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Characterization of phase I and phase II metabolites of hop (Humulus lupulus L.) bitter acids: In vitro and in vivo metabolic profiling by UHPLC-Q-Orbitrap.

J Pharm Biomed Anal 2021 Apr 30;201:114107. Epub 2021 Apr 30.

Department of Pharmacy, University of Salerno, Fisciano, SA, Italy; European Biomedical Research Institute of Salerno, Via De Renzi 50, I-84125, Salerno, Italy. Electronic address:

Bitter acids are a class of prenylated phloroglucinol derivatives present in Humulus lupulus L., known for their multiple healthy properties, nevertheless, research regarding their metabolism and stability is lacking. This study was aimed to elucidate the metabolic stability of hop α- and β-acids and characterize I and II phase metabolites in vitro and in vivo. Read More

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Enantiomeric profiling of mefentrifluconazole in watermelon across China: Enantiochemistry, environmental fate, storage stability, and comparative dietary risk assessment.

J Hazard Mater 2021 May 5;417:125985. Epub 2021 May 5.

State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, PR China. Electronic address:

Elucidating the enantiomeric chemistry and enantioselective fate of the novel chiral triazole fungicide mefentrifluconazole is of vital importance for agroecosystem safety and human health. The absolute configuration of mefentrifluconazole was identified firstly as S-(+)-mefentrifluconazole and R-(-)-mefentrifluconazole on a cellulose tris(3-chloro-4-methylphenylcarbamate) chiral phase. A baseline resolution (Rs, 2. Read More

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Label-free tracking of whole-cell response on RGD functionalized surfaces to varied flow velocities generated by fluidic rotation.

J Colloid Interface Sci 2021 Apr 20;599:620-630. Epub 2021 Apr 20.

Nanobiosensorics Laboratory, ELKH EK MFA, Budapest, Hungary. Electronic address:

Fluidic flow plays important roles in colloid and interface sciences. Measuring adsorption, aggregation processes and living cell behavior under a fluidic environment with varied flow velocities in a parallel and high-throughput manner remains to be a challenging task. Here a method is introduced to monitor cell response to well-defined flow with varied velocities over an array of label-free resonant waveguide grating (RWG) based optical biosensors. Read More

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Multi-response optimal hot pressurized liquid recovery of extractable polyphenols from leaves of maqui (Aristotelia chilensis [Mol.] Stuntz).

Food Chem 2021 Mar 29;357:129729. Epub 2021 Mar 29.

Chemical and Bioprocess Engineering Department, School of Engineering, Pontificia Universidad Católica de Chile, Vicuña Mackenna 4860, P.O. Box 306, Santiago 7820436, Chile. Electronic address:

Multi-response optimization of hot pressurized liquid extraction (HPLE) was applied for the first time to obtain maqui (Aristotelia chilensis [Mol.] Stuntz) leaf extracts. The total polyphenol content (TPC), the antioxidant capacity (AC) as well as the total polyphenol purity of the maqui leaf extracts were accurately predicted (RSD < 8%) at the evaluated extraction scales. Read More

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Assessing the distributions and fate of household and personal care chemicals (HPCCs) in the Songhua Catchment, Northeast China.

Sci Total Environ 2021 May 3;786:147484. Epub 2021 May 3.

International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, China.

Many household and personal care chemicals (HPCCs) are of environmental concern due to their potential toxicity to humans and wildlife. However, few studies investigate the spatiotemporal variations and fate of HPCCs in large-scale river systems. Here, river water and sediment samples from the Songhua River in Northeast China were analyzed for seven classes of HPCCs. Read More

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Rapid determination of folic acid and riboflavin in urine by polypyrrole magnetic solid-phase extractant combined ultra-performance liquid chromatography.

J Chromatogr A 2021 Apr 27;1648:462192. Epub 2021 Apr 27.

Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China. Electronic address:

Determination of folic acid and riboflavin in biological samples is difficult due to their high polarity, low concentration, chemical instability, and complex matrix. In this study, the polypyrrole-coated magnetic nanocomposite (FeO@PPy) was synthesized innovatively with the assistance of hexadecyltrimethylammonium bromide. To evaluate the adsorption mechanism and the feasibility of synthesized FeO@PPy as an adsorbent, the adsorption capacities, kinetics and thermodynamics of folic acid and riboflavin were investigated systemically. Read More

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Solid-phase extraction of non-steroidal anti-inflammatory drugs in human plasma and water samples using sol-gel-based metal-organic framework coating.

J Chromatogr A 2021 May 2;1648:462168. Epub 2021 May 2.

Department of Chemical and Process Engineering, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia (UKM), Bangi, Selangor 43600, Malaysia. Electronic address:

In this research, the Cu-based metal-organic framework (MOF-199) was fabricated and coated on the stainless steel mesh as substrates through sol-gel procedure. Then the coated substrates were placed in a small column known as solid-phase extraction cartridge. The SPE based coated stainless steel mesh coupled with high-performance liquid chromatography-UV detector (HPLC-UV) was used for the fast extraction, and quantification of non-steroidal anti-inflammatory drugs (NSAIDs) from human plasma and water samples. Read More

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Detailed structural characterization of cardiolipins from various biological sources using a complex analytical strategy comprising fractionation, hydrolysis and chiral chromatography.

J Chromatogr A 2021 Apr 26;1648:462185. Epub 2021 Apr 26.

Institute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, 142 20 Prague, Czech Republic. Electronic address:

Cardiolipins (1,3-bis(sn-3'-phosphatidyl)-sn-glycerol) (CLs) are widespread in many organisms, from bacteria to higher green plants and mammals. CLs were observed in Gram-positive bacterium of the genus Kocuria, brewer's yeast Saccharomyces, the green alga Chlamydomonas, spinach and beef heart. A mixture of molecular species of CLs was obtained from total lipids by hydrophilic interaction liquid chromatography (HILIC), and these were further separated and identified by reversed phase LC/MS with negative tandem electrospray ionization. Read More

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Optimization and application of high-throughput supported liquid extraction for simultaneous determination of carotenoids and fat-soluble vitamins in serum.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Mar 24;1173:122672. Epub 2021 Mar 24.

School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shanxi 710061, PR China. Electronic address:

The demand for analysis of carotenoids (CAR) and fat-soluble vitamins (FSV) is continuously expanding, but currently used sample preparation methods either require complicated extraction procedure or large sample volume, let alone the reliability of the results. This study aimed to develop a fast, high-efficient, and high-throughput method based on supported liquid extraction (SLE) for the simultaneous extraction of FSV and CAR from human serum before using high-performance liquid chromatography-diode array detector (HPLC-DAD) analysis. The optimization of SLE parameters was achieved through response surface methodology (RSM) based on the Box-Behnken design (BBD) and included serum-water-extraction solvent ratio and eluent volume. Read More

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Canine mast cell tumour cells regulate tryptophan catabolism via the expression of indoleamine 2,3-dioxygenase.

Res Vet Sci 2021 Apr 30;137:159-162. Epub 2021 Apr 30.

Laboratory of Comparative Animal Medicine, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan.

Indoleamine 2,3-deoxygenase (IDO) produced by cancer cells catabolizes tryptophan (TRP) to kynurenine (KYN) in the environment, resulting induction of cancer immune escape through induction of T cell anergy and enhancement of regulatory T cells. Recently, inhibition of IDO has been recognized as one of therapeutic strategies for human neoplastic diseases. However, there have been few reports about IDO-expressing cancers in dogs. Read More

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Biomarkers of poly- and perfluoroalkyl substances (PFAS) in Sub-Arctic and Arctic communities in Canada.

Int J Hyg Environ Health 2021 May 10;235:113754. Epub 2021 May 10.

School of Public Health and Health Systems, Faculty of Applied Health Sciences, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, N2L 3G1, Canada. Electronic address:

Polyfluoroalkyl substances and perfluoroalkyl substances (PFAS) are a family of anthropogenic chemicals that are used in food packaging, waterproof clothing, and firefighting foams for their water and oil resistant properties. Though levels of some PFAS appear to be decreasing in Canada's south, environmental levels have been increasing in the Arctic due to long-range transport. However, the implications of this on human exposures in sub-Arctic and Arctic populations in Canada have yet to be established. Read More

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Fuzheng Jiedu Xiaoji formulation inhibits hepatocellular carcinoma progression in patients by targeting the AKT/CyclinD1/p21/p27 pathway.

Phytomedicine 2021 Apr 18;87:153575. Epub 2021 Apr 18.

Center of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China. Electronic address:

Background: Hepatocellular carcinoma (HCC) is a common malignant tumor with limited treatment options. Conventional antitumor therapy combined with traditional Chinese medicine (TCM) to limit tumor progression has gradually become the focus of complementary and alternative therapies for HCC treatment. The Fuzheng Jiedu Xiaoji formulation (FZJDXJ) alleviates the clinical symptoms of patients and inhibits tumor progression, but its curative effect still requires extensive clinical research and mechanistic analysis. Read More

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Digestion liquid based alkaline pretreatment of waste activated sludge promotes methane production from anaerobic digestion.

Water Res 2021 Apr 29;199:117198. Epub 2021 Apr 29.

Hunan Qing Zhi Yuan Environmental Protection Technology Co., Ltd, Changsha 410004, PR China.

This work proved an efficient method to significantly increase methane production from anaerobic digestion of WAS. This method is to reflux proper of digestion liquid into waste activated sludge pretreatment unit (pH 9.5 for 24 h). Read More

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Interactions of functional microorganisms and their contributions to methane bioconversion to short-chain fatty acids.

Water Res 2021 Apr 26;199:117184. Epub 2021 Apr 26.

Advanced Water Management Centre, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia. Electronic address:

Methane bioconversion to value-added liquid chemicals has been proposed as a promising solution to augment the petroleum-dominated chemical market. Recent investigations have reported that various electron acceptors (e.g. Read More

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Environmental exposure to perfluoroalkyl substances in early pregnancy, maternal glucose homeostasis and the risk of gestational diabetes: A prospective cohort study.

Environ Int 2021 May 10;156:106621. Epub 2021 May 10.

Ministry of Education -Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Jiao Tong University School of Public Health, Shanghai, China. Electronic address:

Background: Humans are widely exposed to environmental perfluoroalkyl substances (PFAS), which may affect glucose homeostasis. However, research linking PFAS exposure to glucose homeostasis during pregnancy is limited and the results were inconsistent. We aimed to investigate the association between PFAS exposure and glucose homeostasis in pregnancy in a large prospective cohort. Read More

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Enhanced water dispersibility and permeability through a Caco-2 cell monolayer of β-cryptoxanthin extracted from kumquats by complexation with casein.

Food Chem 2021 Apr 20;360:129822. Epub 2021 Apr 20.

Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki, 1-1 Gakuen Kibanadai Nishi, Miyazaki 889-2192, Japan.

β-Cryptoxanthin (BCX) possesses potential therapeutic and health benefits. However, BCX absorption is low because of its poor aqueous solubility. In this study, a complex between BCX and casein (Cas) was prepared to improve the water dispersibility and bioavailability of BCX. Read More

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Variations in phenolic acids and antioxidant activity of navel orange at different growth stages.

Food Chem 2021 May 6;360:129980. Epub 2021 May 6.

State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, China. Electronic address:

Ripe navel orange has abundant amounts of phenolic compounds. Few studies monitored changes in these compounds during ripening. In this study, the effects of navel orange maturation on dynamic changes in antioxidant activity, total phenolic content (TPC), total flavonoid content (TFC) and phenolic acids were investigated. Read More

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Egg residue and depletion in Rhode Island Red hens (Gallus gallus domesticus) following multiple oral doses of Trimethoprim-Sulfamethoxazole.

Regul Toxicol Pharmacol 2021 May 10:104941. Epub 2021 May 10.

Comparative Medicine Institute, North Carolina State University, Raleigh, NC, USA; Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 27607. Electronic address:

Sulfamethoxazole-Trimethoprim residues in eggs can cause risks to human health. The most common cause of residues in eggs results from failure to meet an appropriate withdrawal interval. The aim of this study was to determine the quantity and duration of sulfamethoxazole- trimethoprim residues in eggs and evaluate the drug elimination parameters in egg components and whole egg to better estimate the withdrawal interval of sulfamethoxazole and trimethoprim following oral administration for 7 days at a purposed dosage regimen (time average 46 mg kg day for sulfamethoxazole, time average 25 mg kg day for trimethoprim). Read More

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Use of Cyclic Ion Mobility Spectrometry (cIM)-Mass Spectrometry to Study the Intramolecular Transacylation of Diclofenac Acyl Glucuronide.

Anal Chem 2021 May 13. Epub 2021 May 13.

Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, U.K.

1-β--Acyl-glucuronides (AGs) are common metabolites of carboxylic acid-containing xenobiotics, including, ., many nonsteroidal anti-inflammatory drugs (NSAIDs). They are of concern to regulatory authorities because of the association of these metabolites with the hepatotoxicity that has resulted in drug withdrawal. Read More

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Superamphiphilic TiO Composite Surface for Protein Antifouling.

Adv Mater 2021 May 13:e2003559. Epub 2021 May 13.

CAS Key Laboratory of Bio-Inspired Materials and Interface Sciences, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.

Unwanted protein adsorption deteriorates fouling processes and reduces analytical device performance. Wettability plays an important role in protein adsorption by affecting interactions between proteins and surfaces. However, the principles of protein adsorption are not completely understood, and surface coatings that exhibit resistance to protein adsorption and long-term stability still need to be developed. Read More

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lncRNA NEAT1 prompts autophagy and apoptosis in MPTP-induced Parkinson's disease by impairing miR-374c-5p.

Acta Biochim Biophys Sin (Shanghai) 2021 May 13. Epub 2021 May 13.

Department of Neurology, The First Affiliated Hospital of South University of Science and Technology, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen 518000, China.

Long non-coding RNAs (lncRNAs) play biological roles in brain disorder and neurodegenerative diseases. As the functions of lncRNA NEAT1 in Parkinson's disease (PD) remain unknown, in the present study, we aimed to explore the roles and underlying molecular mechanisms of NEAT1 in PD. A PD mouse model induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and a cell model of SH-SY5Y induced by N-methyl-4-phenylpyridinium (MPP+) were established. Read More

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, and membrane phospholipid remodelling in response to human serum.

Microbiology (Reading) 2021 May;167(5)

Department of Biological Sciences, The University of Texas at Dallas, Richardson, TX, USA.

, (Group A ; GAS) and (Group B ; GBS) are major aetiological agents of diseases in humans. The cellular membrane, a crucial site in host-pathogen interactions, is poorly characterized in streptococci. Moreover, little is known about whether or how environmental conditions influence their lipid compositions. Read More

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Analytical Methods for Determination of Antiviral Drugs in Different Matrices: Recent Advances and Trends.

Crit Rev Anal Chem 2021 May 13:1-33. Epub 2021 May 13.

Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, Turkey.

Viruses are the main pathogenic substances that cause severe diseases in humans and other living things. They are among the most common microorganisms, and consequently, antiviral drugs have emerged to prevent and treat viral infections. Antiviral drugs are an essential drug group considering their prescription and consumption rates for different diseases and indications. Read More

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Atomic-Scale Imaging of Interfacial Water under 3D Nanoscale Confinement.

Nano Lett 2021 May 13. Epub 2021 May 13.

Instituto de Ciencia de Materiales de Madrid, CSIC, c/Sor Juana Inés de la Cruz 3, 28049 Madrid, Spain.

Capillary condensation of water from vapor is an everyday phenomenon which has a wide range of scientific and technological implications. Many aspects of capillary condensation are not well understood such as the structure of interfacial water, the existence of distinct properties of confined water, or the validity of the Kelvin equation at nanoscale. We note the absence of high-spatial resolution images inside a meniscus. Read More

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Antisurfactant (Autophobic) Behavior of Superspreader Surfactant Solutions.

Langmuir 2021 May 13. Epub 2021 May 13.

Institute of Physics, Science Park 904, 1098XH Amsterdam, The Netherlands.

Surfactants are often added to water to increase the wetting of hydrophobic surfaces. We previously showed that most surfactant solutions behave identically to simple liquids with the same surface tension, indicating that the surfactants do not change the wettability of the solid surface itself. Here, we show that the superspreading surfactant Silwet results in a systematically higher contact angle on a hydrophobic surface than other surfactant solutions of comparable liquid-vapor surface tension. Read More

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Aromatic Polyketides and Hydroxamate Siderophores from a Marine-Algae-Derived Species.

J Nat Prod 2021 May 13. Epub 2021 May 13.

Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.

Four new aromatic polyketides, wailupemycins M-P (-), and two new hydroxamate siderophores, streptamides A () and B (), together with the previously reported nocardamine (), were isolated from the marine-algae-derived sp. OUCMDZ-3434. Wailupemycins M-P (-), possessing an α-pyrone moiety, were isolated from the extract of a liquid fermentation, and the siderophores (-) were isolated from the extract of a solid fermentation. Read More

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Molecular Dynamics Study of the Dispersion Stability and Fluidity of Porous Liquids with Different Canopy Structures.

J Phys Chem B 2021 May 13. Epub 2021 May 13.

School of Energy and Environment, Southeast University, Nanjing 210096, P. R. China.

Porous liquids (PLs) as a new class of materials have broad application prospects in many areas such as gas separation and storage, air separation, and homogeneous catalysis. Here, molecular dynamics simulations were used to advance the understanding of PLs with different canopy structures. PLs composed of hollow SiO molecules, which were functionalized with polymer chains containing coronas and canopies to make them liquid at accessible temperatures, were quite different from pure SiO nanoparticles. Read More

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Method Development and Validation of Per- and Polyfluoroalkyl Substances in Foods from FDA's Total Diet Study Program.

J Agric Food Chem 2021 May 13. Epub 2021 May 13.

U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5001 Campus Drive, College Park, Maryland 20740, United States.

Human exposure to per- and polyfluoroalkyl substances (PFAS) through the US diet has not been well-characterized. Highly consumed foods are routinely monitored through FDA's Total Diet Study program. Portions of these samples were used to develop and validate a method for PFAS in a wide variety of foods. Read More

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Cobalt Phosphorous Trisulfide as a High-Performance Electrocatalyst for the Oxygen Evolution Reaction.

ACS Appl Mater Interfaces 2021 May 13. Epub 2021 May 13.

Department of Inorganic Chemistry, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic.

Two-dimensional (2D) layered materials are currently one of the most explored materials for developing efficient and stable electrocatalysts in energy conversion applications. Some of the 2D metal phosphorous trichalcogenides (MPX or MPX in its simplified form) have been reported to be useful catalysts for water splitting, although results have been less promising for the sluggish oxygen evolution reaction (OER) due to insufficient activity or compromised stability. Herein, we report the OER catalysis of a series of MPX (M = Mn, Fe, Co, Zn, Cd; X = S, Se). Read More

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Ionic Liquid-Enabled Topical Delivery of Immunomodulators.

ACS Biomater Sci Eng 2021 May 13. Epub 2021 May 13.

John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, United States.

Skin is one of the most immunologically active organs of the body due to the presence of diverse immune cells and its active involvement in the innate and adaptive immunity. Because of its unique location and immunological role, skin offers an excellent site for the introduction of immunomodulators to synergize with the active immune microenviroment for the desired outcome. However, delivery of immunomodulators to the skin remains a significant challenge due to the skin's barrier properties. Read More

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