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Multi-frequency localized wave energy for delamination identification using laser ultrasonic guided wave.

Ultrasonics 2021 Jun 10;116:106486. Epub 2021 Jun 10.

School of Aerospace Engineering, Xiamen University, Xiamen 361005, China. Electronic address:

Delamination is the most common and dangerous failure mode for multilayered structures. Delamination defects of different shapes and sizes have different sensitivity to guided wave of different frequencies and modes. So that it is necessary to study the application of multi-frequency methods for achieving detection. Read More

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Low intensity pulsed ultrasound (LIPUS) use for the management of instrumented, infected, and fragility non-unions: a systematic review and meta-analysis of healing proportions.

BMC Musculoskelet Disord 2021 Jun 11;22(1):532. Epub 2021 Jun 11.

Department of Orthopaedic Surgery, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.

Background: Non-union occurs in approximately 5 to 10% of fracture patients, with certain bones at greater risk of failing to heal. Non-unions have a significant impact on socioeconomic costs and the patients short and long-term quality of life. Low intensity pulsed ultrasound (LIPUS) is a non-invasive therapy for non-union treatment that can improve the long-term outcome. Read More

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Delayed Union of Stress Fracture of the First Rib in a Yoga Instructor: A Case Report.

JBJS Case Connect 2021 06 11;11(2). Epub 2021 Jun 11.

Department of Orthopaedic Surgery, Showa University School of Medicine, Tokyo, Japan.

Case: We describe the case of a 38-year-old woman, a yoga instructor, who had pain in the right shoulder and scapular region of 4 months' duration while performing yoga. Radiography and computed tomography diagnosed delayed union of a first rib stress fracture. The delayed union of stress fracture of the first rib was successfully treated with the limiting of yoga activity and low-intensity pulsed ultrasound (LIPUS). Read More

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Ultrasound-Engineered fabrication of immobilized molybdenum complex on Cross-Linked poly (Ionic Liquid) as a new acidic catalyst for the regioselective synthesis of pharmaceutical polysubstituted spiro compounds.

Ultrason Sonochem 2021 Jun 1;75:105614. Epub 2021 Jun 1.

Department of Chemistry, Qom Branch, Islamic Azad University, Qom, Islamic Republic of Iran.

A novel supported molybdenum complex on cross-linked poly (1-Aminopropyl-3-vinylimidazolium bromide) entrapped cobalt oxide nanoparticles has been successfully fabricated through two different procedures, i.e. ultrasound (US) irradiations (100 W, 40 kHz) and reflux. Read More

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Automatic Quantification Of Subsurface Defects By Analyzing Laser Ultrasonic Signals Using Convolutional Neural Networks And Wavelet Transform.

IEEE Trans Ultrason Ferroelectr Freq Control 2021 Jun 9;PP. Epub 2021 Jun 9.

The conventional machine learning algorithm for analyzing ultrasonic signals to detect structural defects necessarily identifies and extracts either time or frequency domain features manually, which has problems in reliability and effectiveness. This work proposes a novel approach by combining convolution neural networks (CNN) and wavelet transform to analyze the laser generated ultrasonic signals for detecting the width of subsurface defects accurately. The novelty of this work is to convert the laser ultrasonic signals into the scalograms (images) via wavelet transform, which are subsequently utilized as the image input for the pre-trained CNN to extract the defect features automatically to quantify the width of defects, avoiding the necessity and inaccuracy induced by artificial feature selection. Read More

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Enhancement of Time Resolution in Ultrasonic time-of-flight Diffraction Technique with Frequency Domain Sparsity-Decomposability Inversion (FDSDI) Method.

IEEE Trans Ultrason Ferroelectr Freq Control 2021 Jun 9;PP. Epub 2021 Jun 9.

The lack of time resolution restricts the quantitative detection of shallow subsurface defects with ultrasonic time-of-flight diffraction (TOFD) technique due to the superposition between lateral wave and diffracted waves from upper and lower tips. In this paper, frequency domain sparsity-decomposability inversion (FDSDI) method was proposed to enhance the time resolution in TOFD based on the sparsity and decomposability of ultrasonic reflection sequence. An optimization problem was formulated in frequency domain by combining l1 and l2 norm constraints. Read More

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Low-intensity pulsed ultrasound promotes osteoarthritic cartilage regeneration by BMSC-derived exosomes via modulating the NF-κB signaling pathway.

Int Immunopharmacol 2021 Jun 5;97:107824. Epub 2021 Jun 5.

Department of Rehabilitation Medicine, Shunde Hospital of Southern Medical University, Foshan 528000, China; Department of Rehabilitation Medicine, Nanfang Hospital of Southern Medical University, Guangzhou 510000, China. Electronic address:

Osteoarthritis is the most common disabling joint disease throughout the world, and the effect of therapy on its course is still unsatisfactory in clinical practice. Recent studies have shown that mesenchymal stem cell (MSC)-derived exosomes can promote cartilage repair and regeneration in osteoarthritis, indicating that these exosomes could be a novel and promising strategy for treating osteoarthritis. This study investigated whether low-intensity pulsed ultrasound (LIPUS) enhances the effects of bone marrow MSC (BMSC)-derived exosomes on cartilage regeneration in osteoarthritis and examined the underlying mechanism. Read More

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A Lamb waves based ultrasonic system for the simultaneous data communication, defect inspection, and power transmission.

IEEE Trans Ultrason Ferroelectr Freq Control 2021 Jun 8;PP. Epub 2021 Jun 8.

Lamb waves based structural health monitoring (SHM) has attracted extensive attention in recent years. This article aims to realize the functions of data communication, defect detection and energy transmission through piezoelectric transducers. In this work, the S0 mode at 500 kHz and A0 mode at 150 kHz are selected as the carrier waves and the optimized excitation frequencies are determined through analytical investigation and frequency sweeping experiments. Read More

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[Connected bras for breast cancer detection in 2021: Analysis and perspectives].

Gynecol Obstet Fertil Senol 2021 Jun 4. Epub 2021 Jun 4.

Service d'anatomie et cytologie pathologiques, hôpital Nord Franche-Comté, 100, route de Moval, 90400 Trévenans, France.

Objectives: Breast cancer is the leading cancer in women worldwide with about 2 million new cases and 685,000 deaths each year. Mammography is the most widely used screening and diagnostic method. Currently, digital technologies advances facilitate the development of connected and portable devices. Read More

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Therapeutic Effects of Low-Intensity Pulsed Ultrasound on Premature Ovarian Insufficiency.

Ultrasound Med Biol 2021 Jun 1. Epub 2021 Jun 1.

State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Biomedical Engineering, Chongqing Medical University, Chongqing, China. Electronic address:

We explored the therapeutic effects of low-intensity pulsed ultrasound (LIPUS) on a rat model of ovarian damage induced by cyclophosphamide. A total of 44 female rats with premature ovarian insufficiency induced by cyclophosphamide were randomly divided into two groups (an ultrasound group and a control group); 22 normal rats without premature ovarian insufficiency were also included as a third group. The ultrasound group was treated with LIPUS, while the other two groups received the same treatment but without any power output. Read More

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Monitoring Hardening Behavior of Cementitious Materials Using Contactless Ultrasonic Method.

Sensors (Basel) 2021 May 14;21(10). Epub 2021 May 14.

School of Architecture, Soongsil University, Seoul 06978, Korea.

We propose a novel contactless ultrasonic method for monitoring the hardening behavior of cementitious materials. The goal of this method is to obtain high-quality data to compare the unique hardening process between rapid setting cement (RSC) and ordinary Portland cement (OPC) mortars without physical coupling to the surface of the specimens. To monitor the hardening behavior of cementitious materials, conventional approaches use contact or embedded-type sensors, which limit field application. Read More

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Microbial Hotspots in Lithic Microhabitats Inferred from DNA Fractionation and Metagenomics in the Atacama Desert.

Microorganisms 2021 May 12;9(5). Epub 2021 May 12.

GFZ German Research Centre for Geosciences, Section Geomicrobiology, Telegrafenberg, 14473 Potsdam, Germany.

The existence of microbial activity hotspots in temperate regions of Earth is driven by soil heterogeneities, especially the temporal and spatial availability of nutrients. Here we investigate whether microbial activity hotspots also exist in lithic microhabitats in one of the most arid regions of the world, the Atacama Desert in Chile. While previous studies evaluated the total DNA fraction to elucidate the microbial communities, we here for the first time use a DNA separation approach on lithic microhabitats, together with metagenomics and other analysis methods (i. Read More

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A New Method of Predicting the Structural and Mechanical Change of Materials during Extrusion by the Method of Multiple Plastic Deformations.

Materials (Basel) 2021 May 16;14(10). Epub 2021 May 16.

Department of Electrical Engineering, Automation and Informatics, Faculty of Engineering, Slovak University of Agriculture in Nitra, Tr. A. Hlinku 2, 949 76 Nitra, Slovakia.

The formulation of the Hall-Petch relationship in the early 1950s has raised immense interest in studying the influence of the grain size of solid materials on their properties. Grain refinement can be achieved through extreme deformation. In the presented study, Equal-Channel Angular Pressing (ECAP) was successfully applied to produce an ultrafine-grained microstructure in a pure commercial Cu of 99. Read More

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Wafer-Bonding Fabricated CMUT Device with Parylene Coating.

Micromachines (Basel) 2021 May 4;12(5). Epub 2021 May 4.

School of Electronic and Computer Engineering, Peking University, Shenzhen 518055, China.

The advantages of the capacitive micromachined ultrasound transducer (CMUT) technology have provided revolutionary advances in ultrasound imaging. Extensive research on CMUT devices for high-frequency medical imaging applications has been conducted because of strong demands and fabrication realization by using standard silicon IC fabrication technology. However, CMUT devices for low-frequency underwater imaging applications have been rarely researched because it is difficult to fabricate thick membrane structures through depositing processes using standard IC fabrication technology due to stress-related problems. Read More

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Investigation of Forging Metal Specimens of Different Relative Reductions Using Ultrasonic Waves.

Materials (Basel) 2021 May 5;14(9). Epub 2021 May 5.

Department of Physics, Faculty of Electrical Engineering and Information Technology, University of Žilina, Univerzitná 8215/1, 010 26 Žilina, Slovakia.

Forgings produced in industry are an irreplaceable basis for subsequent elaborating on machine tools. The quality of the semi-finished product produced by forging is a necessary prerequisite for ensuring the final quality of the final product because the forging can produce some defects. The presented paper is aimed at investigation of selected characteristics of forging steel specimens for various levels of their relative reduction. Read More

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Discharge of lithium-ion batteries in salt solutions for safer storage, transport, and resource recovery.

Waste Manag Res 2021 Jun 1:734242X211022658. Epub 2021 Jun 1.

School of Environment, College of Engineering, University of Tehran, Tehran, Iran.

The use of lithium-ion batteries (LIBs) has grown in recent years, making them a promising source of secondary raw materials due to their rich composition of valuable materials, such as Cobalt and Nickel. Recycling LIBs can help reduce fossil energy consumption, CO emissions, environmental pollution, and consumption of valuable materials with limited supplies. On the other hand, the hazards associated with spent LIBs recycling are mainly due to fires and explosions caused by unwanted short-circuiting. Read More

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Feasibility of Model-Assisted Probability of Detection Principles for Structural Health Monitoring Systems based on Guided Waves for Fibre-Reinforced Composites.

IEEE Trans Ultrason Ferroelectr Freq Control 2021 May 31;PP. Epub 2021 May 31.

In many industrial sectors, Structural Health Monitoring (SHM) is considered as an addition to Non-Destructive Testing (NDT) that can reduce maintenance effort during lifetime of a technical facility, structural component or vehicle. A large number of SHM methods is based on ultrasonic waves, whose properties change depending on structural health. However, the wide application of SHM systems is limited due to the lack of suitable methods to assess their reliability. Read More

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Particle separation in microfluidics using different modal ultrasonic standing waves.

Ultrason Sonochem 2021 May 21;75:105603. Epub 2021 May 21.

College of Transportation, Ludong University, Yantai, Shandong 264025, China. Electronic address:

Microfluidic technology has great advantages in the precise manipulation of micro and nano particles, and the separation of micro and nano particles based on ultrasonic standing waves has attracted much attention for its high efficiency and simplicity of structure. This paper proposes a device that uses three modes of ultrasonic standing waves to continuously separate particles with positive acoustic contrast factor in microfluidics. Three modes of acoustic standing waves are used simultaneously in different parts of the microchannel. Read More

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Unidirectional shear horizontal wave generation by periodic permanent magnets electromagnetic acoustic transducer with dual linear-coil array.

IEEE Trans Ultrason Ferroelectr Freq Control 2021 May 27;PP. Epub 2021 May 27.

Shear horizontal (SH) waves are commonly generated by periodic permanent magnet (PPM) electromagnetic acoustic transducers (EMATs) in metallic media. Conventional PPM EMATs generate ultrasonic waves, which simultaneously propagate both forwards and backwards. This can be an undesirable characteristic, since the backward wave can be eventually reflected, reaching the receiver transducer where it can mix with the signal of interest. Read More

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The use of low intensity pulsed ultrasound in the foot and ankle.

EFORT Open Rev 2021 Apr 1;6(4):217-224. Epub 2021 Apr 1.

Princess Alexandra Hospital, Harlow, UK.

Low intensity pulsed ultrasound (LIPUS) therapy has demonstrated clinical effectiveness in achieving union in a variety of fracture situations.Few studies have investigated the effectiveness of LIPUS therapy in foot and ankle surgery.The overall rate of union in all published studies relating to the use of LIPUS in a variety of foot and ankle fracture and fusion situations is 95%. Read More

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A Novel NaCl Concentration Detection Method Based on Ultrasonic Impedance Method.

IEEE Trans Ultrason Ferroelectr Freq Control 2021 May 26;PP. Epub 2021 May 26.

In this paper, we propose a novel method for real-time detection of NaCl concentration based on ultrasonic impedance method. Specifically, our method is based on the fact that different concentration of NaCl leads to differences in acoustic characteristics of ultrasonic waves. We conducted an experimental study on the relationship between the concentration and the amplitude of ultrasonic echo. Read More

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Disturbance of osteonal bone remodeling and high tensile stresses on the lateral cortex in atypical femoral fracture after long-term treatment with Risedronate and Alfacalcidol for osteoporosis.

Bone Rep 2021 Jun 7;14:101091. Epub 2021 May 7.

Niigata Rehabilitation Hospital, 761 Kizaki, Kita-ku, Niigata-shi, Niigata 950-3304, Japan.

An 83 year-old Japanese woman complained of left lateral thigh pain following a low-energy fall 4 months prior to admission. She had been treated for osteoporosis with Risedronate and Alfacalcidol for the previous five years. She was diagnosed with an atypical femoral fracture (AFF) according to the American Society for Bone and Mineral Research (ASBMR) Task Force revised criteria. Read More

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Biostimulatory Effects of Low-Intensity Pulsed Ultrasound on Rate of Orthodontic Tooth Movement and Associated Pain, Applied at 3-Week Intervals: A Split-Mouth Study.

Pain Res Manag 2021 5;2021:6624723. Epub 2021 May 5.

Prosthodontic Unit, School of Dental Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kota Bharu, Kelantan, Malaysia.

Objective: Low-intensity pulsed ultrasound (LIPUS) is a noninvasive modality to stimulate bone remodeling (BR) and the healing of hard and soft tissues. This research evaluates the biostimulatory effect of LIPUS on the rate of orthodontic tooth movement (OTM) and associated pain, when applied at 3-week intervals.

Methods: Twenty-two patients (11 males and 11 females; mean age 19. Read More

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Low-intensity pulsed ultrasound (LIPUS) for stimulation of bone healing - A narrative review.

Injury 2021 Jun 12;52 Suppl 2:S91-S96. Epub 2021 May 12.

Department of Trauma Surgery, University Hospital Regensburg, Germany. Electronic address:

The use of low intensity pulsed ultrasound (LIPUS) to accelerate the fracture repair process in humans was first reported by Xavier & Duarte in 1983 [1]. This success led to clinical trials and the 1994 approval of LIPUS in the United States for the accelerated healing of certain fresh fractures. LIPUS was approved in the US for the treatment of established non-unions in 2000, and is also approved around the world. Read More

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Growth Modulation by Stimulating the Growth Plate: A Pilot Study.

Ultrasound Med Biol 2021 May 17. Epub 2021 May 17.

Department of Orthopaedics, Duke University Medical Center, Durham, NC, USA. Electronic address:

This study investigates the ability of low-intensity pulsed ultrasound (LIPUS) or direct injection of recombinant growth hormone (rGH) to stimulate local growth of long bones. In a randomized controlled animal trial, healthy immature rabbits were allocated to 1 of the following 4 conditions: epiphyseal rGH periosteal injection, transdermal LIPUS, saline periosteal injection, or no treatment. New bone deposition was labeled with calcein at days 1 and 18, and microscopic measurements of growth were conducted by blinded observers. Read More

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Ultrasound Therapy, Chemotherapy and Their Combination for Prostate Cancer.

Technol Cancer Res Treat 2021 Jan-Dec;20:15330338211011965

College of Biomedical Sciences, College of Health Sciences, College of Osteopathic Medicine of the Pacific and College of Pharmacy, 6645Western University of Health Sciences, Pomona, CA, USA.

Prostate cancer is the second leading cause of cancer death in men. Its current treatment includes various physical and chemical approaches for the localized and advanced prostate cancer [e.g. Read More

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Neuroprotective Effect of Low-Intensity Pulsed Ultrasound on the Mouse MPTP/MPP Model of Dopaminergic Neuron Injury.

Ultrasound Med Biol 2021 May 16. Epub 2021 May 16.

Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Engineering Research Center of Stem Cell Therapy, Children's Hospital of Chongqing Medical University, Chongqing, China. Electronic address:

Ultrasound mediated neuromodulation has been demonstrated to a safe treatment strategy in the field of neuroscience. In this study, low-intensity pulsed ultrasound (LIPUS) was used to treat Parkinson's disease (PD) models induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridinium (MPP) to explore the possibility of ultrasound neuroprotective effect on PD. The results demonstrated that LIPUS treatment can attenuate the central neurotoxicity of MPTP in mice, reduce the loss of tyrosine hydroxylase positive neurons in the substantia nigra pars compacta and decrease the apoptosis in the section of substantia nigra. Read More

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Low-intensity pulsed ultrasound enhances angiogenesis in rabbit capsule tissue that acts as a novel vascular bed in vivo.

Adv Clin Exp Med 2021 May 18. Epub 2021 May 18.

Department of Urology, Shanghai Children's Hospital, Shanghai Jiao Tong University, China.

Background: In vivo prevascularization followed by pedicled transfer has emerged as a promising strategy for tissue engineering in recent years. We recently demonstrated that capsule tissue could serve as a novel axial in vivo vascular bed, although its high-density microvessels could only be maintained for about a week.

Objectives: In this present study, we aimed to demonstrate whether low-intensity pulsed ultrasound (LIPUS) promotes angiogenesis in capsule tissue. Read More

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Improved activity of MC3T3-E1 cells by the exciting piezoelectric BaTiO/TC4 using low-intensity pulsed ultrasound.

Bioact Mater 2021 Nov 21;6(11):4073-4082. Epub 2021 Apr 21.

School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang, 110001, China.

Developing bioactive materials for bone implants to enhance bone healing and bone growth has for years been the focus of clinical research. Barium titanate (BT) is an electroactive material that can generate electrical signals in response to applied mechanical forces. In this study, a BT piezoelectric ceramic coating was synthesized on the surface of a TC4 titanium alloy, forming a BT/TC4 material, and low-intensity pulsed ultrasound (LIPUS) was then applied as a mechanical stimulus. Read More

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November 2021

Exploring ligand binding pathways on proteins using hypersound-accelerated molecular dynamics.

Nat Commun 2021 05 14;12(1):2793. Epub 2021 May 14.

Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Capturing the dynamic processes of biomolecular systems in atomistic detail remains difficult despite recent experimental advances. Although molecular dynamics (MD) techniques enable atomic-level observations, simulations of "slow" biomolecular processes (with timescales longer than submilliseconds) are challenging because of current computer speed limitations. Therefore, we developed a method to accelerate MD simulations by high-frequency ultrasound perturbation. Read More

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