41,122 results match your criteria list treatment


Ferroptosis in infection, inflammation, and immunity.

J Exp Med 2021 Jun 12;218(6). Epub 2021 May 12.

Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, The Third Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.

Ferroptosis is a type of regulated necrosis that is triggered by a combination of iron toxicity, lipid peroxidation, and plasma membrane damage. The upstream inducers of ferroptosis can be divided into two categories (biological versus chemical) and activate two major pathways (the extrinsic/transporter versus the intrinsic/enzymatic pathways). Excessive or deficient ferroptotic cell death is implicated in a growing list of physiological and pathophysiological processes, coupled to a dysregulated immune response. Read More

View Article and Full-Text PDF

Paradigm Shift in Utilization of Livers from Hepatitis C-Viremic Donors into Hepatitis C Virus-Negative Patients.

Authors:
Eric F Martin

Clin Liver Dis 2021 Feb 5;25(1):195-207. Epub 2020 Nov 5.

Division of Digestive Health and Liver Disease, University of Miami Miller School of Medicine, 1120 Northwest 14th Street, Suite 1112, Miami, FL 33136, USA. Electronic address:

Despite record-breaking numbers of liver transplants (LTs) performed in the United States in each of the last 7 years, many patients remain on the wait list as the demand for LT continues to exceed the supply of available donors. The emergence of highly effective and well-tolerated direct-acting antiviral therapy has transformed the clinical course and management of hepatitis C virus (HCV) in both the pretransplant and posttransplant setting. Historically, donor livers infected with HCV were either transplanted into patients already infected with HCV or discarded. Read More

View Article and Full-Text PDF
February 2021

Training of advanced practice nurses in oncology for the best care: a systematic review.

Rev Esc Enferm USP 2021 10;55:e03700. Epub 2021 May 10.

Universidade Estadual de Maringá, Programa de Pós-Graduação em Enfermagem, Maringá, PR, Brazil.

Objective: To search for evidence on the training of advanced practice nurses, through clinical practice and nursing care with cancer patients.

Method: Systematic review, searching the databases: MEDLINE-PubMed, LILACS, Web of Science, Scopus, CINAHL and Cochrane CENTRAL. A manual search of the reference list and Google Scholar was also carried out. Read More

View Article and Full-Text PDF

Antibiotics Therapy in the Multi-Resistant Patient.

Methods Mol Biol 2021 ;2296:423-439

Faculty of Health Sciences, University of León, León, Spain.

Antibiotic resistance is not only a European or American problem: it is a global crisis. The emergence of resistance to multiple antimicrobial agents has become a major threat to public health. The main objective of the institution's antimicrobial policy is to adapt the effective treatment to each patient, with a minimum of complications, avoid adverse reactions, control the development and spread of strains of resistant microorganisms as well as reduce hospital costs whenever possible. Read More

View Article and Full-Text PDF
January 2021

A core outcome set for genitourinary symptoms associated with menopause: the COMMA (Core Outcomes in Menopause) global initiative.

Menopause 2021 May 10. Epub 2021 May 10.

Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Australia Women's Health Research Program, School of Public Health and Preventive Medicine, Monash University. Melbourne, Australia School of Nursing, Indiana University, Indianapolis, IN Department of Obstetrics and Gynaecology, University of Chicago, Chicago, IL Red Hot Mamas North America, Inc., New York, NY Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY Department of Obstetrics and Gynaecology, University Hospitals Dorset NHS Trust, Poole, Dorset, UK Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK Centre for Women's Health, Institute of Population Health Sciences, Queen Mary University London, UK Department of Obstetrics and Gynaecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand Department of Obstetrics and Gynaecology, Fortis Escort Hospital, Jaipur, India Department of Gynaecology and Obstetrics, University of Muenster, Muenster, Germany Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia Department of Reproductive and Maternal Medicine, School of Medicine, University of Glasgow, Glasgow, UK Departments of Psychiatry, Psychology and Obstetrics and Gynecology, University of Illinois at Chicago, Chicago IL Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, Research Center for Reproductive Medicine, Gynecological Endocrinology and Menopause, IRCCS San Matteo Foundation, University of Pavia, Pavia, Italy Department of Urology, UIC College of Medicine, Chicago IL Queen Charlotte's and Chelsea and Westminster Hospitals, Imperial College London, London, UK Auckland District Health Board, Auckland, New Zealand Department of Obstetrics and Gynecology, Midlife Women's Health Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA Department of Obstetrics and Gynecology, George Washington University, Washington, DC Department of Obstetrics and Gynecology, University Clinic Inselspital Bern, Bern, Switzerland Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia Department of Obstetrics and Gynaecology, University of Toronto, Toronto, Canada.

Objective: Genitourinary symptoms, such as vaginal dryness and pain with sex, are commonly experienced by postmenopausal women. Comparing treatments for these genitourinary symptoms are restricted by the use of different outcome measures in clinical trials and the omission of outcomes, which may be relevant to women. The aim of this project was to develop a Core Outcome Set (COS) to be reported in clinical trials of treatments for genitourinary symptoms associated with menopause. Read More

View Article and Full-Text PDF

Protocol for the development of a core outcome set for lateral elbow tendinopathy (COS-LET).

Trials 2021 May 10;22(1):339. Epub 2021 May 10.

School of Health and Rehabilitation Sciences: Physiotherapy, The University of Queensland, St Lucia, Brisbane, Australia.

Background: Lateral elbow tendinopathy (LET) is a common condition that can cause significant disability and associated socioeconomic cost. Although it has been widely researched, outcome measures are highly variable which restricts evidence synthesis across studies. In 2019, a working group of international experts, health care professionals and patients, in the field of tendinopathy (International Scientific Tendinopathy Symposium Consensus (ICON) Group), published the results of a consensus exercise defining the nine core domains that should be measured in tendinopathy research. Read More

View Article and Full-Text PDF

Knowledge bases and software support for variant interpretation in precision oncology.

Brief Bioinform 2021 May 10. Epub 2021 May 10.

Health Data Science Unit, Heidelberg University Hospital, Im Neuenheimer Feld 267, 69120 Heidelberg, Germany.

Precision oncology is a rapidly evolving interdisciplinary medical specialty. Comprehensive cancer panels are becoming increasingly available at pathology departments worldwide, creating the urgent need for scalable cancer variant annotation and molecularly informed treatment recommendations. A wealth of mainly academia-driven knowledge bases calls for software tools supporting the multi-step diagnostic process. Read More

View Article and Full-Text PDF

"Headache" Online Information: An Evaluation of Readability, Quality, Credibility, and Content.

Perm J 2021 May;25

Introduction: Headache is experienced by more than half of the world population each year. In this study, we evaluate the content, quality, and health literacy required to understand online information for patients with headaches.

Methods: We selected 4 commonly used search engines (Google, Yahoo, Bing, and Ask. Read More

View Article and Full-Text PDF

Impact of an integrated medication reconciliation model led by a hospital clinical pharmacist on the reduction of post-discharge unintentional discrepancies.

J Clin Pharm Ther 2021 May 9. Epub 2021 May 9.

Faculty of Health Sciences, Libertas International University, Zagreb, Croatia.

What Is Known And Objective: There is no optimal standardized model in the transfer of care between hospitals and primary healthcare facilities. Transfer of care is a critical point during which unintentional discrepancies, that can jeopardize pharmacotherapy outcomes, can occur. The objective was to determine the effect that an integrated medication reconciliation model has on the reduction of the number of post-discharge unintentional discrepancies. Read More

View Article and Full-Text PDF

Vibrotactile biofeedback devices in Parkinson's disease: a narrative review.

Med Biol Eng Comput 2021 May 10. Epub 2021 May 10.

Center for MicroElectroMechanical Systems, University of Minho, Guimarães, Portugal.

Parkinson's disease (PD) is often associated with a vast list of gait-associated disabilities, for which there is still a limited pharmacological/surgical treatment efficacy. Therefore, alternative approaches have emerged as vibrotactile biofeedback systems (VBS). This review aims to focus on the technologies supporting VBS and identify their effects on improving gait-associated disabilities by verifying how VBS were applied and validated with end-users. Read More

View Article and Full-Text PDF

Validation of the Functions and Prognostic Values of Synapse Associated Proteins in Lower-grade Glioma.

Biosci Rep 2021 May 10. Epub 2021 May 10.

Guangdong Provincial People's Hospital, Guangzhou, China.

Synapse and synapse associated proteins (SAPs) play critical roles in various neurodegeneration diseases and brain tumors. However, in lower-grade gliomas (LGG), SAPs have not been explored systematically. Herein, we are going to explore SAPs expression profile and its clinicopathological significance in LGG which can offer new insights to glioma therapy. Read More

View Article and Full-Text PDF

Demanding and effective: participants' experiences of internet-delivered prolonged exposure provided within two months after exposure to trauma.

Eur J Psychotraumatol 2021 Mar 16;12(1):1885193. Epub 2021 Mar 16.

Department of Clinical Neuroscience, Division of Psychology, Karolinska Institutet, Stockholm, Sweden.

: The use of remotely delivered early intervention after trauma may prevent and/or reduce symptoms of post-traumatic stress. Our research group evaluated a novel three-week therapist-guided internet-delivered intervention based on prolonged exposure (Condensed Internet-Delivered Prolonged Exposure; CIPE) in a pilot trial. The results indicated that the intervention was feasible, acceptable and reduced symptoms of post-traumatic stress at post-intervention compared to a waiting-list condition. Read More

View Article and Full-Text PDF

Network Pharmacology-Based Prediction of Mechanism of Shenzhuo Formula for Application to DKD.

Evid Based Complement Alternat Med 2021 17;2021:6623010. Epub 2021 Apr 17.

Department of Endocrinology, Affiliated Hospital to Changchun University of Chinese Medicine, Changchun 130021, China.

Background: Shenzhuo formula (SZF) is a traditional Chinese medicine (TCM) prescription which has significant therapeutic effects on diabetic kidney disease (DKD). However, its mechanism remains unknown. Therefore, this study aimed to explore the underlying anti-DKD mechanism of SZF. Read More

View Article and Full-Text PDF

The NIDA clinical trials network: evolving, expanding, and addressing the opioid epidemic.

Addict Sci Clin Pract 2021 May 8;16(1):28. Epub 2021 May 8.

Center for the Clinical Trials Network, National Institute On Drug Abuse, National Institutes of Health, 3WFN Room 09A48 MSC 6022, 301 North Stonestreet Avenue, Bethesda, MD, 20892, USA.

Over the past two decades, the National Drug Abuse Treatment Clinical Trials Network (CTN), a program of the National Institute on Drug Abuse (NIDA), has expanded from the initial six Nodes to 16 Nodes, as a nationwide consortium of research scientists and treatment providers working together to improve care for substance use in the nation's communities. Encompassing both specialty care programs and general medical settings, the Network has become a unique resource for expertise on clinically focused research, bridging the gap between research and treatment delivery. Over 22 years, the CTN has completed 101 studies, resulting in 650 publications. Read More

View Article and Full-Text PDF

Organic carbon bioavailability: Is it a good driver to choose the best biological nitrogen removal process?

Sci Total Environ 2021 Apr 29;786:147390. Epub 2021 Apr 29.

Western Paraná State University, 85819-110 Cascavel, PR, Brazil; Federal University of Fronteira Sul, 99700-000 Erechim, Brazil; Embrapa Suínos e Aves, 89715-899 Concórdia, SC, Brazil. Electronic address:

Organic carbon can affect the biological nitrogen removal process since the Anammox, heterotrophic and denitrifying bacteria have different affinities and feedback in relation to carbon/nitrogen ratio. Therefore, we reviewed the wastewater carbon concentration, its biodegradability and bioavailability to choose the appropriate nitrogen removal process between conventional (nitrification-denitrification) and Anammox-based process (i.e. Read More

View Article and Full-Text PDF

Ozone therapy versus surgery for lumbar disc herniation: a randomized double-blind controlled trial.

Complement Ther Med 2021 May 5:102724. Epub 2021 May 5.

Research Network on Health Services in Chronic Diseases (REDISSEC), Madrid, Spain; Canary Islands Health Research Institute Foundation (FIISC), Tenerife, Spain; Evaluation Unit of the Canary Islands Health Service (SESCS), Tenerife, Spain.

Objectives: Surgery is the treatment of choice for symptomatic disc herniation after conservative management. Several studies have suggested the potential utility of intradiscal ozone infiltration in this pathology. The aim of this trial was to compare intradiscal ozone infiltration vs. Read More

View Article and Full-Text PDF

A comprehensive review on pharmacology of efflux pumps and their inhibitors in antibiotic resistance.

Eur J Pharmacol 2021 May 5;903:174151. Epub 2021 May 5.

Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (BHU), Varanasi, UP, India. Electronic address:

The potential for the build-up of resistance to a particular antibiotic endangers its therapeutic application over time. In recent decades, antibiotic resistance has become one of the most severe threats to public health. It can be attributed to the relentless and unchecked use of antibiotics in healthcare sectors, cell culture, animal husbandry, and agriculture. Read More

View Article and Full-Text PDF

Clinical, Immunological, and Genetic Features in 780 Patients with Autoimmune Lymphoproliferative Syndrome (ALPS) and ALPS-like diseases: A Systematic Review.

Pediatr Allergy Immunol 2021 May 8. Epub 2021 May 8.

Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.

Background: Autoimmune lymphoproliferative syndrome (ALPS) is a group of genetic disorders characterized by early-onset lymphoproliferation, autoimmune cytopenias, and susceptibility to lymphoma. The majority of ALPS patients carry heterozygous germline mutations in the TNFRSF6 gene. In this study, we conducted a systematic review of patients with ALPS and ALPS-like syndrome. Read More

View Article and Full-Text PDF

EphA2: A promising therapeutic target in breast cancer.

J Genet Genomics 2021 Mar 29. Epub 2021 Mar 29.

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China; KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China; Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, 510095, China. Electronic address:

EphA2 (ephrin type-A receptor 2), a receptor tyrosine kinase, is overexpressed in human breast cancers often linked to poor patient prognosis. Accumulating evidence demonstrates that EphA2 plays important roles in several critical processes associated with malignant breast progression, such as proliferation, survival, migration, invasion, drug resistance, metastasis, and angiogenesis. As its inhibition through multiple approaches can inhibit the growth of breast cancer and restore drug sensitivity, EphA2 has become a promising therapeutic target for breast cancer treatment. Read More

View Article and Full-Text PDF

A systematic review of population pharmacokinetic analyses of polyclonal immunoglobulin G therapy.

Int Immunopharmacol 2021 May 4;97:107721. Epub 2021 May 4.

Centre for Quality Management of Medicines, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia. Electronic address:

Background: Population pharmacokinetics (popPK) using the nonlinear mixed-effect (NLME) modeling approach is an essential tool for guiding dose individualization. Several popPK analyses using the NLME have been conducted to characterize the pharmacokinetics of immunoglobulin G (IgG).

Objective: To summarize the current information on popPK of polyclonal IgG therapy. Read More

View Article and Full-Text PDF

Effect of early intervention for anxiety on sleep outcomes in adolescents: a randomized trial.

Eur Child Adolesc Psychiatry 2021 May 7. Epub 2021 May 7.

Regional Centre for Child and Youth Mental Health and Child Welfare, Norwegian Research Center, NORCE, Bergen, Norway.

The potential effect of early intervention for anxiety on sleep outcomes was examined in a sample of adolescents with anxiety (N = 313, mean 14.0 years, SD = 0.84, 84% girls, 95. Read More

View Article and Full-Text PDF

Comparison of Orthodontic Bracket Debonding Force and Bracket Failure Pattern on Different Teeth In Vivo by a Prototype Debonding Device.

Biomed Res Int 2021 17;2021:6663683. Epub 2021 Apr 17.

Orthodontic Division, Preventive Dentistry Department, College of Dentistry, Jouf University, Sakaka, Saudi Arabia.

Objective: To compare the orthodontic bracket debonding force and assess the bracket failure pattern clinically between different teeth by a validated prototype debonding device. . Thirteen (13) patients at the end of comprehensive fixed orthodontic treatment, awaiting for bracket removal, were selected from the list. Read More

View Article and Full-Text PDF

Smoking cessation during COVID-19: the top to-do list.

NPJ Prim Care Respir Med 2021 05 6;31(1):22. Epub 2021 May 6.

National Heart and Lung Institute, Imperial College London, London, UK.

View Article and Full-Text PDF

Seromucinous hamartoma of ethmoid sinus in pediatric patient (case report).

Int J Surg Case Rep 2021 Apr 27;82:105915. Epub 2021 Apr 27.

Dar AlUloom University, Riyadh, Saudi Arabia.

Introduction And Importance: Seromucinous hamartoma is a rare benign glandular proliferation arising from the respiratory epithelium, which was originally described by Baillie and Batsakis in 1974. Since this time, case reports started to be published on SH, as a middle aged and elderly disease, here we report a case of a pediatric patient who found to have SH.

Presentation Of The Case: 2-year-old girl, brought by her parent with a complain of a mass at the right medial canthal area for one year. Read More

View Article and Full-Text PDF

Comparative macrolide use in humans and animals: should macrolides be moved off the World Health Organisation's critically important antimicrobial list?

J Antimicrob Chemother 2021 May 6. Epub 2021 May 6.

Veterinary Medicine Research and Development, Zoetis, Inc, Kalamazoo, MI, USA.

Macrolide antibiotics are categorized by the WHO as Highest Priority, Critically Important Antimicrobials due to their recommendation as treatment for severe cases of campylobacteriosis in humans; a self-limiting, rarely life-threatening, zoonotic foodborne infection. Low rates of macrolide resistance in Campylobacter jejuni and the availability of alternative treatments have prompted some regulatory schemes to assign macrolides to a lower importance category. Apart from rare, specific infections, macrolides largely play a supportive role to other drug classes in human medicine. Read More

View Article and Full-Text PDF

Yogic Pranayama and Diaphragmatic Breathing: Adjunct Therapy for Intraocular Pressure in Patients With Primary Open-angle Glaucoma: A Randomized Controlled Trial.

J Glaucoma 2021 Feb;30(2):115-123

Departments of Ophthalmology.

Prcis: Yogic pranayama and diaphragmatic breathing are potential adjunctive therapies for patients with glaucoma; however, they are not substitutes for medicine or eye drops.

Purpose: Currently, medical or surgical lowering of intraocular pressure is the only therapeutic approach for treating primary open-angle glaucoma. Intraocular pressure maintenance is influenced by autonomic activity (sympathetic and parasympathetic). Read More

View Article and Full-Text PDF
February 2021

Effectiveness of Acceptance and Commitment Therapy (ACT) in Professional Dementia Caregivers Burnout.

Clin Gerontol 2021 May 6:1-12. Epub 2021 May 6.

Universitat Autònoma de Barcelona Facultat de Psicologia, Bellaterra, Spain.

: To implement and assess the efficacy of a 6-week Acceptance and Commitment Therapy intervention to reduce anxiety and burnout in healthcare professionals working with dementia, and to increase their psychological flexibility and life satisfaction.: A total of 105 workers from the XXXXX Hospital were randomly assigned to an intervention group (Acceptance and Commitment Therapy) or a wait list control group. Psychological Flexibility (AAQ-II), Life Satisfaction (SWLS), Anxiety (STAI-T), and Burnout (MBI) were measured before and after the intervention. Read More

View Article and Full-Text PDF

COVID-19 pandemic did not affect emergency theatre patient demographic and length of stay in the first phase of UK countrywide lockdown in a district general hospital.

Ann R Coll Surg Engl 2021 May 6. Epub 2021 May 6.

Macclesfield District General Hospital, UK.

Introduction: We aim to identify any changes in outcome for patients undergoing nonelective surgery at the start of the UK pandemic in our district general hospital. This was a single-centre retrospective cohort review of a UK district general hospital serving a population of over 250,000 people.

Methods: Participants were all patients undergoing a surgical procedure in the acute theatre list between 23 March to 11 May in both 2019 and 2020. Read More

View Article and Full-Text PDF

Use of neck circumference as a predictor of cardiovascular risk in chronic kidney patients undergoing hemodialysis candidates for transplantation.

J Hum Nutr Diet 2021 May 6. Epub 2021 May 6.

Universidade Federal do Ceará.

Introduction: Patients undergoing hemodialysis have a great cardiovascular risk. Neck circumference is a simple and low-cost measure that can estimate this risk precociously.

Objective: To evaluate whether the cardiovascular risk obtained by Neck Circumference (NC) is associated with the main cardiometabolic risk factors in patients on hemodialysis treatment on waiting list for transplantation. Read More

View Article and Full-Text PDF