189,840 results match your criteria lipids rat

The effects of neuronostatin on proliferation and differentiation of rat primary preadipocytes and 3T3-L1 cells.

Biochim Biophys Acta Mol Cell Biol Lipids 2021 Jul 28:159018. Epub 2021 Jul 28.

Department of Animal Physiology, Biochemistry and Biostructure, Poznan University of Life Sciences, 60-637 Poznan, Poland. Electronic address:

Neuronostatin is a peptide hormone encoded by the somatostatin gene. Biological effects of neuronostatin are mediated through activation of GPR107. There is evidence indicating that neuronostatin modulates energy homeostasis by suppressing food intake and insulin secretion, while stimulating glucagon secretion. Read More

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Synthesis of a novel glibenclamide-pioglitazone hybrid compound and its effects on glucose homeostasis in normal and insulin-resistant rats.

Bioorg Chem 2021 Jul 7;114:105157. Epub 2021 Jul 7.

Universidade Federal de Santa Catarina, Departamento de Bioquímica - Centro de Ciências Biológicas, Campus Universitário, Trindade, CEP: 88040-900 - Florianópolis, SC, Brazil. Electronic address:

A new library of hybrid compounds that combine the functional parts of glibenclamide and pioglitazone was designed and developed. Compounds were screened for their antihyperglycemic effects on the glucose tolerance curve. This approach provided a single molecule that optimizes the pharmacological activities of two drugs used for the treatment of diabetes mellitus type 2 (DM2) and that have distinct biological activities, potentially minimizing the adverse effects of the original drugs. Read More

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Supplementation of cumin seed powder prevents oxidative stress, hyperlipidemia and non-alcoholic fatty liver in high fat diet fed rats.

Biomed Pharmacother 2021 Jul 10;141:111908. Epub 2021 Jul 10.

Department of Pharmaceutical Sciences, North South University Bangladesh, Bangladesh. Electronic address:

The present investigation was an attempt to evaluate the hypoglycemic, lipid-lowering, antioxidant and hepatoprotective effects of cumin (Cuminum cyminum family: Apiaceae) supplementation in high fat (HF) diet fed rats. Male Wistar rats were divided into four groups, such as control, control+ cumin, HF and HF+ cumin. Oral glucose tolerance test, plasma lipids, oxidative stress parameters, antioxidant enzymes activities, and liver dysfunction marker enzyme activities were evaluated. Read More

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The methods of vibrational microspectroscopy reveals long-term biochemical anomalies within the region of mechanical injury within the rat brain.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jul 22;263:120214. Epub 2021 Jul 22.

AGH University of Science and Technology, Faculty of Physics and Applied Computer Science, Krakow, Poland. Electronic address:

Traumatic brain injury (TBI), meaning functional or structural brain damage which appear as a result of the application of the external physical force, constitutes the main cause of death and disability of individuals and a great socioeconomic problem. To search for the new therapeutic strategies for TBI, better knowledge about posttraumatic pathological changes occurring in the brain is necessary. Therefore in the present paper the Fourier transform infrared microspectroscopy and Raman microscopy were used to examine local and remote biochemical changes occurring in the rat brain as a result of focal cortex injury. Read More

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[Animal Experimental Study of the Role of Menthol and Cineole, Two Tobacco Additives, on Nicotine Dependence].

Sichuan Da Xue Xue Bao Yi Xue Ban 2021 Jul;52(4):649-654

Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China.

Objective: To establish a nicotine intravenous self-administration rat model, and to examine, with this model, the effects of two flavoring additives, menthol and cineole, on nicotine dependence.

Methods: Thirty male Sprague-Dawley (SD) rats were included in the study. After jugular venous catheterization was performed, fixed concentration of nicotine was administered in order to train the rats and establish the rat model of intravenous self-administration groups, receiving intraperitoneal injection of menthol, cineole, and dimethyl sulfoxide (DMSO), the vehicle that was used for the control group. Read More

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[Preparation, Characterization and Pharmacokinetic Study of Arginine Deiminase Lipid Nanoparticles].

Sichuan Da Xue Xue Bao Yi Xue Ban 2021 Jul;52(4):619-623

Chongqing Research Center for Pharmaceutical Engineering, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.

Objective: To prepare and characterize D-alpha-Tocopheryl polyethylene glycol 1000 succinate (TPGS) modified arginine deiminase (ADI) sulfobutyl-β-Cyclodextrin liposome nanoparticles (ATCL), and to investigate the pharmacokinetic characteristics of ATCL in animals.

Methods: The reverse evaporation method was used to prepare ATCL, and the particle size and Zeta potential of ATCL were measured. Thiosemicarbazone-diacetylmonooxime colorimetric method was used to measure the activity of ADI. Read More

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[Preparation and Evaluation of Intranasal Gel of Volatile Oil and Baicalin].

Sichuan Da Xue Xue Bao Yi Xue Ban 2021 Jul;52(4):585-591

Key Laboratory of Smart Drug Delivery of the Ministry of Education, School of Pharmacy, Fudan University, Shanghai 201203, China.

Objective: To prepare and evaluate a new formulation of thermosensitive and ion-sensitive gel for nasal administration, using the volatile oil of and baicalin, the effective component extracted from .

Methods: Formulation of nasal gel of volatile oil and baicalin was prepared by using poloxamer 407 and deacetylated gellan gum as the gel base, 10% pharmasolve and 2% polysorbate 80 as the solubilizer, and 0.8% triethanolamine as the pH regulator. Read More

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Long-term cold storage preservation does not affect fatty livers from rats fed with a methionine and choline deficient diet.

Lipids Health Dis 2021 Jul 28;20(1):78. Epub 2021 Jul 28.

Department of Internal Medicine and Therapeutics, University of Pavia, 27100, Pavia, Italy.

Background: Waiting lists that continue to grow and the lack of organs available for transplantation necessitate the use of marginal livers, such as fatty livers. Since steatotic livers are more susceptible to damage from ischemia and reperfusion, it was investigated whether fatty livers with different lipidomic profiles show a different outcome when subjected to long-term cold storage preservation.

Methods: Eight-week-old male Wistar rats fed for 2 weeks by a methionine-choline-deficient (MCD) diet or control diet were employed in this study. Read More

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The effects of long-term moderate exercise and Western-type diet on oxidative/nitrosative stress, serum lipids and cytokines in female Sprague Dawley rats.

Eur J Nutr 2021 Jul 28. Epub 2021 Jul 28.

Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, 15/1 Auenbruggerplatz, 8036, Graz, Austria.

Purpose: Regular exercise reduces obesity and the risk of cardiovascular disease. However, health-promoting benefits of physical activity are commonly associated with increased inflammation and oxidative stress. Here, we tested whether constant moderate exercise is able to prevent or attenuate the oxidative/nitrosative stress, inflammation, and serum lipids in lean and obese rats. Read More

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Combats Oxidative Stress, Protein and Lipid Dyshomeostasis, Inflammation, Hepatic Injury, and Glomerular Blockage in Rats.

Prev Nutr Food Sci 2021 Jun;26(2):177-185

Department of Biochemistry, College of Health Sciences, School of Basic Medical Sciences, Igbinedion University Okada, Benin City, Edo State 302110, Nigeria.

, better known as 'pepperfruit', is a medicinal plant consumed in West Africa. possesses strong antioxidant properties and contains uvariopsine, an alkaloid which improves bile secretion and liver function. In the present study, the ethanolic extract of fruits was tested for its ability to alleviate pathophysiological conditions bordering on oxidative stress, including protein and lipid dyshomeostasis, inflammation, and hepatic and glomerular injury. Read More

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Vitamin D modulates hepatic microRNAs and mitigates tamoxifen-induced steatohepatitis in female rats.

Fundam Clin Pharmacol 2021 Jul 27. Epub 2021 Jul 27.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Background: Tamoxifen (TAM) is a life-saving and cost-effective drug widely used in the prevention and treatment of breast cancer. However, the adverse effects of tamoxifen can lead to non-adherence and poor patient outcomes. Therefore, exploring novel strategies to improve TAM safety profile is crucial. Read More

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[Effects of brown rice on metabolomics related to glucose and lipid in normal rats].

Wei Sheng Yan Jiu 2021 Jul;50(4):600-608

National Health and Family Planning Commission, National Institute for Nutrition and Health, China CDC, Beijing 100050, China.

Objective: To investigate the effects of whole grain rice on blood sugar, blood lipid and metabonomics compared with ordinary feed and refined rice.

Methods: According to the initial body weight and fasting blood glucose, 36 male SD rats were randomly divided into 3 groups: control group, RG-rice group and WG-rice group, fed with AIN-93 G feed, feeds prepared with refined rice flour or brown rice flour, respectively, for 18 weeks. Food intake and body weight were monitored weekly. Read More

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[2, 3, 5, 4'-tetrahydroxystilbene-2-O-β-d-glucoside alleviates lipopolysaccharide-induced acute lung injury in rats].

J Chen H Liu

Nan Fang Yi Ke Da Xue Xue Bao 2021 Jul;41(7):1101-1106

Department of General Practice, First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510030, China.

Objective: To observe the protective effect of 2, 3, 5, 4'-tetrahydroxystilbene-2-O-β-d-glucoside (TSG) against lipopolysaccharide (LPS)-induced acute lung injury (ALI) in rats and explore the underlying mechanism.

Methods: Thirty-six SD rats were randomized equally into 4 groups: the normal control group, ALI model group, and low- and high-dose TSG groups (treated with 50 and 100 mg/kg TSG via intragastric administration, respectively). In all but the normal control group, the rats were subjected to tail vein injection of LPS to induced ALI. Read More

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Protective effect of exosomes derived from bone marrow mesenchymal stem cells on rats with diabetic nephropathy and its possible mechanism.

Am J Transl Res 2021 15;13(6):6423-6430. Epub 2021 Jun 15.

Department of Endocrinology, The First Affiliated Hospital of Ji'nan University Guangzhou, Guangdong Province, China.

Objective: To investigate the effect of exosomes derived from bone marrow mesenchymal stem cells (BMMSC-Exos) on diabetic nephropathy (DN) rats and its possible mechanism.

Methods: Thirty rats were divided into the following three groups of 10 rats each: the NC group (normal rats), the DN group (rats with DN), and the BM group (DN rats injected with BMMSC-Exo). Blood glucose level, renal function, blood lipid level, and plasma viscosity of the rats were detected. Read More

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Transcatheter arterial chemoembolization combined with Hippo/YAP inhibition significantly improve the survival of rats with transplanted hepatocellular carcinoma.

Lipids Health Dis 2021 Jul 25;20(1):74. Epub 2021 Jul 25.

Department of Oncology Medilcal Center, The First People's Hospital of Zhaoqing, Zhaoqing, Guangdong, 526000, China.

Background: This study aimed to explore the effect of inhibiting the Hippo/Yes-associated protein (YAP) signaling pathway on the outcomes of transcatheter arterial chemoembolization (TACE) in treating transplanted hepatocellular carcinoma (HCC).

Methods: A transplanted HCC rat model was established. Then, rats were randomly divided into four groups: Sham, TACE, verteporfin (inhibitor of Hippo/YAP), and TACE+verteporfin. Read More

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Magnetic nanostructured lipid carrier for dual triggered curcumin delivery: Preparation, characterization and toxicity evaluation on isolated rat liver mitochondria.

J Biomater Appl 2021 Jul 26:8853282211034625. Epub 2021 Jul 26.

Department of Pharmaceutical Biomaterials, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran.

In this research, magnetic nanostructured lipid carriers (Mag-NLCs) were synthesized for curcumin (CUR) delivery. NLCs are drug-delivery systems prepared by mixing solid and liquid (oil) lipids. For preparation of NLCs, cetylpalmitate was selected as solid lipid and fish oil as liquid lipid. Read More

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Timosaponin alleviates oxidative stress in rats with high fat diet-induced obesity via activating Nrf2/HO-1 and inhibiting the NF-κB pathway.

Eur J Pharmacol 2021 Jul 21:174377. Epub 2021 Jul 21.

Department of Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China. Electronic address:

Anemarrhena asphodeloides originated from the rhizome of Liliaceae Anemarrhena asphodeloides. One of the active pharmacological components of Anemarrhena asphodeloides is timosaponin (TSA), which reduces blood lipids and shows antioxidation and anti-inflammatory effects, but its mechanism is unclear. The objective of this study was to investigate the effect of TSA on oxidative stress induced by a long-term high-fat diet in obese rats. Read More

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SCD inhibition protects from Alpha Synuclein induced neurotoxicity but is toxic to early neuron cultures.

eNeuro 2021 Jul 22. Epub 2021 Jul 22.

Neurodegeneration Research Unit, Biogen, Cambridge, MA, 02142 USA

Here we report the independent discovery and validation of Stearoyl-CoA desaturase (SCD) as a modulator of alpha-synuclein (αSyn) induced pathology and toxicity in cell-based Parkinson's Disease models (PD). We identified SCD as top altered gene from transcriptional profiling in primary neurons exogenously expressing αSyn with the amplified familial PD mutation 3K. Thus, we sought to further explore SCD as a therapeutic target in neurodegeneration. Read More

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Metformin Affects Cardiac Arachidonic Acid Metabolism and Cardiac Lipid Metabolite Storage in a Prediabetic Rat Model.

Int J Mol Sci 2021 Jul 19;22(14). Epub 2021 Jul 19.

Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, 14021 Prague, Czech Republic.

Metformin can reduce cardiovascular risk independent of glycemic control. The mechanisms behind its non-glycemic benefits, which include decreased energy intake, lower blood pressure and improved lipid and fatty acid metabolism, are not fully understood. In our study, metformin treatment reduced myocardial accumulation of neutral lipids-triglycerides, cholesteryl esters and the lipotoxic intermediates-diacylglycerols and lysophosphatidylcholines in a prediabetic rat model ( < 0. Read More

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Increased Beta-Hydroxybutyrate Level Is Not Sufficient for the Neuroprotective Effect of Long-Term Ketogenic Diet in an Animal Model of Early Parkinson's Disease. Exploration of Brain and Liver Energy Metabolism Markers.

Int J Mol Sci 2021 Jul 14;22(14). Epub 2021 Jul 14.

Deptartment of Neuropsychopharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, Smętna 12 St., 31-343 Krakow, Poland.

The benefits of a ketogenic diet in childhood epilepsy steered up hope for neuroprotective effects of hyperketonemia in Parkinson's disease (PD). There are multiple theoretical reasons but very little actual experimental proof or clinical trials. We examined the long-term effects of the ketogenic diet in an animal model of early PD. Read More

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Jabuticaba [ (O. Berg) Kausel] Protects Liver of Diabetic Rats Against Mitochondrial Dysfunction and Oxidative Stress Through the Modulation of SIRT3 Expression.

Front Physiol 2021 6;12:665747. Epub 2021 Jul 6.

Laboratório de Estresse Oxidativo e Antioxidantes, Instituto de Biotecnologia, Universidade de Caxias do Sul (UCS), Caxias do Sul, Brazil.

Complications generated by hyperglycemia present in diabetes mellitus (DM) have been constantly related to oxidative stress and dysfunction in the mitochondrial electron transport chain (ETC). Sirtuin 3 (SIRT3), which is present in mitochondria, is responsible for regulating several proteins involved in metabolic homeostasis and oxidative stress. Studies have suggested alterations in the expression of SIRT3 in DM. Read More

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Maternal Rat Metabolomics: Amniotic Fluid and Placental Metabolic Profiling Workflows.

J Proteome Res 2021 Jul 20. Epub 2021 Jul 20.

UMR 1253 iBrain, Université de Tours, Inserm, Tours 37000, France.

Studying the metabolome of specific gestational compartments is of growing interest in the context of fetus developmental disorders. However, the metabolomes of the placenta and amniotic fluid (AF) are poorly characterized. Therefore, we present the validation of a fingerprinting methodology. Read More

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Curcumin Decreases Hippocampal Neurodegeneration and Nitro-Oxidative Damage to Plasma Proteins and Lipids Caused by Short-Term Exposure to Ozone.

Molecules 2021 Jul 3;26(13). Epub 2021 Jul 3.

Laboratorio de Neurofisiología, Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco ZC 44340, Mexico.

Neurodegeneration is the consequence of harmful events affecting the nervous system that lead to neuronal death. Toxic substances, including air pollutants, are capable of inducing neurodegeneration. Ozone (O) is the most oxidative toxic pollutant. Read More

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Dihydrosphingosine driven enrichment of sphingolipids attenuates TGFβ induced collagen synthesis in cardiac fibroblasts.

Int J Cardiol Heart Vasc 2021 Aug 6;35:100837. Epub 2021 Jul 6.

Biomarker Discovery Laboratory, Baker Heart and Diabetes Institute, Melbourne, Australia.

The sphingolipid de novo synthesis pathway, encompassing the sphingolipids, the enzymes and the cell membrane receptors, are being investigated for their role in diseases and as potential therapeutic targets. The intermediate sphingolipids such as dihydrosphingosine (dhSph) and sphingosine (Sph) have not been investigated due to them being thought of as precursors to other more active lipids such as ceramide (Cer) and sphingosine 1 phosphate (S1P). Here we investigated their effects in terms of collagen synthesis in primary rat neonatal cardiac fibroblasts (NCFs). Read More

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Delayed Meal Timing, a Breakfast Skipping Model, Increased Hepatic Lipid Accumulation and Adipose Tissue Weight by Disintegrating Circadian Oscillation in Rats Fed a High-Cholesterol Diet.

Front Nutr 2021 1;8:681436. Epub 2021 Jul 1.

Laboratory of Nutritional Biochemistry, Department of Applied Molecular Biosciences, Nagoya University, Nagoya, Japan.

To investigate whether shifted timing of eating, breakfast skipping, induces alterations in the circadian clock and abnormal lipid metabolism, we have established a delayed meal timing (DMT) protocol for rats, which started eating food 4 h delay. In the present study, control and DMT rats were fed a high-cholesterol diet during zeitgeber time (ZT) 12-24 and ZT 16-4, respectively. The DMT protocol increased the hepatic lipids and epididymal adipose tissue weight without changes in food intake and body weight. Read More

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Non-targeted metabonomics to investigate the differences in the properties of ginseng and American ginseng based on rapid resolution liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry.

J Sep Sci 2021 Jul 16. Epub 2021 Jul 16.

Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, 130117, P.R. China.

The basic properties of herbal medicines are cold, hot, warm, and cool. The differentiation of these properties is important for the diagnosis and treatment of diseases. Ginseng and American ginseng possess opposite properties of warm and cool, respectively. Read More

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A randomized open-label trial to evaluate the efficacy and safety of triple therapy with aspirin, atorvastatin, and nicorandil in hospitalised patients with SARS Cov-2 infection: A structured summary of a study protocol for a randomized controlled trial.

Trials 2021 Jul 15;22(1):451. Epub 2021 Jul 15.

Department of Internal Medicine, Dr. Rajendra Prasad Government Medical College, Tanda, Kangra, Himachal Pradesh, 176001, India.

Objectives: The pathophysiology of SARS-Cov-2 is characterized by inflammation, immune dysregulation, coagulopathy, and endothelial dysfunction. No single therapeutic agent can target all these pathophysiologic substrates. Moreover, the current therapies are not fully effective in reducing mortality in moderate and severe disease. Read More

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Specific amino acid supplementation rescues the heart from lipid overload-induced insulin resistance and contractile dysfunction by targeting the endosomal mTOR-v-ATPase axis.

Mol Metab 2021 Jul 13:101293. Epub 2021 Jul 13.

Departments of Genetics & Cell Biology and, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands; Departments of Clinical Genetics, Maastricht University Medical Center+, Maastricht, the Netherlands. Electronic address:

Objective: The diabetic heart is characterized by extensive lipid accumulation which often leads to cardiac contractile dysfunction. The underlying mechanism involves a pivotal role for vacuolar-type H-ATPase (v-ATPase, functioning as endosomal/lysosomal proton pump). Specifically, lipid oversupply to the heart causes disassembly of v-ATPase and endosomal deacidification. Read More

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[Mechanism of electroacupuncture for regulation of lipid production and improvement in obesity by mediating Wnt/ β-catenin pathway through activating SIRT1].

Zhongguo Zhen Jiu 2021 Jul;41(7):774-80

College of Acupuncture-Moxibustion, Orthopedics and Traumatology, Hubei University of CM/Hubei Provincial Cooperative Innovation Center of Acupuncture and Moxibustion for Disease Prevention, Wuhan 430061, China.

Objective: To explore the mechanism of electroacupuncture (EA) for the regulation of lipid production and improvement in obesity by mediating Wnt/β-catenin pathway through activating silent information regulator 1 (SIRT1).

Methods: Of 75 Wistar male rats, 10 rats were selected randomly as the normal group and fed with standard diet. The rest rats were fed with high-fat diet for 8 weeks to establish the obesity model. Read More

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High Fructose-Induced Hypertension and Renal Damage Are Exaggerated in Dahl Salt-Sensitive Rats via Renal Renin-Angiotensin System Activation.

J Am Heart Assoc 2021 Jul 14;10(14):e016543. Epub 2021 Jul 14.

Department of Internal Medicine and Rehabilitation Science Tohoku University Graduate School of Medicine Sendai Japan.

Background High-fructose diet (HFr) induces hypertension and renal damage. However, it has been unknown whether the HFr-induced hypertension and renal damage are exaggerated in subjects with salt sensitivity. We tested impacts of HFr in Dahl salt-sensitive (DS) and salt-resistant (DR) rats. Read More

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