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Bicruciate retaining total knee arthroplasty : results throughout history.

Acta Orthop Belg 2021 Mar;87(1):73-83

Approximately 20% amongst patients are dissatisfied after total knee arthroplasty (TKA). Bicruciate retaining (BCR) TKA offers superior knee kinematics and proprioception, but many surgeons abandoned its use because of complications and technical difficulties. Recently, two new BCR implant designs were introduced : Vanguard XP (Zimmer Biomet) and Journey XR (Smith&Nephew). Read More

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Pain, Goal Engagement, and Eudaemonic Well-Being: Moderation by Autonomous Motivation.

J Gerontol B Psychol Sci Soc Sci 2021 Jun 15. Epub 2021 Jun 15.

Department of Internal Medicine, Vanderbilt University School of Medicine.

Objectives: Pain may decrease well-being in older adults by limiting social and leisure activities. However, some activities can exacerbate pain. We hypothesized that autonomously motivated goal engagement could ameliorate negative effects of pain on goal engagement and amplify positive effects of goal engagement on eudaemonic well-being (EWB). Read More

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A comparative study of the efficiency and safety of chemotherapy as a therapeutic method for recurrent or resistant gestational trophoblastic neoplasia: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jun;100(24):e26263

Department of Obstetrics and Gynecology, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China.

Background: Gestational trophoblastic neoplasia (GTN) is an infrequent spectrum of placental malignant cases. Generally, single-agent or multiple-agent chemotherapy is used to treat the condition. The condition has a significant impact on women in the childbearing age, which makes post-chemo fertility and obstetrical results a significant contemplation. Read More

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Safety of COVID-19 vaccines, their components or their platforms for pregnant women: A rapid review.

medRxiv 2021 Jun 6. Epub 2021 Jun 6.

Background: Pregnant women with COVID-19 are at an increased risk of severe COVID-19 illness as well as adverse pregnancy and birth outcomes. Many countries are vaccinating or considering vaccinating pregnant women with limited available data about the safety of this strategy. Early identification of safety concerns of COVID-19 vaccines, including their components, or their technological platforms is therefore urgently needed. Read More

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Monoclonal B lymphocytosis in a kidney transplant recipient.

BMJ Case Rep 2021 Jun 14;14(6). Epub 2021 Jun 14.

Department of Surgical, Medical, Dental and Morphological Sciences, Università degli Studi di Modena e Reggio Emilia, Modena, Emilia-Romagna, Italy.

Monoclonal B lymphocytosis (MBL) is a lymphoproliferative condition characterised by expansion of a B-cell clone in peripheral blood, with an often indolent clinical course. The presence of a B clonal population alone is several hundred times more common in the general population than chronic lymphocytic leukaemia and other non-Hodgkin's lymphoma subtypes, it usually does not represent a malignant condition and it requires follow-up only, without specific treatment. There are few studies describing MBL in solid organ transplant recipients, thus, the concern is raised when enrolling MBL affected subjects in waiting lists. Read More

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Primary care professionals' attitudes towards digital health interventions for common mental disorders: study protocol for a mixed methods systematic review.

BMJ Open 2021 06 14;11(6):e045657. Epub 2021 Jun 14.

Institute of General Practice, University of Frankfurt, Frankfurt am Main, Germany

Introduction: Mental disorders such as depression are common, and an estimated 264 million people are affected by them throughout the world. In recent years, studies on digital health interventions to treat mental disorders have shown evidence of their efficacy, and interest in using them has increased as a result. In the primary care setting, depression and anxiety are the two most frequently diagnosed and treated mental disorders. Read More

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Pelvic Floor Physical Therapy for Pelvic Floor Hypertonicity: A Systematic Review of Treatment Efficacy.

Sex Med Rev 2021 Jun 11. Epub 2021 Jun 11.

Amsterdam University Medical Centers, University of Amsterdam, Department of Sexology and Psychosomatic Gynaecology, The Netherlands.

Introduction: Hypertonicity of the pelvic floor (PFH) is a disabling condition with urological, gynecological and gastrointestinal symptoms, sexual problems and chronic pelvic pain, impacting quality of life. Pelvic floor physical therapy (PFPT) is a first-line intervention, yet no systematic review on the efficacy of PFPT for the treatment of PFH has been conducted.

Objectives: To systematically appraise the current literature on efficacy of PFPT modalities related to PFH. Read More

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Designing centralized waiting lists for attachment to a primary care provider: Considerations from a logic analysis.

Eval Program Plann 2021 May 29:101962. Epub 2021 May 29.

Departments of Family Medicine and Public Health Sciences, Queen's University, CTAQ Chair in Applied Health Economics/Health Policy, Centre for Health Services and Policy Research, Centre for Studies in Primary Care, Institute for Clinical Evaluative Sciences, Kingston, ON, Canada.

Access to a regular primary care provider is essential to quality care. In Canada, where 15 % of patients are unattached (i.e. Read More

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Surgery school-who, what, when, and how: results of a national survey of multidisciplinary teams delivering group preoperative education.

Perioper Med (Lond) 2021 Jun 15;10(1):20. Epub 2021 Jun 15.

Manchester University NHS Foundation Trust, Manchester, UK.

Background: Group education is increasing in popularity as a means of preparing patients for surgery. In recent years, these 'surgery schools' have evolved from primarily informing patients of what to expect before and after surgery, to providing support and encouragement for patients to 'prehabilitate' prior to surgery, through improving physical fitness, nutrition and emotional wellbeing.

Method: A survey aimed at clinicians delivering surgery schools was employed to capture a national overview of activity to establish research and practice priorities in this area. Read More

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Perceptions of anonymised data use and awareness of the NHS data opt-out amongst patients, carers and healthcare staff.

Res Involv Engagem 2021 Jun 14;7(1):40. Epub 2021 Jun 14.

PIONEER, HDR-UK Health Data Research Hub in Acute Care, Birmingham Acute Care Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, B15 2GW, UK.

Background: England operates a National Data Opt-Out (NDOO) for the secondary use of confidential health data for research and planning. We hypothesised that public awareness and support for the secondary use of health data and the NDOO would vary by participant demography and healthcare experience. We explored patient/public awareness and perceptions of secondary data use, grouping potential researchers into National Health Service (NHS), academia or commercial. Read More

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The use of complementary and alternative medicine by adults with allergies: a Czech national representative survey.

BMC Complement Med Ther 2021 Jun 14;21(1):171. Epub 2021 Jun 14.

Department of Clinical Immunology and Allergy, Charles University, University Hospital Hradec Kralove, Hradec Králové, Czech Republic.

Background: The prevalence rates of the use of Complementary and Alternative Medicine (CAM) in allergy patients range from 42% in the United States up to 50% in Europe. In the Czech Republic, no such data exists. Our aim was to examine patterns in CAM use in populations with self-reported allergies in the Czech Republic. Read More

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Subclinical depression and anxiety impact verbal memory functioning differently in men and women -an fMRI study.

J Psychiatr Res 2021 May 27;140:308-315. Epub 2021 May 27.

Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain; Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.

Background: Depressive symptoms are known to affect memory efficiency in various populations. More specifically, several studies conducted in patients suffering from schizophrenia have indicated that memory efficiency is affected by depressed mood in female patients and by anxiety in male patients. We investigated, using neuroimaging techniques, whether similar gender-specific associations with subclinical depression and anxiety could be observed in a non-clinical sample. Read More

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Pre-emptive and preventive NSAIDs for postoperative pain in adults undergoing all types of surgery.

Cochrane Database Syst Rev 2021 Jun 14;6:CD012978. Epub 2021 Jun 14.

Department of Surgery and Anaesthesia, Division of Medical Sciences and Graduate Entry Medicine, School of Medicine, University of Nottingham, Derby, UK.

Background: Postoperative pain is a common consequence of surgery and can have many negative perioperative effects. It has been suggested that the administration of analgesia before a painful stimulus may improve pain control. We defined pre-emptive nonsteroidal anti-inflammatories (NSAIDs) as those given before surgery but not continued afterwards and preventive NSAIDs as those given before surgery and continued afterwards. Read More

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Endovascular thrombectomy and intra-arterial interventions for acute ischaemic stroke.

Cochrane Database Syst Rev 2021 Jun 14;6:CD007574. Epub 2021 Jun 14.

University Hospital of North Norway, Tromsø, Norway.

Background: Most disabling strokes are due to a blockage of a large artery in the brain by a blood clot. Prompt removal of the clot with intra-arterial thrombolytic drugs or mechanical devices, or both, can restore blood flow before major brain damage has occurred, leading to improved recovery. However, these so-called endovascular interventions can cause bleeding in the brain. Read More

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"Should I keep studying? Consequences of a decision to stop learning in young and older adults." Correction to Krogulska et al. (2021).


Psychol Aging 2021 Jun;36(4):543

Reports an error in "Should I keep studying? Consequences of a decision to stop learning in young and older adults" by Aleksandra Krogulska, Karolina Golik, Krystian Barzykowski, Jennifer Cox, Agata Jakubiak and Elizabeth A. Maylor (, 2021[Mar], Vol 36[2], 158-171). In the article (https:// doi. Read More

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Visual or visual-tactile examination to detect and inform the diagnosis of enamel caries.

Cochrane Database Syst Rev 2021 Jun 14;6:CD014546. Epub 2021 Jun 14.

Dundee Dental School, University of Dundee, Dundee, UK.

Background: The detection and diagnosis of caries at the initial (non-cavitated) and moderate (enamel) levels of severity is fundamental to achieving and maintaining good oral health and prevention of oral diseases. An increasing array of methods of early caries detection have been proposed that could potentially support traditional methods of detection and diagnosis. Earlier identification of disease could afford patients the opportunity of less invasive treatment with less destruction of tooth tissue, reduce the need for treatment with aerosol-generating procedures, and potentially result in a reduced cost of care to the patient and to healthcare services. Read More

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Using Expert Elicitation to Abridge the Welfare Quality® Protocol for Monitoring the Most Adverse Dairy Cattle Welfare Impairments.

Front Vet Sci 2021 28;8:634470. Epub 2021 May 28.

Animal Sciences Unit, Institute for Agricultural and Fisheries Research (ILVO), Merelbeke, Belgium.

The Welfare Quality® consortium has developed and proposed standard protocols for monitoring farm animal welfare. The uptake of the dairy cattle protocol has been below expectation, however, and it has been criticized for the variable quality of the welfare measures and for a limited number of measures having a disproportionally large effect on the integrated welfare categorization. Aiming for a wide uptake by the milk industry, we revised and simplified the Welfare Quality® protocol into a user-friendly tool for cost- and time-efficient on-farm monitoring of dairy cattle welfare with a minimal number of key animal-based measures that are aggregated into a continuous (and thus discriminative) welfare index (WI). Read More

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Needs of Young African Neurosurgeons and Residents: A Cross-Sectional Study.

Front Surg 2021 28;8:647279. Epub 2021 May 28.

NIHR Global Health Research Group on Neurotrauma, University of Cambridge, Cambridge, United Kingdom.

Africa has many untreated neurosurgical cases due to limited access to safe, affordable, and timely care. In this study, we surveyed young African neurosurgeons and trainees to identify challenges to training and practice. African trainees and residents were surveyed online by the Young Neurosurgeons Forum from April 25th to November 30th, 2018. Read More

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Independent Calculation of Move Lists for Incumbent Protection in a Multi-SAS Shared Spectrum Environment.

IEEE Wirel Commun Lett 2021 ;10(1)

National Institute of Standards and Technology, Communications Technology Laboratory, Gaithersburg, MD, 20899 USA.

In the 3.5 GHz Citizens Broadband Radio Service (CBRS), secondary users are managed by spectrum access systems (SASs) to protect incumbents from interference. Current practice requires each SAS to exchange detailed user information with other SASs, and to use a common algorithm to suspend transmissions so that an aggregate interference percentile is below a predefined threshold. Read More

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January 2021

The Effectiveness of Psychosocial Interventions for Elder Abuse in Community Settings: A Systematic Review and Meta-Analysis.

Front Psychol 2021 26;12:679541. Epub 2021 May 26.

Graduate School of Social Work, University of Denver, Denver, CO, United States.

As a global public health concern, elder abuse negatively affects health, psychosocial wellbeing, and mortality among elders. Research and practice efforts made to explore effective prevention and intervention strategies are growing. Despite the growing number of intervention studies on elder abuse, research synthesis on the empirical literature seems lacking. Read More

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Effects of hospital funding reform on wait times for hip fracture surgery: a population-based interrupted time-series analysis.

BMC Health Serv Res 2021 Jun 13;21(1):576. Epub 2021 Jun 13.

ICES, Toronto, Canada.

Background: Health care funding reforms are being used worldwide to improve system performance but may invoke unintended consequences. We assessed the effects of introducing a targeted hospital funding model, based on fixed price and volume, for hip fractures. We hypothesized the policy change was associated with reduction in wait times for hip fracture surgery, increase in wait times for non-hip fracture surgery, and increase in the incidence of after-hours hip fracture surgery. Read More

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Effects of gait adaptability training on falls and fall-related fractures in older adults: a systematic review and meta-analysis.

Age Ageing 2021 Jun 11. Epub 2021 Jun 11.

Department of Geriatric Medicine, Aalborg University Hospital, DK-9000 Aalborg, Denmark.

Objective: falls among older adults are common and can have devastating consequences. A novel task-specific exercise modality, gait adaptability training (GAT), has shown promising preventive effects. This systematic review and meta-analysis synthesise the evidence regarding GATs effect on falls and fall-related fractures in community-dwelling older adults. Read More

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Time to retire? A register-based study of GPs' practice style prior to retirement.

Soc Sci Med 2021 Jun 6;281:114099. Epub 2021 Jun 6.

Danish Centre for Health Economics, Department of Public Health, University of Southern Denmark, J.B. Winsløws Vej 9B, 1st Floor, 5000, Odense C, Denmark. Electronic address:

In many healthcare systems a large share of general practitioners (GPs) is retiring. The literature has shown a negative correlation between physicians' age and their quality of care. However, little is known about whether GPs exhibit different practice styles in the years prior to retirement. Read More

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Barriers and facilitators influencing the sustainment of health behaviour interventions in schools and childcare services: a systematic review.

Implement Sci 2021 Jun 12;16(1):62. Epub 2021 Jun 12.

School of Medicine and Public Health, The University of Newcastle, University Drive, Callaghan, 2308, NSW, Australia.

Background: Sustainment has been defined as the sustained use or delivery of an intervention in practice following cessation of external implementation support. This review aimed to identify and synthesise factors (barriers and facilitators) that influence the sustainment of interventions (policies, practices, or programmes) in schools and childcare services that address the leading risk factors of chronic disease.

Methods: Seven electronic databases and relevant reference lists were searched for articles, of any design, published in English, from inception to March 2020. Read More

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Pertussis in Individuals with Co-morbidities: A Systematic Review.

Infect Dis Ther 2021 Jun 12. Epub 2021 Jun 12.

inScience Communications, Chowley Oak Business Park, Chowley Oak Lane, Tattenhall, Cheshire, UK.

Pertussis is a highly contagious disease of the respiratory tract caused by Bordetella pertussis. Although the burden of pertussis is highest in children, available data suggests that pertussis in the elderly and those with underlying chronic conditions or illnesses can result in significant morbidity, mortality and costs. We undertook a comprehensive review to assess the association between pertussis and chronic conditions/illnesses. Read More

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Revealing the Modular Similarities and Differences Among Alzheimer's Disease, Vascular Dementia, and Parkinson's Disease in Genomic Networks.

Neuromolecular Med 2021 Jun 12. Epub 2021 Jun 12.

Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.

Alzheimer's disease (AD), vascular dementia (VD), and Parkinson's disease (PD) exert increasingly lethal or disabling effects on humans, but the associations among these diseases at the molecular level remain unclear. In our research, lists of genes related to these three diseases were acquired from public databases. We constructed gene-gene networks of the lists of disease-related genes using the STRING database and selected the plug-in MCODE as the most suitable method to divide the three disease-associated networks into modules through an entropy calculation. Read More

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Association between the Urinary Sodium to Potassium Ratio and Blood Pressure in Adults: A Systematic Review and Meta-Analysis.

Adv Nutr 2021 Jun 11. Epub 2021 Jun 11.

School of Medicine, University of Wollongong, Wollongong, NSW, Australia.

While sodium and potassium are individually important for blood pressure (BP) regulation, the relative contribution of sodium to potassium intake has not been sufficiently investigated. This study aimed to evaluate the association between urinary sodium to potassium ratio (UNa: K) and systolic and diastolic BP in adults. A systematic review (PROSPERO; CRD42016035296) was conducted and was reported according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Read More

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Safeguarding Skin Grafts: An Evidence-Based Summary of Fixation Techniques.

Ann Plast Surg 2021 Jun 10. Epub 2021 Jun 10.

From the Department of Plastic Surgery, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Background: Effective skin graft fixation is vital in preventing sheering forces, seroma, and hematoma from compromising graft take. Yet, selecting the ideal technique for securing skin grafts remains a contentious subject, with significant variation in practice existing between surgeons. There is, therefore, benefit to be derived from assessing the literature for evidence-based recommendations to guide the decision-making process. Read More

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Symptomatic Val122del mutated hereditary transthyretin amyloidosis: Need for early diagnosis and prioritization for heart and liver transplantation.

Hepatobiliary Pancreat Dis Int 2021 May 27. Epub 2021 May 27.

Institute for Experimental and Clinical Research (IREC), Catholic University of Louvain (UCL), Avenue Hippocrate 55, Brussels 1200, Belgium. Electronic address:

Background Hereditary transthyretin (ATTRv) amyloidosis is an autosomal dominant disease linked to transthyretin gene mutations which cause instability of the transthyretin tetramer. After dissociation and misfolding they reassemble as insoluble fibrils (i.e. Read More

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Sodium-Glucose Cotransporter-2 Inhibitors and Risk of Diabetic Ketoacidosis Among Adults With Type 2 Diabetes: A Systematic Review and Meta-Analysis.

Can J Diabetes 2021 Apr 28. Epub 2021 Apr 28.

Department of Medicine, Sinai Health System and the University of Toronto, Toronto, Ontario, Canada; Department of Medicine, General Internal Medicine, University of Toronto, Toronto, Ontario, Canada.

Objectives: The magnitude and precision regarding the risk of diabetic ketoacidosis (DKA) with sodium-glucose cotransporter-2 (SGLT2) inhibitors is unclear. Thus, we examined the risk of DKA with SGLT2 inhibitors in both observational studies and large clinical trials.

Methods: Searches were performed in PubMed, Embase, CENTRAL and Google Scholar (from inception to April 15, 2019) without language restrictions, including conference proceedings and reference lists. Read More

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