1,071 results match your criteria lipoprotein-associated phospholipase


Fetal High-Density Lipoproteins: Current Knowledge on Particle Metabolism, Composition and Function in Health and Disease.

Biomedicines 2021 Mar 30;9(4). Epub 2021 Mar 30.

Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Universitätsplatz 4, 8010 Graz, Austria.

Cholesterol and other lipids carried by lipoproteins play an indispensable role in fetal development. Recent evidence suggests that maternally derived high-density lipoprotein (HDL) differs from fetal HDL with respect to its proteome, size, and function. Compared to the HDL of adults, fetal HDL is the major carrier of cholesterol and has a unique composition that implies other physiological functions. Read More

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Differential Effects of Serum Lipoprotein-Associated Phospholipase A2 on Periventricular and Deep Subcortical White Matter Hyperintensity in Brain.

Front Neurol 2021 8;12:605372. Epub 2021 Mar 8.

Department of Neurology, The Affiliated Jiangning Hospital With Nanjing Medical University, Nanjing, China.

Serum level of lipoprotein-associated phospholipase A2 (Lp-PLA2) was associated with white matter hyperintensity (WMH). There were differences in the anatomical structure and pathophysiological mechanism between periventricular WMH (PVWMH) and deep subcortical WMH (DSWMH). In this study, we aimed to investigate the effects of serum Lp-PLA2 on the PVWMH and DSWMH. Read More

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Clinical Utility of the Serum Level of Lipoprotein-Related Phospholipase A2 in Acute Ischemic Stroke With Cerebral Artery Stenosis.

Front Neurol 2021 4;12:642483. Epub 2021 Mar 4.

Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

We aimed to study the clinical utility of serum lipoprotein-associated phospholipase A2 (Lp-PLA2) in acute ischemic stroke (AIS) with cerebral artery stenosis (CAS). We included 200 AIS patients and 90 healthy controls in this study. AIS patients were classified into three subgroups depending on the severity of CAS. Read More

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A novel prognosis prediction model, including cytotoxic T lymphocyte-associated antigen-4, ischemia-modified albumin, lipoprotein-associated phospholipase A2, glial fibrillary acidic protein, and homocysteine, for ischemic stroke in the Chinese hypertensive population.

J Clin Lab Anal 2021 Mar 18:e23756. Epub 2021 Mar 18.

Department of Emergency Medicine, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, P.R. China.

Background: There is still a lack of tools to assess the prognosis of ischemic stroke patients induced by hypertension. In this study, we built a novel prognostic assessment model for ischemic stroke in the Chinese hypertensive population.

Methods: Mass spectrometry technique was used to analyze the changes in serum protein profiles of hypertensive patients with ischemic stroke. Read More

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Negative association between lipoprotein associated phospholipase A2 activity and baroreflex sensitivity in subjects with high normal blood pressure and a positive family history of hypertension.

Physiol Res 2021 Mar 8. Epub 2021 Mar 8.

Department of Internal Medicine, Faculty of Medicine, Comenius University, Bratislava, Slovak Republic.

The relationship between baroreflex sensitivity (BRS) and inflammatory vascular biomarker Lipoprotein associated phospholipase A2 (Lp-PLA2) in subjects with high normal blood pressure (HNBP, prehypertensives) with a positive family history of hypertension (FHH+) and hypertension history free control subjects (FHH-) was evaluated. A total of 24 HNBP participants (age 39.5 ± 2. Read More

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Phospholipase A2 and Ischemic Stroke Etiology.

Neurologist 2021 Mar 4;26(2):32-35. Epub 2021 Mar 4.

Departments of Neurology.

Background: Lipoprotein-associated phospholipase A2 (Lp-PLA2), which is involved in the inflammatory atherosclerotic process, has emerged as an independent risk factor for atheromatous vascular events. Its impact on coronary disease has already been demonstrated, however, its influence in cerebrovascular etiology is still unknown. We aimed to observe and describe the potential association between Lp-PLA2 levels and the etiologic subtype of ischemic stroke. Read More

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Switching the substrate specificity of lysoplasmalogen-specific phospholipase D.

FEBS Open Bio 2021 Apr 19;11(4):1132-1143. Epub 2021 Mar 19.

Materials Science Course, Faculty of Symbiotic Systems Science and Technology, Fukushima University, Japan.

Lysoplasmalogen-specific phospholipase D (LyPls-PLD) catalyzes reactions in a manner similar to those catalyzed by glycerophosphodiester phosphodiesterase (GDPD) and other well-known PLDs. Although these enzymes hydrolyze the glycerophosphodiester bond, their substrate specificities are completely different. Previously, we reported that LyPls-PLD from Thermocrispum sp. Read More

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Lipoprotein-associated phospholipase A2 levels, endothelial dysfunction and arterial stiffness in patients with stable coronary artery disease.

Lipids Health Dis 2021 Feb 14;20(1):12. Epub 2021 Feb 14.

1st Cardiology Department, Hippokration Hospital, Athens Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Background: Lipoprotein-associated Phospholipase A2 (Lp-PLA2), can exert proinflammatory as well as proatherogenic properties on the vascular wall. The current study sought to evaluate the influence of high Lp-PLA2 levels on indices of arterial wall properties in patients with stable coronary artery disease (CAD).

Methods: Three hundred seventy-four consecutive patients with stable CAD (mean age 61 ± 11 years, 89% males) were enrolled in this single-center cross-sectional study. Read More

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February 2021

Vascular inflammation, atherosclerosis, and lipid metabolism and the occurrence of non-high albuminuria diabetic kidney disease: A cross-sectional study.

Diab Vasc Dis Res 2021 Jan-Feb;18(1):1479164121992524

Department of Laboratory Medicine, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China.

Aim: Atherosclerosis involves vascular endothelial damage and lipid metabolism disorder, which is closely related to the occurrence and development of diabetic kidney disease (DKD). However, studies on non-high albuminuria DKD (NHADKD) with an albumin to creatinine ratio (ACR) <30 mg/g are rare. This study is to investigate the relationship between atherogenic factors and the occurrence of NHADKD. Read More

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February 2021

Lp-PLA2, a potential protector of lung cancer patients complicated with pleural effusion from lung diseases, proves effective for the diagnosis and pathological classification of lung cancer.

Transl Oncol 2021 Apr 5;14(4):101030. Epub 2021 Feb 5.

Department of Clinical Laboratory, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, 150 Ximen Road, Linhai, Taizhou, Zhejiang Province, China. Electronic address:

Abnormal lipid metabolism plays a crucial role in cancers, but few studies have investigated the relationship between lipoprotein-associated phospholipase A2 (Lp-PLA2) and lung cancer. In this study, 58 benign lung disease (LB) and 57 lung cancer (LC) patients complicated with pleural effusion (PE) were included, and their fasting serum and PE samples were collected. Results showed that serum Lp-PLA2 in the LC group was lower than that in the LB group, and other serum lipids were higher (P < 0. Read More

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Prediction of Lipoprotein-Associated Phospholipase A2 and Inflammatory Markers in Subclinical Atherosclerosis in Premature Ovarian Failure Patients.

Acta Cardiol Sin 2021 Jan;37(1):30-37

Department of Internal Medicine, Ege University Faculty of Medicine, İzmir, Turkey.

Background: Lipoprotein-associated phospholipase A2 (Lp-PLA2) activity has been associated with the risk of clinical cardiovascular events.

Objectives: In this study, we aimed to investigate whether the activity of Lp-PLA2 presents a risk for subclinical atherosclerosis in young patients with premature ovarian failure (POF).

Methods: Consecutive patients with clinical and biochemical evidence of naïve POF (n = 66) in January and February 2018 and age-matched healthy controls (n = 73) were enrolled. Read More

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January 2021

The diagnostic and prognostic performance of Lp-PLA2 in acute ischemic stroke.

Med Clin (Barc) 2021 Jan 19. Epub 2021 Jan 19.

The Department of Neurology, China-Japan Union Hospital of Jilin University, PR China. Electronic address:

Objective: We aimed to investigate the correlation between serum lipoprotein-associated phospholipase A2 (Lp-PLA2) level and acute ischemic stroke (AIS) severity and recurrence, which could indicate the diagnostic and prognostic values of Lp-PLA2.

Methods: Two hundred and fifty-one AIS patients who were diagnosed in the department of neurology, China-Japan Union Hospital, from April 2018 to June 2019 and 100 non-cerebrovascular disease patients were included in this study. Demographic data and clinical materials including age, sex, BMI, medical history, bad habits, imaging data, blood tests, etc. Read More

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January 2021

Lp-PLA2 evaluates the severity of carotid artery stenosis and predicts the occurrence of cerebrovascular events in high stroke-risk populations.

J Clin Lab Anal 2021 Mar 17;35(3):e23691. Epub 2021 Jan 17.

Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, China.

Background: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an independent risk factor for cardiovascular disease. However, relationship between carotid artery stenosis and cerebrovascular events in high stroke-risk populations is still unclear.

Methods: A total of 835 people at a high risk of stroke were screened from 15,933 people aged >40 years in April 2013 and followed at 3, 6, 12, and 24 months. Read More

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Association of neuroimaging markers of cerebral small vessel disease with short-term outcomes in patients with minor cerebrovascular events.

BMC Neurol 2021 Jan 13;21(1):21. Epub 2021 Jan 13.

Department of Neurology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, 211100, Jiangsu, China.

Background: Increasing evidences have showed that neuroimaging markers of SVD can predict the short-term outcome of acute ischemic stroke (AIS). It is unclear that whether neuroimaging markers of SVD are also associated with short-term outcomes of minor cerebrovascular events. In the present study, we investigate neuroimaging markers of SVD in order to explore their roles in prediction of short-term outcome in patients with minor cerebrovascular events. Read More

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January 2021

Oxygenated phosphatidylethanolamine navigates phagocytosis of ferroptotic cells by interacting with TLR2.

Cell Death Differ 2021 Jan 11. Epub 2021 Jan 11.

Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou, 510632, China.

During cancer therapy, phagocytic clearance of dead cells plays a vital role in immune homeostasis. The nonapoptotic form of cell death, ferroptosis, exhibits extraordinary potential in tumor treatment. However, the phagocytosis mechanism that regulates the engulfment of ferroptotic cells remains unclear. Read More

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January 2021

The recent effects of small dose of folic acid on lipoprotein-associated phospholipase A2 and systolic blood pressure variability in coronary heart disease patients with hyperhomocysteinemia: A single-center prospective cohort study.

Medicine (Baltimore) 2020 Dec;99(51):e23573

Department of Physical Diagnostics, Yue Bei People's Hospital Affiliated to Shantou University, Shaoguan, Guangdong, China.

Abstract: To Investigate the recent effects of small dose of folic acid on lipoprotein-associated phospholipase A2 (LP-PLA2) and systolic blood pressure variability in coronary heart disease (CHD) patients with hyperhomocysteinemia.In this prospective cohort study, a total of 167 CHD patients with hyperhomocysteinemia were consecutively enrolled, and they were divided into Group A (without folic acid intervention, n = 99), Group B (with 0.4 mg of folic acid intervention, n = 34), Group C (0. Read More

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December 2020

Hydrogen influences HDL-associated enzymes and reduces oxidized phospholipids levels in rats fed with a high-fat diet.

Life Sci 2021 Feb 29;267:118945. Epub 2020 Dec 29.

Taishan Institute for Hydrogen Biomedicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, PR China; Key Laboratory of Atherosclerosis in Universities of Shandong Province, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, PR China. Electronic address:

Aims: Oxidized phospholipids (OxPLs) are formed as a result of oxidative stress, which potentially mediate multiple pathological effects. We aimed to evaluate the effects of hydrogen (H) on OxPLs in vivo and the underlying mechanism.

Main Methods: Rats were randomly assigned to three groups: control group fed with a chow diet, model group fed with a high-fat diet, and H-treated group fed with a high-fat diet and treated by 4% H inhalation for ten weeks. Read More

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February 2021

Puerarin alleviates coronary heart disease via suppressing inflammation in a rat model.

Gene 2021 Mar 15;771:145354. Epub 2020 Dec 15.

Department of Cardiology, The Second Affiliated Hospital of Soochow University, Gusu District, Suzhou, Jiangsu Province 215004, China.

Background: Puerarin shows inhibitory effects on inflammation in chronic heart failure (CHF), but its efficacy in coronary heart disease (CHD) remained vague.

Methods: Rat CHD model was constructed, and serum parameters were determined using a blood liquid biochemical analyzer. Also, contents of creatine kinase (CK), creatine kinase MB isoenzyme (CK-MB), lactate dehydrogenase (LDH) and cardiac troponin (cTnT) were measured using colorimetry. Read More

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Expression of Hypoxia-Inducible Factor-1α (HIF1A) and Lp-PLA2 in Low, Intermediate, and High Cardiovascular Disease Risk Population.

Vasc Health Risk Manag 2020 1;16:507-513. Epub 2020 Dec 1.

Department of Biomedicine, Faculty of Medicine, Brawijaya University, Malang 65145, Indonesia.

Background: The pathomechanism of CVD is a complex and multifactorial process. The primary mechanism of CVD is atherosclerosis. Inflammation in atherogenesis raises the risk of hypoxia, which will activate hypoxia-inducible factor-1α (HIF1A). Read More

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December 2020

[Study on the relationship between occupational stress and metabolic syndrome in operating room nursing staff of a third-class A hospital].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2020 Nov;38(11):839-842

The Operating Room of Qilu Hospital, Shandong University, Jinan 250012, China.

To explore the relationship between occupational stress and metabolic syndrome (MS) in operating room nurses. In July 2019, 179 nurses in the operating room of a third-class A hospital in Shandong Province were selected as the research objects. The self-designed questionnaire was used to investigate the general situation, and "Nurse Job Stressor Scale" was used to investigate the occupational stress level of nursing staff. Read More

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November 2020

The role of lipoprotein-associated phospholipase A2 in acute kidney injury of septic mice.

Transl Androl Urol 2020 Oct;9(5):2192-2199

Department of Emergency Medicine, Affiliated Hospital of Nantong University, Nantong, China.

Background: This experiment aimed to investigate the role and mechanism of lipoprotein-associated phospholipase A2 (Lp-PLA2) in kidney injury in septic mice induced by cecal ligation and perforation (CLP).

Methods: Male BALB/c mice were randomly divided into two groups: sham-operation group (Sham group) and septic group (CLP group). The septic model was simulated by cecal ligation and puncture method, but only cecal ligation was used for the sham operation group. Read More

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October 2020

Correlation of Serum BACE1 With Emergence Delirium in Postoperative Patients: A Preliminary Study.

Front Aging Neurosci 2020 28;12:555594. Epub 2020 Oct 28.

Department of Anesthesiology, Xiangya Hospital Central South University, Changsha, China.

: The mechanism underlying delirium, a common acute fluctuating mental state, may be related to the activation of a neuroinflammatory response. In this study, we attempted to investigate whether plasma inflammatory response markers, vascular and cerebrovascular injury-related markers, and neurodegeneration-associated markers were associated with emergence delirium (ED). : Patients aged 50 years or above who underwent elective laparoscopic surgery under general anesthesia were included in this study. Read More

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October 2020

Association of Carotid Plaque and Serum Lipoprotein-Associated Phospholipase A2 (LP-PLA2) with Postoperative Delirium in Geriatric Patients Undergoing Hip Replacement: A Prospective Cohort Study.

Med Sci Monit 2020 Nov 14;26:e927763. Epub 2020 Nov 14.

Department of Anesthesiology, Qilu Hospital of Shandong University (Qingdao), Qingdao, Shandong, China (mainland).

BACKGROUND The aim of this study was to investigate the relationships among carotid plaque (CP), serum lipoprotein-associated phospholipase (LP-PLA2), and POD in elderly patients. MATERIAL AND METHODS Sixty-two elderly patients undergoing hip replacement with spinal-epidural anesthesia were divided into CP and non-CP groups based on the preoperative presence or absence of carotid atherosclerotic plaques, as assessed by ultrasound. POD was diagnosed by means of the Confusion Assessment Method (CAM). Read More

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November 2020

Lipoprotein-associated phospholipase A2 (Lp-PLA2) - possible diagnostic and risk biomarker in chronic ischaemic heart disease.

J Enzyme Inhib Med Chem 2021 Dec;36(1):68-73

Faculty of Medicine, Titu Maiorescu University, Bucharest, Romania.

In a group of 208 patients with chronic ischaemic heart disease, the variation of A-associated-LDL phosphatase (Lp-PLA) serum concentration values was analysed in dynamics at a two-week interval. The conclusion of the study is that the values of serum concentration of Lp-PLA can be accepted as a biomarker with diagnostic specificity for chronic ischaemic heart disease, a parameter of real utility in medical practice, both in situations where the patient, although clinically reporting the existence of angina pectoris, does not show specific changes on an EKG, and for the assessment of the response to personalised therapy. Read More

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December 2021

Association Between Plasma Lipoprotein-Associated Phospholipase A2 and Plaque Vulnerability in TIA Patients With Unilateral Middle Cerebral Artery Stenosis.

Front Neurol 2020 16;11:574036. Epub 2020 Oct 16.

Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) has emerged as a novel biomarker for coronary atherosclerosis. However, the association between Lp-PLA2 and plaque vulnerability in atherosclerosis of cervicocerebral arteries remains poorly defined, especially for intracranial atherosclerotic stenosis (ICAS). We aimed to investigate the association between Lp-PLA2 and plaque vulnerability in transient ischemic attack (TIA) patients with unilateral middle cerebral artery stenoses (MCAs). Read More

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October 2020

The diagnostic efficacy and predictive value of combined lipoprotein laboratory indexes for atherosclerosis.

J Pak Med Assoc 2020 Sep;70 [Special Issue](9):115-119

Department of Clinical Laboratory, Xianning Central Hospital, The First Affiliated Hospital of Hubei University of Science and Technology, Xianning, China.

Objective: To investigate the diagnostic efficacy and predictive value of combined lipoprotein laboratory indexes for atherosclerosis.

Methods: Clinical data of 250 patients with atherosclerosis admitted to Xianning central hospital, China from January 2015 to December 2018 and 80 healthy subjects on physical examination in the same period were analyzed retrospectively. Serological laboratory indices related to lipid metabolism were measured, and their diagnostic efficacy and predictive value for atherosclerosis were evaluated by univariate and multivariate statistical methods. Read More

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September 2020

Pro B-type Natriuretic Peptide and Midregional Proadrenomedullin are Associated with Incident Carotid Stenosis During Long Term Follow-up.

J Stroke Cerebrovasc Dis 2021 Jan 4;30(1):105403. Epub 2020 Nov 4.

Department of Clinical Sciences, Malmö, Sweden; Vascular Centre, Department of Cardiothoracic and Vascular Surgery, Malmö, Sweden. Electronic address:

Background: Plasma biomarkers may be useful to detect healthy individuals at increased risk for atherosclerotic manifestations, such as carotid artery stenosis. The aim of this longitudinal cohort study was to evaluate new biomarkers in relation to C-reactive protein and conventional risk factors for carotid artery stenosis during long term follow-up METHODS: The following markers were measured in 5550 middle-aged subjects: C-reactive protein, lipoprotein-associated phospholipase A2, proneurotensin, midregional pro-adrenomedullin, midregional pro-atrial natriuretic peptide, N-terminal pro B-type natriuretic peptide, copeptin, and cystatin C. Subjects with prevalent carotid artery stenosis were excluded. Read More

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January 2021

[Role of markers of inflammation and endothelial dysfunction in the prognosis of the development of cardiovascular complications in patients with coronary artery disease and metabolic syndrome after coronary stenting].

Kardiologiia 2020 Sep 17;60(8):98-105. Epub 2020 Sep 17.

Cardiology Research Institute, Tomsk National Research Medical Centre, Russian Academy of Sciences, Russia.

Aim To study the role of inflammation markers and endothelial dysfunction in predicting the risk of cardiovascular event following a percutaneous coronary intervention (PCI) in patients with ischemic heart disease (IHD) and metabolic syndrome (MS).Materials and methods 80 patients (72 men; median age, 56 (50;63) years) with IHD and PCI were evaluated. Based on the presence of MS according to NCEP-ATP III criteria, patients were divided into two groups, group 1 without MS (n=32) and group 2 with MS (n=48). Read More

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September 2020

Transfer and Enzyme-Mediated Metabolism of Oxidized Phosphatidylcholine and Lysophosphatidylcholine between Low- and High-Density Lipoproteins.

Antioxidants (Basel) 2020 Oct 26;9(11). Epub 2020 Oct 26.

Division of Biological Chemistry, Department of Pharmaceutical Sciences, Showa University School of Pharmacy, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.

Oxidized low-density lipoprotein (oxLDL) and oxidized high-density lipoprotein (oxHDL), known as risk factors for cardiovascular disease, have been observed in plasma and atheromatous plaques. In a previous study, the content of oxidized phosphatidylcholine (oxPC) and lysophosphatidylcholine (lysoPC) species stayed constant in isolated in vivo oxLDL but increased in copper-induced oxLDL in vitro. In this study, we prepared synthetic deuterium-labeled 1-palmitoyl lysoPC and palmitoyl-glutaroyl PC (PGPC), a short chain-oxPC to elucidate the metabolic fate of oxPC and lysoPC in oxLDL in the presence of HDL. Read More

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October 2020

Carotid Plaque Inflammation Assessed by F-FDG PET/CT and Lp-PLA Is Higher in Symptomatic Patients.

Angiology 2021 03 22;72(3):260-267. Epub 2020 Oct 22.

Angiology and Vascular Surgery Department, 16503Hospital Universitario de Getafe, Madrid, Spain.

Carotid plaque inflammation assessed by 2-deoxy-2-[F]fluoro-D-glucose (F-FDG) positron emission tomography/computed tomography (PET/CT) and lipoprotein-associated phospholipase A2 (Lp-PLA) levels are higher in symptomatic patients. The aim of this study was to assess correlations between F-FDG uptake on PET scan of carotid artery plaques, plasma levels of Lp-PLA, and cerebrovascular symptoms. The study included 45 consecutive patients (22 symptomatic, 23 asymptomatic) with >70% carotid stenosis. Read More

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