health status and management practices of chronic pain patients in Spain. To this end, we performed a bibliographic search in LitCOVID and PubMed, and reviewed official websites and documents, and expert reports. Read More

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February 2021

Prognostic Value of Serum Procalcitonin in COVID-19 Patients: A Systematic Review.

Indian J Crit Care Med 2021 Jan;25(1):77-84

Department of Pathology and Laboratory Medicine, The Aga Khan University, Karachi, Pakistan.

Background: This study is aimed at reviewing the published literature on the prognostic role of serum procalcitonin (PCT) in COVID-19 cases.

Data Retrieval: We systematically reviewed the literature available on PubMed, MEDLINE, LitCovid NLM, and WHO: to assess the utility of PCT in prognosis of coronavirus disease. Scrutiny for eligible studies comprising articles that have evaluated the prognostic utility of PCT and data compilation was undertaken by two separate investigators. Read More

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January 2021

More than 50 Long-term effects of COVID-19: a systematic review and meta-analysis.

medRxiv 2021 Jan 30. Epub 2021 Jan 30.

Department of Neurosurgery, Center for Neuroregeneration, Houston Methodist Research Institute, Houston, Texas, USA.

COVID-19, caused by SARS-CoV-2, can involve sequelae and other medical complications that last weeks to months after initial recovery, which has come to be called Long-COVID or COVID long-haulers. This systematic review and meta-analysis aims to identify studies assessing long-term effects of COVID-19 and estimates the prevalence of each symptom, sign, or laboratory parameter of patients at a post-COVID-19 stage. LitCOVID (PubMed and Medline) and Embase were searched by two independent researchers. Read More

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January 2021

The nurse COVID and historical epidemics literature repository: Development, description, and summary.

Nurs Outlook 2021 May-Jun;69(3):257-264. Epub 2021 Jan 30.

Division of Patient Care Services, Children's Hospital Colorado, Aurora, CO; University of Colorado College of Nursing, CU Anschutz, Aurora, CO.

Background: During COVID-19, a Kaggle challenge was issued to data scientists to leverage text mining to provide high-level summaries of full-text articles in the COVID-19 Open Research Dataset (CORD-19) data set, a data set containing articles around COVID-19 and other epidemics. A question was asked: "What if nursing had something similar?"

Purpose: Describe the development and function of the Nursing COVID and Historical Epidemic Literature and describe high-level summaries of abstracts within the repository.

Method: Nurse-specific literature was abstracted from two data sets: CORD-19 and LitCOVID. Read More

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Universal screening for SARS-CoV-2 infection: a rapid review.

Cochrane Database Syst Rev 2020 09 15;9:CD013718. Epub 2020 Sep 15.

Cochrane Austria, Department for Evidence-based Medicine and Evaluation, Danube University Krems, Krems, Austria.

Background: Coronavirus disease 2019 (COVID-19) is caused by the novel betacoronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Most people infected with SARS-CoV-2 have mild disease with unspecific symptoms, but about 5% become critically ill with respiratory failure, septic shock and multiple organ failure. An unknown proportion of infected individuals never experience COVID-19 symptoms although they are infectious, that is, they remain asymptomatic. Read More

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September 2020

Potential beneficial role of probiotics on the outcome of COVID-19 patients: An evolving perspective.

Diabetes Metab Syndr 2021 Jan-Feb;15(1):295-301. Epub 2021 Jan 13.

Department of Biomedical Sciences and Human Oncology - Section of Pharmacology, Medical School, University of Bari "Aldo Moro", Policlinico University Hospital of Bari, p.zza G. Cesare 11, 70124, Bari, Italy.

Background And Aims: Probiotics can support the body's systems in fighting viral infections. This review is aimed to focus current knowledge about the use of probiotics as adjuvant therapy for COVID-19 patients.

Methods: We performed an extensive research using the PubMed-LitCovid, Cochrane Library, Embase databases, and conducting manual searches on Google Scholar, Elsevier Connect, Web of Science about this issue. Read More

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Emerging Evidence on Multisystem Inflammatory Syndrome in Children Associated with SARS-CoV-2 Infection: a Systematic Review with Meta-analysis.

SN Compr Clin Med 2021 Jan 7:1-10. Epub 2021 Jan 7.

Department of Pediatrics, University of Iowa Carver College of Medicine, 2720 Stone Park Blvd, Sioux City, IA 51104 USA.

With the increased spread of severe acute respiratory syndrome coronavirus 2 infection, more patients with multisystem inflammatory syndrome in children (MIS-C) are being reported worldwide. This systematic review with meta-analysis aims to analyse the clinical features, proposed pathogenesis and current treatment options for effective management of children with this novel entity. Electronic databases (Medline, Google Scholar, WHO, CDC, UK National Health Service, LitCovid, and other databases with unpublished pre-prints) were extensively searched, and all articles on MIS-C published from January 1, 2020, to October 10, 2020, were retrieved. Read More

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January 2021

Clinical Characteristics, Treatment, and Outcomes of Critically Ill Patients With COVID-19: A Scoping Review.

Mayo Clin Proc 2021 01 26;96(1):183-202. Epub 2020 Oct 26.

Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN.

A growing number of studies on coronavirus disease 2019 (COVID-19) are becoming available, but a synthesis of available data focusing on the critically ill population has not been conducted. We performed a scoping review to synthesize clinical characteristics, treatment, and clinical outcomes among critically ill patients with COVID-19. Between January 1, 2020, and May 15, 2020, we identified high-quality clinical studies describing critically ill patients with a sample size of greater than 20 patients by performing daily searches of the World Health Organization and LitCovid databases on COVID-19. Read More

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January 2021

A rapid review of the pathoetiology, presentation, and management of delirium in adults with COVID-19.

J Psychosom Res 2021 02 25;141:110350. Epub 2020 Dec 25.

Department of Psychiatry, University of Toronto, Toronto, Canada; Centre for Mental Health, University Health Network, Toronto, Canada.

Background COVID-19 causes significant morbidity and mortality. Despite the high prevalence of delirium and delirium-related symptoms in COVID-19 patients, data and evidence-based recommendations on the pathophysiology and management of delirium are limited. Objective We conducted a rapid review of COVID-19-related delirium literature to provide a synthesis of literature on the prevalence, pathoetiology, and management of delirium in these patients. Read More

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February 2021

Meningoencephalitis associated with COVID-19: a systematic review.

J Neurovirol 2021 02 26;27(1):12-25. Epub 2020 Dec 26.

Bangur Institute of Neurosciences, Institute of Post Graduate Medical Education and Research, SSKM Hospital, Kolkata, India.

With the growing number of COVID-19 cases in recent times. significant set of patients with extra pulmonary symptoms has been reported worldwide. Here we venture out to summarize the clinical profile, investigations, and radiological findings among patients with SARS-CoV-2-associated meningoencephalitis in the form of a systemic review. Read More

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February 2021